Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

Cellular Microbiology

Volumn 12, Issue 8, 2010, Pages 1046-1063

  Mishra, Bibhuti B ^a,g   Moura Alves, Pedro ^b,c   Sonawane, Avinash ^d   Hacohen, Nir ^e,f   Griffiths, Gareth ^d   Moita, Luis F ^b   Anes, Elsa ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF OSLO   (Norway)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AG 85; BACTERIAL PROTEIN; BACTERIAL PROTEIN ESX1; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CRYOPYRIN; EARLY SECRETORY ANTIGENIC TARGET 6; IMMUNOSTIMULATING AGENT; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; CARRIER PROTEIN; CYTOSKELETON PROTEIN; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HOST CELL; HUMAN; HUMAN CELL; MACROPHAGE; MEMBRANE DAMAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUBERCULOSIS; BIOSYNTHESIS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PATHOGENICITY; SECRETION (PROCESS);

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CARRIER PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERLEUKIN-1BETA; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 77957133396     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2010.01450.x     Document Type: Article

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