Integrin α5β1 Activates the NLRP3 Inflammasome by Direct Interaction with a Bacterial Surface Protein

Immunity

Volumn 36, Issue 5, 2012, Pages 755-768

  Jun, Hye Kyoung ^a   Lee, Sung Hoon ^b   Lee, Hae Ri ^a   Choi, Bong Kyu ^a  

^a Seoul National University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARGINYLGLYCYLASPARTIC ACID; BACTERIAL PROTEIN; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PHORBOL 13 ACETATE 12 MYRISTATE; TD92 PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; INTERNALIZATION; MACROPHAGE ACTIVATION; PERIPHERAL BLOOD MONONUCLEAR CELL; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; TRANSCRIPTION INITIATION; TREPONEMA DENTICOLA;

ADENOSINE TRIPHOSPHATE; BACTERIAL OUTER MEMBRANE PROTEINS; CARRIER PROTEINS; CASPASE 1; CELL DEATH; CELL LINE; HUMANS; INFLAMMASOMES; INFLAMMATION; INTEGRIN ALPHA5BETA1; INTERLEUKIN-1BETA; MACROPHAGES; POTASSIUM; RECEPTORS, PURINERGIC P2; TREPONEMA DENTICOLA; UP-REGULATION;

EID: 84861461121     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2012.05.002     Document Type: Article

References (29)

1. Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004, 20:319-325.
2. Arnaout M.A., Mahalingam B., Xiong J.P. Integrin structure, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 2005, 21:381-410.
3. Bauernfeind F.G., Horvath G., Stutz A., Alnemri E.S., MacDonald K., Speert D., Fernandes-Alnemri T., Wu J., Monks B.G., Fitzgerald K.A., et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 2009, 183:787-791.
4. Bellis S.L. Variant glycosylation: an underappreciated regulatory mechanism for beta1 integrins. Biochim. Biophys. Acta 2004, 1663:52-60.
5. Benko S., Philpott D.J., Girardin S.E. The microbial and danger signals that activate Nod-like receptors. Cytokine 2008, 43:368-373.
6. Bostanci N., Emingil G., Saygan B., Turkoglu O., Atilla G., Curtis M.A., Belibasakis G.N. Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. Clin. Exp. Immunol. 2009, 157:415-422.
7. Buensuceso C., de Virgilio M., Shattil S.J. Detection of integrin α IIbbeta 3 clustering in living cells. J. Biol. Chem. 2003, 278:15217-15224.
8. Chen X., Wang J., Fu B., Yu L. RGD-containing peptides trigger apoptosis in glomerular mesangial cells of adult human kidneys. Biochem. Biophys. Res. Commun. 1997, 234:594-599.
9. Cruz C.M., Rinna A., Forman H.J., Ventura A.L., Persechini P.M., Ojcius D.M. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J. Biol. Chem. 2007, 282:2871-2879.
10. Dinarello C.A. Blocking IL-1 in systemic inflammation. J. Exp. Med. 2005, 201:1355-1359.
11. Ferreira S.B., Trombone A.P., Repeke C.E., Cardoso C.R., Martins W., Santos C.F., Trevilatto P.C., Avila-Campos M.J., Campanelli A.P., Silva J.S., Garlet G.P. An interleukin-1beta (IL-1beta) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues. Infect. Immun. 2008, 76:3725-3734.
12. Fiser A., Sali A. Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol. 2003, 374:461-491.
13. Franchi L., Eigenbrod T., Muñoz-Planillo R., Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 2009, 10:241-247.
14. Hoffman H.M., Rosengren S., Boyle D.L., Cho J.Y., Nayar J., Mueller J.L., Anderson J.P., Wanderer A.A., Firestein G.S. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 2004, 364:1779-1785.
15. Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., Fitzgerald K.A., Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008, 9:847-856.
16. Isaji T., Sato Y., Zhao Y., Miyoshi E., Wada Y., Taniguchi N., Gu J. N-glycosylation of the β-propeller domain of the integrin α5 subunit is essential for α5β1 heterodimerization, expression on the cell surface, and its biological function. J. Biol. Chem. 2006, 281:33258-33267.
17. Jun H.K., Lee H.R., Lee S.H., Choi B.K. Mapping of the proinflammatory domains of MspTL of Treponema lecithinolyticum. Microbiology 2007, 153:2386-2392.
18. Jun H.K., Kang Y.M., Lee H.R., Lee S.H., Choi B.K. Highly conserved surface proteins of oral spirochetes as adhesins and potent inducers of proinflammatory and osteoclastogenic factors. Infect. Immun. 2008, 76:2428-2438.
19. + release. Am. J. Physiol. Cell Physiol. 2004, 286:C1100-C1108.
20. Liu C.M., Hou L.T., Wong M.Y., Rossomando E.F. Relationships between clinical parameters, Interleukin 1B and histopathologic findings of gingival tissue in periodontitis patients. Cytokine 1996, 8:161-167.
21. Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., Dixit V.M. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006, 440:228-232.
22. Martinon F., Mayor A., Tschopp J. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 2009, 27:229-265.
23. Miao E.A., Leaf I.A., Treuting P.M., Mao D.P., Dors M., Sarkar A., Warren S.E., Wewers M.D., Aderem A. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 2010, 11:1136-1142.
24. Netea M.G., Nold-Petry C.A., Nold M.F., Joosten L.A., Opitz B., van der Meer J.H., van de Veerdonk F.L., Ferwerda G., Heinhuis B., Devesa I., et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages. Blood 2009, 113:2324-2335.
25. Pétrilli V., Papin S., Dostert C., Mayor A., Martinon F., Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 2007, 14:1583-1589.
26. Roman J., Ritzenthaler J.D., Fenton M.J., Roser S., Schuyler W. Transcriptional regulation of the human interleukin 1beta gene by fibronectin: role of protein kinase C and activator protein 1 (AP-1). Cytokine 2000, 12:1581-1596.
27. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
28. Teles R., Sakellari D., Teles F., Konstantinidis A., Kent R., Socransky S., Haffajee A. Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota. J. Periodontol. 2010, 81:89-98.
29. Tschopp J., Schroder K. NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?. Nat. Rev. Immunol. 2010, 10:210-215.