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Volumn 57, Issue 16, 2009, Pages 1727-1740

Regulatory role of cytosolic phospholipase A2α in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42 in microglia

Author keywords

Microglia; NADPH oxidase; Phospholipase A2

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; ANTISENSE OLIGONUCLEOTIDE; CD68 ANTIGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROSTAGLANDIN E2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; SUPEROXIDE; UNCLASSIFIED DRUG;

EID: 71249160483     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20886     Document Type: Article
Times cited : (51)

References (66)
  • 1
    • 0031455935 scopus 로고    scopus 로고
    • 2 activity in human polymorphonuclear leukocytes
    • DOI 10.1016/S0304-3835(97)00347-9, PII S0304383597003479
    • Abe M, Kitsuki H, Saruwatari S, Asoh H, Sakurada T, Kuwata H, Nakatani Y, Kudo I, Furukawa T. 1997. Cancer cells isolated from malignant pleural and peritoneal effusions inhibit phospholipase A2 activity in human polymorphonuclear leukocytes. Cancer Lett 121: 155-161. (Pubitemid 28008914)
    • (1997) Cancer Letters , vol.121 , Issue.2 , pp. 155-161
    • Abe, M.1    Kitsuki, H.2    Saruwatari, S.3    Asoh, H.4    Sakurada, T.5    Kuwata, H.6    Nakatani, Y.7    Kudo, I.8    Furukawa, T.9
  • 2
    • 0033105874 scopus 로고    scopus 로고
    • NADPH oxidase: An update
    • Babior BM. 1999. NADPH oxidase: An update. Blood 93:1464-1476.
    • (1999) Blood , vol.93 , pp. 1464-1476
    • Babior, B.M.1
  • 3
    • 0034655127 scopus 로고    scopus 로고
    • 1 in Trp-Lys-Tyr-Met-Val-D-Met-induced superoxide generation in human monocytes
    • Bae YS, Kim Y, Kim JH, Lee TG, Suh PG, Ryu SH. 2000. Independent functioning of cytosolic phospholipase A2 and phospholipase D1 in Trp-Lys-Tyr-Met-Val-D-Met-induced superoxide generation in human monocytes. J Immunol 164:4089-4096. (Pubitemid 30215064)
    • (2000) Journal of Immunology , vol.164 , Issue.8 , pp. 4089-4096
    • Bae, Y.-S.1    Kim, Y.2    Kim, J.H.3    Lee, T.G.4    Kim, Y.5    Suh, P.-G.6    Ryu, S.H.7
  • 4
    • 0036273352 scopus 로고    scopus 로고
    • Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production
    • DOI 10.1046/j.0022-3042.2001.00675.x
    • Bal-Price A, Matthias A, Brown GC. 2002. Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. J Neurochem 80:73-80. (Pubitemid 34614579)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.1 , pp. 73-80
    • Bal-Price, A.1    Matthias, A.2    Brown, G.C.3
  • 6
    • 0032983334 scopus 로고    scopus 로고
    • Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
    • Bianca VD, Dusi S, Bianchini E, Dal Pra I, Rossi F. 1999. Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. J Biol Chem 274:15493-15499.
    • (1999) J Biol Chem , vol.274 , pp. 15493-15499
    • Bianca, V.D.1    Dusi, S.2    Bianchini, E.3    Dal Pra, I.4    Rossi, F.5
  • 7
    • 0035879599 scopus 로고    scopus 로고
    • Microglia and prion disease
    • Brown DR. 2001. Microglia and prion disease. Microsc Res Tech 54: 71-80.
    • (2001) Microsc Res Tech , vol.54 , pp. 71-80
    • Brown, D.R.1
  • 8
    • 0036828769 scopus 로고    scopus 로고
    • Alzheimer's disease: Treatments in discovery and development
    • DOI 10.1038/nn940
    • Citron M. 2002a. Alzheimer's disease: Treatments in discovery and development. Nat Neurosci 5(Suppl):1055-1057. (Pubitemid 35247198)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1055-1057
    • Citron, M.1
  • 9
    • 0036861132 scopus 로고    scopus 로고
    • Emerging Alzheimer's disease therapies: Inhibition of beta-secretase
    • DOI 10.1016/S0197-4580(02)00122-7, PII S0197458002001227
    • Citron M. 2002b. Emerging Alzheimer's disease therapies: Inhibition of beta-secretase. Neurobiol Aging 23:1017-1022. (Pubitemid 35447782)
    • (2002) Neurobiology of Aging , vol.23 , Issue.6 , pp. 1017-1022
    • Citron, M.1
  • 11
    • 0037010289 scopus 로고    scopus 로고
    • Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling
    • Colangelo VSJ, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ. 2002. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 70:462-473.
    • (2002) J Neurosci Res , vol.70 , pp. 462-473
    • Colangelo, V.S.J.1    Ball, M.J.2    Pelaez, R.P.3    Bazan, N.G.4    Lukiw, W.J.5
  • 12
    • 0035866060 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao SC, Landreth GE. 2001. Beta-amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 21:1179-1188.
    • (2001) J Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3    Landreth, G.E.4
  • 13
    • 0029912056 scopus 로고    scopus 로고
    • Mechanisms of neuronal death in Alzheimer's disease
    • Cotman C. 1996. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 6:493-506. (Pubitemid 26388719)
    • (1996) Brain Pathology , vol.6 , Issue.4 , pp. 493-506
    • Cotman, C.W.1    Su, J.H.2
  • 14
    • 0031982707 scopus 로고    scopus 로고
    • 2 for activation of the phagocyte NADPH oxidase
    • DOI 10.1074/jbc.273.1.441
    • Dana R, Leto TL, Malech HL, Levy R. 1998. Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J Biol Chem 273:441-445. (Pubitemid 28042230)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.1 , pp. 441-445
    • Dana, R.1    Leto, T.L.2    Malech, H.L.3    Levy, R.4
  • 15
    • 0028181632 scopus 로고
    • The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils
    • Dana R, Malech HL, Levy R. 1994. The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem J 297:217-223.
    • (1994) Biochem J , vol.297 , pp. 217-223
    • Dana, R.1    Malech, H.L.2    Levy, R.3
  • 16
    • 33746238205 scopus 로고    scopus 로고
    • Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
    • de la Monte SM, Wands JR. 2006. Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease. J Alzheimers Dis 9:167-181.
    • (2006) J Alzheimers Dis , vol.9 , pp. 167-181
    • De La Monte, S.M.1    Wands, J.R.2
  • 17
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. 1993. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75-83.
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 18
    • 0034733046 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation
    • Gijon MA, Spencer DM, Siddiqi AR, Bonventre JV, Leslie CC. 2000. Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation. J Biol Chem 275:20146-20156.
    • (2000) J Biol Chem , vol.275 , pp. 20146-20156
    • Gijon, M.A.1    Spencer, D.M.2    Siddiqi, A.R.3    Bonventre, J.V.4    Leslie, C.C.5
  • 19
    • 2442515338 scopus 로고    scopus 로고
    • 2 Translocates to Forming Phagosomes during Phagocytosis of Zymosan in Macrophages
    • DOI 10.1074/jbc.M313867200
    • Girotti M, Evans JH, Burke D, Leslie CC. 2004. Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J Biol Chem 279:19113-19121. (Pubitemid 38623342)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.18 , pp. 19113-19121
    • Girotti, M.1    Evans, J.H.2    Burke, D.3    Leslie, C.C.4
  • 20
    • 0020448709 scopus 로고
    • 15N]nitrate in biological fluids
    • DOI 10.1016/0003-2697(82)90118-X
    • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126:131-138. (Pubitemid 13203451)
    • (1982) Analytical Biochemistry , vol.126 , Issue.1 , pp. 131-138
    • Green, L.C.1    Wagner, D.A.2    Glogowski, J.3
  • 21
    • 71249128880 scopus 로고    scopus 로고
    • Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin
    • Grinshpun J, Tveria L, Fleisher-Berkovich S. 2008. Differential regulation of prostaglandin synthesis in neonatal rat microglia and astrocytes by somatostatin. Eur J Pharmacol 19:19.
    • (2008) Eur J Pharmacol , vol.19 , pp. 19
    • Grinshpun, J.1    Tveria, L.2    Fleisher-Berkovich, S.3
  • 23
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • DOI 10.1038/nrm2101, PII NRM2101
    • Haass C, Selkoe DJ. 2007. Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112. (Pubitemid 46432529)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 24
    • 0030821702 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan. Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase
    • Hazan I, Dana R, Granot Y, Levy R. 1997. Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan. Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase. Biochem J 326:867-876.
    • (1997) Biochem J , vol.326 , pp. 867-876
    • Hazan, I.1    Dana, R.2    Granot, Y.3    Levy, R.4
  • 25
    • 33748163485 scopus 로고    scopus 로고
    • 2
    • DOI 10.1182/blood-2006-05-021881
    • Hazan-Eitan Z, Weinstein Y, Hadad N, Konforty A, Levy R. 2006. Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2. Blood 108:1758-1766. (Pubitemid 44316147)
    • (2006) Blood , vol.108 , Issue.5 , pp. 1758-1766
    • Hazan-Eitan, Z.1    Weinstein, Y.2    Hadad, N.3    Konforty, A.4    Levy, R.5
  • 26
    • 0034656413 scopus 로고    scopus 로고
    • 2 stimulates AP-1-mediated CD14 expression in mouse macrophages via cyclic AMP-dependent protein kinase a
    • Iwahashi H, Takeshita A, Hanazawa S. 2000. Prostaglandin E2 stimulates AP-1-mediated CD14 expression in mouse macrophages via cyclic AMP-dependent protein kinase A. J Immunol 164:5403-5408. (Pubitemid 30305222)
    • (2000) Journal of Immunology , vol.164 , Issue.10 , pp. 5403-5408
    • Iwahashi, H.1    Takeshita, A.2    Hanazawa, S.3
  • 27
    • 34249289745 scopus 로고    scopus 로고
    • 276 phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway
    • DOI 10.1016/j.cellsig.2007.01.020, PII S0898656807000344
    • Jamaluddin M, Wang S, Boldogh I, Tian B, Brasier AR. 2007. TNF-alpha- induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cell Signal 19:1419-1433. (Pubitemid 46818908)
    • (2007) Cellular Signalling , vol.19 , Issue.7 , pp. 1419-1433
    • Jamaluddin, M.1    Wang, S.2    Boldogh, I.3    Tian, B.4    Brasier, A.R.5
  • 28
    • 0032077890 scopus 로고    scopus 로고
    • Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
    • DOI 10.1016/S0165-5728(97)00204-X, PII S016557289700204X
    • Jeohn GH, Kong LY, Wilson B, Hudson P, Hong JS. 1998. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures. J Neuroimmunol 85:1-10. (Pubitemid 28255432)
    • (1998) Journal of Neuroimmunology , vol.85 , Issue.1 , pp. 1-10
    • Jeohn, G.-H.1    Kong, L.-Y.2    Wilson, B.3    Hudson, P.4    Hong, J.-S.5
  • 29
    • 30144442688 scopus 로고    scopus 로고
    • phox and can be rescued by exogenous arachidonic acid
    • DOI 10.1189/jlb.0705371
    • Kim C, Dinauer MC. 2006. Impaired NADPH oxidase activity in Rac2- deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid. J Leukoc Biol 79:223-234. (Pubitemid 43054268)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.1 , pp. 223-234
    • Kim, C.1    Dinauer, M.C.2
  • 30
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. 1996. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 31
    • 0036098848 scopus 로고    scopus 로고
    • Role of oxidative stress in advanced glycation end product- Induced mesangial cell activation
    • Lal MA. 2002. Role of oxidative stress in advanced glycation end product- induced mesangial cell activation. Kidney Int 61:2006-2014.
    • (2002) Kidney Int , vol.61 , pp. 2006-2014
    • Lal, M.A.1
  • 32
    • 0025988892 scopus 로고
    • Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses
    • Leto TL, Garrett MC, Fujii H, Nunoi H. 1991. Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses. J Biol Chem 266:19812-19818. (Pubitemid 21908299)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.29 , pp. 19812-19818
    • Leto, T.L.1    Garrett, M.C.2    Fujii, H.3    Nunoi, H.4
  • 35
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • DOI 10.1016/0165-0173(95)00011-9
    • McGeer P. 1995. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 21:195-218. (Pubitemid 26061873)
    • (1995) Brain Research Reviews , vol.21 , Issue.2 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 36
    • 0034857992 scopus 로고    scopus 로고
    • Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: Involvement of reactive oxygen species
    • Mendes AF, Carvalho AP, Caramona MM, Lopes MC. 2001. Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: Involvement of reactive oxygen species. Mediators Inflamm 10:209-215.
    • (2001) Mediators Inflamm , vol.10 , pp. 209-215
    • Mendes, A.F.1    Carvalho, A.P.2    Caramona, M.M.3    Lopes, M.C.4
  • 37
    • 0031081781 scopus 로고    scopus 로고
    • 2 and by cyclooxygenase inhibitors
    • DOI 10.1002/(SICI)1098-1136(199702)19:2<152::AID-GLIA6>3.0.CO;2-2
    • Minghetti L, Nicolini A, Polazzi E, Creminon C, Maclouf J, Levi G. 1997. Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors. Glia 19:152-160. (Pubitemid 27094132)
    • (1997) GLIA , vol.19 , Issue.2 , pp. 152-160
    • Minghetti, L.1    Nicolini, A.2    Polazzi, E.3    Creminon, C.4    Maclouf, J.5    Levi, G.6
  • 38
    • 0029996739 scopus 로고    scopus 로고
    • The concept of microglia in relation to central nervous system disease and regeneration
    • DOI 10.1016/0301-0082(95)00051-8
    • Moore STS. 1996. The concept of microglia in relation to central nervous system disease and regeneration. Prog Neurobiol 48:441-460. (Pubitemid 26189424)
    • (1996) Progress in Neurobiology , vol.48 , Issue.4-5 , pp. 441-460
    • Moore, S.1    Thanos, S.2
  • 39
    • 44949248404 scopus 로고    scopus 로고
    • Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege
    • Neumann J. 2008. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: A new mechanism of CNS immune privilege. J Neurosci 28:5965-5975.
    • (2008) J Neurosci , vol.28 , pp. 5965-5975
    • Neumann, J.1
  • 41
    • 0345549372 scopus 로고    scopus 로고
    • 2 activity but not p47phox phosphorylation and translocation
    • DOI 10.1016/j.bcp.2003.08.026
    • O'Dowd YM, El-Benna J, Perianin A, Newsholme P. 2004. Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: Inhibition of phospholipase A2 activity but not p47phox phosphorylation and translocation. Biochem Pharmacol 67:183-190. (Pubitemid 37518546)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.1 , pp. 183-190
    • O'Dowd, Y.M.1    El-Benna, J.2    Perianin, A.3    Newsholme, P.4
  • 42
    • 0031973672 scopus 로고    scopus 로고
    • 6 glial cells and astrocytes
    • DOI 10.1016/S0891-5849(97)00137-8, PII S0891584997001378
    • Pahan K, Sheikh FG, Namboodiri AM, Singh I. 1998. N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radic Biol Med 24:39-48. (Pubitemid 28006434)
    • (1998) Free Radical Biology and Medicine , vol.24 , Issue.1 , pp. 39-48
    • Pahan, K.1    Sheikh, F.G.2    Namboodiri, A.M.S.3    Singh, I.4
  • 43
    • 3042841602 scopus 로고    scopus 로고
    • A novel role of lactosylceramide in the regulation of lipopolysaccharide/ interferon-gamma-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases
    • DOI 10.1523/JNEUROSCI.1271-04.2004
    • Pannu R, Won JS, Khan M, Singh AK, Singh I. 2004. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma- mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases. J Neurosci 24:5942-5954. (Pubitemid 38859392)
    • (2004) Journal of Neuroscience , vol.24 , Issue.26 , pp. 5942-5954
    • Pannu, R.1    Won, J.-S.2    Khan, M.3    Singh, A.K.4    Singh, I.5
  • 45
    • 3442888512 scopus 로고    scopus 로고
    • Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma
    • DOI 10.1002/jnr.20180
    • Pawate S, Shen Q, Fan F, Bhat NR. 2004. Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res 77:540-551. (Pubitemid 39007006)
    • (2004) Journal of Neuroscience Research , vol.77 , Issue.4 , pp. 540-551
    • Pawate, S.1    Shen, Q.2    Fan, F.3    Bhat, N.R.4
  • 46
    • 33747885659 scopus 로고    scopus 로고
    • Cyclooxygenases, lipoxy-genases, and epoxygenases in CNS: Their role and involvement in neurological disorders
    • Phillis JW, Horrocks LA, Farooqui AA. 2006. Cyclooxygenases, lipoxy-genases, and epoxygenases in CNS: Their role and involvement in neurological disorders. Brain Res Rev 52:201-243.
    • (2006) Brain Res Rev , vol.52 , pp. 201-243
    • Phillis, J.W.1    Horrocks, L.A.2    Farooqui, A.A.3
  • 48
    • 0028304387 scopus 로고
    • Multiple sclerosis: Immune system molecule expression in the central nervous system
    • Raine CS. 1994. Multiple sclerosis: Immune system molecule expression in the central nervous system. J Neuropathol Exp Neurol 53:328-337. (Pubitemid 24216030)
    • (1994) Journal of Neuropathology and Experimental Neurology , vol.53 , Issue.4 , pp. 328-337
    • Raine, C.S.1
  • 49
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    • DOI 10.1002/glia.10153
    • Rogers JSR, Kovelowski CJ, Li R. 2002. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40:260-269. (Pubitemid 35337383)
    • (2002) GLIA , vol.40 , Issue.2 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Kovelowski, C.J.3    Li, R.4
  • 50
    • 0034790541 scopus 로고    scopus 로고
    • Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- And ERK-MAP kinases and NF-kappaB
    • DOI 10.1046/j.1471-4159.2001.00520.x
    • Rosenberger J. 2001. Oxidative stress induces proorphanin FQ, proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-kappaB. J Neurochem 79:35-44. (Pubitemid 32946640)
    • (2001) Journal of Neurochemistry , vol.79 , Issue.1 , pp. 35-44
    • Rosenberger, J.1    Petrovics, G.2    Buzas, B.3
  • 52
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • DOI 10.1089/ars.2006.8.929
    • Saha RN, Pahan K. 2006. Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal 8:929-947. (Pubitemid 44036510)
    • (2006) Antioxidants and Redox Signaling , vol.8 , Issue.5-6 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 53
    • 0023792919 scopus 로고
    • Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
    • Scudiero DA, Shoemaker RH, Paull KD, Monks A, Tierney S, Nofziger TH, Currens MJ, Seniff D, Boyd MR. 1988. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 48:4827-4833. (Pubitemid 18224442)
    • (1988) Cancer Research , vol.48 , Issue.17 , pp. 4827-4833
    • Scudiero, D.A.1    Shoemaker, R.H.2    Paull, K.D.3    Monks, A.4    Tierney, S.5    Nofziger, T.H.6    Currens, M.J.7    Seniff, D.8    Boyd, M.R.9
  • 54
    • 0032852479 scopus 로고    scopus 로고
    • CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
    • Shaywitz AJ. 1999. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 68:821-861.
    • (1999) Annu Rev Biochem , vol.68 , pp. 821-861
    • Shaywitz, A.J.1
  • 57
    • 0037648458 scopus 로고    scopus 로고
    • 2
    • DOI 10.1074/jbc.M212864200
    • Stahelin RV, Rafter JD, Das S, Cho W. 2003. The molecular basis of differential subcellular localization of C2 domains of protein kinase Calpha and group IVa cytosolic phospholipase A2. J Biol Chem 278: 12452-12460. (Pubitemid 36800232)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12452-12460
    • Stahelin, R.V.1    Rafter, J.D.2    Das, S.3    Cho, W.4
  • 58
    • 0032588897 scopus 로고    scopus 로고
    • 2 is induced in reactive glia following different forms of neurodegeneration
    • DOI 10.1002/(SICI)1098-1136(199908)27:2<110::AID-GLIA2>3.0.CO;2-C
    • Stephenson D, Rash K, Smalstig B, Roberts E, Johnstone E, Sharp J, Panetta J, Little S, Kramer R, Clemens J. 1999. Cytosolic phospholipase A2 is induced in reactive glia following different forms of neuro-degeneration. Glia 27:110-128. (Pubitemid 29365748)
    • (1999) GLIA , vol.27 , Issue.2 , pp. 110-128
    • Stephenson, D.1    Rash, K.2    Smalstig, B.3    Roberts, E.4    Johnstone, E.5    Sharp, J.6    Panetta, J.7    Little, S.8    Kramer, R.9    Clemens, J.10
  • 59
    • 0029657725 scopus 로고    scopus 로고
    • 2) immunoreactivity is elevated in Alzheimer's disease brain
    • DOI 10.1006/nbdi.1996.0005
    • Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. 1996. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis 3:51-63. (Pubitemid 26145405)
    • (1996) Neurobiology of Disease , vol.3 , Issue.1 , pp. 51-63
    • Stephenson, D.T.1    Lemere, C.A.2    Selkoe, D.J.3    Clemens, J.A.4
  • 60
    • 0025968709 scopus 로고
    • Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs
    • Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF. 1991. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J 5: 98-103. (Pubitemid 21892842)
    • (1991) FASEB Journal , vol.5 , Issue.1 , pp. 98-103
    • Stuehr, D.J.1    Fasehun, O.A.2    Kwon, N.S.3    Gross, S.S.4    Gonzalez, J.A.5    Levi, R.6    Nathan, C.F.7
  • 61
    • 22444448496 scopus 로고    scopus 로고
    • 2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells
    • DOI 10.1002/glia.20178
    • Won JS, Im YB, Khan M, Singh AK, Singh I. 2005. Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Glia 51:13-21. (Pubitemid 41059154)
    • (2005) GLIA , vol.51 , Issue.1 , pp. 13-21
    • Won, J.-S.1    Im, Y.-B.2    Khan, M.3    Singh, A.K.4    Singh, I.5
  • 62
    • 23444447291 scopus 로고    scopus 로고
    • NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells
    • DOI 10.1016/j.freeradbiomed.2005.04.019, PII S089158490500211X
    • Yu JH, Lim JW, Kim KH, Morio T, Kim H. 2005. NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells. Free Radic Biol Med 39:590-602. (Pubitemid 41112101)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.5 , pp. 590-602
    • Ji, H.Y.1    Joo, W.L.2    Kyung, H.K.3    Morio, T.4    Kim, H.5
  • 63
    • 0037067321 scopus 로고    scopus 로고
    • Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox)
    • Zhao X, Bey EA, Wientjes FB, Cathcart MK. 2002. Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). J Biol Chem 277:25385-25392.
    • (2002) J Biol Chem , vol.277 , pp. 25385-25392
    • Zhao, X.1    Bey, E.A.2    Wientjes, F.B.3    Cathcart, M.K.4
  • 64
    • 0030991201 scopus 로고    scopus 로고
    • The transcriptional activity of NF-kappaB is regulated by the IkappaB- Associated PKAc subunit through a cyclic AMP-independent mechanism
    • DOI 10.1016/S0092-8674(00)80222-6
    • Zhong H. 1997. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413-424. (Pubitemid 27220886)
    • (1997) Cell , vol.89 , Issue.3 , pp. 413-424
    • Zhong, H.1    Suyang, H.2    Erdjument-Bromage, H.3    Tempst, P.4    Ghosh, S.5
  • 65
    • 0031573401 scopus 로고    scopus 로고
    • A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases
    • DOI 10.1006/abio.1997.2391
    • Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP. 1997. A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem 253: 162-168. (Pubitemid 27508167)
    • (1997) Analytical Biochemistry , vol.253 , Issue.2 , pp. 162-168
    • Zhou, M.1    Diwu, Z.2    Panchuk-Voloshina, N.3    Haugland, R.P.4
  • 66
    • 33751079341 scopus 로고    scopus 로고
    • 2 mediate amyloid-beta peptide-induced mitochondrial dysfunction
    • DOI 10.1523/JNEUROSCI.3505-06.2006
    • Zhu D, Lai Y, Shelat PB, Hu C, Sun GY, Lee JC. 2006. Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction. J Neurosci 26:11111-11119. (Pubitemid 44772199)
    • (2006) Journal of Neuroscience , vol.26 , Issue.43 , pp. 11111-11119
    • Zhu, D.1    Lai, Y.2    Shelat, P.B.3    Hu, C.4    Sun, G.Y.5    Lee, J.C.-M.6


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