Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 2, 2012, Pages 317-329

  Blednov, Yuri A ^a   Benavidez, Jill M ^a   Homanics, Gregg E ^b   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ALCOHOL; BUTANOL; FLURAZEPAM; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1 SUBUNIT; KETAMINE; PENTOBARBITAL; STRYCHNINE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG DEPENDENCE; DRUG SENSITIVITY; FEMALE; GENE MUTATION; GENE TARGETING; HETEROZYGOTE; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RIGHTING REFLEX; ROTAROD TEST; SEIZURE; STARTLE REFLEX; TASTE AVERSION; WILD TYPE;

1-BUTANOL; ALCOHOL DRINKING; ALCOHOL WITHDRAWAL SEIZURES; AMINO ACID SUBSTITUTION; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, CLASSICAL; DRUG SYNERGISM; EATING; ETHANOL; FEMALE; FOOD PREFERENCES; GENE KNOCK-IN TECHNIQUES; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR SKILLS; MUTATION; N-METHYLASPARTATE; NICOTINE; PENTYLENETETRAZOLE; QUININE; RECEPTORS, GLYCINE; REFLEX, RIGHTING; ROTAROD PERFORMANCE TEST; SACCHARIN; SEIZURES; SEX CHARACTERISTICS; STARTLE REACTION; STRYCHNINE; TASTE PERCEPTION;

EID: 84856014926     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.185124     Document Type: Article

References (45)

1. Aguayo LG and Pancetti FC (1994) Ethanol modulation of the -aminobutyric acid A-and glycine-activated Cl- current in cultured mouse neurons. J Pharmacol Exp Ther 270:61-69.
2. Akk G, Mennerick S, and Steinbach JH (2008) Actions of anesthetics on excitatory transmitter-gated channels. Handb Exp Pharmacol 53-84.
3. Albrecht J and Schousboe A (2005) Taurine interaction with neurotransmitter receptors in the CNS: an update. Neurochem Res 30:1615-1621. (Pubitemid 41813726)
4. Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff- Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, et al. (2011) Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABAA receptors. J Pharmacol Exp Ther 336: 145-154.
5. Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, and Harris RA (2003) Deletion of the α1 or β2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J Pharmacol Exp Ther 304:30-36. (Pubitemid 36008909)
6. Boehm SL 2nd, Ponomarev I, Blednov YA, and Harris RA (2006) From gene to behavior and back again: new perspectives on GABAA receptor subunit selectivity of alcohol actions. Adv Pharmacol 54:171-203.
7. Borghese CM, Blednov YA, Quan Y, Iyer SV, Postdoc, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, et al. (2012) Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols and anesthetics. J Pharmacol Exp Ther 340:304-316.
8. Bowers BJ, McClure-Begley TD, Keller JJ, Paylor R, Collins AC, and Wehner JM (2005) Deletion of the α7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol. Alcohol Clin Exp Res 29:295-302. (Pubitemid 40446119)
9. Celentano JJ, Gibbs TT, and Farb DH (1988) Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons. Brain Res 455:377- 380.
10. Crabbe JC, Merrill C, and Belknap JK (1991) Acute dependence on depressant drugs is determined by common genes in mice. J Pharmacol Exp Ther 257:663-667.
11. Eggers ED, O'Brien JA, and Berger AJ (2000) Developmental changes in the modulation of synaptic glycine receptors by ethanol. J Neurophysiol 84:2409-2416.
12. Enoch MA (2008) The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav 90:95-104.
13. Ericson M, Chau P, Clarke RB, Adermark L, and Söderpalm B (2011) Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration. Addict Biol 16:377-385.
14. Ericson M, Molander A, Stomberg R, and Söderpalm B (2006) Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine. Eur J Neurosci 23:3225-3229.
15. Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, and Harris RA (2003) Glycine receptor knock-in mice and hyperekplexia- like phenotypes: comparisons with the null mutant. J Neurosci 23:8051- 8059.
16. Findlay GS, Wick MJ, Mascia MP, Wallace D, Miller GW, Harris RA, and Blednov YA (2002) Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice. J Pharmacol Exp Ther 300:526-534.
17. Flood P and Krasowski MD (2000) Intravenous anesthetics differentially modulate ligand-gated ion channels. Anesthesiology 92:1418-1425. (Pubitemid 30257204)
18. Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, and Blednov YA (2011) Testing the silence of mutations: Transcriptomic and behavioral studies of GABAA receptor α1 and α2 subunit knock-in mice. Neurosci Lett 488:31-35.
19. Harrison NL and Simmonds MA (1985) Quantitative studies on some antagonists of N-methyl-D-aspartate in slices of rat cerebral cortex. Br J Pharmacol 84: 381-391. (Pubitemid 15169227)
20. Harvey RJ, Topf M, Harvey K, and Rees MI (2008) The genetics of hyperekplexia: more than startle! Trends Genet 24:439-447.
21. Hernandes MS and Troncone LR (2009) Glycine as a neurotransmitter in the forebrain: a short review. J Neural Transm 116:1551-1560.
22. Hevers W, Hadley SH, Lüddens H, and Amin J (2008) Ketamine, but not phencyclidine, selectively modulates cerebellar GABAA receptors containing α6 and δ subunits. J Neurosci 28:5383-5393.
23. Kling C, Koch M, Saul B, and Becker CM (1997) The frameshift mutation oscillator (Glra1(spd-ot)) produces a complete loss of glycine receptor α1-polypeptide in mouse central nervous system. Neuroscience 78:411-417. (Pubitemid 27170333)
24. Korkosz A, Zatorski P, Taracha E, Plaznik A, Kostowski W, and Bienkowski P (2006) Ethanol blocks nicotine-induced seizures in mice: comparison with midazolam and baclofen. Alcohol 40:151-157. (Pubitemid 46528101)
25. Legendre P (2001) The glycinergic inhibitory synapse. Cell Mol Life Sci 58:760-793.
26. Lewis MC and Gould TJ (2003) Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice. Pharmacol Biochem Behav 76:179-186. (Pubitemid 38366181)
27. Lundquist F (1959) The determination of ethyl alcohol in blood and tissue. Methods Biochem Anal 7:217-251.
28. Mascia MP, Machu TK, and Harris RA (1996) Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol 119: 1331-1336. (Pubitemid 26402009)
29. Matsubayashi H, Alkondon M, Pereira EF, Swanson KL, and Albuquerque EX (1998) Strychnine: a potent competitive antagonist of α-bungarotoxin- sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J Pharmacol Exp Ther 284: 904-913. (Pubitemid 28130816)
30. McCool BA and Chappell A (2007) Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent. Behav Brain Res 178:70-81. (Pubitemid 46240341)
31. McSwigan JD, Crabbe JC, and Young ER (1984) Specific ethanol withdrawal seizures in genetically selected mice. Life Sci 35:2119-2126. (Pubitemid 15211966)
32. Molander A, Lidö HH, Löf E, Ericson M, and Söderpalm B (2007) The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male Wistar rats. Alcohol Alcohol 42:11-18. (Pubitemid 46062634)
33. Molander A, Löf E, Stomberg R, Ericson M, and Söderpalm B (2005) Involvement of accumbal glycine receptors in the regulation of voluntary ethanol intake in the rat. Alcohol Clin Exp Res 29:38-45. (Pubitemid 40129209)
34. Molander A and Söderpalm B (2005) Glycine receptors regulate dopamine release in the rat nucleus accumbens. Alcohol Clin Exp Res 29:17-26. (Pubitemid 40129207)
35. Olive MF (2002) Interactions between taurine and ethanol in the central nervous system. Amino Acids 23:345-357.
36. Owens JC, Balogh SA, McClure-Begley TD, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, and Collins AC (2003) α4 β2*Nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. Alcohol Clin Exp Res 27:1867-1875. (Pubitemid 38005054)
37. Rajalu M, Müller UC, Caley A, Harvey RJ, and Poisbeau P (2009) Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor α3 subunit gene. Eur J Neurosci 30:2284-2292.
38. Sigel E and Lüscher BP (2011) A closer look at the high affinity benzodiazepine binding site on GABAA receptors. Curr Top Med Chem 11:241-246.
39. Takahashi T, Momiyama A, Hirai K, Hishinuma F, and Akagi H (1992) Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron 9:1155-1161. (Pubitemid 23007185)
40. Takazawa T and MacDermott AB (2010) Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons. J Physiol 588:2571-2587.
41. van den Pol AN and Gorcs T (1988) Glycine and glycine receptor immunoreactivity in brain and spinal cord. J Neurosci 8:472-492.
42. Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, and Spanagel R (2010) Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biol Psychiatry 68:704-711.
43. Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, et al. (2006) Knockin mice with ethanol-insensitive α1-containing γ-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther 319:219-227. (Pubitemid 44455126)
44. Williams KL, Ferko AP, Barbieri EJ, and DiGregorio GJ (1995) Glycine enhances the central depressant properties of ethanol in mice. Pharmacol Biochem Behav 50: 199-205.
45. Yamakura T and Harris RA (2000) Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 93:1095-1101.