Magnitude of a conformational change in the glycine receptor β1-β2 loop is correlated with agonist efficacy

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27370-27376

  Pless, Stephen A ^a   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATION CHANGE; CONFORMATIONAL CHANGE; ENVIRONMENTALLY SENSITIVE; FLUORESCENCE SIGNALS; GLYCINE RECEPTOR; HIGH EFFICACY; ION CHANNEL RECEPTORS; LIGAND BINDING DOMAIN; MICROENVIRONMENTS; STRUCTURAL REARRANGEMENT; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; FLUOROMETERS; LIGANDS;

FLUOROPHORES;

BETA ALANINE; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR BETA1; GLYCINE RECEPTOR BETA2; TAURINE; UNCLASSIFIED DRUG; ALANINE; GLYCINE RECEPTOR ALPHA1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION FUNCTION; FLUORESCENCE; FLUOROMETRY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; VOLTAGE CLAMP; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HUMAN; ISOMERISM; KINETICS; METABOLISM; PATCH CLAMP; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ALANINE; ANIMALS; FEMALE; GLYCINE; HUMANS; ISOMERISM; KINETICS; MODELS, MOLECULAR; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; TAURINE;

EID: 70350433227     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.048405     Document Type: Article

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