-
1
-
-
13444271681
-
Refined structure of the nicotinic acetylcholine receptor at 4 resolution
-
Unwin, N. Refined structure of the nicotinic acetylcholine receptor at 4 resolution. J. Mol. Biol. 346, 967-989 (2005).
-
(2005)
J. Mol. Biol
, vol.346
, pp. 967-989
-
-
Unwin, N.1
-
2
-
-
0035902009
-
Crystal structure of an Ach-binding protein reveals the ligand-binding domain of nicotinic receptors
-
Brejc, K. et al. Crystal structure of an Ach-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411, 269-276 (2001).
-
(2001)
Nature
, vol.411
, pp. 269-276
-
-
Brejc, K.1
-
3
-
-
33745860948
-
Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses
-
Chen, Y., Reilly, K. & Chang, Y. Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses. J. Biol. Chem. 281, 18184-18192 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 18184-18192
-
-
Chen, Y.1
Reilly, K.2
Chang, Y.3
-
4
-
-
26944481188
-
Interfaces and the driving force of hydrophobic assembly
-
Chandler, D. Interfaces and the driving force of hydrophobic assembly. Nature 437, 640-647 (2005).
-
(2005)
Nature
, vol.437
, pp. 640-647
-
-
Chandler, D.1
-
5
-
-
17544372511
-
Nicotinic receptors at the amino acid level
-
Corringer, P.J., Le, N.N. & Changeux, J.P. Nicotinic receptors at the amino acid level. Annu. Rev. Pharmacol. Toxicol. 40, 431-458 (2000).
-
(2000)
Annu. Rev. Pharmacol. Toxicol
, vol.40
, pp. 431-458
-
-
Corringer, P.J.1
Le, N.N.2
Changeux, J.P.3
-
6
-
-
2542432136
-
Cys-loop receptors: New twists and turns
-
Lester, H.A., Dibas, M.I., Dahan, D.S., Leite, J.F. & Dougherty, D.A. Cys-loop receptors: new twists and turns. Trends Neurosci. 27, 329-336 (2004).
-
(2004)
Trends Neurosci
, vol.27
, pp. 329-336
-
-
Lester, H.A.1
Dibas, M.I.2
Dahan, D.S.3
Leite, J.F.4
Dougherty, D.A.5
-
7
-
-
33645302360
-
Recent advances in Cys-loop receptor structure and function
-
Sine, S.M. & Engel, A.G. Recent advances in Cys-loop receptor structure and function. Nature 440, 448-455 (2006).
-
(2006)
Nature
, vol.440
, pp. 448-455
-
-
Sine, S.M.1
Engel, A.G.2
-
8
-
-
18744363916
-
A gating mechanism proposed from a simulation of a human α7 nicotinic acetylcholine receptor
-
Law, R.J., Henchman, R.H. & McCammon, J.A. A gating mechanism proposed from a simulation of a human α7 nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA 102, 6813-6818 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6813-6818
-
-
Law, R.J.1
Henchman, R.H.2
McCammon, J.A.3
-
9
-
-
1842475289
-
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures
-
Celie, P.H. et al. Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41, 907-914 (2004).
-
(2004)
Neuron
, vol.41
, pp. 907-914
-
-
Celie, P.H.1
-
10
-
-
0042355340
-
Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors
-
Lyford, L.K., Sproul, A.D., Eddins, D., McLaughlin, J.T. & Rosenberg, R.L. Agonist-induced conformational changes in the extracellular domain of α7 nicotinic acetylcholine receptors. Mol. Pharmacol. 64, 650-658 (2003).
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 650-658
-
-
Lyford, L.K.1
Sproul, A.D.2
Eddins, D.3
McLaughlin, J.T.4
Rosenberg, R.L.5
-
11
-
-
33745263765
-
Role of the outer β-sheet in divalent cation modulation of α7 nicotinic receptors
-
McLaughlin, J.T., Fu, J., Sproul, A.D. & Rosenberg, R.L. Role of the outer β-sheet in divalent cation modulation of α7 nicotinic receptors. Mol. Pharmacol. 70, 16-22 (2006).
-
(2006)
Mol. Pharmacol
, vol.70
, pp. 16-22
-
-
McLaughlin, J.T.1
Fu, J.2
Sproul, A.D.3
Rosenberg, R.L.4
-
12
-
-
34247536305
-
Agonist-driven conformational changes in the inner β-sheet of α7 nicotinic receptors
-
McLaughlin, J.T., Fu, J. & Rosenberg, R.L. Agonist-driven conformational changes in the inner β-sheet of α7 nicotinic receptors. Mol. Pharmacol. 71, 1312-1318 (2007).
-
(2007)
Mol. Pharmacol
, vol.71
, pp. 1312-1318
-
-
McLaughlin, J.T.1
Fu, J.2
Rosenberg, R.L.3
-
13
-
-
36549080807
-
Acetylcholine receptor gating: Movement in the α-subunit extracellular domain
-
Purohit, P. & Auerbach, A. Acetylcholine receptor gating: movement in the α-subunit extracellular domain. J. Gen. Physiol. 130, 569-579 (2007).
-
(2007)
J. Gen. Physiol
, vol.130
, pp. 569-579
-
-
Purohit, P.1
Auerbach, A.2
-
14
-
-
34547520128
-
Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 resolution
-
Dellisanti, C.D., Yao, Y., Stroud, J.C., Wang, Z.Z. & Chen, L. Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 resolution. Nat. Neurosci. 10, 953-962 (2007).
-
(2007)
Nat. Neurosci
, vol.10
, pp. 953-962
-
-
Dellisanti, C.D.1
Yao, Y.2
Stroud, J.C.3
Wang, Z.Z.4
Chen, L.5
-
15
-
-
1842686239
-
Gating dynamics of the acetylcholine receptor extracellular domain
-
Chakrapani, S., Bailey, T.D. & Auerbach, A. Gating dynamics of the acetylcholine receptor extracellular domain. J. Gen. Physiol. 123, 341-356 (2004).
-
(2004)
J. Gen. Physiol
, vol.123
, pp. 341-356
-
-
Chakrapani, S.1
Bailey, T.D.2
Auerbach, A.3
-
16
-
-
0036304564
-
Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits
-
Unwin, N., Miyazawa, A., Li, J. & Fujiyoshi, Y. Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits. J. Mol. Biol. 319, 1165-1176 (2002).
-
(2002)
J. Mol. Biol
, vol.319
, pp. 1165-1176
-
-
Unwin, N.1
Miyazawa, A.2
Li, J.3
Fujiyoshi, Y.4
-
17
-
-
34247536305
-
Agonist-driven conformational changes in the inner β-sheet of α7 nicotinic receptors
-
McLaughlin, J.T., Fu, J. & Rosenberg, R.L. Agonist-driven conformational changes in the inner β-sheet of α7 nicotinic receptors. Mol. Pharmacol. 71, 1312-1318 (2007).
-
(2007)
Mol. Pharmacol
, vol.71
, pp. 1312-1318
-
-
McLaughlin, J.T.1
Fu, J.2
Rosenberg, R.L.3
-
18
-
-
33750942341
-
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors
-
Taly, A. et al. Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors. Proc. Natl. Acad. Sci. USA 103, 16965-16970 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16965-16970
-
-
Taly, A.1
-
19
-
-
34247109679
-
An intersubunit trigger of channel gating in the muscle nicotinic receptor
-
Mukhtasimova, N. & Sine, S.M. An intersubunit trigger of channel gating in the muscle nicotinic receptor. J. Neurosci. 27, 4110-4119 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 4110-4119
-
-
Mukhtasimova, N.1
Sine, S.M.2
-
20
-
-
33750978141
-
2+ as an essential endogenous modulator of glycinergic neurotransmission
-
2+ as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52, 679-690 (2006).
-
(2006)
Neuron
, vol.52
, pp. 679-690
-
-
Hirzel, K.1
-
22
-
-
0028943569
-
Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors
-
Laube, B. et al. Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. J. Physiol. (Lond.) 483, 613-619 (1995).
-
(1995)
J. Physiol. (Lond.)
, vol.483
, pp. 613-619
-
-
Laube, B.1
-
23
-
-
27844445687
-
Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
-
Miller, P.S., Da Silva, H.M. & Smart, T.G. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J. Biol. Chem. 280, 37877-37884 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 37877-37884
-
-
Miller, P.S.1
Da Silva, H.M.2
Smart, T.G.3
-
25
-
-
0041706182
-
Insights into the structural basis for zinc inhibition of the glycine receptor
-
Nevin, S.T. et al. Insights into the structural basis for zinc inhibition of the glycine receptor. J. Biol. Chem. 278, 28985-28992 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 28985-28992
-
-
Nevin, S.T.1
-
27
-
-
22144470470
-
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant
-
Celie, P.H. et al. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant. Nat. Struct. Mol. Biol. 12, 582-588 (2005).
-
(2005)
Nat. Struct. Mol. Biol
, vol.12
, pp. 582-588
-
-
Celie, P.H.1
-
28
-
-
0029969731
-
Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor
-
Fu, D.X. & Sine, S.M. Asymmetric contribution of the conserved disulfide loop to subunit oligomerization and assembly of the nicotinic acetylcholine receptor. J. Biol. Chem. 271, 31479-31484 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 31479-31484
-
-
Fu, D.X.1
Sine, S.M.2
-
29
-
-
0027136282
-
Comparative protein modelling by satisfaction of spatial restraints
-
Sali, A. & Blundell, T.L. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815 (1993).
-
(1993)
J. Mol. Biol
, vol.234
, pp. 779-815
-
-
Sali, A.1
Blundell, T.L.2
-
30
-
-
0034758221
-
Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β-amino acid agonist, taurine
-
Han, N.L., Haddrill, J.L. & Lynch, J.W. Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β-amino acid agonist, taurine. J. Neurochem. 79, 636-647 (2001).
-
(2001)
J. Neurochem
, vol.79
, pp. 636-647
-
-
Han, N.L.1
Haddrill, J.L.2
Lynch, J.W.3
-
31
-
-
0034650875
-
2+ modulation of recombinant human inhibitory glycine receptors
-
2+ modulation of recombinant human inhibitory glycine receptors. J. Physiol. (Lond.) 522, 215-230 (2000).
-
(2000)
J. Physiol. (Lond.)
, vol.522
, pp. 215-230
-
-
Laube, B.1
Kuhse, J.2
Betz, H.3
-
32
-
-
0035690880
-
Zinc coordination sphere in biochemical zinc sites
-
Auld, D.S. Zinc coordination sphere in biochemical zinc sites. Biometals 14, 271-313 (2001).
-
(2001)
Biometals
, vol.14
, pp. 271-313
-
-
Auld, D.S.1
-
33
-
-
33846341182
-
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor
-
Cashin, A.L., Torrice, M.M., McMenimen, K.A., Lester, H.A. & Dougherty, D.A. Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. Biochemistry 46, 630-639 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 630-639
-
-
Cashin, A.L.1
Torrice, M.M.2
McMenimen, K.A.3
Lester, H.A.4
Dougherty, D.A.5
-
34
-
-
0025247748
-
Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses
-
Lerma, J., Zukin, R.S. & Bennett, M.V. Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses. Proc. Natl. Acad. Sci. USA 87, 2354-2358 (1990).
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 2354-2358
-
-
Lerma, J.1
Zukin, R.S.2
Bennett, M.V.3
-
35
-
-
14644414132
-
The β subunit determines the ligand binding properties of synaptic glycine receptors
-
Grudzinska, J. et al. The β subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45, 727-739 (2005).
-
(2005)
Neuron
, vol.45
, pp. 727-739
-
-
Grudzinska, J.1
-
37
-
-
0035999833
-
Openings of the rat recombinant α 1 homomeric glycine receptor as a function of the number of agonist molecules bound
-
Beato, M., Groot-Kormelink, P.J., Colquhoun, D. & Sivilotti, L.G. Openings of the rat recombinant α 1 homomeric glycine receptor as a function of the number of agonist molecules bound. J. Gen. Physiol. 119, 443-466 (2002).
-
(2002)
J. Gen. Physiol
, vol.119
, pp. 443-466
-
-
Beato, M.1
Groot-Kormelink, P.J.2
Colquhoun, D.3
Sivilotti, L.G.4
-
38
-
-
33749578940
-
Statistical potential for assessment and prediction of protein structures
-
Shen, M.Y. & Sali, A. Statistical potential for assessment and prediction of protein structures. Protein Sci. 15, 2507-2524 (2006).
-
(2006)
Protein Sci
, vol.15
, pp. 2507-2524
-
-
Shen, M.Y.1
Sali, A.2
-
39
-
-
0028402735
-
The energetic ups and downs of protein folding
-
Creighton, T.E. The energetic ups and downs of protein folding. Nat. Struct. Biol. 1, 135-138 (1994).
-
(1994)
Nat. Struct. Biol
, vol.1
, pp. 135-138
-
-
Creighton, T.E.1
-
40
-
-
0027439867
-
Proline-dependent structural and biological properties of peptides and proteins
-
Yaron, A. & Naider, F. Proline-dependent structural and biological properties of peptides and proteins. Crit. Rev. Biochem. Mol. Biol. 28, 31-81 (1993).
-
(1993)
Crit. Rev. Biochem. Mol. Biol
, vol.28
, pp. 31-81
-
-
Yaron, A.1
Naider, F.2
-
41
-
-
34247109679
-
An intersubunit trigger of channel gating in the muscle nicotinic receptor
-
Mukhtasimova, N. & Sine, S.M. An intersubunit trigger of channel gating in the muscle nicotinic receptor. J. Neurosci. 27, 4110-4119 (2007).
-
(2007)
J. Neurosci
, vol.27
, pp. 4110-4119
-
-
Mukhtasimova, N.1
Sine, S.M.2
-
42
-
-
0037448581
-
Coupling of agonist binding to channel gating in the GABA(A) receptor
-
Kash, T.L., Jenkins, A., Kelley, J.C., Trudell, J.R. & Harrison, N.L. Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature 421, 272-275 (2003).
-
(2003)
Nature
, vol.421
, pp. 272-275
-
-
Kash, T.L.1
Jenkins, A.2
Kelley, J.C.3
Trudell, J.R.4
Harrison, N.L.5
-
43
-
-
27744438169
-
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
-
Lee, W.Y. & Sine, S.M. Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature 438, 243-247 (2005).
-
(2005)
Nature
, vol.438
, pp. 243-247
-
-
Lee, W.Y.1
Sine, S.M.2
-
44
-
-
27744608733
-
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel
-
Lummis, S.C. et al. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature 438, 248-252 (2005).
-
(2005)
Nature
, vol.438
, pp. 248-252
-
-
Lummis, S.C.1
-
45
-
-
0037169532
-
2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions
-
2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions. J. Biol. Chem. 277, 2931-2937 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 2931-2937
-
-
Boileau, A.J.1
Newell, J.G.2
Czajkowski, C.3
-
46
-
-
0242583056
-
The role of loop 5 in acetylcholine receptor channel gating
-
Chakrapani, S., Bailey, T.D. & Auerbach, A. The role of loop 5 in acetylcholine receptor channel gating. J. Gen. Physiol. 122, 521-539 (2003).
-
(2003)
J. Gen. Physiol
, vol.122
, pp. 521-539
-
-
Chakrapani, S.1
Bailey, T.D.2
Auerbach, A.3
-
47
-
-
0034677524
-
Mapping the conformational wave of acetylcholine receptor channel gating
-
Grosman, C., Zhou, M. & Auerbach, A. Mapping the conformational wave of acetylcholine receptor channel gating. Nature 403, 773-776 (2000).
-
(2000)
Nature
, vol.403
, pp. 773-776
-
-
Grosman, C.1
Zhou, M.2
Auerbach, A.3
-
49
-
-
18744410192
-
Ligand-induced conformational change in the α7 nicotinic receptor ligand binding domain
-
Henchman, R.H., Wang, H.L., Sine, S.M., Taylor, P. & McCammon, J.A. Ligand-induced conformational change in the α7 nicotinic receptor ligand binding domain. Biophys. J. 88, 2564-2576 (2005).
-
(2005)
Biophys. J
, vol.88
, pp. 2564-2576
-
-
Henchman, R.H.1
Wang, H.L.2
Sine, S.M.3
Taylor, P.4
McCammon, J.A.5
-
50
-
-
0032868182
-
A novel domain of the inhibitory glycine receptor determining antagonist efficacies: Further evidence for partial agonism resulting from self-inhibition
-
Schmieden, V., Kuhse, J. & Betz, H. A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition. Mol. Pharmacol. 56, 464-472 (1999).
-
(1999)
Mol. Pharmacol
, vol.56
, pp. 464-472
-
-
Schmieden, V.1
Kuhse, J.2
Betz, H.3
-
51
-
-
0036830645
-
Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism
-
Chang, Y. & Weiss, D.S. Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism. Nat. Neurosci. 5, 1163-1168 (2002).
-
(2002)
Nat. Neurosci
, vol.5
, pp. 1163-1168
-
-
Chang, Y.1
Weiss, D.S.2
-
52
-
-
0030746608
-
High-affinity zinc inhibition of NMDA NR1-NR2A receptors
-
Paoletti, P., Ascher, P. & Neyton, J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J. Neurosci. 17, 5711-5725 (1997).
-
(1997)
J. Neurosci
, vol.17
, pp. 5711-5725
-
-
Paoletti, P.1
Ascher, P.2
Neyton, J.3
-
53
-
-
0022272338
-
Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate
-
Colquhoun, D. & Sakmann, B. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J. Physiol. (Lond.) 369, 501-557 (1985).
-
(1985)
J. Physiol. (Lond.)
, vol.369
, pp. 501-557
-
-
Colquhoun, D.1
Sakmann, B.2
-
54
-
-
0027968068
-
CLUSTALW: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson, J.D., Higgins, D.G. & Gibson, T.J. CLUSTALW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (1994).
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
55
-
-
0031715982
-
Protein structure alignment by incremental combinatorial extension (CE) of the optimal path
-
Shindyalov, I.N. & Bourne, P.E. Protein structure alignment by incremental combinatorial extension (CE) of the optimal path. Protein Eng. 11, 739-747 (1998).
-
(1998)
Protein Eng
, vol.11
, pp. 739-747
-
-
Shindyalov, I.N.1
Bourne, P.E.2
-
56
-
-
4444221565
-
UCSF Chimera - a visualization system for exploratory research and analysis
-
Pettersen, E.F. et al. UCSF Chimera - a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605-1612 (2004).
-
(2004)
J. Comput. Chem
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
-
57
-
-
0042511005
-
A graph-theory algorithm for rapid protein side-chain prediction
-
Canutescu, A.A., Shelenkov, A.A. & Dunbrack, R.L., Jr. A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci. 12, 2001-2014 (2003).
-
(2003)
Protein Sci
, vol.12
, pp. 2001-2014
-
-
Canutescu, A.A.1
Shelenkov, A.A.2
Dunbrack Jr., R.L.3
-
58
-
-
34547592557
-
MolProbity: All-atom contacts and structure validation for proteins and nucleic acids
-
Davis, I.W. et al. MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res. 35, W375-W383 (2007).
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Davis, I.W.1
-
59
-
-
0033578684
-
Protein secondary structure prediction based on position-specific scoring matrices
-
Jones, D.T. Protein secondary structure prediction based on position-specific scoring matrices. J. Mol. Biol. 292, 195-202 (1999).
-
(1999)
J. Mol. Biol
, vol.292
, pp. 195-202
-
-
Jones, D.T.1
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