메뉴 건너뛰기




Volumn 25, Issue 1, 2008, Pages 27-35

Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-κB as a biomarker for relapse of multiple sclerosis

Author keywords

KeyMolnet; Multiple sclerosis; Nuclear factor kappa B; Relapse; T cells

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RNA; TRANSCRIPTOME;

EID: 50249125248     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2008/824640     Document Type: Article
Times cited : (41)

References (33)
  • 1
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • A. Compston and A. Coles, Multiple sclerosis, Lancet 359 (2002), 1221-1231.
    • (2002) Lancet , vol.359 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 2
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune function
    • H.S. Panitch, R.L. Hirsch, J. Schindler and K.P. Johnson, Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune function, Neurology 37 (1987), 1097-1102.
    • (1987) Neurology , vol.37 , pp. 1097-1102
    • Panitch, H.S.1    Hirsch, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 3
    • 33846966636 scopus 로고    scopus 로고
    • H2 hypothesis of T cell-mediated tissue damage
    • H2 hypothesis of T cell-mediated tissue damage, Nat Med 13 (2007), 139-145.
    • (2007) Nat Med , vol.13 , pp. 139-145
    • Steinman, L.1
  • 5
    • 36549059089 scopus 로고    scopus 로고
    • Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy
    • M. Eggert, R. Goertsches, U. Seeck, S. Dilk, G. Neeck and U.K. Zettl, Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy, J Neurol Sci 264 (2008), 145-150.
    • (2008) J Neurol Sci , vol.264 , pp. 145-150
    • Eggert, M.1    Goertsches, R.2    Seeck, U.3    Dilk, S.4    Neeck, G.5    Zettl, U.K.6
  • 7
    • 34248548647 scopus 로고    scopus 로고
    • Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis
    • F.M. Martín-Saavedra, N. Flores, B. Dorado, C. Eguiluz, B. Bravo, A. García-Merino and S. Ballester, Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis, Mol Immunol 44 (2007), 3597-3607.
    • (2007) Mol Immunol , vol.44 , pp. 3597-3607
    • Martín-Saavedra, F.M.1    Flores, N.2    Dorado, B.3    Eguiluz, C.4    Bravo, B.5    García-Merino, A.6    Ballester, S.7
  • 10
    • 0242667881 scopus 로고    scopus 로고
    • Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult
    • U. Graumann, R. Reynolds, A.J. Steck and N. Schaeren-Wiemers, Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult, Brain Pathol 13 (2003), 554-573.
    • (2003) Brain Pathol , vol.13 , pp. 554-573
    • Graumann, U.1    Reynolds, R.2    Steck, A.J.3    Schaeren-Wiemers, N.4
  • 12
    • 1442304886 scopus 로고    scopus 로고
    • Blood transcriptional signatures of multiple sclerosis: Unique gene expression of disease activity
    • A. Achiron, M. Gurevich, N. Friedman, N. Kaminski and M. Mandel, Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity, Ann Neurol 55 (2004), 410-417.
    • (2004) Ann Neurol , vol.55 , pp. 410-417
    • Achiron, A.1    Gurevich, M.2    Friedman, N.3    Kaminski, N.4    Mandel, M.5
  • 14
    • 33745594580 scopus 로고    scopus 로고
    • Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFN β-responsive genes in peripheral blood lymphocytes: An implication for IFNβ-related adverse effects in multiple sclerosis
    • J. Satoh, Y. Nanri, H. Tabunoki and T. Yamamura, Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFN β-responsive genes in peripheral blood lymphocytes: an implication for IFNβ-related adverse effects in multiple sclerosis, BMC Neurol 6 (2006), 18.
    • (2006) BMC Neurol , vol.6 , pp. 18
    • Satoh, J.1    Nanri, Y.2    Tabunoki, H.3    Yamamura, T.4
  • 18
    • 21744436757 scopus 로고    scopus 로고
    • H. Sato, S. Ishida, K. Toda, R. Matsuda, Y. Hayashi, M. Shigetaka, M. Fukuda, Y. Wakamatsu and A. Itai A, New approaches to mechanism analysis for drug discovery using DNA microarray data combined with KeyMolnet, Curr Drug Discov Technol 2 (2005), 89-98.
    • H. Sato, S. Ishida, K. Toda, R. Matsuda, Y. Hayashi, M. Shigetaka, M. Fukuda, Y. Wakamatsu and A. Itai A, New approaches to mechanism analysis for drug discovery using DNA microarray data combined with KeyMolnet, Curr Drug Discov Technol 2 (2005), 89-98.
  • 20
    • 34248182034 scopus 로고    scopus 로고
    • Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells
    • T. Kuzuhara, M. Suganuma, M. Kurusu and H. Fujiki, Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells, J Cancer Res Clin Oncol 133 (2007), 287-296.
    • (2007) J Cancer Res Clin Oncol , vol.133 , pp. 287-296
    • Kuzuhara, T.1    Suganuma, M.2    Kurusu, M.3    Fujiki, H.4
  • 21
    • 33847162049 scopus 로고    scopus 로고
    • F. Rapaport, A. Zinovyev, M. Dutreix, E. Barillot E and J.P. Vert, Classification of microarray data using gene networks, BMC Bioinformatics 8 (2007), 35.
    • F. Rapaport, A. Zinovyev, M. Dutreix, E. Barillot E and J.P. Vert, Classification of microarray data using gene networks, BMC Bioinformatics 8 (2007), 35.
  • 22
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB. A pivotal transcription factor in chronic inflammatory diseases
    • P.J. Barnes and M. Karin, Nuclear factor-κB. A pivotal transcription factor in chronic inflammatory diseases, N Engl J Med 336 (1997), 1066-1071.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 23
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Q. Li and I.M. Verma, NF-κB regulation in the immune system, Nat Rev Immunol 2 (2002), 725-734.
    • (2002) Nat Rev Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 24
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • H.L. Pahl, Activators and target genes of Rel/NF-κB transcription factors, Oncogene 18 (1999), 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 25
    • 0036144763 scopus 로고    scopus 로고
    • Regulatory functions of ubiquitination in the immune system
    • Y. Ben-Neriah, Regulatory functions of ubiquitination in the immune system, Nat Immunol 3 (2002), 20-26.
    • (2002) Nat Immunol , vol.3 , pp. 20-26
    • Ben-Neriah, Y.1
  • 27
    • 33645271646 scopus 로고    scopus 로고
    • Advances in NF-κB signaling transduction and transcription
    • W. Xiao, Advances in NF-κB signaling transduction and transcription, Cell Mol Immunol 1 (2004), 425-435.
    • (2004) Cell Mol Immunol , vol.1 , pp. 425-435
    • Xiao, W.1
  • 28
    • 0031951041 scopus 로고    scopus 로고
    • Transcription factor NF-κB and inhibitor IκBα are localized in macrophages in active multiple sclerosis lesions
    • D. Gveric, C. Laltschmidt, M.L. Cuzner and J. Newcombe, Transcription factor NF-κB and inhibitor IκBα are localized in macrophages in active multiple sclerosis lesions, J Neuropathol Exp Neurol 57 (1998), 168-178.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 168-178
    • Gveric, D.1    Laltschmidt, C.2    Cuzner, M.L.3    Newcombe, J.4
  • 29
    • 0032589563 scopus 로고    scopus 로고
    • Activation of NF-κB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
    • B. Bonetti, C. Stegagno, B. Cannella, N. Rizzuto, G. Moretto and C.S. Raine, Activation of NF-κB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology, Am J Pathol 155 (1999), 1433-1438.
    • (1999) Am J Pathol , vol.155 , pp. 1433-1438
    • Bonetti, B.1    Stegagno, C.2    Cannella, B.3    Rizzuto, N.4    Moretto, G.5    Raine, C.S.6
  • 30
    • 0036615454 scopus 로고    scopus 로고
    • Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations
    • B. Miterski, S. Böhringer, W. Klein, E. Sindern, M. Haupts, S. Schimrigk and J.T. Epplen, Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations, Genes Immun 3 (2002), 211-219.
    • (2002) Genes Immun , vol.3 , pp. 211-219
    • Miterski, B.1    Böhringer, S.2    Klein, W.3    Sindern, E.4    Haupts, M.5    Schimrigk, S.6    Epplen, J.T.7
  • 31
    • 0033198141 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: Roles of NF-κB in the activation and differentiation of autoreactive T cells
    • B. Hilliard, E.B. Samoilova, T.S.T. Liu, A. Rostami and Y. Chen, Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells, J Immunol 163 (1999), 2937-2943.
    • (1999) J Immunol , vol.163 , pp. 2937-2943
    • Hilliard, B.1    Samoilova, E.B.2    Liu, T.S.T.3    Rostami, A.4    Chen, Y.5
  • 32
    • 0034674520 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB in the spinal cord of experimental allergic encephalomyelitis
    • K. Pahan and M. Schmid, Activation of nuclear factor-κB in the spinal cord of experimental allergic encephalomyelitis, Neurosci Lett 287 (2000), 17-20.
    • (2000) Neurosci Lett , vol.287 , pp. 17-20
    • Pahan, K.1    Schmid, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.