메뉴 건너뛰기




Volumn 17, Issue 1-2, 2011, Pages 95-102

Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLATIRAMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; MESSENGER RNA;

EID: 78651496815     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2010.00071     Document Type: Article
Times cited : (14)

References (31)
  • 2
    • 0021856495 scopus 로고
    • Clinical viral infections and multiple sclerosis
    • Sibley WA, Bamford CR, Clark K. (1985) Clinical viral infections and multiple sclerosis. Lancet. 1:1313-1315.
    • (1985) Lancet , vol.1 , pp. 1313-1315
    • Sibley, W.A.1    Bamford, C.R.2    Clark, K.3
  • 3
    • 0036237054 scopus 로고    scopus 로고
    • Prospective study on the relationship between infections and multiple sclerosis exacerbations
    • Buljevac D, et al. (2002) Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain. 125:952-960.
    • (2002) Brain , vol.125 , pp. 952-960
    • Buljevac, D.1
  • 4
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebocontrolled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, et al. (2006) A randomized, placebocontrolled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 354:899-910.
    • (2006) N. Engl. J. Med , vol.354 , pp. 899-910
    • Polman, C.H.1
  • 5
    • 1442304886 scopus 로고    scopus 로고
    • Blood transcriptional signatures of multiple sclerosis: Unique gene expression of disease activity
    • Achiron A, Gurevich M, Friedman N, Kaminski N, Mandel M. (2004) Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol. 55:410-7.
    • (2004) Ann. Neurol , vol.55 , pp. 410-417
    • Achiron, A.1    Gurevich, M.2    Friedman, N.3    Kaminski, N.4    Mandel, M.5
  • 6
    • 42449106065 scopus 로고    scopus 로고
    • Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission
    • Arthur AT, et al. (2008) Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Med. Genet. 9:17.
    • (2008) BMC Med. Genet , vol.9 , pp. 17
    • Arthur, A.T.1
  • 7
    • 44349181984 scopus 로고    scopus 로고
    • Relapses in multiple sclerosis are associated with increased CD8(+) T-cell mediated cytotoxicity in CSF
    • Malmestrom C, et al. (2008) Relapses in multiple sclerosis are associated with increased CD8(+) T-cell mediated cytotoxicity in CSF. J. Neuroimmunol. 196:159-165.
    • (2008) J. Neuroimmunol , vol.196 , pp. 159-165
    • Malmestrom, C.1
  • 8
    • 50249125248 scopus 로고    scopus 로고
    • Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis
    • Satoh J, Misawa T, Tabunoki H, Yamamura T. (2008) Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis. Dis. Markers. 25:27-35.
    • (2008) Dis. Markers , vol.25 , pp. 27-35
    • Satoh, J.1    Misawa, T.2    Tabunoki, H.3    Yamamura, T.4
  • 9
    • 0348143180 scopus 로고    scopus 로고
    • A random variance model for detection of differential gene expression in small microarray experiments
    • Wright GW, Simon RM. (2003) A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics. 19:2448-2455.
    • (2003) Bioinformatics , vol.19 , pp. 2448-2455
    • Wright, G.W.1    Simon, R.M.2
  • 10
    • 70350100445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serum
    • Dillon SP, D'Souza A, Kurien BT, Scofield RH. (2009) Systemic lupus erythematosus and C1q: A quantitative ELISA for determining C1q levels in serum. Biotechnol. J. 4:1210-1214.
    • (2009) Biotechnol. J , vol.4 , pp. 1210-1214
    • Dillon, S.P.1    D'souza, A.2    Kurien, B.T.3    Scofield, R.H.4
  • 11
    • 47049116653 scopus 로고    scopus 로고
    • The classical and regulatory functions of C1q in immunity and autoimmunity
    • Lu JH, et al. (2008) The classical and regulatory functions of C1q in immunity and autoimmunity. Cell. Mol. Immunol. 5:9-21.
    • (2008) Cell. Mol. Immunol , vol.5 , pp. 9-21
    • Lu, J.H.1
  • 12
    • 67649833763 scopus 로고    scopus 로고
    • Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    • Christophi GP, et al. (2009) Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype. Lab. Invest. 89:742-759.
    • (2009) Lab. Invest , vol.89 , pp. 742-759
    • Christophi, G.P.1
  • 13
    • 34648835408 scopus 로고    scopus 로고
    • Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse
    • Achiron A, Feldman A, Mandel M, Gurevich M. (2007) Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann. N. Y. Acad. Sci. 1107:155-167.
    • (2007) Ann. N. Y. Acad. Sci , vol.1107 , pp. 155-167
    • Achiron, A.1    Feldman, A.2    Mandel, M.3    Gurevich, M.4
  • 14
    • 69049102091 scopus 로고    scopus 로고
    • Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
    • Gurevich M, Tuller T, Rubinstein U, Or-Bach R, Achiron A. (2009) Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells. BMC Med. Genomics. 2:46.
    • (2009) BMC Med. Genomics , vol.2 , pp. 46
    • Gurevich, M.1    Tuller, T.2    Rubinstein, U.3    Or-Bach, R.4    Achiron, A.5
  • 15
    • 75949086212 scopus 로고    scopus 로고
    • Gene expression profiling in multiple sclerosis: A disease of the central nervous system, but with relapses triggered in the periphery?
    • Brynedal B, et al. (2009) Gene expression profiling in multiple sclerosis: A disease of the central nervous system, but with relapses triggered in the periphery? Neurobiol. Dis. 37:613-621.
    • (2009) Neurobiol. Dis , vol.37 , pp. 613-621
    • Brynedal, B.1
  • 16
    • 0035363488 scopus 로고    scopus 로고
    • In vivo gene expression revealed by cDNA arrays: The pattern in relapsing- remitting multiple sclerosis patients compared with normal subjects
    • Ramanathan M, et al. (2001) In vivo gene expression revealed by cDNA arrays: the pattern in relapsing- remitting multiple sclerosis patients compared with normal subjects. J. Neuroimmunol. 116:213-219.
    • (2001) J. Neuroimmunol , vol.116 , pp. 213-219
    • Ramanathan, M.1
  • 17
    • 50149102578 scopus 로고    scopus 로고
    • Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
    • Corvol JC, et al. (2008) Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc. Natl. Acad. Sci. U. S. A. 105:11839-11844.
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 11839-11844
    • Corvol, J.C.1
  • 18
    • 10744231299 scopus 로고    scopus 로고
    • Gene expression profile in multiple sclerosis patients and healthy controls: Identifying pathways relevant to disease
    • Bomprezzi R, et al. (2003) Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum. Mol. Genet. 12:2191-2199.
    • (2003) Hum. Mol. Genet , vol.12 , pp. 2191-2199
    • Bomprezzi, R.1
  • 19
    • 1842687455 scopus 로고    scopus 로고
    • Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells
    • Iglesias AH, et al. (2004) Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J. Neuroimmunol. 150:163-177.
    • (2004) J. Neuroimmunol , vol.150 , pp. 163-177
    • Iglesias, A.H.1
  • 20
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, et al. (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 41:776-782.
    • (2009) Nat. Genet , vol.41 , pp. 776-782
    • de Jager, P.L.1
  • 21
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • (2009) Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat. Genet. 41:824-828.
    • (2009) Nat. Genet , vol.41 , pp. 824-828
  • 22
    • 0027573467 scopus 로고
    • Changes of serum complement and of circulating immune complexes in patients with multiple sclerosis
    • Cojocaru M, Serbanescu A, Cojocaru IM. (1993) Changes of serum complement and of circulating immune complexes in patients with multiple sclerosis. Rom. J. Intern. Med. 31:131-137.
    • (1993) Rom. J. Intern. Med , vol.31 , pp. 131-137
    • Cojocaru, M.1    Serbanescu, A.2    Cojocaru, I.M.3
  • 23
    • 33747881230 scopus 로고    scopus 로고
    • Not-sosweet sixteen: The role of IL-16 in infectious andimmune-mediated inflammatory diseases
    • Glass WG, Sarisky RT, Vecchio AM. (2006) Not-sosweet sixteen: the role of IL-16 in infectious andimmune-mediated inflammatory diseases. J. Interferon Cytokine Res. 26:511-520.
    • (2006) J. Interferon Cytokine Res , vol.26 , pp. 511-520
    • Glass, W.G.1    Sarisky, R.T.2    Vecchio, A.M.3
  • 24
    • 33745786381 scopus 로고    scopus 로고
    • Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions
    • Skundric DS, Cai J, Cruikshank WW, Gveric D. (2006) Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions. J. Neuroinflammation. 3:13.
    • (2006) J. Neuroinflammation , vol.3 , pp. 13
    • Skundric, D.S.1    Cai, J.2    Cruikshank, W.W.3    Gveric, D.4
  • 25
    • 27844498722 scopus 로고    scopus 로고
    • Increased levels of bioactive IL-16 correlate with disease activity during relapsing experimental autoimmune encephalomyelitis (EAE)
    • Skundric DS, Zhou W, Cruikshank WW, Dai R. (2005) Increased levels of bioactive IL-16 correlate with disease activity during relapsing experimental autoimmune encephalomyelitis (EAE). J. Autoimmun. 25:206-214.
    • (2005) J. Autoimmun , vol.25 , pp. 206-214
    • Skundric, D.S.1    Zhou, W.2    Cruikshank, W.W.3    Dai, R.4
  • 26
    • 33847377610 scopus 로고    scopus 로고
    • Gene expression profiles reveal homeostatic dynamics during interferonbeta therapy in multiple sclerosis
    • Annibali V, et al. (2007) Gene expression profiles reveal homeostatic dynamics during interferonbeta therapy in multiple sclerosis. Autoimmunity. 40:16-22.
    • (2007) Autoimmunity , vol.40 , pp. 16-22
    • Annibali, V.1
  • 27
    • 0034212944 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis
    • Feakes R, et al. (2000) Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis. J. Neuroimmunol. 105:96-101.
    • (2000) J. Neuroimmunol , vol.105 , pp. 96-101
    • Feakes, R.1
  • 28
    • 60049088657 scopus 로고    scopus 로고
    • Induction of serum soluble tumor necrosis factor receptor II (sTNFRII) and interleukin-1 receptor antagonist (IL- 1ra) by interferon beta-1b in patients with progressive multiple sclerosis
    • Comabella M, et al. (2008) Induction of serum soluble tumor necrosis factor receptor II (sTNFRII) and interleukin-1 receptor antagonist (IL- 1ra) by interferon beta-1b in patients with progressive multiple sclerosis. J. Neurol. 255:1136-1141.
    • (2008) J. Neurol , vol.255 , pp. 1136-1141
    • Comabella, M.1
  • 29
    • 63149114677 scopus 로고    scopus 로고
    • Glatiramer acetate increases IL-1 receptor antagonist but decreases T cellinduced IL-1beta in human monocytes and multiple sclerosis
    • Burger D, et al. (2009) Glatiramer acetate increases IL-1 receptor antagonist but decreases T cellinduced IL-1beta in human monocytes and multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 106:4355-4359.
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 4355-4359
    • Burger, D.1
  • 30
    • 0030015204 scopus 로고    scopus 로고
    • Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-beta treatment
    • Nicoletti F, et al. (1996) Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-beta treatment. Cytokine. 8:395-400.
    • (1996) Cytokine , vol.8 , pp. 395-400
    • Nicoletti, F.1
  • 31
    • 0030787571 scopus 로고    scopus 로고
    • Correlation between interferon production and clinical disease activity in patients with multiple sclerosis
    • Dettke M, Scheidt P, Prange H, Kirchner H. (1997) Correlation between interferon production and clinical disease activity in patients with multiple sclerosis. J. Clin. Immunol. 17:293-300.
    • (1997) J. Clin. Immunol , vol.17 , pp. 293-300
    • Dettke, M.1    Scheidt, P.2    Prange, H.3    Kirchner, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.