Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome

Journal of Immunology

Volumn 182, Issue 10, 2009, Pages 6460-6469

  Duncan, Joseph A ^a   Gao, Xi ^a   Huang, Max Tze Han ^a,b   O'Connor, Brian P ^b   Thomas, Christopher E ^a   Willingham, Stephen B ^b   Bergstralh, Daniel T ^b   Jarvis, Gary A ^c   Sparling, P Frederick ^a   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE; CATHEPSIN B; COLLAGENASE 3; CRYOPYRIN; GELATINASE B; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GONORRHEA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MONOCYTE; MOUSE; NECROSIS; NEISSERIA CINEREA; NEISSERIA GONORRHOEAE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CATHEPSIN B; CYTOKINES; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HMGB1 PROTEIN; HUMANS; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MICE; MICE, KNOCKOUT; MONOCYTES; NECROSIS; NEISSERIA GONORRHOEAE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 70449448992     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802696     Document Type: Article

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