The secretome signature of reactive glial cells and its pathological implications

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1834, Issue 11, 2013, Pages 2418-2428

  Jha, Mithilesh Kumar ^a   Seo, Minchul ^a   Kim, Jong Heon ^a   Kim, Byung Gyu ^b   Cho, Je Yoel ^c   Suk, Kyoungho ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Biomarkers; Glia; Neuroinflammation; Proteomics; Secretome; Therapeutic targets

Indexed keywords

APOLIPOPROTEIN D; APOLIPOPROTEIN E; CATHEPSIN D; CHITINASE; CHITINASE 3 LIKE 1 PROTEIN; GALECTIN 1; GALECTIN 1 LIKE 2 PROTEIN; GLYPICAN; INTERLEUKIN 1BETA; INTERLEUKIN 6; METALLOTHIONEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; NITRIC OXIDE; OSTEOPONTIN; PENTRAXIN 3; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROGRANULIN; PROSTAGLANDIN D SYNTHASE; PROTEIN S100B; REACTIVE OXYGEN METABOLITE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SECRETORY PHOSPHOLIPASE A2; SECRETORY PHOSPHOLIPASE A2 IIA; SERUM AMYLOID A; STRESS INDUCIBLE PROTEIN 1; THROMBOSPONDIN; TRANSFERRIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG; UROKINASE;

ANTIGEN PRESENTATION; ASTROCYTE; BRAIN FUNCTION; BRAIN INJURY; CELL COMMUNICATION; CELL INTERACTION; CELL MIGRATION; CELL PHAGOCYTOSIS; CENTRAL NERVOUS SYSTEM; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GLIA CELL; HUMAN; IMMUNOCOMPETENT CELL; INDUCED HYPOTHERMIA; MICROGLIA; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OLFACTORY ENSHEATHING CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; SCHWANN CELL; SIGNAL TRANSDUCTION;

BIOMARKERS; GLIA; NEUROINFLAMMATION; PROTEOMICS; SECRETOME; THERAPEUTIC TARGETS;

ANIMALS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; HYPOTHERMIA, INDUCED; NEUROGLIA; PROTEOME; PROTEOMICS; SECRETORY PATHWAY; TRANSCRIPTOME;

EID: 84884669792     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2012.12.006     Document Type: Review

References (229)

1. F.A. Azevedo, L.R. Carvalho, L.T. Grinberg, J.M. Farfel, R.E. Ferretti, R.E. Leite, W. Jacob Filho, R. Lent, and S. Herculano-Houzel Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain J. Comp. Neurol. 513 2009 532 541
2. S.C. Noctor, V. Martinez-Cerdeno, and A.R. Kriegstein Contribution of intermediate progenitor cells to cortical histogenesis Arch. Neurol. 64 2007 639 642 (Pubitemid 46789829)
3. A. Nishiyama, Z. Yang, and A. Butt Astrocytes and NG2-glia: what's in a name? J. Anat. 207 2005 687 693 (Pubitemid 43019728)
4. F. Doetsch The glial identity of neural stem cells Nat. Neurosci. 6 2003 1127 1134 (Pubitemid 37346029)
5. E.M. Ullian, S.K. Sapperstein, K.S. Christopherson, and B.A. Barres Control of synapse number by glia Science 291 2001 657 661 (Pubitemid 32150425)
6. H.H. Tsai, H. Li, L.C. Fuentealba, A.V. Molofsky, R. Taveira-Marques, H. Zhuang, A. Tenney, A.T. Murnen, S.P. Fancy, F. Merkle, N. Kessaris, A. Alvarez-Buylla, W.D. Richardson, and D.H. Rowitch Regional astrocyte allocation regulates CNS synaptogenesis and repair Science 337 2012 358 362
7. V. Hughes Microglia: the constant gardeners Nature 485 2012 570 572
8. I. Schmidt, S. Thomas, P. Kain, B. Risse, E. Naffin, and C. Klambt Kinesin heavy chain function in Drosophila glial cells controls neuronal activity J. Neurosci. 32 2012 7466 7476
9. U. Funfschilling, L.M. Supplie, D. Mahad, S. Boretius, A.S. Saab, J. Edgar, B.G. Brinkmann, C.M. Kassmann, I.D. Tzvetanova, W. Mobius, F. Diaz, D. Meijer, U. Suter, B. Hamprecht, M.W. Sereda, C.T. Moraes, J. Frahm, S. Goebbels, and K.A. Nave Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity Nature 485 2012 517 521
10. F. Wang, N.A. Smith, Q. Xu, T. Fujita, A. Baba, T. Matsuda, T. Takano, L. Bekar, and M. Nedergaard Astrocytes modulate neural network activity by Ca(2)+-dependent uptake of extracellular K + Sci. Signal. 5 2012 ra26
11. D.D. Wang, and A. Bordey The astrocyte odyssey Prog. Neurobiol. 86 2008 342 367
12. Y. Jiang, and L. Uhrbom On the origin of glioma Ups. J. Med. Sci. 117 2012 113 121
13. Y. Wu, Y. Lu, W. Chen, J. Fu, and R. Fan In silico experimentation of glioma microenvironment development and anti-tumor therapy PLoS Comput. Biol. 8 2012 e1002355
14. C. Liu, J.C. Sage, M.R. Miller, R.G. Verhaak, S. Hippenmeyer, H. Vogel, O. Foreman, R.T. Bronson, A. Nishiyama, L. Luo, and H. Zong Mosaic analysis with double markers reveals tumor cell of origin in glioma Cell 146 2011 209 221
15. A.I. Persson, C. Petritsch, F.J. Swartling, M. Itsara, F.J. Sim, R. Auvergne, D.D. Goldenberg, S.R. Vandenberg, K.N. Nguyen, S. Yakovenko, J. Ayers-Ringler, A. Nishiyama, W.B. Stallcup, M.S. Berger, G. Bergers, T.R. McKnight, S.A. Goldman, and W.A. Weiss Non-stem cell origin for oligodendroglioma Cancer Cell 18 2010 669 682
16. N. Lindberg, M. Kastemar, T. Olofsson, A. Smits, and L. Uhrbom Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma Oncogene 28 2009 2266 2275
17. E. Miller Multiple sclerosis Adv. Exp. Med. Biol. 724 2012 222 238
18. J.A. Smith, A. Das, S.K. Ray, and N.L. Banik Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases Brain Res. Bull. 87 2012 10 20
19. D.T. Lioy, S.K. Garg, C.E. Monaghan, J. Raber, K.D. Foust, B.K. Kaspar, P.G. Hirrlinger, F. Kirchhoff, J.M. Bissonnette, N. Ballas, and G. Mandel A role for glia in the progression of Rett's syndrome Nature 475 2011 497 500
20. K. Tanaka, T. Kanno, Y. Yanagisawa, K. Yasutake, S. Hadano, F. Yoshii, and J.E. Ikeda Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis Exp. Neurol. 232 2011 41 52
21. E. Czirr, and T. Wyss-Coray The immunology of neurodegeneration J. Clin. Invest. 122 2012 1156 1163
22. H. Braak, and K. Del Tredici Alzheimer's disease: pathogenesis and prevention Alzheimers Dement. 8 2012 227 233
23. J. Zhao, T. O'Connor, and R. Vassar The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis J. Neuroinflammation 8 2011 150
24. N.A. Oberheim, G.F. Tian, X. Han, W. Peng, T. Takano, B. Ransom, and M. Nedergaard Loss of astrocytic domain organization in the epileptic brain J. Neurosci. 28 2008 3264 3276 (Pubitemid 351469330)
25. C.S. Lobsiger, and D.W. Cleveland Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease Nat. Neurosci. 10 2007 1355 1360 (Pubitemid 350014678)
26. O.K. Bitzer-Quintero, and I. Gonzalez-Burgos Immune system in the brain: a modulatory role on dendritic spine morphophysiology? Neural Plast. 2012 2012 348642
27. J. Vinet, H.R. Weering, A. Heinrich, R.E. Kalin, A. Wegner, N. Brouwer, F.L. Heppner, N. Rooijen, H.W. Boddeke, and K. Biber Neuroprotective function for ramified microglia in hippocampal excitotoxicity J. Neuroinflammation 9 2012 27
28. R. Yirmiya, and I. Goshen Immune modulation of learning, memory, neural plasticity and neurogenesis Brain Behav. Immun. 25 2011 181 213
29. C. Webber, and D. Zochodne The nerve regenerative microenvironment: early behavior and partnership of axons and Schwann cells Exp. Neurol. 223 2010 51 59
30. J.J. Dore, J.C. DeWitt, N. Setty, M.D. Donald, E. Joo, M.A. Chesarone, and S.J. Birren Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression Dev. Neurosci. 31 2009 473 486
31. S.M. Grimmond, K.C. Miranda, Z. Yuan, M.J. Davis, D.A. Hume, K. Yagi, N. Tominaga, H. Bono, Y. Hayashizaki, Y. Okazaki, and R.D. Teasdale The mouse secretome: functional classification of the proteins secreted into the extracellular environment Genome Res. 13 2003 1350 1359 (Pubitemid 36827231)
32. D. Greenbaum, N.M. Luscombe, R. Jansen, J. Qian, and M. Gerstein Interrelating different types of genomic data, from proteome to secretome: 'oming in on function Genome Res. 11 2001 1463 1468 (Pubitemid 32894671)
33. N.J. Maragakis, and J.D. Rothstein Mechanisms of disease: astrocytes in neurodegenerative disease Nat. Clin. Pract. Neurol. 2 2006 679 689 (Pubitemid 44782682)
34. R.B. Rock, G. Gekker, S. Hu, W.S. Sheng, M. Cheeran, J.R. Lokensgard, and P.K. Peterson Role of microglia in central nervous system infections Clin. Microbiol. Rev. 17 2004 942 964 (table of contents) (Pubitemid 39372525)
35. F. Aloisi Immune function of microglia Glia 36 2001 165 179 (Pubitemid 33055905)
36. V. Parpura, and P.G. Haydon Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons Proc. Natl. Acad. Sci. U. S. A. 97 2000 8629 8634 (Pubitemid 30639724)
37. S. Hashioka, A. Klegeris, C. Schwab, and P.L. McGeer Interferon-gamma- dependent cytotoxic activation of human astrocytes and astrocytoma cells Neurobiol. Aging 30 2009 1924 1935
38. Y.J. Lee, S.B. Han, S.Y. Nam, K.W. Oh, and J.T. Hong Inflammation and Alzheimer's disease Arch. Pharm. Res. 33 2010 1539 1556
39. S.A. Frautschy, and G.M. Cole Why pleiotropic interventions are needed for Alzheimer's disease Mol. Neurobiol. 41 2010 392 409
40. C.A. Colton, and D.M. Wilcock Assessing activation states in microglia CNS Neurol. Disord. Drug Targets 9 2010 174 191
41. R.C. Chang, K. Chiu, Y.S. Ho, and K.F. So Modulation of neuroimmune responses on glia in the central nervous system: implication in therapeutic intervention against neuroinflammation Cell. Mol. Immunol. 6 2009 317 326
42. A. Wunder, J. Klohs, and U. Dirnagl Non-invasive visualization of CNS inflammation with nuclear and optical imaging Neuroscience 158 2009 1161 1173
43. S.D. Skaper The brain as a target for inflammatory processes and neuroprotective strategies Ann. N. Y. Acad. Sci. 1122 2007 23 34 (Pubitemid 350249539)
44. P.T. Nelson, L.A. Soma, and E. Lavi Microglia in diseases of the central nervous system Ann. Med. 34 2002 491 500 (Pubitemid 36113806)
45. I. Gozes, and D.E. Brenneman A new concept in the pharmacology of neuroprotection J. Mol. Neurosci. 14 2000 61 68 (Pubitemid 30368300)
46. M. Schwartz, O. Butovsky, W. Bruck, and U.K. Hanisch Microglial phenotype: is the commitment reversible? Trends Neurosci. 29 2006 68 74 (Pubitemid 43202595)
47. J.A. Dowell, J.A. Johnson, and L. Li Identification of astrocyte secreted proteins with a combination of shotgun proteomics and bioinformatics J. Proteome Res. 8 2009 4135 4143
48. N.H. Moore, L.G. Costa, S.A. Shaffer, D.R. Goodlett, and M. Guizzetti Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation J. Neurochem. 108 2009 891 908
49. S.D. Keene, T.M. Greco, I. Parastatidis, S.H. Lee, E.G. Hughes, R.J. Balice-Gordon, D.W. Speicher, and H. Ischiropoulos Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome Proteomics 9 2009 768 782
50. N. Delcourt, P. Jouin, J. Poncet, E. Demey, E. Mauger, J. Bockaert, P. Marin, and N. Galeotti Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes Mol. Cell. Proteomics 4 2005 1085 1094 (Pubitemid 41223368)
51. M. Lafon-Cazal, O. Adjali, N. Galeotti, J. Poncet, P. Jouin, V. Homburger, J. Bockaert, and P. Marin Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome J. Biol. Chem. 278 2003 24438 24448 (Pubitemid 37548595)
52. J. Liu, Z. Hong, J. Ding, J. Zhang, and S. Chen Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies J. Proteome Res. 7 2008 2033 2049
53. S. Kim, J. Ock, A.K. Kim, H.W. Lee, J.Y. Cho, D.R. Kim, J.Y. Park, and K. Suk Neurotoxicity of microglial cathepsin D revealed by secretome analysis J. Neurochem. 103 2007 2640 2650
54. H.L. Chen, H. Seol, K.J. Brown, H. Gordish-Dressman, A. Hill, V. Gallo, R. Packer, and Y. Hathout Secretome survey of human plexiform neurofibroma derived Schwann cells reveals a secreted form of the RARRES1 protein Int. J. Mol. Sci. 13 2012 9380 9399
55. Y. Liu, X. Teng, X. Yang, Q. Song, R. Lu, J. Xiong, B. Liu, N. Zeng, Y. Zeng, J. Long, R. Cao, Y. Lin, Q. He, P. Chen, M. Lu, and S. Liang Shotgun proteomics and network analysis between plasma membrane and extracellular matrix proteins from rat olfactory ensheathing cells Cell Transplant. 19 2010 133 146
56. K. Biber, J. Vinet, and H.W. Boddeke Neuron-microglia signaling: chemokines as versatile messengers J. Neuroimmunol. 198 2008 69 74
57. C. Rohl, E. Armbrust, K. Kolbe, R. Lucius, E. Maser, S. Venz, and M. Gulden Activated microglia modulate astroglial enzymes involved in oxidative and inflammatory stress and increase the resistance of astrocytes to oxidative stress in vitro Glia 56 2008 1114 1126
58. T. Wang, N. Gong, J. Liu, I. Kadiu, S.D. Kraft-Terry, J.D. Schlautman, P. Ciborowski, D.J. Volsky, and H.E. Gendelman HIV-1-infected astrocytes and the microglial proteome J. Neuroimmune Pharmacol. 3 2008 173 186
59. I. Mohri, M. Taniike, H. Taniguchi, T. Kanekiyo, K. Aritake, T. Inui, N. Fukumoto, N. Eguchi, A. Kushi, H. Sasai, Y. Kanaoka, K. Ozono, S. Narumiya, K. Suzuki, and Y. Urade Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher J. Neurosci. 26 2006 4383 4393 (Pubitemid 44315397)
60. E. Hansson, and L. Ronnback Glial neuronal signaling in the central nervous system FASEB J. 17 2003 341 348 (Pubitemid 36292950)
61. E. Ambrosini, and F. Aloisi Chemokines and glial cells: a complex network in the central nervous system Neurochem. Res. 29 2004 1017 1038 (Pubitemid 39011351)
62. J.G. Glanzer, Y. Enose, T. Wang, I. Kadiu, N. Gong, W. Rozek, J. Liu, J.D. Schlautman, P.S. Ciborowski, M.P. Thomas, and H.E. Gendelman Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation J. Neurochem. 102 2007 627 645 (Pubitemid 47057284)
63. E. Yoles, and M. Schwartz Potential neuroprotective therapy for glaucomatous optic neuropathy Surv. Ophthalmol. 42 1998 367 372 (Pubitemid 28092777)
64. R.M. Ransohoff, and V.H. Perry Microglial physiology: unique stimuli, specialized responses Annu. Rev. Immunol. 27 2009 119 145
65. N.M. Desforges, M.L. Hebron, N.K. Algarzae, I. Lonskaya, and C.E. Moussa Fractalkine mediates communication between pathogenic proteins and microglia: implications of anti-inflammatory treatments in different stages of neurodegenerative diseases Int. J. Alzheimers Dis. 2012 2012 345472
66. G.C. Brown, and J.J. Neher Inflammatory neurodegeneration and mechanisms of microglial killing of neurons Mol. Neurobiol. 41 2010 242 247
67. O. Takeuchi, and S. Akira Pattern recognition receptors and inflammation Cell 140 2010 805 820
68. C.R. Balistreri, G. Colonna-Romano, D. Lio, G. Candore, and C. Caruso TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases J. Clin. Immunol. 29 2009 406 415
69. F. Di Virgilio, S. Ceruti, P. Bramanti, and M.P. Abbracchio Purinergic signalling in inflammation of the central nervous system Trends Neurosci. 32 2009 79 87
70. J. Husemann, J.D. Loike, R. Anankov, M. Febbraio, and S.C. Silverstein Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system Glia 40 2002 195 205 (Pubitemid 35337377)
71. W.J. Streit Microglia as neuroprotective, immunocompetent cells of the CNS Glia 40 2002 133 139 (Pubitemid 35337371)
72. J.M. Pocock, and A.C. Liddle Microglial signalling cascades in neurodegenerative disease Prog. Brain Res. 132 2001 555 565
73. P.J. Khandelwal, A.M. Herman, and C.E. Moussa Inflammation in the early stages of neurodegenerative pathology J. Neuroimmunol. 238 2011 1 11
74. C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization J. Clin. Invest. 117 2007 175 184 (Pubitemid 46048464)
75. A. Nimmerjahn, F. Kirchhoff, and F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318 (Pubitemid 40746128)
76. E.B. Villanueva, J.P. Little, G. Lambeau, and A. Klegeris Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells Mol. Cell. Neurosci. 49 2012 430 438
77. R. Martin, C. Cordova, and M.L. Nieto Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding J. Neuroinflammation 9 2012 154
78. J.J. Watters, J.M. Schartner, and B. Badie Microglia function in brain tumors J. Neurosci. Res. 81 2005 447 455 (Pubitemid 41359299)
79. M.B. Graeber, B.W. Scheithauer, and G.W. Kreutzberg Microglia in brain tumors Glia 40 2002 252 259 (Pubitemid 35337382)
80. B. Badie, and J.M. Schartner Flow cytometric characterization of tumor-associated macrophages in experimental gliomas Neurosurgery 46 2000 957 961 (discussion 961-952)
81. A.C. Fonseca, L. Romao, R.F. Amaral, S. Assad Kahn, D. Lobo, S. Martins, J. Marcondes de Souza, V. Moura-Neto, and F.R. Lima Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells Neuroscience 200 2012 130 141
82. H. Jeon, S. Lee, W.H. Lee, and K. Suk Analysis of glial secretome: the long pentraxin PTX3 modulates phagocytic activity of microglia J. Neuroimmunol. 229 2010 63 72
83. I. Szaingurten-Solodkin, N. Hadad, and R. Levy Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia Glia 57 2009 1727 1740
84. I. Kadiu, J.G. Glanzer, J. Kipnis, H.E. Gendelman, and M.P. Thomas Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases Neurotox. Res. 8 2005 25 50
85. I. Shaked, Z. Porat, R. Gersner, J. Kipnis, and M. Schwartz Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system J. Neuroimmunol. 146 2004 84 93 (Pubitemid 38032959)
86. K. Nakajima, S. Honda, Y. Tohyama, Y. Imai, S. Kohsaka, and T. Kurihara Neurotrophin secretion from cultured microglia J. Neurosci. Res. 65 2001 322 331 (Pubitemid 32727034)
87. A. Shibata, M. Zelivyanskaya, J. Limoges, K.A. Carlson, S. Gorantla, C. Branecki, S. Bishu, H. Xiong, and H.E. Gendelman Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function J. Neuroimmunol. 142 2003 112 129 (Pubitemid 38368594)
88. P.E. Batchelor, M.J. Porritt, P. Martinello, C.L. Parish, G.T. Liberatore, G.A. Donnan, and D.W. Howells Macrophages and microglia produce local trophic gradients that stimulate axonal sprouting toward but not beyond the wound edge Mol. Cell. Neurosci. 21 2002 436 453 (Pubitemid 36062730)
89. M.C. Caroleo, N. Costa, L. Bracci-Laudiero, and L. Aloe Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors J. Neuroimmunol. 113 2001 193 201 (Pubitemid 32112745)
90. K.D. Dougherty, C.F. Dreyfus, and I.B. Black Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury Neurobiol. Dis. 7 2000 574 585 (Pubitemid 32044283)
91. K. Satake, Y. Matsuyama, M. Kamiya, H. Kawakami, H. Iwata, K. Adachi, and K. Kiuchi Up-regulation of glial cell line-derived neurotrophic factor (GDNF) following traumatic spinal cord injury Neuroreport 11 2000 3877 3881
92. P.E. Batchelor, G.T. Liberatore, J.Y. Wong, M.J. Porritt, F. Frerichs, G.A. Donnan, and D.W. Howells Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor J. Neurosci. 19 1999 1708 1716 (Pubitemid 29094189)
93. S. Elkabes, E.M. DiCicco-Bloom, and I.B. Black Brain microglia/ macrophages express neurotrophins that selectively regulate microglial proliferation and function J. Neurosci. 16 1996 2508 2521 (Pubitemid 26122673)
94. S. Arkins, N. Rebeiz, A. Biragyn, D.L. Reese, and K.W. Kelley Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts Endocrinology 133 1993 2334 2343 (Pubitemid 23324746)
95. E.V. Voss, J. Skuljec, V. Gudi, T. Skripuletz, R. Pul, C. Trebst, and M. Stangel Characterisation of microglia during de- and remyelination: can they create a repair promoting environment? Neurobiol. Dis. 45 2012 519 528
96. S.H. Appel, D.R. Beers, and J.S. Henkel T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol. 31 2010 7 17
97. K.A. Young, W.D. Hirst, E. Solito, and G.P. Wilkin De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum Glia 26 1999 333 343 (Pubitemid 29257195)
98. C.S. Moore, S.L. Abdullah, A. Brown, A. Arulpragasam, and S.J. Crocker How factors secreted from astrocytes impact myelin repair J. Neurosci. Res. 89 2011 13 21
99. R.M. Bachoo, R.S. Kim, K.L. Ligon, E.A. Maher, C. Brennan, N. Billings, S. Chan, C. Li, D.H. Rowitch, W.H. Wong, and R.A. DePinho Molecular diversity of astrocytes with implications for neurological disorders Proc. Natl. Acad. Sci. U. S. A. 101 2004 8384 8389 (Pubitemid 38736584)
100. B. Stevens Neuron-astrocyte signaling in the development and plasticity of neural circuits Neurosignals 16 2008 278 288
101. J. Sen, and A. Belli S100B in neuropathologic states: the CRP of the brain? J. Neurosci. Res. 85 2007 1373 1380 (Pubitemid 46724380)
102. C. Eroglu The role of astrocyte-secreted matricellular proteins in central nervous system development and function J. Cell Commun. Signal. 3 2009 167 176
103. K. Imamura, T. Takeshima, K. Nakaso, S. Ito, and K. Nakashima Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity Neurosci. Lett. 440 2008 97 102
104. X. Zhang, Z. Zhou, D. Wang, A. Li, Y. Yin, X. Gu, F. Ding, X. Zhen, and J. Zhou Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2 + signaling J. Neurosci. 29 2009 7766 7775
105. C. Figueiredo, T.F. Pais, J.R. Gomes, and S. Chatterjee Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2 J. Neurochem. 107 2008 73 85
106. C. Li, R. Zhao, K. Gao, Z. Wei, M.Y. Yin, L.T. Lau, D. Chui, and A.C. Hoi Yu Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease Curr. Alzheimer Res. 8 2011 67 80
107. P. Agostinho, R.A. Cunha, and C. Oliveira Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease Curr. Pharm. Des. 16 2010 2766 2778
108. J.J. Rodriguez, M. Olabarria, A. Chvatal, and A. Verkhratsky Astroglia in dementia and Alzheimer's disease Cell Death Differ. 16 2009 378 385
109. L.J. Van Eldik, W.L. Thompson, H. Ralay Ranaivo, H.A. Behanna, and D. Martin Watterson Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches Int. Rev. Neurobiol. 82 2007 277 296
110. E. Croisier, and M.B. Graeber Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration Acta Neuropathol. 112 2006 517 530 (Pubitemid 44550676)
111. L. Meda, P. Baron, and G. Scarlato Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins Neurobiol. Aging 22 2001 885 893 (Pubitemid 34066555)
112. K. Kobayashi, M. Hayashi, H. Nakano, Y. Fukutani, K. Sasaki, M. Shimazaki, and Y. Koshino Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease Neuropathol. Appl. Neurobiol. 28 2002 238 251 (Pubitemid 34639446)
113. G. Wang, M. Dinkins, Q. He, G. Zhu, C. Poirier, A. Campbell, M. Mayer-Proschel, and E. Bieberich Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD) J. Biol. Chem. 287 2012 21384 21395
114. H.M. Gao, F. Zhang, H. Zhou, W. Kam, B. Wilson, and J.S. Hong Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease Environ. Health Perspect. 119 2011 807 814
115. E.C. Hirsch, and S. Hunot Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8 2009 382 397
116. J. Miklossy, D.D. Doudet, C. Schwab, S. Yu, E.G. McGeer, and P.L. McGeer Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys Exp. Neurol. 197 2006 275 283 (Pubitemid 43077135)
117. S. Hunot, N. Dugas, B. Faucheux, A. Hartmann, M. Tardieu, P. Debre, Y. Agid, B. Dugas, and E.C. Hirsch FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells J. Neurosci. 19 1999 3440 3447 (Pubitemid 29203124)
118. L.S. Forno, L.E. DeLanney, I. Irwin, D. Di Monte, and J.W. Langston Astrocytes and Parkinson's disease Prog. Brain Res. 94 1992 429 436 (Pubitemid 23026667)
119. P.M. Rappold, and K. Tieu Astrocytes and therapeutics for Parkinson's disease Neurotherapeutics 7 2010 413 423
120. C.M. Long-Smith, A.M. Sullivan, and Y.M. Nolan The influence of microglia on the pathogenesis of Parkinson's disease Prog. Neurobiol. 89 2009 277 287
121. J. Henning, U. Strauss, A. Wree, J. Gimsa, A. Rolfs, R. Benecke, and U. Gimsa Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease Neurosci. Res. 62 2008 246 253
122. Y. Yasuda, T. Shimoda, K. Uno, N. Tateishi, S. Furuya, K. Yagi, K. Suzuki, and S. Fujita The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains J. Neuroimmunol. 204 2008 43 51
123. A. Gerhard, N. Pavese, G. Hotton, F. Turkheimer, M. Es, A. Hammers, K. Eggert, W. Oertel, R.B. Banati, and D.J. Brooks In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease Neurobiol. Dis. 21 2006 404 412 (Pubitemid 43099863)
124. N.S. Tousi, D.J. Buck, J.T. Curtis, and R.L. Davis alpha-Synuclein potentiates interleukin-1beta-induced CXCL10 expression in human A172 astrocytoma cells Neurosci. Lett. 507 2012 133 136
125. S.A. Austin, A.M. Floden, E.J. Murphy, and C.K. Combs Alpha-synuclein expression modulates microglial activation phenotype J. Neurosci. 26 2006 10558 10563 (Pubitemid 44564607)
126. K. Suk Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers Expert Rev. Proteomics 7 2010 263 274
127. D. Schubert, F. Herrera, R. Cumming, J. Read, W. Low, P. Maher, and W.H. Fischer Neural cells secrete a unique repertoire of proteins J. Neurochem. 109 2009 427 435
128. H.S. Suh, N. Choi, L. Tarassishin, and S.C. Lee Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12) PLoS One 7 2012 e35115
129. S. Cao, C. Wu, Y. Yang, L.F. Sniderhan, S.B. Maggirwar, S. Dewhurst, and Y. Lu Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS J. Neuroinflammation 8 2011 48
130. Y.J. Shin, H.L. Kim, J.S. Choi, J.Y. Choi, J.H. Cha, and M.Y. Lee Osteopontin: correlation with phagocytosis by brain macrophages in a rat model of stroke Glia 59 2011 413 423
131. S.M. Shin, K.S. Cho, M.S. Choi, S.H. Lee, S.H. Han, Y.S. Kang, H.J. Kim, J.H. Cheong, C.Y. Shin, and K.H. Ko Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9 Neurochem. Res. 35 2010 976 985
132. N.J. Allen, M.L. Bennett, L.C. Foo, G.X. Wang, C. Chakraborty, S.J. Smith, and B.A. Barres Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors Nature 486 2012 410 414
133. W.C. Risher, and C. Eroglu Thrombospondins as key regulators of synaptogenesis in the central nervous system Matrix Biol. 31 2012 170 177
134. K.S. Christopherson, E.M. Ullian, C.C. Stokes, C.E. Mullowney, J.W. Hell, A. Agah, J. Lawler, D.F. Mosher, P. Bornstein, and B.A. Barres Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis Cell 120 2005 421 433 (Pubitemid 40222435)
135. H. Hara, Y. Nanri, E. Tabata, S. Mitsutake, and T. Tabira Identification of astrocyte-derived immune suppressor factor that induces apoptosis of autoreactive T cells J. Neuroimmunol. 233 2011 135 146
136. R. Donato, G. Sorci, F. Riuzzi, C. Arcuri, R. Bianchi, F. Brozzi, C. Tubaro, and I. Giambanco S100B's double life: intracellular regulator and extracellular signal Biochim. Biophys. Acta 1793 2009 1008 1022
137. W. Tian, A. Sawyer, F.B. Kocaoglu, and T.R. Kyriakides Astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier Am. J. Pathol. 179 2011 860 868
138. B. Karten, R.B. Campenot, D.E. Vance, and J.E. Vance Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia J. Biol. Chem. 281 2006 4049 4057 (Pubitemid 43847830)
139. D.F. Leitner, and J.R. Connor Functional roles of transferrin in the brain Biochim. Biophys. Acta 1820 2012 393 402
140. Y. Eshed, K. Feinberg, S. Poliak, H. Sabanay, O. Sarig-Nadir, I. Spiegel, J.R. Bermingham Jr., and E. Peles Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier Neuron 47 2005 215 229 (Pubitemid 41019253)
141. S.E. Craig, R. Thummel, H. Ahmed, G.R. Vasta, D.R. Hyde, and P.F. Hitchcock The zebrafish galectin Drgal1-l2 is expressed by proliferating Muller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors Invest. Ophthalmol. Vis. Sci. 51 2010 3244 3252
142. P. Ciborowski, I. Kadiu, W. Rozek, L. Smith, K. Bernhardt, M. Fladseth, M. Ricardo-Dukelow, and H.E. Gendelman Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome Virology 363 2007 198 209 (Pubitemid 46678164)
143. P. Yin, A.M. Knolhoff, H.J. Rosenberg, L.J. Millet, M.U. Gillette, and J.V. Sweedler Peptidomic analyses of mouse astrocytic cell lines and rat primary cultured astrocytes J. Proteome Res. 11 2012 3965 3973
144. T.M. Greco, S.H. Seeholzer, A. Mak, L. Spruce, and H. Ischiropoulos Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion J. Proteome Res. 9 2010 2764 2774
145. H. Skalnikova, J. Motlik, S.J. Gadher, and H. Kovarova Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines Proteomics 11 2011 691 708
146. C.A. Ribeiro, A.J. Salgado, J.S. Fraga, N.A. Silva, R.L. Reis, and N. Sousa The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures) J. Tissue Eng. Regen. Med. 5 2011 668 672
147. F. Casse, I. Bardou, L. Danglot, A. Briens, A. Montagne, J. Parcq, A. Alahari, T. Galli, D. Vivien, and F. Docagne Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals J. Neurosci. 32 2012 5186 5199
148. M. Rosito, C. Deflorio, C. Limatola, and F. Trettel CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS J. Neurosci. 32 2012 3154 3163
149. A. Nakamura-Ishizu, T. Kurihara, Y. Okuno, Y. Ozawa, K. Kishi, N. Goda, K. Tsubota, H. Okano, T. Suda, and Y. Kubota The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner Dev. Biol. 363 2012 106 114
150. E. Shavit, D.M. Michaelson, and J. Chapman Anatomical localization of protease-activated receptor-1 and protease-mediated neuroglial crosstalk on peri-synaptic astrocytic endfeet J. Neurochem. 119 2011 460 473
151. D.Y. Kim, G.U. Hong, and J.Y. Ro Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L J. Neuroinflammation 8 2011 25
152. J. Shimabukuro, S. Awata, and H. Matsuoka Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients Psychiatry Clin. Neurosci. 59 2005 274 279 (Pubitemid 40897198)
153. J.H. Kim, Y.P. Nam, S.M. Jeon, H.S. Han, and K. Suk Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work J. Neurochem. 121 2012 751 762
154. H. Jeon, J.H. Kim, W.H. Lee, M.S. Lee, and K. Suk Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity J. Neuroinflammation 9 2012 149
155. M. Shen, Y. Ji, S. Zhang, H. Shi, G. Chen, X. Gu, and F. Ding A proteome map of primary cultured rat Schwann cells Proteome Sci. 10 2012 20
156. K. Suk Unexpected role of lipocalin-type prostaglandin D synthase in brain: regulation of glial cell migration and morphology Cell Adh. Migr. 6 2012 160 163
157. J. Choi, H.W. Lee, and K. Suk Increased plasma levels of lipocalin 2 in mild cognitive impairment J. Neurol. Sci. 305 2011 28 33
158. H. Kim, S. Lee, H.C. Park, W.H. Lee, M.S. Lee, and K. Suk Modulation of glial and neuronal migration by lipocalin-2 in zebrafish Immune Netw. 11 2011 342 347
159. K.I. Rathore, J.L. Berard, A. Redensek, S. Chierzi, R. Lopez-Vales, M. Santos, S. Akira, and S. David Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury J. Neurosci. 31 2011 13412 13419
160. R. Bajo-Graneras, M.D. Ganfornina, E. Martin-Tejedor, and D. Sanchez Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems Glia 59 2011 1551 1566
161. R. Bajo-Graneras, D. Sanchez, G. Gutierrez, C. Gonzalez, S. Do Carmo, E. Rassart, and M.D. Ganfornina Apolipoprotein D alters the early transcriptional response to oxidative stress in the adult cerebellum J. Neurochem. 117 2011 949 960
162. M.D. Ganfornina, S. Do Carmo, E. Martinez, J. Tolivia, A. Navarro, E. Rassart, and D. Sanchez ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury Glia 58 2010 1320 1334
163. L. Gonzalez-Malerva, J. Park, L. Zou, Y. Hu, Z. Moradpour, J. Pearlberg, J. Sawyer, H. Stevens, E. Harlow, and J. LaBaer High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy Proc. Natl. Acad. Sci. U. S. A. 108 2011 2058 2063
164. E. Szutowicz, and R. Dziadziuszko Quantitative immunohistochemistry in lung cancer: clinical perspective Folia Histochem. Cytobiol. 48 2010 7 11
165. Q. Fu, J. Zhu, and J.E. Van Eyk Comparison of multiplex immunoassay platforms Clin. Chem. 56 2010 314 318
166. C. Chen, D. Li, and N. Guo Regulation of cellular and viral protein expression by the Epstein-Barr virus transcriptional regulator Zta: implications for therapy of EBV associated tumors Cancer Biol. Ther. 8 2009 987 995
167. M. Pierobon, V. Calvert, C. Belluco, E. Garaci, J. Deng, M. Lise, D. Nitti, E. Mammano, F.D. Marchi, L. Liotta, and E. Petricoin Multiplexed cell signaling analysis of metastatic and nonmetastatic colorectal cancer reveals COX2-EGFR signaling activation as a potential prognostic pathway biomarker Clin. Colorectal Cancer 8 2009 110 117
168. V.V. Krishhan, I.H. Khan, and P.A. Luciw Multiplexed microbead immunoassays by flow cytometry for molecular profiling: basic concepts and proteomics applications Crit. Rev. Biotechnol. 29 2009 29 43
169. J. Lee, S.A. Soper, and K.K. Murray Microfluidic chips for mass spectrometry-based proteomics J. Mass Spectrom. 44 2009 579 593
170. L.A. Liotta, V. Espina, A.I. Mehta, V. Calvert, K. Rosenblatt, D. Geho, P.J. Munson, L. Young, J. Wulfkuhle, and E.F. Petricoin III Protein microarrays: meeting analytical challenges for clinical applications Cancer Cell 3 2003 317 325 (Pubitemid 38340301)
171. L. Hu, M. Ye, X. Jiang, S. Feng, and H. Zou Advances in hyphenated analytical techniques for shotgun proteome and peptidome analysis - a review Anal. Chim. Acta 598 2007 193 204 (Pubitemid 47299081)
172. A.I. Nesvizhskii Protein identification by tandem mass spectrometry and sequence database searching Methods Mol. Biol. 367 2007 87 119
173. M.L. Fournier, J.M. Gilmore, S.A. Martin-Brown, and M.P. Washburn Multidimensional separations-based shotgun proteomics Chem. Rev. 107 2007 3654 3686 (Pubitemid 47322747)
174. D.A. Wolters, M.P. Washburn, and J.R. Yates III An automated multidimensional protein identification technology for shotgun proteomics Anal. Chem. 73 2001 5683 5690 (Pubitemid 33126725)
175. M.P. Washburn, D. Wolters, and J.R. Yates III Large-scale analysis of the yeast proteome by multidimensional protein identification technology Nat. Biotechnol. 19 2001 242 247 (Pubitemid 32220565)
176. A. Ishii, R. Dutta, G.M. Wark, S.I. Hwang, D.K. Han, B.D. Trapp, S.E. Pfeiffer, and R. Bansal Human myelin proteome and comparative analysis with mouse myelin Proc. Natl. Acad. Sci. U. S. A. 106 2009 14605 14610
177. D. Martins-De-Souza, E. Dias-Neto, A. Schmitt, P. Falkai, P. Gormanns, G. Maccarrone, C.W. Turck, and W.F. Gattaz Proteome analysis of schizophrenia brain tissue World J. Biol. Psychiatry 11 2010 110 120
178. K.H. Polderman Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: indications and evidence Intensive Care Med. 30 2004 556 575 (Pubitemid 38530090)
179. J.W. Seo, J.H. Kim, M. Seo, H.S. Han, J. Park, and K. Suk Time-dependent effects of hypothermia on microglial activation and migration J. Neuroinflammation 9 2012 164
180. T. Li, X. Lin, Y. Zhu, L. Li, and L. Liu Short-term, mild hypothermia can increase the beneficial effect of permissive hypotension on uncontrolled hemorrhagic shock in rats Anesthesiology 116 2012 1288 1298
181. J. Thundyil, D. Pavlovski, Y.H. Hsieh, M. Gelderblom, T. Magnus, D.P. Fairlie, and T.V. Arumugam C5a receptor (CD88) inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model Neuromolecular Med. 14 2012 30 39
182. M. Chenoune, F. Lidouren, C. Adam, S. Pons, L. Darbera, P. Bruneval, B. Ghaleh, R. Zini, J.L. Dubois-Rande, P. Carli, B. Vivien, J.D. Ricard, A. Berdeaux, and R. Tissier Ultrafast and whole-body cooling with total liquid ventilation induces favorable neurological and cardiac outcomes after cardiac arrest in rabbits Circulation 124 2011 901 911 (901-907)
183. J. Li, S. Benashski, and L.D. McCullough Post-stroke hypothermia provides neuroprotection through inhibition of AMP-activated protein kinase J. Neurotrauma 28 2011 1281 1288
184. Z.C. Chen, W.S. Wu, M.T. Lin, and C.C. Hsu Protective effect of transgenic expression of porcine heat shock protein 70 on hypothalamic ischemic and oxidative damage in a mouse model of heatstroke BMC Neurosci. 10 2009 111
185. W.D. Dietrich, C.M. Atkins, and H.M. Bramlett Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia J. Neurotrauma 26 2009 301 312
186. T. Matsui, and T. Kakeda IL-10 production is reduced by hypothermia but augmented by hyperthermia in rat microglia J. Neurotrauma 25 2008 709 715 (Pubitemid 351918442)
187. T. Miyazawa, A. Tamura, S. Fukui, and K.A. Hossmann Effect of mild hypothermia on focal cerebral ischemia. Review of experimental studies Neurol. Res. 25 2003 457 464 (Pubitemid 36870526)
188. H. Yanamoto, I. Nagata, Y. Niitsu, Z. Zhang, J.H. Xue, N. Sakai, and H. Kikuchi Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia Stroke 32 2001 232 239 (Pubitemid 32065700)
189. N. Kawai, M. Okauchi, K. Morisaki, and S. Nagao Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats Stroke 31 2000 1982 1989 (discussion 1989) (Pubitemid 30620483)
190. P. Gancia, and G. Pomero Therapeutic hypothermia in the prevention of hypoxic-ischaemic encephalopathy: new categories to be enrolled J. Matern. Fetal Neonatal Med. 25 Suppl. 4 2012 86 88
191. L. Filippi, P. Fiorini, M. Daniotti, S. Catarzi, S. Savelli, C. Fonda, L. Bartalena, A. Boldrini, M. Giampietri, R. Scaramuzzo, P. Papoff, F. Del Balzo, A. Spalice, G. la Marca, S. Malvagia, M.L. Della Bona, G. Donzelli, F. Tinelli, G. Cioni, T. Pisano, M. Falchi, and R. Guerrini Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI) BMC Pediatr. 12 2012 144
192. J.H. Kim, J.Y. Lee, and K. Suk Therapeutic hypothermia in brain injuries and related diseases Recent Pat. Inflamm. Allergy Drug Discov. 5 2011 155 164
193. T. Zgavc, A.G. Ceulemans, S. Sarre, Y. Michotte, and S. Hachimi-Idrissi Experimental and clinical use of therapeutic hypothermia for ischemic stroke: opportunities and limitations Stroke Res. Treat. 2011 2011 689290
194. M.A. Tuma, L.G. Stansbury, D.M. Stein, K.A. McQuillan, and T.M. Scalea Induced hypothermia after cardiac arrest in trauma patients: a case series J. Trauma 71 2011 1524 1527
195. H.A. Jensen, S. Loukogeorgakis, F. Yannopoulos, E. Rimpilainen, A. Petzold, H. Tuominen, P. Lepola, R.J. Macallister, J.E. Deanfield, T. Makela, K. Alestalo, K. Kiviluoma, V. Anttila, V. Tsang, and T. Juvonen Remote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest Circulation 123 2011 714 721
196. M.T. Froehler, and B. Ovbiagele Therapeutic hypothermia for acute ischemic stroke Expert Rev. Cardiovasc. Ther. 8 2010 593 603
197. A.D. Nichol, and D.J. Cooper Can we improve neurological outcomes in severe traumatic brain injury? Something old (early prophylactic hypothermia) and something new (erythropoietin) Injury 40 2009 471 478
198. P.O. Grande, P. Reinstrup, and B. Romner Active cooling in traumatic brain-injured patients: a questionable therapy? Acta Anaesthesiol. Scand. 53 2009 1233 1238
199. A.M. Buga, A. Balseanu, A. Popa-Wagner, and L. Mogoanta Strategies to improve post-stroke behavioral recovery in aged subjects Rom. J. Morphol. Embryol. 50 2009 559 582
200. S. Fukuda, and D.S. Warner Cerebral protection Br. J. Anaesth. 99 2007 10 17 (Pubitemid 47072554)
201. J. Sahuquillo, and A. Vilalta Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury Curr. Pharm. Des. 13 2007 2310 2322 (Pubitemid 47317037)
202. S.A. Bernard, T.W. Gray, M.D. Buist, B.M. Jones, W. Silvester, G. Gutteridge, and K. Smith Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia N. Engl. J. Med. 346 2002 557 563 (Pubitemid 34438816)
203. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest N. Engl. J. Med. 346 2002 549 556
204. J. Arcure, and E.E. Harrison A review of the use of early hypothermia in the treatment of traumatic brain injuries J. Spec. Oper. Med. 9 2009 22 25
205. M. Ma, B.T. Matthews, J.W. Lampe, D.F. Meaney, F.S. Shofer, and R.W. Neumar Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury Exp. Neurol. 215 2009 119 127
206. B. Florian, R. Vintilescu, A.T. Balseanu, A.M. Buga, O. Grisk, L.C. Walker, C. Kessler, and A. Popa-Wagner Long-term hypothermia reduces infarct volume in aged rats after focal ischemia Neurosci. Lett. 438 2008 180 185
207. K.H. Polderman Induced hypothermia and fever control for prevention and treatment of neurological injuries Lancet 371 2008 1955 1969 (Pubitemid 351780491)
208. M.N. Diringer, N.L. Reaven, S.E. Funk, and G.C. Uman Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients Crit. Care Med. 32 2004 1489 1495 (Pubitemid 38925177)
209. L.P. Kammersgaard, H.S. Jorgensen, J.A. Rungby, J. Reith, H. Nakayama, U.J. Weber, J. Houth, and T.S. Olsen Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study Stroke 33 2002 1759 1762 (Pubitemid 34761056)
210. D.W. Krieger, M.A. De Georgia, A. Abou-Chebl, J.C. Andrefsky, C.A. Sila, I.L. Katzan, M.R. Mayberg, and A.J. Furlan Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke Stroke 32 2001 1847 1854 (Pubitemid 32772218)
211. S. Schwab, S. Schwarz, M. Spranger, E. Keller, M. Bertram, and W. Hacke Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction Stroke 29 1998 2461 2466 (Pubitemid 28543990)
212. M. Penkowa, J. Camats, H. Hadberg, A. Quintana, S. Rojas, M. Giralt, A. Molinero, I.L. Campbell, and J. Hidalgo Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide J. Neurosci. Res. 73 2003 481 496 (Pubitemid 36944841)
213. M. Penkowa, M. Giralt, N. Lago, J. Camats, J. Carrasco, J. Hernandez, A. Molinero, I.L. Campbell, and J. Hidalgo Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury Exp. Neurol. 181 2003 130 148 (Pubitemid 36629235)
214. K.R. Swartz, F. Liu, D. Sewell, T. Schochet, I. Campbell, M. Sandor, and Z. Fabry Interleukin-6 promotes post-traumatic healing in the central nervous system Brain Res. 896 2001 86 95 (Pubitemid 32244151)
215. W.B. Cafferty, N.J. Gardiner, P. Das, J. Qiu, S.B. McMahon, and S.W. Thompson Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice J. Neurosci. 24 2004 4432 4443 (Pubitemid 38608154)
216. C.L. Parish, D.I. Finkelstein, W. Tripanichkul, A.R. Satoskar, J. Drago, and M.K. Horne The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice J. Neurosci. 22 2002 8034 8041 (Pubitemid 35379109)
217. K.R. Schmitt, C. Kern, F. Berger, O. Ullrich, S. Hendrix, and H. Abdul-Khaliq Methylprednisolone attenuates hypothermia- and rewarming-induced cytotoxicity and IL-6 release in isolated primary astrocytes, neurons and BV-2 microglia cells Neurosci. Lett. 404 2006 309 314 (Pubitemid 44131623)
218. K.R. Schmitt, C. Kern, P.E. Lange, F. Berger, H. Abdul-Khaliq, and S. Hendrix S100B modulates IL-6 release and cytotoxicity from hypothermic brain cells and inhibits hypothermia-induced axonal outgrowth Neurosci. Res. 59 2007 68 73 (Pubitemid 47285395)
219. B. Liu, and J.S. Hong Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention J. Pharmacol. Exp. Ther. 304 2003 1 7 (Pubitemid 36008905)
220. R.E. Hulse, W.G. Swenson, P.E. Kunkler, D.M. White, and R.P. Kraig Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha J. Neurosci. 28 2008 12199 12211
221. U.K. Hanisch Microglia as a source and target of cytokines Glia 40 2002 140 155
222. A. Diestel, S. Troeller, N. Billecke, I.M. Sauer, F. Berger, and K.R. Schmitt Mechanisms of hypothermia-induced cell protection mediated by microglial cells in vitro Eur. J. Neurosci. 31 2010 779 787
223. J.H. Kim, Y.E. Cho, M. Seo, M.C. Baek, and K. Suk Glial proteome changes in response to moderate hypothermia Proteomics 12 2012 2571 2583
224. K.R. Schmitt, A. Diestel, S. Lehnardt, R. Schwartlander, P.E. Lange, F. Berger, O. Ullrich, and H. Abdul-Khaliq Hypothermia suppresses inflammation via ERK signaling pathway in stimulated microglial cells J. Neuroimmunol. 189 2007 7 16 (Pubitemid 47385827)
225. Y.P. Yan, B.T. Lang, R. Vemuganti, and R.J. Dempsey Galectin-3 mediates post-ischemic tissue remodeling Brain Res. 1288 2009 116 124
226. M. Walther, S. Kuklinski, P. Pesheva, O. Guntinas-Lichius, D.N. Angelov, W.F. Neiss, H. Asou, and R. Probstmeier Galectin-3 is upregulated in microglial cells in response to ischemic brain lesions, but not to facial nerve axotomy J. Neurosci. Res. 61 2000 430 435 (Pubitemid 30620227)
227. K. Satoh, M. Niwa, W. Goda, N.H. Binh, M. Nakashima, M. Takamatsu, and A. Hara Galectin-3 expression in delayed neuronal death of hippocampal CA1 following transient forebrain ischemia, and its inhibition by hypothermia Brain Res. 1382 2011 266 274
228. Y. Terao, H. Ohta, A. Oda, Y. Nakagaito, Y. Kiyota, and Y. Shintani Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia Neurosci. Res. 64 2009 75 82
229. K.D. McCarthy, and J. de Vellis Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J. Cell Biol. 85 1980 890 902 (Pubitemid 10007455)