Myelin activates FAK/Akt/NF-κB pathways and provokes CR3-dependent inflammatory response in murine system

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Sun, Xin ^a,b   Wang, Xi ^a   Chen, Tianxiang ^a   Li, Tianyi ^a   Cao, Kai ^a   Lu, Andrew ^a   Chen, Yongxiong ^a   Sun, Dongming ^a   Luo, Jianhong ^b   Fan, Jianqing ^c   Young, Wise ^a   Ren, Yi ^a  

^a RUTGERS UNIVERSITY   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; COMPLEMENT COMPONENT C3 RECEPTOR; CYTOKINE; FOCAL ADHESION KINASE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; MYELIN BASIC PROTEIN; PROTEIN KINASE B; SPHINGOMYELIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CD11B ANTIGEN; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, MOUSE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE ACTIVATION; MOUSE; MULTIPLE SCLEROSIS; NERVE FIBER; NERVOUS SYSTEM INJURY; NEUROPATHOLOGY; NONHUMAN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE MUTANT; MYELIN SHEATH; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; TUMOR CELL LINE;

ANIMALIA; MURINAE;

ANIMALS; ANTIGENS, CD11B; BONE MARROW CELLS; CELL LINE, TUMOR; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION KINASE 1; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN SHEATH; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 77949616373     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009380     Document Type: Article

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