Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg

European Journal of Immunology

Volumn 39, Issue 8, 2009, Pages 2106-2119

  Shi, Zhe ^a   Okuno, Yusuke ^a   Rifa'i, Muhaimin ^b   Endharti, Agustina Tri ^a   Akane, Kazuyuki ^a   Isobe, Ken Ichi ^a   Suzuki, Haruhiko ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b BRAWIJAYA UNIVERSITY   (Indonesia)

Author keywords

CD8 cells; Cytokine receptors; Human; Treg

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR BETA; CXCR3 PROTEIN, HUMAN; CXCR3 PROTEIN, MOUSE; HERMES ANTIGEN; IL2RB PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CD8+ CD122+ T LYMPHOCYTE; CD8+ CXCR3+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA MICROARRAY; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD44; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, SCID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CXCR3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY;

EID: 70249127941     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939314     Document Type: Article

References (39)

1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chain (CD25). J. Immunol. 1995. 155: 1151-1164.
2. + Treg for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004. 22: 531-562.
3. Shevach, E. M. Treg in autoimmunity. Annu. Rev. Immunol. 2000. 18: 423-449.
4. Sakaguchi, S. Treg: key controllers of immunologic self-tolerance. Cell 2000. 101: 455-458.
5. + Treg in the maintenance of T cell homeostasis. J. Exp. Med. 2004. 200: 1123-1134.
6. + T cells. J. Immunol. 2005. 175: 7093-7097.
7. + Treg recognize activated T cells via conventional MHC class I-αβTCR interaction and become IL-10 producing active regulatory cells. Int. Immunol. 2008. 20: 937-947.
8. + Treg. Immunology 2008. 124: 121-128.
9. Sakaguchi, S., Wing, K. and Miyara, M. Treg - a brief history and perspective. Eur. J. Immunol. 2007. 37S1: S116-S123. (Pubitemid 350131275)
10. + Treg: from basic research to potential therapeutic use. Swiss Med. Wkly. 2007. 137: 625-634.
11. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001. 193: 1285-1294.
12. + T cells with regulatory properties from human blood. J. Exp. Med. 2001. 193: 1303-1310.
13. Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J. L., Buist, N., Levy- Lahad, E., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 2001. 27: 18-20.
14. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 2001. 27: 20-21.
15. Sallusto, F., Lenig, D., Förster, R., Lipp, M. and Lanzavecchia, L. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712. (Pubitemid 129515761)
16. Sallusto, F., Geginat, J. and Lanzavecchia, A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 2004. 22: 745-763.
17. Wherry, E.J.,Teichgraber,V., Becker,T.C.,Masopust,D., Kaech, S.M.,Antia,R., von Andrian, U. H. and Ahmed, R. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 2003. 4: 225-234.
18. - regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology 2006. 131: 1775-1785.
19. + T lymphocytes in human peripheral blood increases with age. J. Leukoc. Biol. 2008. 84: 1454-1461.
20. + T cells suppress allograft rejection. J. Immunol. 2008. 180: 113-121.
21. + Treg in the recovery from experimental autoimmune encephalomyelitis. J. Immunol. 2008. 180: 825-832.
22. + Treg. J. Immunol. 2006. 177: 896-904.
23. Singh, U. P., Venkataraman, C., Singh, R. and Lillard J.W., Jr., CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication. Endocr. Metab. Immune Disord. Drug Targets 2007. 7: 111-123.
24. Liu, L., Callahan,M.K., Huang, D. and Ransohoff, R.M. Chemokine receptor CXCR3: an unexpected enigma. Curr. Top. Dev. Biol. 2005. 68: 149-181.
25. Hancock,W.W., Lu, B., Gao,W., Csizmadia, V., Faia, K., King, J. A., Smiley, S. T. et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 2000. 192: 1515-1520.
26. Panzer, U., Steinmetz, O. M., Paust, H. J., Meyer-Schwesinger, C., Peters, A., Turner, J. E., Zahner, G. et al. Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. J. Am. Soc. Nephrol. 2007. 18: 2071-2084.
27. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R. et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 1995. 268: 1472-1476.
28. + Treg. J. Immunol. 2007. 178: 280-290.
29. Soper, D. M., Kasprowicz, D. J. and Ziegler, S. F. IL-2Rb links IL-2R signaling with Foxp3 expression. Eur. J. Immunol. 2007. 37: 1817-1826.
30. Malek, T. R., Yu, A., Vincek, V., Scibelli, P. and Kong, L. CD4 Treg prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002. 17: 167-178.
31. Malek, T. R., Porter, B. O., Codias, E. K., Scibelli, P. and Yu, A. Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J. Immunol. 2000. 164: 2905-2914. (Pubitemid 30148947)
32. -/- mice with experimental autoimmune encephalomyelitis. J. Immunol. 2006. 176: 4399-4409.
33. Müller, M., Carter, S. L., Hofer, M. J., Manders, P., Getts, D. R., Getts, M. T., Dreykluft, A., et al., CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and Treg in the central nervous system. J. Immunol. 2007. 179: 2774-2786.
34. Cardona, A. E., Sasse, M. E., Liu, L., Cardona, S. M., Mizutani, M., Savarin, C., Hu, T. and Ransohoff, R. M. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 2008. 112: 256-263.
35. Narumi, S., Kaburaki, T., Yoneyama, H., Iwamura, H., Kobayashi, Y. and Matsushima, K. Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2002. 32: 1784-1791.
36. Christensen, J. E., Nansen, A., Moos, T., Lu, B., Gerard, C., Christensen, J. P. and Thomsen, A. R. Efficient T-Cell Surveillance of the CNS Requires Expression of the CXC Chemokine Receptor 3. J. Neurosci. 2004. 24: 4849-4858. (Pubitemid 38668209)
37. Zhang, Y., Burger, D., Saruhan, G., Jeannet, M. and Steck, A. J. The T-lymphocyte response against myelin-associated glycoprotein and myelin basic protein in patients with multiple sclerosis. Neurology 1993. 43: 403-407. (Pubitemid 23060279)
38. Kühn, R., Löhler, J., Rennick, D., Rajewsky, K. and Müller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993. 75: 263-274. (Pubitemid 23320290)
39. + T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J. Exp. Med. 1996. 184: 241-251.