The β subunit determines the ligand binding properties of synaptic glycine receptors

Neuron

Volumn 45, Issue 5, 2005, Pages 727-739

  Grudzinska, Joanna ^a   Schemm, Rudolf ^a   Haeger, Svenja ^b   Nicke, Annette ^a   Schmalzing, Guenther ^b   Betz, Heinrich ^a   Laube, Bodo ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BINDING PROTEIN; GLYCINE RECEPTOR; SYNAPSE RECEPTOR;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

EID: 14644414132     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2005.01.028     Document Type: Article

References (59)

1. M. Beato, P.J. Groot-Kormelink, D. Colquhoun, and L.G. Sivilotti Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound J. Gen. Physiol. 119 2002 443 466
2. C.M. Becker Convulsants acting at the inhibitory glycine receptor H. Herken F. Hucho Handbook of Experimental Pharmacology 1992 Springer Heidelberg, Germany 539 575
3. H. Betz Glycine receptors: heterogeneous and widespread in the mammalian brain Trends Neurosci. 14 1991 458 461
4. J. Bormann, N. Rundstrom, H. Betz, and D. Langosch Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers EMBO J. 12 1993 3729 3737
5. H.G. Breitinger, and C.M. Becker The inhibitory glycine receptor - simple views of a complicated channel ChemBioChem 3 2002 1042 1052
6. K. Brejc, W.J. van Dijk, R.V. Klaassen, M. Schuurmans, J. van Der Oost, A.B. Smit, and T.K. Sixma Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors Nature 411 2001 269 276
7. V. Burzomato, P.J. Groot-Kormelink, L.G. Sivilotti, and M. Beato Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation Receptors Channels 9 2003 353 361
8. C. Büttner, S. Sadtler, A. Leyendecker, B. Laube, N. Griffon, H. Betz, and G. Schmalzing Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors J. Biol. Chem. 276 2001 42978 42985
9. P.H. Celie, S.E. van Rossum-Fikkert, W.J. van Dijk, K. Brejc, A.B. Smit, and T.K. Sixma Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures Neuron 41 2004 907 914
10. S.C. Chattipakorn, and L.L. McMahon Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices J. Neurophysiol. 87 2002 1515 1525
11. D. Colquhoun Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors Br. J. Pharmacol. 125 1998 924 947
12. D. Colquhoun, and L.G. Sivilotti Function and structure in glycine receptors and some of their relatives Trends Neurosci. 27 2004 337 344
13. P.J. Corringer, N. Le Novere, and J.P. Changeux Nicotinic receptors at the amino acid level Annu. Rev. Pharmacol. Toxicol. 40 2000 431 458
14. B.A. Cromer, C.J. Morton, and M.W. Parker Anxiety over GABA(A) receptor structure relieved by AChBP Trends Biochem. Sci. 27 2002 280 287
15. S. Cull-Candy, S. Brickley, and M. Farrant NMDA receptor subunits: diversity, development and disease Curr. Opin. Neurobiol. 11 2001 327 335
16. M. Dahan, S. Levi, C. Luccardini, P. Rostaing, B. Riveau, and A. Triller Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking Science 302 2003 442 445
17. M. Fujita, K. Sato, M. Sato, T. Inoue, T. Kozuka, and M. Tohyama Regional distribution of the cells expressing glycine receptor beta subunit mRNA in the rat brain Brain Res. 560 1991 23 37
18. H. Furukawa, and E. Gouaux Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core EMBO J. 22 2003 2873 2885
19. T. Grutter, and J.P. Changeux Nicotinic receptors in wonderland Trends Biochem. Sci. 26 2001 459 463
20. B. Hartenstein, J. Schenkel, J. Kuhse, B. Besenbeck, C. Kling, C.M. Becker, H. Betz, and H. Weiher Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice EMBO J. 15 1996 1275 1282
21. R.J. Harvey, U.B. Depner, H. Wassle, S. Ahmadi, C. Heindl, H. Reinold, T.G. Smart, K. Harvey, B. Schutz, and O.M. Abo-Salem GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization Science 304 2004 884 887
22. H. Hirai, J. Kirsch, B. Laube, H. Betz, and J. Kuhse The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region Proc. Natl. Acad. Sci. USA 93 1996 6031 6036
23. S.F. Kingsmore, B. Giros, D. Suh, M. Bieniarz, M.G. Caron, and M.F. Seldin Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion Nat. Genet. 7 1994 136 141
24. M. Kneussel, and H. Betz Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model Trends Neurosci. 23 2000 429 435
25. J. Kuhse, B. Laube, D. Magalei, and H. Betz Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry Neuron 11 1993 1049 1056
26. J. Kuhse, H. Betz, and J. Kirsch The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex Curr. Opin. Neurobiol. 5 1995 318 323
27. D. Langosch, L. Thomas, and H. Betz Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer Proc. Natl. Acad. Sci. USA 85 1988 7394 7398
28. B. Laube, H. Hirai, M. Sturgess, H. Betz, and J. Kuhse Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit Neuron 18 1997 493 503
29. B. Laube, J. Kuhse, and H. Betz Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors J. Physiol. 522 2000 215 230
30. B. Laube, G. Maksay, R. Schemm, and H. Betz Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol. Sci. 23 2002 519 527
31. P. Legendre The glycinergic inhibitory synapse Cell. Mol. Life Sci. 58 2001 760 793
32. N. Le Novere, T. Grutter, and J.P. Changeux Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites Proc. Natl. Acad. Sci. USA 99 2002 3210 3215
33. G. Maksay, Z. Bikadi, and M. Simonyi Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models J. Recept. Signal Transduct. Res. 23 2003 255 270
34. M.L. Malosio, B. Marqueze-Pouey, J. Kuhse, and H. Betz Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain EMBO J. 10 1991 2401 2409
35. G. Meyer, J. Kirsch, H. Betz, and D. Langosch Identification of a gephyrin binding motif on the glycine receptor beta subunit Neuron 15 1995 563 572
36. C. Mulhardt, M. Fischer, P. Gass, D. Simon-Chazottes, J.L. Guenet, J. Kuhse, H. Betz, and C.M. Becker The spastic mouse: aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element Neuron 13 1994 1003 1015
37. A. Nicke, H.G. Baumert, J. Rettinger, A. Eichele, G. Lambrecht, E. Mutschler, and G. Schmalzing P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels EMBO J. 17 1998 3016 3028
38. F. Pfeiffer, D. Graham, and H. Betz Purification by affinity chromatography of the glycine receptor of rat spinal cord J. Biol. Chem. 257 1982 9389 9393
39. I. Pribilla, T. Takagi, D. Langosch, J. Bormann, and H. Betz The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels EMBO J. 11 1992 4305 4311
40. L.M. Pullan, and R.J. Powel Comparison of binding at strychnine-sensitive (inhibitory glycine receptor) and strychnine-insensitive (N-methyl-D-aspartate receptor) glycine binding sites Neurosci. Lett. 148 1992 199 201
41. C. Racca, A. Gardiol, and A. Triller Dendritic and postsynaptic localizations of glycine receptor alpha subunit mRNAs J. Neurosci. 17 1997 1691 1700
42. S. Rajendra, R.J. Vandenberg, K.D. Pierce, A.M. Cunningham, P.W. French, P.H. Barry, and P.R. Schofield The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element EMBO J. 14 1995 2987 2998
43. S. Rajendra, J.W. Lynch, and P.R. Schofield The glycine receptor Pharmacol. Ther. 73 1997 121 146
44. M.I. Rees, T.M. Lewis, J.B. Kwok, G.R. Mortier, P. Govaert, R.G. Snell, P.R. Schofield, and M.J. Owen Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB) Hum. Mol. Genet. 11 2002 853 860
45. S. Sadtler, B. Laube, A. Lashub, A. Nicke, H. Betz, and G. Schmalzing A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit J. Biol. Chem. 278 2003 16782 16790
46. V. Schmieden, J. Kuhse, and H. Betz Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA Science 262 1993 256 258
47. P.R. Schofield The role of glycine and glycine receptors in myoclonus and startle syndromes Adv. Neurol. 89 2002 263 274
48. J.H. Singer, and A.J. Berger Development of inhibitory synaptic transmission to motoneurons Brain Res. Bull. 53 2000 553 560
49. T.K. Sixma, and A.B. Smit Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels Annu. Rev. Biophys. Biomol. Struct. 32 2003 311 334
50. M. Sola, M. Kneussel, I.S. Heck, H. Betz, and W. Weissenhorn X-ray crystal structure of the trimeric N-terminal domain of gephyrin J. Biol. Chem. 276 2001 25294 25301
51. M. Sola, V.N. Bavro, J. Timmins, T. Franz, S. Ricard-Blum, G. Schoehn, R.W. Ruigrok, I. Paarmann, T. Saiyed, and G.A. O'Sullivan Structural basis of dynamic glycine receptor clustering by gephyrin EMBO J. 23 2004 2510 2519
52. T. Takahashi, A. Momiyama, K. Hirai, F. Hishinuma, and H. Akagi Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels Neuron 9 1992 1155 1161
53. N. Unwin Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy FEBS Lett. 555 2003 91 95
54. N. Unwin, A. Miyazawa, J. Li, and Y. Fujiyoshi Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits J. Mol. Biol. 319 2002 1165 1176
55. R.J. Vandenberg, C.R. French, P.H. Barry, J. Shine, and P.R. Schofield Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site Proc. Natl. Acad. Sci. USA 89 1992 1765 1769
56. R.J. Vandenberg, C.A. Handford, and P.R. Schofield Distinct agonist- and antagonist-binding sites on the glycine receptor Neuron 9 1992 491 496
57. B. Wittekindt, S. Malany, R. Schemm, L. Otvos, M.L. Maccecchini, B. Laube, and H. Betz Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of conantokin-G inhibition Neuropharmacology 41 2001 753 761
58. Y. Zhou, M.E. Nelson, A. Kuryatov, C. Choi, J. Cooper, and J. Lindstrom Human alpha4beta2 acetylcholine receptors formed from linked subunits J. Neurosci. 23 2003 9004 9015
59. H.Y. Zoghbi, F.H. Gage, and D.W. Choi Neurobiology of disease Curr. Opin. Neurobiol. 10 2000 655 660