Glycine receptor mouse mutants: Model systems for human hyperekplexia

British Journal of Pharmacology

Volumn 170, Issue 5, 2013, Pages 933-952

  Schaefer, Natascha ^a   Langlhofer, Georg ^a   Kluck, Christoph J ^b   Villmann, Carmen ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

domain complementation; glycine receptor; knock in; mouse models; spontaneous

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BETA ALANINE; CHLORDIAZEPOXIDE; CLONAZEPAM; ENDOCANNABINOID; GLYCINE RECEPTOR; GLYCINE TRANSPORTER 2; INHALATION ANESTHETIC AGENT; IVERMECTIN; PHENOBARBITAL; PICROTOXIN; SESTERTERPENE; STRYCHNINE; TAURINE; TUBOCURARINE CHLORIDE; ZINC ION;

ALLOSTERISM; AUTOSOMAL DOMINANT INHERITANCE; AUTOSOMAL RECESSIVE INHERITANCE; EXTRACELLULAR DOMAIN; GENE TARGETING; GENE THERAPY; GLRA1 GENE; GLRB GENE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPEREKPLEXIA; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MOUSE MODEL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; RIGHTING REFLEX; SIGNAL TRANSDUCTION; SPONTANEOUS MUTATION; STARTLE REFLEX; SYNAPTOSOME; TRANSGENIC MOUSE;

DOMAIN COMPLEMENTATION; GLYCINE RECEPTOR; KNOCK-IN; MOUSE MODELS; SPONTANEOUS;

ANIMALS; DISEASE MODELS, ANIMAL; GAMMA-AMINOBUTYRIC ACID; GENETIC PREDISPOSITION TO DISEASE; GLYCINE; HUMANS; MICE; MICE, MUTANT STRAINS; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PRESYNAPTIC TERMINALS; PROTEIN CONFORMATION; RECEPTORS, GLYCINE; STIFF-PERSON SYNDROME; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC TRANSMISSION;

EID: 84885619985     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12335     Document Type: Review

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