Novel regulatory site within the TM3-4 loop of human recombinant α3 glycine receptors determines channel gating and domain structure

Journal of Biological Chemistry

Volumn 284, Issue 42, 2009, Pages 28624-28633

  Breitinger, Hans Georg ^a   Villmann, Carmen ^a   Melzer, Nima ^a   Rennert, Janine ^a   Breitinger, Ulrike ^a,c   Schwarzinger, Stephan ^b   Becker, Cord Michael ^a,d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF BAYREUTH   (Germany)

^c GERMAN UNIVERSITY IN CAIRO   (Egypt)

^d NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL NERVOUS SYSTEMS; CHANNEL GATING; CHARGED RESIDUES; CONTROL UNIT; CYTOPLASMIC DOMAINS; DOMAIN STRUCTURE; GLYCINE RECEPTOR; IN-CHANNELS; ION CHANNEL; LIGAND-GATED ION CHANNELS; PROTEIN SURFACE; REGULATORY MOTIFS; SECONDARY STRUCTURES; SPATIAL STRUCTURE; SPLICE VARIANTS; SYNAPTIC TRANSMISSION; WHOLE CELL;

AMINES; AMINO ACIDS; CELL MEMBRANES; MAMMALS; OLIGOMERS; ORGANIC ACIDS; STOICHIOMETRY;

IONS;

ALPHA3 GLYCINE RECEPTOR; GLYCINE RECEPTOR; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; ION CHANNELS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA;

EID: 70350381026     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.043174     Document Type: Article

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