On-line stoichiometry and identification of metabolic state under dynamic process conditions

Biotechnology and Bioengineering

Volumn 75, Issue 3, 2001, Pages 345-354

  Herwig, Christoph ^a   Marison, Ian ^a   Von Stockar, Urs ^a  

^a EPFL   (Switzerland)

Author keywords

Data reconciliation; Mass and elemental balances; On line stoichiometry; Saccharomyces cerevisiae; Transient experiments

Indexed keywords

BIOCONVERSION; BIOSYNTHESIS; CELL CULTURE; GLUCOSE; METABOLISM; STOICHIOMETRY;

AEROBIC CULTURES;

BIOTECHNOLOGY;

GLUCOSE;

ARTICLE; BIOSYNTHESIS; CALCULATION; CATABOLISM; CONCENTRATION RESPONSE; DYNAMICS; FUNGUS CULTURE; METABOLISM; NONHUMAN; QUANTITATIVE ASSAY; SACCHAROMYCES CEREVISIAE; STOICHIOMETRY; TECHNIQUE;

BIOREACTORS; CULTURE MEDIA; FLOW INJECTION ANALYSIS; GLUCOSE; KINETICS; SACCHAROMYCES CEREVISIAE;

EID: 0035813388     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10058     Document Type: Article

References (25)

1. Semi-on-line analysis for fast and precise monitoring of bioreaction processes
2. Computer-aided material balancing for prediction of fermentation parameters
3. Method for the statistical treatment of elemental and energy balances with application to steady-state continuous culture growth of Saccharomyces cerevisiae in the respiratory region
4. Identification and control of oxidative metabolism in Saccharomyces cerevisiae during transient growth using calorimetric measurements
5. Energetic investigation of Saccharomyces cerevisiae during transitions 1. Mass balances
6. Systematic errors in data evaluation due to ethanol stripping and water vaporization
7. Simple generic model for dyanmic experiments with S. cerevisiae in continuous culture: Decoupling between anabolism and catabolism
8. On-line capillary gas chromatography with automated liquid sampling, a powerful tool in biotechnology
9. Growth requirements of pyruvate-decarhoxylase-negative Saccharomyces cerevisiae
10. Proposals for a standardized sample handling procedure for the determination of elemental composition and enthalpy combustion of biological material
11. On-line fermentation gas analysis: Error analysis and application of mass spectrometry
12. Statistical analysis of material balance of a chemical reactor
13. Control strategies for continuous bioprocesses based on biological activities
14. Trehalose reserve in Saccharomyces cerevisiae: Phenomenon of transport, accumulation and role in cell viability
15. Online state recognition in a yeast fed-batch culture using error vectors
16. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis
17. Online simultaneous monitoring of ammonia and glutamine in a hollow-fiber reactor using Flow-Injection Analysis
18. Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates
19. Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors
20. Linear constraint relations in biochemical reaction systems: III. Sequential application of data reconciliation for sensitive detection of systematic errors
21. Heat flux measurements for the fast monitoring of dynamic responses to glucose additions by yeasts that were subjected to different feeding regimes in continuous culture
22. Effect on benzoic acid on metabolic fluxes in yeasts
23. Adaptive online model for aerobic Saccharomyces cerevisiae fermentation
24. Computer-aided baker's yeast fermentations
25. Application of macroscopic balances to the identification of gross measurement errors