Galectin-3 is upregulated in microglial cells in response to ischemic brain lesions, but not to facial nerve axotomy

Journal of Neuroscience Research

Volumn 61, Issue 4, 2000, Pages 430-435

  Walther, Michael ^b   Kuklinski, Stephan ^a   Pesheva, Penka ^a   Guntinas Lichius, Orlando ^b   Angelov, Doychin N ^b   Neiss, Wolfram F ^b   Asou, Hiroaki ^c   Probstmeier, Rainer ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Axotomy; Facial nerve; Galectin 3; Ischemia; Microglia

Indexed keywords

GALECTIN;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CELL MIGRATION; FACIAL NERVE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE ACTIVATION; MIDDLE CEREBRAL ARTERY; NERVE ANASTOMOSIS; NERVE FIBER TRANSECTION; NONHUMAN; PERIPHERAL NERVE; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANIMAL; ANTIGENS, DIFFERENTIATION; AXOTOMY; BRAIN ISCHEMIA; FACIAL NERVE INJURIES; FEMALE; GALECTIN 3; MACROPHAGES; MICROGLIA; RATS; RATS, LONG-EVANS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; UP-REGULATION;

EID: 0034663480     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20000815)61:4<430::AID-JNR9>3.0.CO;2-3     Document Type: Article

References (34)

1. ED2-positive perivascular cells act as neuronophages during delayed neuronal loss in the facial nucleus of the rat
2. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurological examination
3. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia
4. BAY x 3702
5. Differential expression, cytokine modulation and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia
6. Cellular reactions at the lesion site after crushing of the rat optic nerve
7. Reactive microglia in cerebral ischemia: An early mediator of tissue damage?
8. Differences in glial, synaptic and motoneuron responses in the facial nucleus of the rat brainstem following facial nerve resection and nerve suture reanastomosis
9. Mac-2, a novel 32,000 Mr mouse macrophage subpopulation specific antigen defined by monoclonal antibodies
10. Transforming growth factor beta's 1, 2 and 3 inhibit proliferation of ramified microglia on an astrocyte monolayer
11. Cytokines and adhesion molecules in stroke and related diseases
12. Impaired microglial activation in interleukin-6 deficient mice
13. Microglia: A sensor for pathological events in the CNS
14. Introduction to galectins
15. S-type mammalian lectins in allergic inflammation
16. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat
17. Periodate-lysine-paraformaldehyde fixative is a new fixative for immunelectron microscopy
18. The hypoglossal-facial anastomosis as model of neuronal plasticity in the rat
19. The blood-brain barrier regulates the expression of a macrophage sialic acid-binding receptor on microglia
20. Murine microglial cells express functionally active galectin-3 in vitro
21. Galectin-3 is expressed by subpopulations of microglial and neuronal cells in the facial nucleus after axotomy
22. Galectins: An evolutionary conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy
23. Regulation of MCSF receptors on microglia in the normal and injured mouse central nervous system: A quantitative immunofluorescence study using confocal laser microscopy
24. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
25. Deficient activation of microglia during optic nerve degeneration
26. Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: Phagocytosis and the galactose-specific lectin MAC-2
27. Granulocyte-macrophage colony stimulating factor produced in lesioned peripheral nerve induces the up-regulation of cell surface expression of Mac-2 by macrophages and Schwann cells
28. Global forebrain ischemia results in differential cellular expression of interleukin-1β (IL-1 β) and its receptor at mRNA and protein level
29. Interleukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia
30. Phagocytic response in photochemically induced infarction of rat cerebral cortex. The role of resident microglia
31. Inflammation and glial responses in ischemic brain lesions
32. Reactive microgliosis
33. Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor β1 (TGF- β1) down-regulate T cell costimulatory molecules 137 and CD40 on cultured rat microgila
34. Biphasic expression of TGF-β1 mRNA in the rat brain following permanent occlusion of the middle cerebral artery