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Volumn 183, Issue 12, 2009, Pages 7877-7889

Neuronal IκB kinase β protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALMODULIN; CD30 LIGAND; CHEMOKINE; COLONY STIMULATING FACTOR RECEPTOR; FLICE INHIBITORY PROTEIN; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TUMOR NECROSIS FACTOR; VASCULOTROPIN; AUTACOID; I KAPPA B KINASE; IMMUNOSUPPRESSIVE AGENT;

EID: 76249086119     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900834     Document Type: Article
Times cited : (29)

References (75)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 34249781999 scopus 로고    scopus 로고
    • Pathogenesis of axonal and neuronal damage in multiple sclerosis
    • DOI 10.1212/01.wnl.0000275229.13012.32, PII 0000611420070529300005
    • Dutta, R., and B. D. Trapp. 2007. Pathogenesis of axonal and neuronal damage in multiple sclerosis. Neurology 68: S22-S31. (Pubitemid 46848608)
    • (2007) Neurology , vol.68 , Issue.22 SUPPL. 3
    • Dutta, R.1    Trapp, B.D.2
  • 3
    • 34249734136 scopus 로고    scopus 로고
    • New concepts on progressive multiple sclerosis
    • DOI 10.1007/s11910-007-0036-0
    • Lassmann, H. 2007. New concepts on progressive multiple sclerosis. Curr. Neurol. Neurosci. Rep. 7: 239-244. (Pubitemid 46831518)
    • (2007) Current Neurology and Neuroscience Reports , vol.7 , Issue.3 , pp. 239-244
    • Lassmann, H.1
  • 4
    • 33646791175 scopus 로고    scopus 로고
    • The neuroprotective effect of inflammation: Implications for the therapy of multiple sclerosis
    • DOI 10.1007/s10072-006-0537-7
    • Hohlfeld, R., M. Kerschensteiner, C. Stadelmann, H. Lassmann, and H. Wekerle. 2006. The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Neurol. Sci. 27(Suppl. 1): S1-S7. (Pubitemid 43756787)
    • (2006) Neurological Sciences , vol.27 , Issue.SUPPL. 1
    • Hohlfeld, R.1    Kerschensteiner, M.2    Stadelmann, C.3    Lassmann, H.4    Wekerle, H.5
  • 5
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp, B. D., and K. A. Nave. 2008. Multiple sclerosis: an immune or neurodegenerative disorder? Annu. Rev. Neurosci. 31: 247-269.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 6
    • 0031984426 scopus 로고    scopus 로고
    • Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration
    • Neumann, H., and H. Wekerle. 1998. Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. J. Neuropathol. Exp. Neurol. 57: 1-9. (Pubitemid 28057171)
    • (1998) Journal of Neuropathology and Experimental Neurology , vol.57 , Issue.1 , pp. 1-9
    • Neumann, H.1    Wekerle, H.2
  • 7
    • 0031054508 scopus 로고    scopus 로고
    • Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α
    • DOI 10.1084/jem.185.2.305
    • Neumann, H., H. Schmidt, A. Cavalie, D. Jenne, and H. Wekerle. 1997. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. J. Exp. Med. 185: 305-316. (Pubitemid 27078287)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.2 , pp. 305-316
    • Neumann, H.1    Schmidt, H.2    Cavalie, A.3    Jenne, D.4    Wekerle, H.5
  • 9
    • 2542421703 scopus 로고    scopus 로고
    • Neuronal expression of CD22: Novel mechanism for inhibiting microglial proinflammatory cytokine production
    • Mott, R. T., G. Ait-Ghezala, T. Town, T. Mori, M. Vendrame, J. Zeng, J. Ehrhart, M. Mullan, and J. Tan. 2004. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia 46: 369-379.
    • (2004) Glia , vol.46 , pp. 369-379
    • Mott, R.T.1    Ait-Ghezala, G.2    Town, T.3    Mori, T.4    Vendrame, M.5    Zeng, J.6    Ehrhart, J.7    Mullan, M.8    Tan, J.9
  • 11
    • 0031567984 scopus 로고    scopus 로고
    • The Neuronal Glycoprotein Telencephalin is a Cellular Ligand for the CD11a/CD18 Leukocyte Integrin
    • Tian, L., Y. Yoshihara, T. Mizuno, K. Mori, and C. G. Gahmberg. 1997. The neuronal glycoprotein telencephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin. J. Immunol. 158: 928-936. (Pubitemid 127492673)
    • (1997) Journal of Immunology , vol.158 , Issue.2 , pp. 928-936
    • Tian, L.1    Yoshihara, Y.2    Mizuno, T.3    Mori, K.4    Gahmberg, C.G.5
  • 12
    • 0033999503 scopus 로고    scopus 로고
    • Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18
    • DOI 10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X
    • Tian, L., P. Kilgannon, Y. Yoshihara, K. Mori, W. M. Gallatin, O. Carpen, and C. G. Gahmberg. 2000. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. Eur. J. Immunol. 30: 810-818. (Pubitemid 30216253)
    • (2000) European Journal of Immunology , vol.30 , Issue.3 , pp. 810-818
    • Tian, L.1    Kilgannon, P.2    Yoshihara, Y.3    Mori, K.4    Gallatin, W.M.5    Carpen, O.6    Gahmberg, C.G.7
  • 13
    • 33646596928 scopus 로고    scopus 로고
    • Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE
    • Liu, Y., I. Teige, B. Birnir, and S. Issazadeh-Navikas. 2006. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 12: 518-525.
    • (2006) Nat. Med. , vol.12 , pp. 518-525
    • Liu, Y.1    Teige, I.2    Birnir, B.3    Issazadeh-Navikas, S.4
  • 14
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
    • DOI 10.1016/0896-6273(94)90159-7
    • Cheng, B., S. Christakos, and M. P. Mattson. 1994. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12: 139-153. (Pubitemid 24044394)
    • (1994) Neuron , vol.12 , Issue.1 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 19
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2: 725-734.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 20
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin, M., and A. Lin. 2002. NF-κB at the crossroads of life and death. Nat. Immunol. 3: 221-227.
    • (2002) Nat. Immunol. , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 22
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109(Suppl.): S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 24
    • 0033989375 scopus 로고    scopus 로고
    • Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity
    • Albensi, B. C., and M. P. Mattson. 2000. Evidence for the involvement of TNF and NF-κB in hippocampal synaptic plasticity. Synapse 35: 151-159.
    • (2000) Synapse , vol.35 , pp. 151-159
    • Albensi, B.C.1    Mattson, M.P.2
  • 27
    • 0030611750 scopus 로고    scopus 로고
    • Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
    • Mattson, M. P., Y. Goodman, H. Luo, W. Fu, and K. Furukawa. 1997. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration. J. Neurosci. Res. 49: 681-697.
    • (1997) J. Neurosci. Res. , vol.49 , pp. 681-697
    • Mattson, M.P.1    Goodman, Y.2    Luo, H.3    Fu, W.4    Furukawa, K.5
  • 32
    • 33747609345 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    • DOI 10.1038/ni1372, PII NI1372
    • van Loo, G., R. De Lorenzi, H. Schmidt, M. Huth, A. Mildner, M. Schmidt-Supprian, H. Lassmann, M. R. Prinz, and M. Pasparakis. 2006. Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat. Immunol. 7: 954-961. (Pubitemid 44263909)
    • (2006) Nature Immunology , vol.7 , Issue.9 , pp. 954-961
    • Van Loo, G.1    De Lorenzi, R.2    Schmidt, H.3    Huth, M.4    Mildner, A.5    Schmidt-Supprian, M.6    Lassmann, H.7    Prinz, M.R.8    Pasparakis, M.9
  • 33
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-κB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation
    • Brambilla, R., T. Persaud, X. Hu, S. Karmally, V. I. Shestopalov, G. Dvoriantchikova, D. Ivanov, L. Nathanson, S. R. Barnum, and J. R. Bethea. 2009. Transgenic inhibition of astroglial NF-κB improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J. Immunol. 182: 2628-2640.
    • (2009) J. Immunol. , vol.182 , pp. 2628-2640
    • Brambilla, R.1    Persaud, T.2    Hu, X.3    Karmally, S.4    Shestopalov, V.I.5    Dvoriantchikova, G.6    Ivanov, D.7    Nathanson, L.8    Barnum, S.R.9    Bethea, J.R.10
  • 34
    • 33747594754 scopus 로고    scopus 로고
    • At once harmful and beneficial: The dual properties of NF-κB
    • DOI 10.1038/ni0906-901, PII NI0906-901
    • Youssef, S., and L. Steinman. 2006. At once harmful and beneficial: the dual properties of NF-κB. Nat. Immunol. 7: 901-902. (Pubitemid 44263900)
    • (2006) Nature Immunology , vol.7 , Issue.9 , pp. 901-902
    • Youssef, S.1    Steinman, L.2
  • 35
    • 0037144590 scopus 로고    scopus 로고
    • Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition
    • Park, J. M., F. R. Greten, Z. W. Li, and M. Karin. 2002. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 297: 2048-2051.
    • (2002) Science , vol.297 , pp. 2048-2051
    • Park, J.M.1    Greten, F.R.2    Li, Z.W.3    Karin, M.4
  • 36
    • 0242416989 scopus 로고    scopus 로고
    • IKKβ is required for peripheral B cell survival and proliferation
    • Li, Z. W., S. A. Omori, T. Labuda, M. Karin, and R. C. Rickert. 2003. IKKβ is required for peripheral B cell survival and proliferation. J. Immunol. 170: 4630-4637. (Pubitemid 36519969)
    • (2003) Journal of Immunology , vol.170 , Issue.9 , pp. 4630-4637
    • Li, Z.-W.1    Omori, S.A.2    Labuda, T.3    Karin, M.4    Rickert, R.C.5
  • 38
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain [1]
    • DOI 10.1038/5007
    • Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21: 70-71. (Pubitemid 29036285)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 70-71
    • Soriano, P.1
  • 41
    • 9144269945 scopus 로고    scopus 로고
    • Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis
    • Tseveleki, V., J. Bauer, E. Taoufik, C. Ruan, L. Leondiadis, S. Haralambous, H. Lassmann, and L. Probert. 2004. Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis. J. Immunol. 173: 6619-6626.
    • (2004) J. Immunol. , vol.173 , pp. 6619-6626
    • Tseveleki, V.1    Bauer, J.2    Taoufik, E.3    Ruan, C.4    Leondiadis, L.5    Haralambous, S.6    Lassmann, H.7    Probert, L.8
  • 42
    • 33748302945 scopus 로고    scopus 로고
    • Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation
    • DOI 10.1172/JCI28330
    • Krishnamoorthy, G., H. Lassmann, H. Wekerle, and A. Holz. 2006. Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J. Clin. Invest. 116: 2385-2392. (Pubitemid 44330137)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.9 , pp. 2385-2392
    • Krishnamoorthy, G.1    Lassmann, H.2    Wekerle, H.3    Holz, A.4
  • 44
    • 0035341498 scopus 로고    scopus 로고
    • Neuroprotection mediated by glial cell line-derived neurotrophic factor: Involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway
    • Nicole, O., C. Ali, F. Docagne, L. Plawinski, E. T. MacKenzie, D. Vivien, and A. Buisson. 2001. Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway. J. Neurosci. 21: 3024-3033. (Pubitemid 32323484)
    • (2001) Journal of Neuroscience , vol.21 , Issue.9 , pp. 3024-3033
    • Nicole, O.1    Ali, C.2    Docagne, F.3    Plawinski, L.4    MacKenzie, E.T.5    Vivien, D.6    Buisson, A.7
  • 45
    • 0023097396 scopus 로고
    • Effect of anticonvulsant drugs on glutamate neurotoxicity in cortical cell culture
    • Koh, J. Y., and D. W. Choi. 1987. Effect of anticonvulsant drugs on glutamate neurotoxicity in cortical cell culture. Neurology 37: 319-322.
    • (1987) Neurology , vol.37 , pp. 319-322
    • Koh, J.Y.1    Choi, D.W.2
  • 47
    • 3543068828 scopus 로고    scopus 로고
    • Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis
    • Brand-Schieber, E., and P. Werner. 2004. Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis. Exp. Neurol. 189: 5-9.
    • (2004) Exp. Neurol. , vol.189 , pp. 5-9
    • Brand-Schieber, E.1    Werner, P.2
  • 48
    • 68349101972 scopus 로고    scopus 로고
    • HIF-1α-deficient mice have increased brain injury after neonatal hypoxiaischemia
    • Sheldon, R. A., D. Osredkar, C. L. Lee, X. Jiang, D. Mu, and D. M. Ferriero. 2009. HIF-1α-deficient mice have increased brain injury after neonatal hypoxiaischemia. Dev. Neurosci. 31: 452-458.
    • (2009) Dev. Neurosci. , vol.31 , pp. 452-458
    • Sheldon, R.A.1    Osredkar, D.2    Lee, C.L.3    Jiang, X.4    Mu, D.5    Ferriero, D.M.6
  • 49
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold, R., C. Linington, and H. Lassmann. 2006. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129: 1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 50
    • 0034744033 scopus 로고    scopus 로고
    • NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    • Kreuz, S., D. Siegmund, P. Scheurich, and H. Wajant. 2001. NF-κB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 21: 3964-3973.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3964-3973
    • Kreuz, S.1    Siegmund, D.2    Scheurich, P.3    Wajant, H.4
  • 51
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin, M., Y. Yamamoto, and Q. M. Wang. 2004. The IKK NF-κB system: a treasure trove for drug development. Nat. Rev. Drug Discov. 3: 17-26. (Pubitemid 38088695)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.1 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 52
    • 0034746288 scopus 로고    scopus 로고
    • NF-κB in neuronal plasticity and neurodegenerative disorders
    • Mattson, M. P., and S. Camandola. 2001. NF-κB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107: 247-254. (Pubitemid 32162153)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.3 , pp. 247-254
    • Mattson, M.P.1    Camandola, S.2
  • 55
    • 0036211764 scopus 로고    scopus 로고
    • Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxiainducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain
    • Bernaudin, M., A. S. Nedelec, D. Divoux, E. T. MacKenzie, E. Petit, and P. Schumann-Bard. 2002. Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxiainducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J. Cereb. Blood Flow Metab. 22: 393-403.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 393-403
    • Bernaudin, M.1    Nedelec, A.S.2    Divoux, D.3    MacKenzie, E.T.4    Petit, E.5    Schumann-Bard, P.6
  • 56
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia
    • Jin, K. L., X. O. Mao, and D. A. Greenberg. 2000. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. USA 97: 10242-10247.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10242-10247
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 57
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • DOI 10.1172/JCI200317977
    • Sun, Y., K. Jin, L. Xie, J. Childs, X. O. Mao, A. Logvinova, and D. A. Greenberg. 2003. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111: 1843-1851. (Pubitemid 38057729)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.12 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 58
    • 4844227301 scopus 로고    scopus 로고
    • Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS
    • DOI 10.1002/ana.20223
    • Zheng, C., I. Nennesmo, B. Fadeel, and J. I. Henter. 2004. Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS. Ann. Neurol. 56: 564-567. (Pubitemid 39319348)
    • (2004) Annals of Neurology , vol.56 , Issue.4 , pp. 564-567
    • Zheng, C.1    Nennesmo, I.2    Fadeel, B.3    Henter, J.-I.4
  • 60
    • 0033199067 scopus 로고    scopus 로고
    • Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice
    • Wang, Y., O. Berezovska, and S. Fedoroff. 1999. Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice. J. Neurosci. Res. 57: 616-632.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 616-632
    • Wang, Y.1    Berezovska, O.2    Fedoroff, S.3
  • 63
    • 0029078778 scopus 로고
    • The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury
    • Berezovskaya, O., D. Maysinger, and S. Fedoroff. 1995. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int. J. Dev. Neurosci. 13: 285-299.
    • (1995) Int. J. Dev. Neurosci. , vol.13 , pp. 285-299
    • Berezovskaya, O.1    Maysinger, D.2    Fedoroff, S.3
  • 64
    • 0029972157 scopus 로고    scopus 로고
    • Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion
    • Berezovskaya, O., D. Maysinger, and S. Fedoroff. 1996. Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion. Acta Neuropathol. 92: 479-486.
    • (1996) Acta Neuropathol. , vol.92 , pp. 479-486
    • Berezovskaya, O.1    Maysinger, D.2    Fedoroff, S.3
  • 65
    • 35748939409 scopus 로고    scopus 로고
    • Neuronal "On" and "Off" signals control microglia
    • Biber, K., H. Neumann, K. Inoue, and H. W. Boddeke. 2007. Neuronal "On" and "Off" signals control microglia. Trends Neurosci. 30: 596-602.
    • (2007) Trends Neurosci. , vol.30 , pp. 596-602
    • Biber, K.1    Neumann, H.2    Inoue, K.3    Boddeke, H.W.4
  • 66
    • 0347362913 scopus 로고    scopus 로고
    • Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain
    • Brionne, T. C., I. Tesseur, E. Masliah, and T. Wyss-Coray. 2003. Loss of TGF-β1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40: 1133-1145.
    • (2003) Neuron , vol.40 , pp. 1133-1145
    • Brionne, T.C.1    Tesseur, I.2    Masliah, E.3    Wyss-Coray, T.4
  • 67
    • 0029079852 scopus 로고
    • Induction of MHC class I genes in neurons
    • Neumann, H., A. Cavalie, D. E. Jenne, and H. Wekerle. 1995. Induction of MHC class I genes in neurons. Science 269: 549-552.
    • (1995) Science , vol.269 , pp. 549-552
    • Neumann, H.1    Cavalie, A.2    Jenne, D.E.3    Wekerle, H.4
  • 68
    • 0032510798 scopus 로고    scopus 로고
    • Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor
    • Neumann, H., T. Misgeld, K. Matsumuro, and H. Wekerle. 1998. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. USA 95: 5779-5784.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5779-5784
    • Neumann, H.1    Misgeld, T.2    Matsumuro, K.3    Wekerle, H.4
  • 70
    • 34848825439 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in neurological disease: Raise, retain, or reduce?
    • Savarin-Vuaillat, C., and R. M. Ransohoff. 2007. Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce? Neurotherapeutics 4: 590-601.
    • (2007) Neurotherapeutics , vol.4 , pp. 590-601
    • Savarin-Vuaillat, C.1    Ransohoff, R.M.2
  • 71
    • 42249114634 scopus 로고    scopus 로고
    • + CXC chemokine pathway is essential for the development of central nervous system autoimmune disease
    • + CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J. Exp. Med. 205: 811-823.
    • (2008) J. Exp. Med. , vol.205 , pp. 811-823
    • Carlson, T.1    Kroenke, M.2    Rao, P.3    Lane, T.E.4    Segal, B.5
  • 72
    • 46949104323 scopus 로고    scopus 로고
    • IL-12-and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke, M. A., T. J. Carlson, A. V. Andjelkovic, and B. M. Segal. 2008. IL-12-and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 205: 1535-1541.
    • (2008) J. Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 73
    • 35848934131 scopus 로고    scopus 로고
    • The role of natural killer cells in curbing neuroinflammation
    • Segal, B. M. 2007. The role of natural killer cells in curbing neuroinflammation. J. Neuroimmunol. 191: 2-7.
    • (2007) J. Neuroimmunol. , vol.191 , pp. 2-7
    • Segal, B.M.1
  • 74
    • 0036548875 scopus 로고    scopus 로고
    • Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: Opposite roles of TNF receptor 1 and TNF receptor 2
    • Fontaine, V., S. Mohand-Said, N. Hanoteau, C. Fuchs, K. Pfizenmaier, and U. Eisel. 2002. Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci. 22: RC216.
    • (2002) J. Neurosci. , vol.22
    • Fontaine, V.1    Mohand-Said, S.2    Hanoteau, N.3    Fuchs, C.4    Pfizenmaier, K.5    Eisel, U.6
  • 75
    • 3543046113 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation: Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-κB pathway
    • Marchetti, L., M. Klein, K. Schlett, K. Pfizenmaier, and U. L. Eisel. 2004. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation: essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-κB pathway. J. Biol. Chem. 279: 32869-32881.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32869-32881
    • Marchetti, L.1    Klein, M.2    Schlett, K.3    Pfizenmaier, K.4    Eisel, U.L.5


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