Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

Bioprocess and Biosystems Engineering

Volumn 36, Issue 9, 2013, Pages 1205-1218

  Wechselberger, Patrick ^a   Sagmeister, Patrick ^a   Herwig, Christoph ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Process analytical technology (PAT); Process model; Real time biomass quantification; Recombinant protein production; Soft sensor

Indexed keywords

PROCESS ANALYTICAL TECHNOLOGY; PROCESS MODELING; REAL-TIME BIOMASS QUANTIFICATION; RECOMBINANT PROTEIN PRODUCTIONS; SOFT SENSORS;

BATCH CELL CULTURE; BATCH DATA PROCESSING; ESTIMATION; PHYSIOLOGY; RECOMBINANT PROTEINS; SENSORS;

BIOMASS;

ARTICLE; BIOMASS; BIOREACTOR; BIOTRANSFORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; FED BATCH CULTURE; FED BATCH FERMENTATION; GROWTH RATE; MICROBIAL GROWTH; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MODEL; QUANTITATIVE ANALYSIS; SENSOR; SOFT SENSOR; STOICHIOMETRY;

BIOMASS; BIOREACTORS; MODELS, BIOLOGICAL;

EID: 84883751965     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-012-0848-4     Document Type: Article

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