Mutation of a zinc-binding residue in the glycine receptor a1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivos

Journal of Pharmacology and Experimental Therapeutics

Volumn 344, Issue 2, 2013, Pages 489-500

  McCracken, Lindsay M ^a   Blednov, Yuri A ^a   Trudell, James R ^b   Benavidez, Jillian M ^a   Betz, Heinrich ^c   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; RECOMBINANT RECEPTOR; STRYCHNINE; TAURINE; UNCLASSIFIED DRUG; ZINC ION;

ALCOHOL CONSUMPTION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; DRINKING BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; GLYR A1 GENE; HETEROZYGOTE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; MOUSE; NEUROCHEMISTRY; NONHUMAN; PHYSICAL SENSITIVITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BINDING; RECEPTOR GENE; RIGHTING REFLEX; STARTLE REFLEX; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ACOUSTIC STIMULATION; ALCOHOL DRINKING; AMINO ACID SUBSTITUTION; ANIMALS; BEHAVIOR, ANIMAL; BINDING SITES; ELECTROPHYSIOLOGICAL PHENOMENA; ETHANOL; FEMALE; GENE KNOCK-IN TECHNIQUES; HOMOZYGOTE; MALE; MICE; MICE, MUTANT STRAINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POINT MUTATION; RECEPTORS, GLYCINE; REFLEX, RIGHTING; ROTAROD PERFORMANCE TEST; STARTLE REACTION; STRYCHNINE; TRANSFECTION; XENOPUS LAEVIS; ZINC;

EID: 84872716093     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.197707     Document Type: Article

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