Opposing Effects of Molecular Volume and Charge at the Hyperekplexia Site α1(P250) Govern Glycine Receptor Activation and Desensitization

Journal of Biological Chemistry

Volumn 276, Issue 32, 2001, Pages 29657-29663

  Breitinger, Hans Georg ^b   Villmann, Carmen ^b   Becker, Kristina ^b   Becker, Cord Michael ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; ELECTROPHYSIOLOGY; GENETIC ENGINEERING; HYDROPHOBICITY; MOLECULAR WEIGHT; MUTAGENESIS; NEUROPHYSIOLOGY;

DESENSITIZATION;

BIOCHEMISTRY;

GLYCINE; GLYCINE RECEPTOR; MUTANT PROTEIN; RECEPTOR SUBUNIT; AMINO ACID RECEPTOR AFFECTING AGENT; GLYCINE RECEPTOR ALPHA1; LIGAND; RECOMBINANT PROTEIN; STRYCHNINE;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; GENE; GLRA1 GENE; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; STARTLE EPILEPSY; AMINO ACID SEQUENCE; CELL LINE; CELL MEMBRANE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; ELECTROPHYSIOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ALLELES; AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GLYCINE; GLYCINE AGENTS; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; STRYCHNINE;

EID: 0035839433     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100446200     Document Type: Article

References (21)

1. Becker, C.-M. (1995) Neuroscientist 1, 130-141
2. Breitinger, H. G., and Becker, C. M. (1998) Curr. Pharm. Des. 4, 315-334
3. Lewis, T. M., and Schofield, P. R. (1999) Ann. N. Y. Acad. Sci. 868, 681-684
4. Becker, K., Becker, C.-M., and Breitinger, H.-G. (2000) in Channelopathies (Lehmann-Horn, F., and Jurkat-Rott, K., eds), pp. 199-224, Elsevier, Amsterdam
5. Becker, C.-M., and Langosch, D. (1998) in Amino Acid Neurotransmission (Stephenson, F. A., and Turner, A. J., eds), pp. 93-112, Portland, London
6. Lynch, J. W., Rajendra, S., Pierce, K. D., Handford, C. A., Barry, P. H., and Schofield, P. R. (1997) EMBO J. 16, 110-120
7. Lewis, T. M., Sivilotti, L. G., Colquhoun, D., Gardiner, R. M., Schoepfer, R., and Rees, M. (1998) J. Physiol. (Lond.) 15, 25-40
8. Saul, B., Kuner, T., Sobetzko, D., Brune, W., Hanefeld, F., Meinck, H. M., and Becker, C. M. (1999) J. Neurosci. 19, 869-877
9. Higuchi, R., Krummel, B., and Saiki, R. K. (1988) Nucleic Acids Res. 16, 7351-7367
10. Sontheimer, H., Becker, C. M., Pritchett, D. B., Schofield, P. R., Grenningloh, G., Kettenmann, H., Betz, H., and Seeburg, P. H. (1989) Neuron 2, 1491-1497
11. Kling, C., Koch, M., Saul, B., and Becker, C. M. (1997) Neuroscience 78, 411-417
12. Krishtal, O. A., and Pidoplichko, V. I. (1980) Neuroscience 5, 2325-2327
13. Udgaonkar, J. B., and Hess, G. P. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 8758-8762
14. Hess, G. P. (1993) Biochemistry 32, 989-1000
15. Zamyatnin, A. A. (1972) Prog. Biophys. Mol. Biol. 24, 107-123
16. Engelman, D. M., Steitz, T. A., and Goldman, A. (1986) Annu. Rev. Biophys. Biophys. Chem. 15, 321-353
17. Breitinger, H.-G. (2001) Neuroscientist 7, 95-103
18. Wick, M. J., Mihic, S. J., Ueno, S., Mascia, M. P., Trudell, J. N., Brozowski, S. J., Ye, Q., Harrison, N. L., and Harris, R. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6504-6509
19. Ye, Q., Koltchine, V. V., Mihic, S. J., Mascia, M. P., Wick, M. J., Finn, S. E., Harrison, N. L., and Harris, R. A. (1998) J. Biol. Chem. 273, 3314-3319
20. Yamakura, T., Mihic, S. J., and Harris, R. A. (1999) J. Biol. Chem. 274, 23006-23012
21. Nikolic, Z., Laube, B., Weber, R. G., Lichter, P., Koschis, P., Poustka, A., Mülhardt, C., and Becker, C.-M. (1998) J. Biol. Chem. 273, 19708-19714