-
1
-
-
34147120188
-
Billion dollar babies-biotech drugs as blockbusters
-
10.1038/nbt0407-380, 17420735
-
Lawrence S. Billion dollar babies-biotech drugs as blockbusters. Nat Biotechnol 2007, 25:380-382. 10.1038/nbt0407-380, 17420735.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 380-382
-
-
Lawrence, S.1
-
2
-
-
77956690413
-
Biopharmaceutical benchmarks 2010
-
10.1038/nbt0910-917, 20829826
-
Walsh G. Biopharmaceutical benchmarks 2010. Nat Biotechnol 2010, 28:917-924. 10.1038/nbt0910-917, 20829826.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 917-924
-
-
Walsh, G.1
-
5
-
-
45149110911
-
Defining process design space for biotech products: case study of Pichia pastoris fermentation
-
10.1021/bp070338y, 18412404
-
Harms J, Wang X, Kim T, Yang X, Rathore AS. Defining process design space for biotech products: case study of Pichia pastoris fermentation. Biotechnol Prog 2008, 24:655-662. 10.1021/bp070338y, 18412404.
-
(2008)
Biotechnol Prog
, vol.24
, pp. 655-662
-
-
Harms, J.1
Wang, X.2
Kim, T.3
Yang, X.4
Rathore, A.S.5
-
6
-
-
70350208809
-
Quality by design case study: an integrated multivariate approach to drug product and process development
-
10.1016/j.ijpharm.2009.07.031, 19664698
-
Huang J, Kaul G, Cai C, Chatlapalli R, Hernandez-Abad P, Ghosh K, Nagi A. Quality by design case study: an integrated multivariate approach to drug product and process development. Int J Pharm 2009, 382:23-32. 10.1016/j.ijpharm.2009.07.031, 19664698.
-
(2009)
Int J Pharm
, vol.382
, pp. 23-32
-
-
Huang, J.1
Kaul, G.2
Cai, C.3
Chatlapalli, R.4
Hernandez-Abad, P.5
Ghosh, K.6
Nagi, A.7
-
7
-
-
68049113335
-
Quality-by-design for biotechnology-related pharmaceuticals
-
10.1002/biot.200800333, 19418475
-
Mandenius C-F, Graumann K, Schultz TW, Premstaller A, Olsson I-M, Petiot E, Clemens C, Welin M. Quality-by-design for biotechnology-related pharmaceuticals. Biotechnol J 2009, 4:600-609. 10.1002/biot.200800333, 19418475.
-
(2009)
Biotechnol J
, vol.4
, pp. 600-609
-
-
Mandenius, C.-F.1
Graumann, K.2
Schultz, T.W.3
Premstaller, A.4
Olsson, I.-M.5
Petiot, E.6
Clemens, C.7
Welin, M.8
-
8
-
-
44449122383
-
Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on-line high-performance liquid chromatography (HPLC) for making real-time pooling decisions for process chromatography
-
10.1002/bit.21759, 18078292
-
Rathore AS, Yu M, Yeboah S, Sharma A. Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on-line high-performance liquid chromatography (HPLC) for making real-time pooling decisions for process chromatography. Biotechnol Bioeng 2008, 100:306-316. 10.1002/bit.21759, 18078292.
-
(2008)
Biotechnol Bioeng
, vol.100
, pp. 306-316
-
-
Rathore, A.S.1
Yu, M.2
Yeboah, S.3
Sharma, A.4
-
9
-
-
45249124065
-
Creating Quality by Design/Process Analytical Technology Management (PAT/QbD) Management Awareness
-
Woelbeling C. Creating Quality by Design/Process Analytical Technology Management (PAT/QbD) Management Awareness. Pharm Eng 2008, 28(3):36-49.
-
(2008)
Pharm Eng
, vol.28
, Issue.3
, pp. 36-49
-
-
Woelbeling, C.1
-
10
-
-
43349088601
-
Pharmaceutical quality by design: product and process development, understanding, and control
-
10.1007/s11095-007-9511-1, 18185986
-
Yu L. Pharmaceutical quality by design: product and process development, understanding, and control. Pharm Res 2008, 25:781-791. 10.1007/s11095-007-9511-1, 18185986.
-
(2008)
Pharm Res
, vol.25
, pp. 781-791
-
-
Yu, L.1
-
12
-
-
33750931964
-
Over-production of human interferon-γ by HCDC of recombinant Escherichia coli
-
Babaeipour V, Shojaosadati SA, Robatjazi SM, Khalilzadeh R, Maghsoudi N. Over-production of human interferon-γ by HCDC of recombinant Escherichia coli. Process Biochem 2007, 42(1):112-117.
-
(2007)
Process Biochem
, vol.42
, Issue.1
, pp. 112-117
-
-
Babaeipour, V.1
Shojaosadati, S.A.2
Robatjazi, S.M.3
Khalilzadeh, R.4
Maghsoudi, N.5
-
13
-
-
0035921173
-
Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations
-
10.1002/bit.1125, 11410859
-
Hellwig S, Emde F, Raven NP, Henke M, van Der Logt P, Fischer R. Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations. Biotechnol Bioeng 2001, 74:344-352. 10.1002/bit.1125, 11410859.
-
(2001)
Biotechnol Bioeng
, vol.74
, pp. 344-352
-
-
Hellwig, S.1
Emde, F.2
Raven, N.P.3
Henke, M.4
van Der Logt, P.5
Fischer, R.6
-
14
-
-
77955337355
-
Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris
-
10.1016/j.jbiosc.2010.03.013, 20547360
-
Min C-K, Lee J-W, Chung K-H, Park H-W. Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris. J Biosci Bioeng 2010, 110:314-319. 10.1016/j.jbiosc.2010.03.013, 20547360.
-
(2010)
J Biosci Bioeng
, vol.110
, pp. 314-319
-
-
Min, C.-K.1
Lee, J.-W.2
Chung, K.-H.3
Park, H.-W.4
-
15
-
-
23944459546
-
Specific growth rate determines the molecular mass of the alginate produced by Azotobacter vinelandii
-
Priego-Jimenéz R, Peña C, Ramírez OT, Galindo E. Specific growth rate determines the molecular mass of the alginate produced by Azotobacter vinelandii. Biochem Eng J 2005, 25:187-193.
-
(2005)
Biochem Eng J
, vol.25
, pp. 187-193
-
-
Priego-Jimenéz, R.1
Peña, C.2
Ramírez, O.T.3
Galindo, E.4
-
16
-
-
77954089972
-
Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli
-
Puertas J-M, Ruiz J, de la Vega MR, Lorenzo J, Caminal G, González G. Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli. Process Biochem 2010, 45:1334-1341.
-
(2010)
Process Biochem
, vol.45
, pp. 1334-1341
-
-
Puertas, J.-M.1
Ruiz, J.2
de la Vega, M.R.3
Lorenzo, J.4
Caminal, G.5
González, G.6
-
17
-
-
12244259063
-
Limiting factors in Escherichia coli fed-batch production of recombinant proteins
-
10.1002/bit.10457, 12451552
-
Sanden AM, Prytz I, Tubulekas I, Forberg C, Le H, Hektor A, Neubauer P, Pragai Z, Harwood C, Ward A, Picon A, de Mattos JT, Postma P, Farewell A, Nystrom T, Reeh S, Pedersen S, Larsson G. Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng 2003, 81:158-166. 10.1002/bit.10457, 12451552.
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 158-166
-
-
Sanden, A.M.1
Prytz, I.2
Tubulekas, I.3
Forberg, C.4
Le, H.5
Hektor, A.6
Neubauer, P.7
Pragai, Z.8
Harwood, C.9
Ward, A.10
Picon, A.11
de Mattos, J.T.12
Postma, P.13
Farewell, A.14
Nystrom, T.15
Reeh, S.16
Pedersen, S.17
Larsson, G.18
-
18
-
-
79952100002
-
A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris
-
Dietzsch C, Spadiut O, Herwig C. A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris. Micro Cell Fact 2011, 10:14.
-
(2011)
Micro Cell Fact
, vol.10
, pp. 14
-
-
Dietzsch, C.1
Spadiut, O.2
Herwig, C.3
-
19
-
-
84870356622
-
Efficient feeding profile optimization for recombinant protein production using physiological information
-
10.1007/s00449-012-0754-9, 3470689, 22740334
-
Wechselberger P, Sagmeister P, Engelking H, Schmidt T, Wenger J, Herwig C. Efficient feeding profile optimization for recombinant protein production using physiological information. Bioprocess Biosyst Eng 2012, 35(9):1637-1649. 10.1007/s00449-012-0754-9, 3470689, 22740334.
-
(2012)
Bioprocess Biosyst Eng
, vol.35
, Issue.9
, pp. 1637-1649
-
-
Wechselberger, P.1
Sagmeister, P.2
Engelking, H.3
Schmidt, T.4
Wenger, J.5
Herwig, C.6
-
20
-
-
84862219036
-
A dynamic fed batch strategy for a Pichia pastoris mixed feed system to increase process understanding
-
10.1002/btpr.1551, 22505140
-
Zalai D, Dietzsch C, Herwig C, Spadiut O. A dynamic fed batch strategy for a Pichia pastoris mixed feed system to increase process understanding. Biotechnol Prog 2012, 28:878-886. 10.1002/btpr.1551, 22505140.
-
(2012)
Biotechnol Prog
, vol.28
, pp. 878-886
-
-
Zalai, D.1
Dietzsch, C.2
Herwig, C.3
Spadiut, O.4
-
21
-
-
33645360262
-
Generic model control of the specific growth rate in recombinant Escherichia coli cultivations
-
10.1016/j.jbiotec.2005.09.013, 16293333
-
Jenzsch M, Simutis R, Luebbert A. Generic model control of the specific growth rate in recombinant Escherichia coli cultivations. J Biotechnol 2006, 122:483-493. 10.1016/j.jbiotec.2005.09.013, 16293333.
-
(2006)
J Biotechnol
, vol.122
, pp. 483-493
-
-
Jenzsch, M.1
Simutis, R.2
Luebbert, A.3
-
22
-
-
84877803588
-
Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development
-
Sagmeister P, Wechselberger P, Jazini M, Meitz A, Langemann T. Soft sensor assisted dynamic bioprocess control: Efficient tools for bioprocess development. Chem Eng Sci 2013, 96:190-198.
-
(2013)
Chem Eng Sci
, vol.96
, pp. 190-198
-
-
Sagmeister, P.1
Wechselberger, P.2
Jazini, M.3
Meitz, A.4
Langemann, T.5
-
23
-
-
35048815442
-
Expression of recombinant proteins in Pichia pastoris
-
10.1007/s12010-007-0003-x, 18025573
-
Li P, Anumanthan A, Gao X-G, Ilangovan K, Suzara VV, Düzgüneş N, Renugopalakrishnan V. Expression of recombinant proteins in Pichia pastoris. Appl Biochem Biotechnol 2007, 142:105-124. 10.1007/s12010-007-0003-x, 18025573.
-
(2007)
Appl Biochem Biotechnol
, vol.142
, pp. 105-124
-
-
Li, P.1
Anumanthan, A.2
Gao, X.-G.3
Ilangovan, K.4
Suzara, V.V.5
Düzgüneş, N.6
Renugopalakrishnan, V.7
-
24
-
-
84862989011
-
Fractional factorial approach combining 4 Escherichia coli strains, 3 culture media, 3 expression temperatures and 5 N-terminal fusion tags for screening the soluble expression of recombinant proteins
-
10.1016/j.pep.2012.05.011, 22705765
-
Noguère C, Larsson AM, Guyot J-C, Bignon C. Fractional factorial approach combining 4 Escherichia coli strains, 3 culture media, 3 expression temperatures and 5 N-terminal fusion tags for screening the soluble expression of recombinant proteins. Protein Expr Purif 2012, 84:204-213. 10.1016/j.pep.2012.05.011, 22705765.
-
(2012)
Protein Expr Purif
, vol.84
, pp. 204-213
-
-
Noguère, C.1
Larsson, A.M.2
Guyot, J.-C.3
Bignon, C.4
-
25
-
-
33846232747
-
Optimization of recombinant human nerve growth factor production in the psychrophilic Pseudoalteromonas haloplanktis
-
10.1016/j.jbiotec.2006.05.019, 16859797
-
Vigentini I, Merico A, Tutino ML, Compagno C, Marino G. Optimization of recombinant human nerve growth factor production in the psychrophilic Pseudoalteromonas haloplanktis. J Biotechnol 2006, 127:141-150. 10.1016/j.jbiotec.2006.05.019, 16859797.
-
(2006)
J Biotechnol
, vol.127
, pp. 141-150
-
-
Vigentini, I.1
Merico, A.2
Tutino, M.L.3
Compagno, C.4
Marino, G.5
-
26
-
-
0347753711
-
Production of recombinant serpins in Escherichia coli
-
10.1016/S1046-2023(03)00208-1, 14698629
-
Bird PI, Pak SC, Worrall DM, Bottomley SP. Production of recombinant serpins in Escherichia coli. Methods 2004, 32:169-176. 10.1016/S1046-2023(03)00208-1, 14698629.
-
(2004)
Methods
, vol.32
, pp. 169-176
-
-
Bird, P.I.1
Pak, S.C.2
Worrall, D.M.3
Bottomley, S.P.4
-
27
-
-
84862785163
-
Cultivation at 6-10°C is an effective strategy to overcome the insolubility of recombinant proteins in Escherichia coli
-
10.1016/j.pep.2012.01.020, 22333528
-
Song JM, An YJ, Kang MH, Lee Y-H, Cha S-S. Cultivation at 6-10°C is an effective strategy to overcome the insolubility of recombinant proteins in Escherichia coli. Protein Expr Purif 2012, 82:297-301. 10.1016/j.pep.2012.01.020, 22333528.
-
(2012)
Protein Expr Purif
, vol.82
, pp. 297-301
-
-
Song, J.M.1
An, Y.J.2
Kang, M.H.3
Lee, Y.-H.4
Cha, S.-S.5
-
28
-
-
0029989229
-
Expression of correctly folded proteins in Escherichia coli
-
10.1016/S0958-1669(96)80012-7, 8791338
-
Georgiou G, Valax P. Expression of correctly folded proteins in Escherichia coli. Curr Opin Biotechnol 1996, 7:190-197. 10.1016/S0958-1669(96)80012-7, 8791338.
-
(1996)
Curr Opin Biotechnol
, vol.7
, pp. 190-197
-
-
Georgiou, G.1
Valax, P.2
-
29
-
-
84863536193
-
Enhancement of alkaline phytase production in Pichia pastoris: influence of gene dosage, sequence optimization and expression temperature
-
10.1016/j.pep.2012.06.001, 22705766
-
Yang M, Johnson SC, Murthy PPN. Enhancement of alkaline phytase production in Pichia pastoris: influence of gene dosage, sequence optimization and expression temperature. Protein Expr Purif 2012, 84:247-254. 10.1016/j.pep.2012.06.001, 22705766.
-
(2012)
Protein Expr Purif
, vol.84
, pp. 247-254
-
-
Yang, M.1
Johnson, S.C.2
Murthy, P.P.N.3
-
30
-
-
84856211526
-
Recombinant Fab expression and secretion in Escherichia coli continuous culture at medium cell densities: influence of temperature
-
Rodríguez-Carmona E, Cano-Garrido O, Dragosits M, Maurer M, Mader A, Kunert R, Mattanovich D, Villaverde A, Vázquez F. Recombinant Fab expression and secretion in Escherichia coli continuous culture at medium cell densities: influence of temperature. Process Biochem 2012, 47:446-452.
-
(2012)
Process Biochem
, vol.47
, pp. 446-452
-
-
Rodríguez-Carmona, E.1
Cano-Garrido, O.2
Dragosits, M.3
Maurer, M.4
Mader, A.5
Kunert, R.6
Mattanovich, D.7
Villaverde, A.8
Vázquez, F.9
-
31
-
-
0037955821
-
Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing
-
10.1002/bit.10610, 12673762
-
Jobé AM, Herwig C, Surzyn M, Walker B, Marison I, von Stockar U. Generally applicable fed-batch culture concept based on the detection of metabolic state by on-line balancing. Biotechnol Bioeng 2003, 82:627-639. 10.1002/bit.10610, 12673762.
-
(2003)
Biotechnol Bioeng
, vol.82
, pp. 627-639
-
-
Jobé, A.M.1
Herwig, C.2
Surzyn, M.3
Walker, B.4
Marison, I.5
von Stockar, U.6
-
32
-
-
80054905919
-
A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains
-
10.1186/1475-2859-10-85, 3214193, 22032177
-
Dietzsch C, Spadiut O, Herwig C. A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains. Microb Cell Fact 2011, 10:85. 10.1186/1475-2859-10-85, 3214193, 22032177.
-
(2011)
Microb Cell Fact
, vol.10
, pp. 85
-
-
Dietzsch, C.1
Spadiut, O.2
Herwig, C.3
-
33
-
-
84872383961
-
Dynamic process conditions in bioprocess development
-
Spadiut O, Rittmann S, Dietzsch C, Herwig C. Dynamic process conditions in bioprocess development. Eng Life Sci 2013, 13:88-101.
-
(2013)
Eng Life Sci
, vol.13
, pp. 88-101
-
-
Spadiut, O.1
Rittmann, S.2
Dietzsch, C.3
Herwig, C.4
-
34
-
-
0028009559
-
Modeling of bacterial growth with shifts in temperature
-
201290, 16349151
-
Zwietering MH, De Wit JC, Cuppers HGAM, Van Riet 't K. Modeling of bacterial growth with shifts in temperature. Appl Environ Microbiol 1994, 60:204-213. 201290, 16349151.
-
(1994)
Appl Environ Microbiol
, vol.60
, pp. 204-213
-
-
Zwietering, M.H.1
De Wit, J.C.2
Cuppers, H.G.A.M.3
Van Riet 't, K.4
-
35
-
-
0028765274
-
Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations
-
10.1002/bit.260440114, 18618451
-
Kurokawa H, Park YS, Iijima S, Kobayashi T. Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations. Biotechnol Bioeng 1994, 44:95-103. 10.1002/bit.260440114, 18618451.
-
(1994)
Biotechnol Bioeng
, vol.44
, pp. 95-103
-
-
Kurokawa, H.1
Park, Y.S.2
Iijima, S.3
Kobayashi, T.4
-
36
-
-
84874337958
-
On-line multiple component analysis for efficient quantitative bioprocess development
-
10.1016/j.jbiotec.2012.03.010, 22484127
-
Dietzsch C, Spadiut O, Herwig C. On-line multiple component analysis for efficient quantitative bioprocess development. J Biotechnol 2013, 163:362-370. 10.1016/j.jbiotec.2012.03.010, 22484127.
-
(2013)
J Biotechnol
, vol.163
, pp. 362-370
-
-
Dietzsch, C.1
Spadiut, O.2
Herwig, C.3
-
37
-
-
84865582207
-
Bioreactor monitoring with spectroscopy and chemometrics: a review
-
10.1007/s00216-012-6073-9, 22644146
-
Lourenço ND, Lopes JA, Almeida CF, Sarraguça MC, Pinheiro HM. Bioreactor monitoring with spectroscopy and chemometrics: a review. Anal Bioanal Chem 2012, 404:1211-1237. 10.1007/s00216-012-6073-9, 22644146.
-
(2012)
Anal Bioanal Chem
, vol.404
, pp. 1211-1237
-
-
Lourenço, N.D.1
Lopes, J.A.2
Almeida, C.F.3
Sarraguça, M.C.4
Pinheiro, H.M.5
-
38
-
-
33846238854
-
A simple method to monitor and control methanol feeding of Pichia pastoris fermentations using mid-IR spectroscopy
-
10.1016/j.jbiotec.2006.09.015, 17067711
-
Schenk J, Marison IW, von Stockar U. A simple method to monitor and control methanol feeding of Pichia pastoris fermentations using mid-IR spectroscopy. J Biotechnol 2007, 128:344-353. 10.1016/j.jbiotec.2006.09.015, 17067711.
-
(2007)
J Biotechnol
, vol.128
, pp. 344-353
-
-
Schenk, J.1
Marison, I.W.2
von Stockar, U.3
-
39
-
-
66149183267
-
Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses
-
Dabros M, Amrhein M, Bonvin D, Marison IW, von Stockar U. Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses. Biotechnol Progr 2009, 25:578-588.
-
(2009)
Biotechnol Progr
, vol.25
, pp. 578-588
-
-
Dabros, M.1
Amrhein, M.2
Bonvin, D.3
Marison, I.W.4
von Stockar, U.5
-
40
-
-
4544236814
-
Monitoring and control of Gluconacetobacter xylinus fed-batch cultures using in situ mid-IR spectroscopy
-
10.1016/j.jbiotec.2004.03.029, 15380658
-
Kornmann H, Valentinotti S, Duboc P, Marison I, von Stockar U. Monitoring and control of Gluconacetobacter xylinus fed-batch cultures using in situ mid-IR spectroscopy. J Biotechnol 2004, 113:231-245. 10.1016/j.jbiotec.2004.03.029, 15380658.
-
(2004)
J Biotechnol
, vol.113
, pp. 231-245
-
-
Kornmann, H.1
Valentinotti, S.2
Duboc, P.3
Marison, I.4
von Stockar, U.5
-
41
-
-
34247247236
-
An on-line approach to monitor ethanol fermentation using FTIR spectroscopy
-
10.1021/bp060306v, 17311406
-
Veale EL, Irudayaraj J, Demirci A. An on-line approach to monitor ethanol fermentation using FTIR spectroscopy. Biotechnol Prog 2007, 23:494-500. 10.1021/bp060306v, 17311406.
-
(2007)
Biotechnol Prog
, vol.23
, pp. 494-500
-
-
Veale, E.L.1
Irudayaraj, J.2
Demirci, A.3
-
42
-
-
0035813388
-
On-line stoichiometry and identification of metabolic state under dynamic process conditions
-
10.1002/bit.10058, 11590607
-
Herwig C, Marison I, von Stockar U. On-line stoichiometry and identification of metabolic state under dynamic process conditions. Biotechnol Bioeng 2001, 75:345-354. 10.1002/bit.10058, 11590607.
-
(2001)
Biotechnol Bioeng
, vol.75
, pp. 345-354
-
-
Herwig, C.1
Marison, I.2
von Stockar, U.3
-
43
-
-
84883751965
-
Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes
-
10.1007/s00449-012-0848-4, 3755222, 23178981
-
Wechselberger P, Sagmeister P, Herwig C. Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes. Bioprocess Biosyst Eng 2013, 36(9):1205-1218. 10.1007/s00449-012-0848-4, 3755222, 23178981.
-
(2013)
Bioprocess Biosyst Eng
, vol.36
, Issue.9
, pp. 1205-1218
-
-
Wechselberger, P.1
Sagmeister, P.2
Herwig, C.3
-
44
-
-
0037677435
-
Metabolic load of recombinant protein production: Inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene inEscherichia coli
-
10.1002/bit.10645, 12740933
-
Neubauer P, Lin HY, Mathiszik B. Metabolic load of recombinant protein production: Inhibition of cellular capacities for glucose uptake and respiration after induction of a heterologous gene inEscherichia coli. Biotechnol Bioeng 2003, 83:53-64. 10.1002/bit.10645, 12740933.
-
(2003)
Biotechnol Bioeng
, vol.83
, pp. 53-64
-
-
Neubauer, P.1
Lin, H.Y.2
Mathiszik, B.3
-
45
-
-
0019452786
-
The influence of temperature on the maximum specific growth rate of Klebsiella pneumoniae
-
Esener AA, Roels JA, Kossen NWF. The influence of temperature on the maximum specific growth rate of Klebsiella pneumoniae. Biotechnol Bioeng 1981, 23:1401-1405.
-
(1981)
Biotechnol Bioeng
, vol.23
, pp. 1401-1405
-
-
Esener, A.A.1
Roels, J.A.2
Kossen, N.W.F.3
-
46
-
-
0025919514
-
Utility of phenomenological models for describing temperature dependence of bacterial growth
-
183636, 1768141
-
Heitzer A, Kohler HP, Reichert P, Hamer G. Utility of phenomenological models for describing temperature dependence of bacterial growth. Appl Environ Microbiol 1991, 57:2656-2665. 183636, 1768141.
-
(1991)
Appl Environ Microbiol
, vol.57
, pp. 2656-2665
-
-
Heitzer, A.1
Kohler, H.P.2
Reichert, P.3
Hamer, G.4
-
47
-
-
18044383152
-
Temperature effect on bacterial growth rate: quantitative microbiology approach including cardinal values and variability estimates to perform growth simulations on/in food
-
10.1016/j.ijfoodmicro.2004.10.015, 15854703
-
Membré J-M, Leporq B, Vialette M, Mettler E, Perrier L, Thuault D, Zwietering M. Temperature effect on bacterial growth rate: quantitative microbiology approach including cardinal values and variability estimates to perform growth simulations on/in food. Int J Food Microbiol 2005, 100:179-186. 10.1016/j.ijfoodmicro.2004.10.015, 15854703.
-
(2005)
Int J Food Microbiol
, vol.100
, pp. 179-186
-
-
Membré, J.-M.1
Leporq, B.2
Vialette, M.3
Mettler, E.4
Perrier, L.5
Thuault, D.6
Zwietering, M.7
-
48
-
-
0025777467
-
Modeling of bacterial growth as a function of temperature
-
182851, 2059034
-
Zwietering MH, de Koos JT, Hasenack BE, de Witt JC, van't Riet K. Modeling of bacterial growth as a function of temperature. Appl Environ Microbiol 1991, 57:1094-1101. 182851, 2059034.
-
(1991)
Appl Environ Microbiol
, vol.57
, pp. 1094-1101
-
-
Zwietering, M.H.1
de Koos, J.T.2
Hasenack, B.E.3
de Witt, J.C.4
van't Riet, K.5
-
49
-
-
0028801765
-
Metabolic load and heterologous gene expression
-
10.1016/0734-9750(95)00004-A, 14537822
-
Glick BR. Metabolic load and heterologous gene expression. Biotechnol Adv 1995, 13:247-261. 10.1016/0734-9750(95)00004-A, 14537822.
-
(1995)
Biotechnol Adv
, vol.13
, pp. 247-261
-
-
Glick, B.R.1
-
50
-
-
0025405549
-
Plasmid-encoded protein: the principal factor in the "metabolic burden" associated with recombinant bacteria
-
10.1002/bit.260350704, 18592563
-
Bentley WE, Mirjalili N, Andersen DC, Davis RH, Kompala DS. Plasmid-encoded protein: the principal factor in the "metabolic burden" associated with recombinant bacteria. Biotechnol Bioeng 1990, 35:668-681. 10.1002/bit.260350704, 18592563.
-
(1990)
Biotechnol Bioeng
, vol.35
, pp. 668-681
-
-
Bentley, W.E.1
Mirjalili, N.2
Andersen, D.C.3
Davis, R.H.4
Kompala, D.S.5
-
51
-
-
84888201692
-
Soft-sensor assisted dynamic investigation of mixed feed bioprocesses
-
Available online 19 September 2013
-
Sagmeister P, Kment M, Wechselberger P, Meitz A, Langemann T, Herwig C. Soft-sensor assisted dynamic investigation of mixed feed bioprocesses. Process Biochem 2013, Available online 19 September 2013.
-
(2013)
Process Biochem
-
-
Sagmeister, P.1
Kment, M.2
Wechselberger, P.3
Meitz, A.4
Langemann, T.5
Herwig, C.6
-
52
-
-
34247161445
-
Simplified Fourier-transform mid-infrared spectroscopy calibration based on a spectra library for the on-line monitoring of bioprocesses
-
10.1016/j.aca.2007.03.056, 17456434
-
Schenk J, Marison IW, von Stockar U. Simplified Fourier-transform mid-infrared spectroscopy calibration based on a spectra library for the on-line monitoring of bioprocesses. Anal Chim Acta 2007, 591:132-140. 10.1016/j.aca.2007.03.056, 17456434.
-
(2007)
Anal Chim Acta
, vol.591
, pp. 132-140
-
-
Schenk, J.1
Marison, I.W.2
von Stockar, U.3
-
53
-
-
12544253860
-
Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures
-
10.1002/bit.20317, 15593097
-
Chee Furng Wong D, Tin Kam Wong K, Tang Goh L, Kiat Heng C, Gek Sim Yap M. Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures. Biotechnol Bioeng 2005, 89:164-177. 10.1002/bit.20317, 15593097.
-
(2005)
Biotechnol Bioeng
, vol.89
, pp. 164-177
-
-
Chee Furng Wong, D.1
Tin Kam Wong, K.2
Tang Goh, L.3
Kiat Heng, C.4
Gek Sim Yap, M.5
-
54
-
-
33747873973
-
Bioprocess control: advances and challenges
-
Alford JS. Bioprocess control: advances and challenges. Comput Chem Eng 2006, 30:1464-1475.
-
(2006)
Comput Chem Eng
, vol.30
, pp. 1464-1475
-
-
Alford, J.S.1
-
55
-
-
0027273935
-
Fuzzy logic control of a fed-batch fermentor
-
Nyttle VG, Chidambaram M. Fuzzy logic control of a fed-batch fermentor. Bioprocess Eng 1993, 9:115-118.
-
(1993)
Bioprocess Eng
, vol.9
, pp. 115-118
-
-
Nyttle, V.G.1
Chidambaram, M.2
-
56
-
-
15944379153
-
Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD)
-
10.1002/bit.20352, 15669089
-
Puskeiler R, Kaufmann K, Weuster-Botz D. Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol Bioeng 2005, 89:512-523. 10.1002/bit.20352, 15669089.
-
(2005)
Biotechnol Bioeng
, vol.89
, pp. 512-523
-
-
Puskeiler, R.1
Kaufmann, K.2
Weuster-Botz, D.3
-
57
-
-
41049096183
-
Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations
-
10.1007/s00449-007-0195-z, 18193293
-
Kusterer A, Krause C, Kaufmann K, Arnold M, Weuster-Botz D. Fully automated single-use stirred-tank bioreactors for parallel microbial cultivations. Bioprocess Biosyst Eng 2008, 31:207-215. 10.1007/s00449-007-0195-z, 18193293.
-
(2008)
Bioprocess Biosyst Eng
, vol.31
, pp. 207-215
-
-
Kusterer, A.1
Krause, C.2
Kaufmann, K.3
Arnold, M.4
Weuster-Botz, D.5
-
58
-
-
0033527396
-
Monitoring GFP-operon fusion protein expression during high cell density cultivation of Escherichia coli using an on-line optical sensor
-
10.1002/(SICI)1097-0290(19991005)65:1<54::AID-BIT7>3.0.CO;2-R, 10440671
-
DeLisa MP, Li J, Rao G, Weigand WA, Bentley WE. Monitoring GFP-operon fusion protein expression during high cell density cultivation of Escherichia coli using an on-line optical sensor. Biotechnol Bioeng 1999, 65:54-64. 10.1002/(SICI)1097-0290(19991005)65:1<54::AID-BIT7>3.0.CO;2-R, 10440671.
-
(1999)
Biotechnol Bioeng
, vol.65
, pp. 54-64
-
-
DeLisa, M.P.1
Li, J.2
Rao, G.3
Weigand, W.A.4
Bentley, W.E.5
-
59
-
-
0028764687
-
Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates
-
10.1002/bit.260430103, 18613305
-
Van der Heijden RTJM, Heijnen JJ, Hellinga C, Romein B, Luyben KCAM. Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol Bioeng 1994, 43:3-10. 10.1002/bit.260430103, 18613305.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 3-10
-
-
Van der Heijden, R.T.J.M.1
Heijnen, J.J.2
Hellinga, C.3
Romein, B.4
Luyben, K.C.A.M.5
-
60
-
-
84873284678
-
Model-based analysis on the extractability of information from data in dynamic fed-batch experiments
-
10.1002/btpr.1649, 3593167, 23125133
-
Wechselberger P, Sagmeister P, Herwig C. Model-based analysis on the extractability of information from data in dynamic fed-batch experiments. Biotechnol Prog 2013, 29:285-296. 10.1002/btpr.1649, 3593167, 23125133.
-
(2013)
Biotechnol Prog
, vol.29
, pp. 285-296
-
-
Wechselberger, P.1
Sagmeister, P.2
Herwig, C.3
|