Activation of the transcription factor NF-κB in Schwann cells is required for peripheral myelin formation

Nature Neuroscience

Volumn 6, Issue 2, 2003, Pages 161-167

  Nickols, Joshua C ^a,b   Valentine, William ^a,b   Kanwal, Sujata ^a,b   Carter, Bruce D ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; MOUSE; MYELINATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; SCHWANN CELL; SCIATIC NERVE; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FETUS; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MUTATION; MYELIN SHEATH; NEURONS, AFFERENT; NF-KAPPA B; PERIPHERAL NERVOUS SYSTEM; PROTEIN SUBUNITS; RATS; SCHWANN CELLS; SCIATIC NERVE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS;

EID: 0037317077     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn995     Document Type: Article

References (29)

1. Monuki, E.S., Weinmaster, G., Kuhn, R. & Lemke, G. SCIP: a glial POU domain gene regulated by cyclic AMP. Neuron 3, 783-793 (1989).
2. Arroyo, E.J., Bermingham, J.R. Jr., Rosenfeld, M.G. & Scherer, S.S. Promyelinating Schwann cells express Tst-1/SC1P/Oct-6. J. Neurosci. 18, 7891-7902 (1998).
3. Jaegle, M. et al. The POU factor Oct-6 and Schwann cell differentiation. Science 273, 507-510 (1996).
4. Bermingham, J.R. Jr. et al. Tst-1/Oct-6/SC1P regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev. 10, 1751-1762 (1996).
5. Nagarajan, R. et al. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron 30, 355-368 (2001).
6. Topilko, P. et al. Krox-20 controls myelination in the peripheral nervous system. Nature 371, 796-799 (1994).
7. Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18, 6853-6866 (1999).
8. Chan, J.R., Cosgaya, J.M., Wu, Y.J. & Shooter, E.M. Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc. Natl. Acad. Sci. USA 98, 14661-14668 (2001).
9. Haggiag, S. et al. Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin-6 receptor-interleukin-6 chimera. J. Neurosci. Res. 64, 564-574 (2001).
10. Xu, J., Zutter, M.M., Santoro, S.A. & Clark, R.A. A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling. J. Cell. Biol. 140, 709-719 (1998).
11. Bushdid, P.B. et al. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature 392, 615-618 (1998).
12. Mattson, M.P., Culmsee, C., Yu, Z. & Camandola, S. Roles of nuclear factor kappaB in neuronal survival and plasticity. J. Neurochem. 74, 443-456 (2000).
13. Ghosh, S., May, M.J. & Kopp, E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260 (1998).
14. Einheber, S., Milner, T.A., Giancotti, F. & Salzer, J.L. Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination. J. Cell Biol. 123, 1223-1236 (1993).
15. Scherer, S.S. The biology and pathobiology of Schwann cells. Curr. Opin. Neurol. 10, 386-397 (1997).
16. Kunsch, C., Ruben, S.M. & Rosen, C.A. Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. MoL Cell. Biol. 12, 4412-4421 (1992).
17. Lin, Y.Z., Yao, S.Y., Veach, R.A., Torgerson, T.R. & Hawiger, J. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 270, 14255-14258 (1995).
18. Feltri, M.L. et al. Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J. Cell Biol. 156, 199-209 (2002).
19. Mattson, M.P., Culmsee, C., Yu, Z. & Camandola, S. Roles of nuclear factor kappaB in neuronal survival and plasticity. J. Neurochem. 74, 443-456 (2000).
20. Zorick, T.S., Syroid, D.E., Brown, A., Gridley, T. & Lemke, G. Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells. Development 126, 1397-4406 (1999).
21. Lee, H.H., Dadgostar, H., Cheng, Q., Shu, J. & Cheng, G. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in lymphocytes. Proc. Natl. Acad. Sci. USA 96, 9136-9141 (1999).
22. Chu, Z.L. et al. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc. Natl. Acad. Sci. USA 94, 10057-10062 (1997).
23. Guttridge, D.C., Albanese, C., Reuther, J.Y., Pestell, R.G. & Baldwin, A.S. Jr. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19, 5785-5799 (1999).
24. Blanchard, A.D. et al. Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: comparison with Oct-1, Krox-20, and Pax-3. J. Neurosci. Res. 46, 630-640 (1996).
25. Huang, C. et al. Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line. Int. J. Dev. Neurosci. 20, 289-296 (2002).
26. Betz, U.A. et al. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic and pulmonary defects. J. Exp. Med. 188, 1955-1965 (1998).
27. Carter, B.D. etal. Selective activation ofNFkB bynerve growth factor through the neurotrophin receptor p75. Science 272, 542-545 (1996).
28. Coetzee, T. et al. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 86, 209-19 (1996).
29. Forghani, R., Nesbitt, J., Snipes, J., Shooter, E.M. & Peterson, A. Preparation of nuclear extracts from myelinating Schwann cells. J. Neurosci. Methods 89, 129-132 (1999).