Subunit-specific inhibition of glycine receptors by curcumol

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 2, 2012, Pages 371-379

  Wang, Li ^a   Li, Wei Guang ^b   Huang, Chen ^a   Zhu, Michael X ^c   Xu, Tian Le ^b   Wu, Da Zheng ^a   Li, Yong ^b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CURCUMIN; CURCUMOL; CURDIONE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR ALPHA2; GLYCINE RECEPTOR ALPHA3; GLYCINE RECEPTOR BETA; PLANT MEDICINAL PRODUCT; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CURCUMA; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; RHIZOME; SITE DIRECTED MUTAGENESIS; SPINAL CORD DORSAL HORN;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CURCUMA; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; HIPPOCAMPUS; MEDICINE, CHINESE TRADITIONAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GLYCINE; RECOMBINANT PROTEINS; SESQUITERPENES; THREONINE;

EID: 84867590702     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.195669     Document Type: Article

References (42)

1. A α5 subunit-containing receptors. Psychopharmacology 202:207-223.
2. Bechade C, Colin I, Kirsch J, Betz H, and Triller A (1996) Expression of glycine receptor α subunits and gephyrin in cultured spinal neurons. Eur J Neurosci 8:429-435.
3. Becker CM, Hoch W, and Betz H (1988) Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J 7:3717-3726.
4. Betz H and Laube B (2006) Glycine receptors: recent insights into their structural organization and functional diversity. J Neurochem 97:1600-1610. (Pubitemid 43873655)
5. Bormann J, Rundström N, Betz H, and Langosch D (1993) Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homoand hetero-oligomers. EMBO J 12:3729-3737. (Pubitemid 23282748)
6. A α5 receptors with cognition enhancing properties. J Med Chem 47:5829-5832.
7. Chang Q and Martin LJ (2011) Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 31:2815-2827.
8. Deng C, Ji J, Li N, Yu Y, Duan G, and Zhang X (2006) Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. J Chromatogr A 1117:115-120.
9. Dohare P, Garg P, Sharma U, Jagannathan NR, and Ray M (2008) Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC Complement Altern Med 8:55.
10. Dong XP and Xu TL (2002) Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons. Brain Res 940:1-9.
11. Eichler SA, Förstera B, Smolinsky B, Jüttner R, Lehmann TN, Fähling M, Schwarz G, Legendre P, and Meier JC (2009) Splice-specific roles of glycine receptor α3 in the hippocampus. Eur J Neurosci 30:1077-1091.
12. Eichler SA, Kirischuk S, Jüttner R, Schaefermeier PK, Schafermeier PK, Legendre P, Lehmann TN, Gloveli T, Grantyn R, and Meier JC (2008) Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy. J Cell Mol Med 12:2848-2866.
13. Farrant M and Nusser Z (2005) Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors. Nat Rev Neurosci 6:215-229. (Pubitemid 40342416)
14. Fucile S, De Saint Jan D, de Carvalho LP, and Bregestovski P (2000) Fast potentiation of glycine receptor channels of intracellular calcium in neurons and transfected cells. Neuron 28:571-583.
15. Grudzinska J, Schemm R, Haeger S, Nicke A, Schmalzing G, Betz H, and Laube B (2005) The β subunit determines the ligand binding properties of synaptic glycine receptors. Neuron 45:727-739. (Pubitemid 40320707)
16. Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem OM, et al. (2004) GlyR α3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science 304:884-887. (Pubitemid 38620190)
17. Kondratskaya EL, Betz H, Krishtal OA, and Laube B (2005) The β subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors. Neuropharmacology 49:945-951. (Pubitemid 41483900)
18. Kuhse J, Laube B, Magalei D, and Betz H (1993) Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11:1049-1056. (Pubitemid 24015279)
19. Legendre P (2001) The glycinergic inhibitory synapse. Cell Mol Life Sci 58:760-793.
20. A and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem 278:38637-38645.
21. A and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport 13:223-226.
22. + modulation of glycinergic response in rat sacral dorsal commissural neurons. J Physiol 552:73-87.
23. A and glycine receptors in ALS-resistant vs. ALS-vulnerable motoneurons: possible implications for selective vulnerability of motoneurons. Eur J Neurosci 23:3161-3170.
24. Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051-1095.
25. Malosio ML, Marquèze-Pouey B, Kuhse J, and Betz H (1991) Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J 10:2401-2409. (Pubitemid 21905713)
26. Meier JC, Henneberger C, Melnick I, Racca C, Harvey RJ, Heinemann U, Schmieden V, and Grantyn R (2005) RNA editing produces glycine receptor α3(P185L), resulting in high agonist potency. Nat Neurosci 8:736-744. (Pubitemid 43085839)
27. Meyer G, Kirsch J, Betz H, and Langosch D (1995) Identification of a gephyrin binding motif on the glycine receptor β subunit. Neuron 15:563-572.
28. Murase K, Randic M, Shirasaki T, Nakagawa T, and Akaike N (1990) Serotonin suppresses N-methyl-D-aspartate responses in acutely isolated spinal dorsal horn neurons of the rat. Brain Res 525:84-91. (Pubitemid 20257719)
29. Pribilla I, Takagi T, Langosch D, Bormann J, and Betz H (1992) The atypical M2 segment of the β-subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBO J 11:4305-4311.
30. Sato K, Kiyama H, and Tohyama M (1992) Regional distribution of cells expressing glycine receptor α2 subunit mRNA in the rat brain. Brain Res 590:95-108.
31. Su CY, Liu XY, Xu HX, and Zhu XY (1980) [The metabolism of 3H-curcumol in normal rats and tumour bearing mice (author's transl)]. Yao Xue Xue Bao 15:257-262.
32. Sun CY, Hu W, Qi SS, Dai KY, Hu SW, and Lou XF (2008) [Effect of Rhizoma curcumae oil on the learning and memory in rats exposed to chronic hypoxia and the possible mechanisms]. Sheng Li Xue Bao 60:228-234.
33. Supplisson S and Chesnoy-Marchais D (2000) Glycine receptor β subunits play a critical role in potentiation of glycine responses by ICS-205,930. Mol Pharmacol 58:763-770.
34. Wang Y and Zhao XJ (2004) [Experimental study on the antiepileptic properties of curcuma oil in different epilepsy models]. Pharmacol Clin Chin Mater Med 20:11-12.
35. Watanabe E and Akagi H (1995) Distribution patterns of mRNAs encoding glycine receptor channels in the developing rat spinal cord. Neurosci Res 23:377-382.
36. Webb TI and Lynch JW (2007) Molecular pharmacology of the glycine receptor chloride channel. Curr Pharm Des 13:2350-2367. (Pubitemid 47317028)
37. Xia Q, Zhao KJ, Huang ZG, Zhang P, Dong TT, Li SP, and Tsim KW (2005) Molecular genetic and chemical assessment of Rhizoma Curcumae in China. J Agric Food Chem 53:6019-6026. (Pubitemid 41126641)
38. Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y, and Zhang L (2011) Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nat Chem Biol 7:296-303.
39. Xu TL and Gong N (2010) Glycine and glycine receptor signaling in hippocampal neurons: diversity, function and regulation. Prog Neurobiol 91:349-361.
40. 2+-permeable AMPA receptors in rat spinal neurones. J Physiol 514:701-711.
41. Zhang R, Wang BJ, Zhao HL, Wei CM, Yuan GY and Guo RC (2009) Tissue distribution of curcumol in rats after intravenous injection of zedoary turmeric oil fat emulsion. Asian J Pharmacodynam Pharmacokinet 9:51-57.
42. Zhang XB, Sun GC, Liu LY, Yu F, and Xu TL (2008) α2 subunit specificity of cyclothiazide inhibition on glycine receptors. Mol Pharmacol 73:1195-1202. (Pubitemid 351439201)