메뉴 건너뛰기




Volumn 41, Issue 1, 2011, Pages 172-181

Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism

Author keywords

Borrelia; Caspase 1; IL 17

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 33;

EID: 78650390305     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040385     Document Type: Article
Times cited : (40)

References (54)
  • 1
    • 14844317314 scopus 로고    scopus 로고
    • Chemokines and toll-like receptors in Lyme disease pathogenesis
    • Guerau-de-Arellano, M. and Huber, B. T., Chemokines and toll-like receptors in Lyme disease pathogenesis. Trends Mol. Med. 2005. 11: 114-120.
    • (2005) Trends Mol. Med. , vol.11 , pp. 114-120
    • Guerau-de-Arellano, M.1    Huber, B.T.2
  • 3
    • 0035849985 scopus 로고    scopus 로고
    • Lyme disease
    • Steere, A. C., Lyme disease. N. Engl. J. Med. 2001. 345: 115-125.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 115-125
    • Steere, A.C.1
  • 4
    • 0029032419 scopus 로고
    • Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato
    • Balmelli, T. and Piffaretti, J. C., Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Res. Microbiol. 1995. 146: 329-340.
    • (1995) Res. Microbiol. , vol.146 , pp. 329-340
    • Balmelli, T.1    Piffaretti, J.C.2
  • 5
    • 0028891871 scopus 로고
    • Simultaneous presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients
    • Demaerschalck, I., Ben, M. A., De, K. M., Hoyois, B., Lobet, Y., Hoet, P., Bigaignon, G. et al., Simultaneous presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients. J. Clin. Microbiol. 1995. 33: 602-608.
    • (1995) J. Clin. Microbiol. , vol.33 , pp. 602-608
    • Demaerschalck, I.1    Ben, M.A.2    De, K.M.3    Hoyois, B.4    Lobet, Y.5    Hoet, P.6    Bigaignon, G.7
  • 6
    • 50949107248 scopus 로고    scopus 로고
    • Pattern of proinflammatory cytokine induction in RAW264.7 mouse macrophages is identical for virulent and attenuated Borrelia burgdorferi
    • Wang, G., Petzke, M. M., Iyer, R., Wu, H. and Schwartz, I., Pattern of proinflammatory cytokine induction in RAW264.7 mouse macrophages is identical for virulent and attenuated Borrelia burgdorferi. J. Immunol. 2008. 180: 8306-8315.
    • (2008) J. Immunol. , vol.180 , pp. 8306-8315
    • Wang, G.1    Petzke, M.M.2    Iyer, R.3    Wu, H.4    Schwartz, I.5
  • 7
    • 53649111609 scopus 로고    scopus 로고
    • Toll-like receptors: insights into their possible role in the pathogenesis of Lyme neuroborreliosis
    • Bernardino, A. L., Myers, T. A., Alvarez, X., Hasegawa, A. and Philipp, M. T., Toll-like receptors: insights into their possible role in the pathogenesis of Lyme neuroborreliosis. Infect. Immun. 2008. 76: 4385-4395.
    • (2008) Infect. Immun. , vol.76 , pp. 4385-4395
    • Bernardino, A.L.1    Myers, T.A.2    Alvarez, X.3    Hasegawa, A.4    Philipp, M.T.5
  • 8
    • 39349110576 scopus 로고    scopus 로고
    • Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    • Jones, K. L., Muellegger, R. R., Means, T. K., Lee, M., Glickstein, L. J., Damle, N., Sikand, V. K. et al., Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis. Clin. Infect. Dis. 2008. 46: 85-92.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 85-92
    • Jones, K.L.1    Muellegger, R.R.2    Means, T.K.3    Lee, M.4    Glickstein, L.J.5    Damle, N.6    Sikand, V.K.7
  • 9
    • 0034541221 scopus 로고    scopus 로고
    • Microbial lipopeptides induce the production of IL-17 in Th cells
    • Infante-Duarte, C., Horton, H. F., Byrne, M. C. and Kamradt, T., Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 2000. 165: 6107-6115.
    • (2000) J. Immunol. , vol.165 , pp. 6107-6115
    • Infante-Duarte, C.1    Horton, H.F.2    Byrne, M.C.3    Kamradt, T.4
  • 11
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    • Mariathasan, S. and Monack, D. M., Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat. Rev. Immunol. 2007. 7: 31-40.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 12
    • 68649102975 scopus 로고    scopus 로고
    • Mechanisms of interleukin-1beta release
    • Eder, C., Mechanisms of interleukin-1beta release. Immunobiology 2009, 214: 543-553.
    • (2009) Immunobiology , vol.214 , pp. 543-553
    • Eder, C.1
  • 15
    • 33646017449 scopus 로고    scopus 로고
    • Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes
    • Ozoren, N., Masumoto, J., Franchi, L., Kanneganti, T. D., Body-Malapel, M., Erturk, I., Jagirdar, R. et al., Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J. Immunol. 2006. 176: 4337-4342.
    • (2006) J. Immunol. , vol.176 , pp. 4337-4342
    • Ozoren, N.1    Masumoto, J.2    Franchi, L.3    Kanneganti, T.D.4    Body-Malapel, M.5    Erturk, I.6    Jagirdar, R.7
  • 16
    • 33645770203 scopus 로고    scopus 로고
    • The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
    • Zamboni, D. S., Kobayashi, K. S., Kohlsdorf, T., Ogura, Y., Long, E. M., Vance, R. E., Kuida, K. et al., The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat. Immunol. 2006. 7: 318-325.
    • (2006) Nat. Immunol. , vol.7 , pp. 318-325
    • Zamboni, D.S.1    Kobayashi, K.S.2    Kohlsdorf, T.3    Ogura, Y.4    Long, E.M.5    Vance, R.E.6    Kuida, K.7
  • 17
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. and Sallusto, F., Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 2007. 8: 942-949.
    • (2007) Nat. Immunol. , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 18
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • Bettelli, E., Oukka, M. and Kuchroo, V. K., T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 2007. 8: 345-350.
    • (2007) Nat. Immunol. , vol.8 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 19
    • 38149108323 scopus 로고    scopus 로고
    • T cell dependence of chronic destructive murine arthritis induced by repeated local activation of toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    • Joosten, L. A., Abdollahi-Roodsaz, S., Heuvelmans-Jacobs, M., Helsen, M. M., van den Bersselaar, L. A., Oppers-Walgreen, B., Koenders, M. I. and van den Berg, W. B., T cell dependence of chronic destructive murine arthritis induced by repeated local activation of toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17. Arthritis Rheum. 2008. 58: 98-108.
    • (2008) Arthritis Rheum. , vol.58 , pp. 98-108
    • Joosten, L.A.1    Abdollahi-Roodsaz, S.2    Heuvelmans-Jacobs, M.3    Helsen, M.M.4    van den Bersselaar, L.A.5    Oppers-Walgreen, B.6    Koenders, M.I.7    van den Berg, W.B.8
  • 20
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton, C., Brereton, C., Keogh, B., Mills, K. H. and Lavelle, E. C., A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 2006. 203: 1685-1691.
    • (2006) J. Exp. Med. , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 22
    • 39349110576 scopus 로고    scopus 로고
    • Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    • Jones, K. L., Muellegger, R. R., Means, T. K., Lee, M., Glickstein, L. J., Damle, N., Sikand, V. K. et al., Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis. Clin. Infect. Dis. 2008. 46: 85-92.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 85-92
    • Jones, K.L.1    Muellegger, R.R.2    Means, T.K.3    Lee, M.4    Glickstein, L.J.5    Damle, N.6    Sikand, V.K.7
  • 23
    • 27744446058 scopus 로고    scopus 로고
    • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    • Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005. 23: 479-490.
    • (2005) Immunity , vol.23 , pp. 479-490
    • Schmitz, J.1    Owyang, A.2    Oldham, E.3    Song, Y.4    Murphy, E.5    McClanahan, T.K.6    Zurawski, G.7
  • 25
    • 67651215923 scopus 로고    scopus 로고
    • The caspase 1 inflammasome is not required for control of murine Lyme borreliosis
    • Liu, N., Belperron, A. A., Booth, C. J. and Bockenstedt, L. K., The caspase 1 inflammasome is not required for control of murine Lyme borreliosis. Infect. Immun. 2009. 77: 3320-3327.
    • (2009) Infect. Immun. , vol.77 , pp. 3320-3327
    • Liu, N.1    Belperron, A.A.2    Booth, C.J.3    Bockenstedt, L.K.4
  • 26
    • 53149091314 scopus 로고    scopus 로고
    • Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway
    • Collins, C., Shi, C., Russell, J. Q., Fortner, K. A. and Budd, R. C., Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway. J. Immunol. 2008. 181: 2392-2398.
    • (2008) J. Immunol. , vol.181 , pp. 2392-2398
    • Collins, C.1    Shi, C.2    Russell, J.Q.3    Fortner, K.A.4    Budd, R.C.5
  • 27
    • 0035370232 scopus 로고    scopus 로고
    • Murine Lyme disease: no evidence for active immune down-regulation in resolving or subclinical infection
    • Montgomery, R. R., Wang, X. M. and Malawista, S. E., Murine Lyme disease: no evidence for active immune down-regulation in resolving or subclinical infection. J. Infect. Dis. 2001. 183: 1631-1637.
    • (2001) J. Infect. Dis. , vol.183 , pp. 1631-1637
    • Montgomery, R.R.1    Wang, X.M.2    Malawista, S.E.3
  • 29
  • 30
    • 0033045395 scopus 로고    scopus 로고
    • Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon
    • Brown, C. R. and Reiner, S. L., Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon. Infect. Immun. 1999. 67: 3329-3333.
    • (1999) Infect. Immun. , vol.67 , pp. 3329-3333
    • Brown, C.R.1    Reiner, S.L.2
  • 31
    • 0035001193 scopus 로고    scopus 로고
    • Gamma interferon is not required for arthritis resistance in the murine Lyme disease model
    • Glickstein, L., Edelstein, M. and Dong, J. Z., Gamma interferon is not required for arthritis resistance in the murine Lyme disease model. Infect. Immun. 2001. 69: 3737-3743.
    • (2001) Infect. Immun. , vol.69 , pp. 3737-3743
    • Glickstein, L.1    Edelstein, M.2    Dong, J.Z.3
  • 32
    • 39349110576 scopus 로고    scopus 로고
    • Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    • Jones, K. L., Muellegger, R. R., Means, T. K., Lee, M., Glickstein, L. J., Damle, N., Sikand, V. K. et al., Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis. Clin. Infect. Dis. 2008. 46: 85-92.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 85-92
    • Jones, K.L.1    Muellegger, R.R.2    Means, T.K.3    Lee, M.4    Glickstein, L.J.5    Damle, N.6    Sikand, V.K.7
  • 33
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D. and Fathman, C. G., Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996. 156: 5-7.
    • (1996) J. Immunol. , vol.156 , pp. 5-7
    • Ferber, I.A.1    Brocke, S.2    Taylor-Edwards, C.3    Ridgway, W.4    Dinisco, C.5    Steinman, L.6    Dalton, D.7    Fathman, C.G.8
  • 34
    • 0034660492 scopus 로고    scopus 로고
    • Cutting edge: T cell-mediated pathology in murine Lyme borreliosis
    • McKisic, M. D., Redmond, W. L. and Barthold, S. W., Cutting edge: T cell-mediated pathology in murine Lyme borreliosis. J. Immunol. 2000. 164: 6096-6099.
    • (2000) J. Immunol. , vol.164 , pp. 6096-6099
    • McKisic, M.D.1    Redmond, W.L.2    Barthold, S.W.3
  • 35
    • 0025789064 scopus 로고
    • Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis
    • Yssel, H., Shanafelt, M. C., Soderberg, C., Schneider, P. V., Anzola, J. and Peltz, G., Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J. Exp. Med. 1991. 174: 593-601.
    • (1991) J. Exp. Med. , vol.174 , pp. 593-601
    • Yssel, H.1    Shanafelt, M.C.2    Soderberg, C.3    Schneider, P.V.4    Anzola, J.5    Peltz, G.6
  • 36
    • 39349110576 scopus 로고    scopus 로고
    • Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis
    • Jones, K. L., Muellegger, R. R., Means, T. K., Lee, M., Glickstein, L. J., Damle, N., Sikand, V. K., Luster, A. D. and Steere, A. C., Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis. Clin. Infect. Dis. 2008. 46: 85-92.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 85-92
    • Jones, K.L.1    Muellegger, R.R.2    Means, T.K.3    Lee, M.4    Glickstein, L.J.5    Damle, N.6    Sikand, V.K.7    Luster, A.D.8    Steere, A.C.9
  • 37
    • 33846231052 scopus 로고    scopus 로고
    • IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation
    • Dame, T. M., Orenzoff, B. L., Palmer, L. E. and Furie, M. B., IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation. J. Immunol. 2007. 178: 1172-1179.
    • (2007) J. Immunol. , vol.178 , pp. 1172-1179
    • Dame, T.M.1    Orenzoff, B.L.2    Palmer, L.E.3    Furie, M.B.4
  • 38
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y., et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 1133-1141.
    • (2005) Nat. Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6    Wang, Y.7
  • 40
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung, Y., Chang, S. H., Martinez, G. J., Yang, X. O., Nurieva, R., Kang, H. S., Ma, L. et al., Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 2009. 30: 576-587.
    • (2009) Immunity , vol.30 , pp. 576-587
    • Chung, Y.1    Chang, S.H.2    Martinez, G.J.3    Yang, X.O.4    Nurieva, R.5    Kang, H.S.6    Ma, L.7
  • 42
    • 0033926254 scopus 로고    scopus 로고
    • Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
    • Chabaud, M., Garnero, P., Dayer, J. M., Guerne, P. A., Fossiez, F. and Miossec, P., Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 2000. 12: 1092-1099.
    • (2000) Cytokine , vol.12 , pp. 1092-1099
    • Chabaud, M.1    Garnero, P.2    Dayer, J.M.3    Guerne, P.A.4    Fossiez, F.5    Miossec, P.6
  • 44
    • 9144225574 scopus 로고    scopus 로고
    • + T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody
    • + T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody. Clin. Diagn. Lab Immunol. 2004. 11: 1075-1084.
    • (2004) Clin. Diagn. Lab Immunol. , vol.11 , pp. 1075-1084
    • Nardelli, D.T.1    Burchill, M.A.2    England, D.M.3    Torrealba, J.4    Callister, S.M.5    Schell, R.F.6
  • 46
    • 67049158193 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    • Cayrol, C. and Girard, J. P., The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc. Natl. Acad. Sci. USA 2009. 106: 9021-9026.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9021-9026
    • Cayrol, C.1    Girard, J.P.2
  • 47
    • 67651053209 scopus 로고    scopus 로고
    • Interleukin-33 is biologically active independently of caspase-1 cleavage
    • Talabot-Ayer, D., Lamacchia, C., Gabay, C. and Palmer, G., Interleukin-33 is biologically active independently of caspase-1 cleavage. J. Biol. Chem. 2009, 284: 19420-19426.
    • (2009) J. Biol. Chem. , vol.284 , pp. 19420-19426
    • Talabot-Ayer, D.1    Lamacchia, C.2    Gabay, C.3    Palmer, G.4
  • 48
    • 73949088791 scopus 로고    scopus 로고
    • Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation
    • Ali, S., Nguyen, D. Q., Falk, W. and Martin, M. U., Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation. Biochem. Biophys. Res. Commun. 2010. 391: 1512-1516.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 1512-1516
    • Ali, S.1    Nguyen, D.Q.2    Falk, W.3    Martin, M.U.4
  • 50
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme
    • Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S. and Flavell, R. A., Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995. 267: 2000-2003.
    • (1995) Science , vol.267 , pp. 2000-2003
    • Kuida, K.1    Lippke, J.A.2    Ku, G.3    Harding, M.W.4    Livingston, D.J.5    Su, M.S.6    Flavell, R.A.7
  • 54
    • 73249144903 scopus 로고    scopus 로고
    • Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    • Joosten, L. A., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M., Sparrer, H., Pham, C. T. et al., Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum. 2009. 60: 3651-3662.
    • (2009) Arthritis Rheum. , vol.60 , pp. 3651-3662
    • Joosten, L.A.1    Netea, M.G.2    Fantuzzi, G.3    Koenders, M.I.4    Helsen, M.M.5    Sparrer, H.6    Pham, C.T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.