-
1
-
-
0027381406
-
The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation
-
Aoki M, et al. 1993. The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. J. Biol. Chem. 268:22723-22732.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 22723-22732
-
-
Aoki, M.1
-
2
-
-
0037025318
-
The death domain of NF-κB1 p105 is essential for signal-induced p105 proteolysis
-
Beinke S, Belich MP, Ley SC. 2002. The death domain of NF-κB1 p105 is essential for signal-induced p105 proteolysis. J. Biol. Chem. 277:24162- 24168.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24162-24168
-
-
Beinke, S.1
Belich, M.P.2
Ley, S.C.3
-
3
-
-
0038112098
-
NF- κB p105 negatively regulates TPL-2 MEK kinase activity
-
Beinke S, et al. 2003. NF-κB p105 negatively regulates TPL-2 MEK kinase activity. Mol. Cell. Biol. 23:4739-4752.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4739-4752
-
-
Beinke, S.1
-
4
-
-
6344264987
-
Lipopolysaccharide activation of the TPL-2/MEK/ extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105
-
Beinke S, et al. 2004. Lipopolysaccharide activation of the TPL-2/MEK/ extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105. Mol. Cell. Biol. 24:9658 -9667.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9658-9667
-
-
Beinke, S.1
-
5
-
-
0033611544
-
TPL- 2 kinase regulates the proteolysis of the NF-κB inhibitory protein NF-κB1 p105
-
Belich MP, Salmeron A, Johnston LH, Ley SC. 1999. TPL-2 kinase regulates the proteolysis of the NF-κB inhibitory protein NF-κB1 p105. Nature 397:363-368.
-
(1999)
Nature
, vol.397
, pp. 363-368
-
-
Belich, M.P.1
Salmeron, A.2
Johnston, L.H.3
Ley, S.C.4
-
6
-
-
20144384547
-
Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an IκB kinase-β-dependent pathway and is required for Tpl2 activation by external signals
-
Cho J, Melnick M, Solidakis GP, Tsichlis PN. 2005. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an IκB kinase-β-dependent pathway and is required for Tpl2 activation by external signals. J. Biol. Chem. 280:20442-20448.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20442-20448
-
-
Cho, J.1
Melnick, M.2
Solidakis, G.P.3
Tsichlis, P.N.4
-
7
-
-
79251566745
-
Novel cross-talk within the IKK family controls innate immunity
-
Clark K, et al. 2011. Novel cross-talk within the IKK family controls innate immunity. Biochem. J. 434:93-104.
-
(2011)
Biochem. J.
, vol.434
, pp. 93-104
-
-
Clark, K.1
-
8
-
-
17744371331
-
TNFα induction by LPS is regulated posttranscriptionally via a TPL2/ERK-dependent pathway
-
Dumitru CD, et al. 2000. TNFα induction by LPS is regulated posttranscriptionally via a TPL2/ERK-dependent pathway. Cell 103:1071- 1083.
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
-
9
-
-
0042525945
-
TPL- 2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40
-
Eliopoulos AG, Wang C-C, Dumitru CD, Tsichlis PN. 2003. TPL-2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J. 22:3855-3864.
-
(2003)
EMBO J
, vol.22
, pp. 3855-3864
-
-
Eliopoulos, A.G.1
Wang, C.-C.2
Dumitru, C.D.3
Tsichlis, P.N.4
-
11
-
-
70350690506
-
IRAK1-independent pathways required for the interleukin 1-stimulated activation of the TPL-2 catalytic subunit and its dissociation from ABIN-2
-
Handoyo H, et al. 2009. IRAK1-independent pathways required for the interleukin 1-stimulated activation of the TPL-2 catalytic subunit and its dissociation from ABIN-2. Biochem. J. 424:109 -118.
-
(2009)
Biochem. J.
, vol.424
, pp. 109-118
-
-
Handoyo, H.1
-
12
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden MS, Ghosh S. 2008. Shared principles in NF-κB signaling. Cell 132:344 -362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
13
-
-
17644391197
-
A rapid method for determining protein kinase phosphorylation specificity
-
Hutti JE, et al. 2004. A rapid method for determining protein kinase phosphorylation specificity. Nat. Methods 1:27-29.
-
(2004)
Nat. Methods
, vol.1
, pp. 27-29
-
-
Hutti, J.E.1
-
14
-
-
23944499553
-
Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinaseCOTand the complexes with its cellular partner NF-κB1 p105
-
Jia Y, et al. 2005. Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinaseCOTand the complexes with its cellular partner NF-κB1 p105. Arch. Biochem. Biophys. 441:64 -74.
-
(2005)
Arch. Biochem. Biophys.
, vol.441
, pp. 64-74
-
-
Jia, Y.1
-
15
-
-
69549129472
-
TPL- 2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells
-
Kaiser F, et al. 2009. TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells. J. Exp. Med. 206:1863-1871.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1863-1871
-
-
Kaiser, F.1
-
16
-
-
0346727295
-
Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
-
Kanters E, et al. 2003. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 112:1176 -1185.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1176-1185
-
-
Kanters, E.1
-
17
-
-
0034084163
-
Phosphorylation meets ubiquitination: the control of NF-κB activity
-
Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621- 663.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
18
-
-
61849157254
-
TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes
-
Karin M, Gallagher E. 2009. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol. Rev. 228:225-240.
-
(2009)
Immunol. Rev.
, vol.228
, pp. 225-240
-
-
Karin, M.1
Gallagher, E.2
-
19
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
-
Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11:373- 384.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
20
-
-
35848929692
-
A probability-based approach for the analysis of large-scale RNAi screens
-
König R, et al. 2007. A probability-based approach for the analysis of large-scale RNAi screens. Nat. Methods 4:847- 849.
-
(2007)
Nat. Methods
, vol.4
, pp. 847-849
-
-
König, R.1
-
21
-
-
0037121941
-
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
-
Kontoyiannis D, et al. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J. Exp. Med. 196:1563-1574.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1563-1574
-
-
Kontoyiannis, D.1
-
22
-
-
0037207474
-
βTrCP-mediated proteolysis of NF-κB1 p105 requires phosphorylation of p105 serines 927 and 932
-
Lang V, et al. 2003. βTrCP-mediated proteolysis of NF-κB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol. Cell. Biol. 23: 402-413.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 402-413
-
-
Lang, V.1
-
23
-
-
2942594766
-
ABIN-2 forms a ternary complex with TPL-2 and NF-κB1 p105 and is essential for TPL-2 protein stability
-
Lang V, et al. 2004. ABIN-2 forms a ternary complex with TPL-2 and NF-κB1 p105 and is essential for TPL-2 protein stability. Mol. Cell. Biol. 24:5235-5248.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5235-5248
-
-
Lang, V.1
-
24
-
-
0035836638
-
IL- 1-induced NF-kB and c-Jun N-terminal kinase (JNK) activation at IL-1 receptor-associated kinase (IRAK)
-
Li X, Commane M, Jiang Z, Stark GR. 2001. IL-1-induced NF-kB and c-Jun N-terminal kinase (JNK) activation at IL-1 receptor-associated kinase (IRAK). Proc. Natl. Acad. Sci. U. S. A. 98:4461- 4465.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4461-4465
-
-
Li, X.1
Commane, M.2
Jiang, Z.3
Stark, G.R.4
-
25
-
-
0033082990
-
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases
-
Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271-280.
-
(1999)
Immunity
, vol.10
, pp. 271-280
-
-
Lin, X.1
Cunningham, E.T.2
Mu, Y.3
Geleziunas, R.4
Greene, W.C.5
-
26
-
-
76249111625
-
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 production
-
Mielke LA, et al. 2009. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 production. J. Immunol. 183:7984 -7993.
-
(2009)
J. Immunol.
, vol.183
, pp. 7984-7993
-
-
Mielke, L.A.1
-
27
-
-
0035503696
-
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress
-
Morita K-I, et al. 2001. Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress. EMBO J. 20:6028- 6036.
-
(2001)
EMBO J
, vol.20
, pp. 6028-6036
-
-
Morita, K.-I.1
-
28
-
-
33744455163
-
ABIN-2 is required for optimal activation of the TPL-2 / ERK MAP kinase pathway in innate immune responses
-
Papoutsopoulou S, et al. 2006. ABIN-2 is required for optimal activation of the TPL-2 / ERK MAP kinase pathway in innate immune responses. Nat. Immunol. 7:606-615.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 606-615
-
-
Papoutsopoulou, S.1
-
29
-
-
35649024803
-
Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages
-
Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC. 2007. Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages. Mol. Cell. Biol. 27:7355-7364.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 7355-7364
-
-
Robinson, M.J.1
Beinke, S.2
Kouroumalis, A.3
Tsichlis, P.N.4
Ley, S.C.5
-
30
-
-
0035933804
-
Direct phosphorylation of NF-κB p105 by the IκB kinase complex on serine 927 is essential for signal-induced p105 proteolysis
-
Salmeron A, et al. 2001. Direct phosphorylation of NF-κB p105 by the IκB kinase complex on serine 927 is essential for signal-induced p105 proteolysis. J. Biol. Chem. 276:22215-22222.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22215-22222
-
-
Salmeron, A.1
-
31
-
-
0028804551
-
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
-
Sha WC, Lious H-C, Tuomanen EI, Baltimore D. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321-330.
-
(1995)
Cell
, vol.80
, pp. 321-330
-
-
Sha, W.C.1
Lious, H.-C.2
Tuomanen, E.I.3
Baltimore, D.4
-
32
-
-
77949971595
-
Selective transcription in response to an inflammatory stimulus
-
Smale ST. 2010. Selective transcription in response to an inflammatory stimulus. Cell 140:833- 844.
-
(2010)
Cell
, vol.140
, pp. 833-844
-
-
Smale, S.T.1
-
33
-
-
57849147589
-
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation
-
Sriskantharajah S, et al. 2009. Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor-induced proliferation. Nat. Immunol. 10:38-47.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 38-47
-
-
Sriskantharajah, S.1
-
34
-
-
30544439770
-
MAP kinase kinase kinases and innate immunity
-
Symons A, Beinke S, Ley SC. 2006. MAP kinase kinase kinases and innate immunity. Trends Immunol. 27:40-48.
-
(2006)
Trends Immunol
, vol.27
, pp. 40-48
-
-
Symons, A.1
Beinke, S.2
Ley, S.C.3
-
35
-
-
0021909157
-
Bone marrow-derived macrophages: development and regulation of differentiation markers by colonystimulating factor and interferons
-
Warren MK, Vogel SN. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colonystimulating factor and interferons. J. Immunol. 134:982-989.
-
(1985)
J. Immunol.
, vol.134
, pp. 982-989
-
-
Warren, M.K.1
Vogel, S.N.2
-
36
-
-
2942707765
-
IKKβ is an essential component of the TPL-2 signaling pathway
-
Waterfield M, Jin W, Reiley W, Zhang MY, Sun S-C. 2004. IKKβ is an essential component of the TPL-2 signaling pathway. Mol. Cell. Biol. 24: 6040-6048.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6040-6048
-
-
Waterfield, M.1
Jin, W.2
Reiley, W.3
Zhang, M.Y.4
Sun, S.-C.5
-
37
-
-
0037349601
-
NF- κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the TPL-2 kinase
-
Waterfield MR, Zhang M, Norman LP, Sun S-C. 2003. NF-κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the TPL-2 kinase. Mol. Cell 11:685- 694.
-
(2003)
Mol. Cell
, vol.11
, pp. 685-694
-
-
Waterfield, M.R.1
Zhang, M.2
Norman, L.P.3
Sun, S.-C.4
-
38
-
-
84866299927
-
Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-kB1 p105
-
Yang HT, et al. 2012. Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-kB1 p105. Mol. Cell. Biol. 32:3438 -3451.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 3438-3451
-
-
Yang, H.T.1
-
39
-
-
79951818786
-
NF- κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation
-
Yang HT, et al. 2011. NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation. J. Immunol. 186:1989 -1996.
-
(2011)
J. Immunol.
, vol.186
, pp. 1989-1996
-
-
Yang, H.T.1
|