메뉴 건너뛰기




Volumn 8, Issue , 2011, Pages

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

Author keywords

secretase; A ; App; Astrocyte; Bace1; Cytokine; Ifn ; Neuroinflammation; Oligomer; Tnf

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; BETA SECRETASE 1; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; JANUS KINASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; OLIGOMER; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; JAK1 PROTEIN, MOUSE; JANUS KINASE 1; SECRETASE;

EID: 80055112704     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-8-150     Document Type: Article
Times cited : (285)

References (63)
  • 1
    • 79953854897 scopus 로고    scopus 로고
    • Alzheimer's disease: the challenge of the second century
    • 10.1126/scitranslmed.3002369, 21471435
    • Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Sci Transl Med 2011, 3:77sr1. 10.1126/scitranslmed.3002369, 21471435.
    • (2011) Sci Transl Med , vol.3
    • Holtzman, D.M.1    Morris, J.C.2    Goate, A.M.3
  • 2
    • 77951060145 scopus 로고    scopus 로고
    • Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process
    • 10.1152/physrev.00023.2009, 20393191
    • De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiol Rev 2010, 90:465-94. 10.1152/physrev.00023.2009, 20393191.
    • (2010) Physiol Rev , vol.90 , pp. 465-494
    • De Strooper, B.1
  • 3
    • 77956961694 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Alzheimer's disease
    • 10.1007/s00702-010-0438-z, 20632195
    • Heneka MT, O'Banion MK, Terwel D, Kummer MP. Neuroinflammatory processes in Alzheimer's disease. J Neural Transm 2010, 117:919-47. 10.1007/s00702-010-0438-z, 20632195.
    • (2010) J Neural Transm , vol.117 , pp. 919-947
    • Heneka, M.T.1    O'Banion, M.K.2    Terwel, D.3    Kummer, M.P.4
  • 4
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • 10.1016/j.neurobiolaging.2004.05.010, 15639313
    • Mrak RE, Griffin WS. Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 2005, 26:349-54. 10.1016/j.neurobiolaging.2004.05.010, 15639313.
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 5
    • 47349086360 scopus 로고    scopus 로고
    • Interactions between APP secretases and inflammatory mediators
    • 10.1186/1742-2094-5-25, 2442055, 18564425
    • Sastre M, Walter J, Gentleman SM. Interactions between APP secretases and inflammatory mediators. J Neuroinflammation 2008, 5:25. 10.1186/1742-2094-5-25, 2442055, 18564425.
    • (2008) J Neuroinflammation , vol.5 , pp. 25
    • Sastre, M.1    Walter, J.2    Gentleman, S.M.3
  • 6
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • 10.1073/pnas.86.19.7611, 298116, 2529544
    • Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989, 86:7611-7615. 10.1073/pnas.86.19.7611, 298116, 2529544.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7611-7615
    • Griffin, W.S.1    Stanley, L.C.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.J.6    White, C.L.7    Araoz, C.8
  • 7
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution
    • 10.1097/00005072-199503000-00014, 7876895
    • Griffin WS, Sheng JG, Roberts GW, Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol 1995, 54:276-281. 10.1097/00005072-199503000-00014, 7876895.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 8
    • 0035177653 scopus 로고    scopus 로고
    • Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease
    • Dandrea MR, Reiser PA, Gumula NA, Hertzog BM, Andrade-Gordon P. Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease. Biotech Histochem 2001, 76:97-106.
    • (2001) Biotech Histochem , vol.76 , pp. 97-106
    • Dandrea, M.R.1    Reiser, P.A.2    Gumula, N.A.3    Hertzog, B.M.4    Andrade-Gordon, P.5
  • 9
    • 0027980967 scopus 로고
    • Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study
    • 10.1097/00005072-199409000-00007, 7521904
    • Maat-Schieman ML, Rozemuller AJ, van Duinen SG, Haan J, Eikelenboom P, Roos RA. Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. J Neuropathol Exp Neurol 1994, 53:483-491. 10.1097/00005072-199409000-00007, 7521904.
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 483-491
    • Maat-Schieman, M.L.1    Rozemuller, A.J.2    van Duinen, S.G.3    Haan, J.4    Eikelenboom, P.5    Roos, R.A.6
  • 10
    • 0028102425 scopus 로고
    • S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions
    • 10.1016/0167-4889(94)90101-5, 7918676
    • Van Eldik LJ, Griffin WS. S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions. Biochim Biophys Acta 1994, 1223:398-403. 10.1016/0167-4889(94)90101-5, 7918676.
    • (1994) Biochim Biophys Acta , vol.1223 , pp. 398-403
    • Van Eldik, L.J.1    Griffin, W.S.2
  • 11
  • 14
    • 3042567711 scopus 로고    scopus 로고
    • Inflammation occurs early during the Abeta deposition process in TgCRND8 mice
    • 10.1016/j.neurobiolaging.2003.08.008, 15212840
    • Dudal S, Krzywkowski P, Paquette J, Morissette C, Lacombe D, Tremblay P, Gervais F. Inflammation occurs early during the Abeta deposition process in TgCRND8 mice. Neurobiol Aging 2004, 25:861-71. 10.1016/j.neurobiolaging.2003.08.008, 15212840.
    • (2004) Neurobiol Aging , vol.25 , pp. 861-871
    • Dudal, S.1    Krzywkowski, P.2    Paquette, J.3    Morissette, C.4    Lacombe, D.5    Tremblay, P.6    Gervais, F.7
  • 15
    • 0344444229 scopus 로고    scopus 로고
    • Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons
    • 10.1007/s00401-003-0760-8, 12923647
    • Gärtner U, Brückner MK, Krug S, Schmetsdorf S, Staufenbiel M, Arendt T. Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons. Acta Neuropathol 2003, 106:535-44. 10.1007/s00401-003-0760-8, 12923647.
    • (2003) Acta Neuropathol , vol.106 , pp. 535-544
    • Gärtner, U.1    Brückner, M.K.2    Krug, S.3    Schmetsdorf, S.4    Staufenbiel, M.5    Arendt, T.6
  • 16
    • 0035805091 scopus 로고    scopus 로고
    • Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease
    • 10.1016/S0006-8993(01)02202-8, 11325345
    • Terai K, Iwai A, Kawabata S, Sasamata M, Miyata K, Yamaguchi T. Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease. Brain Res 2001, 900:48-56. 10.1016/S0006-8993(01)02202-8, 11325345.
    • (2001) Brain Res , vol.900 , pp. 48-56
    • Terai, K.1    Iwai, A.2    Kawabata, S.3    Sasamata, M.4    Miyata, K.5    Yamaguchi, T.6
  • 19
    • 72449204160 scopus 로고    scopus 로고
    • Does neuroinflammation fan the flame in neurodegenerative diseases?
    • 10.1186/1750-1326-4-47, 2784760, 19917131
    • Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG. Does neuroinflammation fan the flame in neurodegenerative diseases?. Mol Neurodegener 2009, 4:47. 10.1186/1750-1326-4-47, 2784760, 19917131.
    • (2009) Mol Neurodegener , vol.4 , pp. 47
    • Frank-Cannon, T.C.1    Alto, L.T.2    McAlpine, F.E.3    Tansey, M.G.4
  • 20
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 1995, 21:195-218.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 21
    • 10544248594 scopus 로고    scopus 로고
    • Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes
    • 10.1074/jbc.271.49.31407, 8940150
    • Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem 1996, 271:31407-11. 10.1074/jbc.271.49.31407, 8940150.
    • (1996) J Biol Chem , vol.271 , pp. 31407-31411
    • Zhao, J.1    Paganini, L.2    Mucke, L.3    Gordon, M.4    Refolo, L.5    Carman, M.6    Sinha, S.7    Oltersdorf, T.8    Lieberburg, I.9    McConlogue, L.10
  • 27
    • 0034652309 scopus 로고    scopus 로고
    • Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
    • 10.1073/pnas.97.4.1456, 26455, 10677483
    • Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci USA 2000, 97:1456-60. 10.1073/pnas.97.4.1456, 26455, 10677483.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1456-1460
    • Lin, X.1    Koelsch, G.2    Wu, S.3    Downs, D.4    Dashti, A.5    Tang, J.6
  • 28
    • 30444440132 scopus 로고    scopus 로고
    • BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
    • 10.1523/JNEUROSCI.2766-05.2005, 2564291, 16354928
    • Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 2005, 25:11693-709. 10.1523/JNEUROSCI.2766-05.2005, 2564291, 16354928.
    • (2005) J Neurosci , vol.25 , pp. 11693-11709
    • Laird, F.M.1    Cai, H.2    Savonenko, A.V.3    Farah, M.H.4    He, K.5    Melnikova, T.6    Wen, H.7    Chiang, H.C.8    Xu, G.9    Koliatsos, V.E.10    Borchelt, D.R.11    Price, D.L.12    Lee, H.K.13    Wong, P.C.14
  • 29
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • 10.1007/s00401-009-0619-8, 2799634, 20012068
    • Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010, 119:7-35. 10.1007/s00401-009-0619-8, 2799634, 20012068.
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 31
    • 0028928520 scopus 로고
    • Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain
    • 10.1073/pnas.92.7.3032, 42353, 7708769
    • Brugg B, Dubreuil YL, Huber G, Wollman EE, Delhaye-Bouchaud N, Mariani J. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci USA 1995, 92:3032-5. 10.1073/pnas.92.7.3032, 42353, 7708769.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3032-3035
    • Brugg, B.1    Dubreuil, Y.L.2    Huber, G.3    Wollman, E.E.4    Delhaye-Bouchaud, N.5    Mariani, J.6
  • 32
    • 0042835437 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice
    • 10.1016/S0969-9961(03)00069-X, 13678674
    • Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE. Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis 2003, 14:133-45. 10.1016/S0969-9961(03)00069-X, 13678674.
    • (2003) Neurobiol Dis , vol.14 , pp. 133-145
    • Sheng, J.G.1    Bora, S.H.2    Xu, G.3    Borchelt, D.R.4    Price, D.L.5    Koliatsos, V.E.6
  • 33
    • 0032621790 scopus 로고    scopus 로고
    • TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs
    • Blasko I, Marx F, Steiner E, Hartmann T, Grubeck-Loebenstein B. TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. FASEB J 1999, 13:63-8.
    • (1999) FASEB J , vol.13 , pp. 63-68
    • Blasko, I.1    Marx, F.2    Steiner, E.3    Hartmann, T.4    Grubeck-Loebenstein, B.5
  • 34
    • 0033525735 scopus 로고    scopus 로고
    • Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
    • 10.1074/jbc.274.10.6421, 10037734
    • Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J Biol Chem 1999, 274:6421-31. 10.1074/jbc.274.10.6421, 10037734.
    • (1999) J Biol Chem , vol.274 , pp. 6421-6431
    • Rogers, J.T.1    Leiter, L.M.2    McPhee, J.3    Cahill, C.M.4    Zhan, S.S.5    Potter, H.6    Nilsson, L.N.7
  • 35
    • 0034523456 scopus 로고    scopus 로고
    • Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
    • 10.1006/nbdi.2000.0321, 11114266
    • Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B. Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis 2000, 7:682-9. 10.1006/nbdi.2000.0321, 11114266.
    • (2000) Neurobiol Dis , vol.7 , pp. 682-689
    • Blasko, I.1    Veerhuis, R.2    Stampfer-Kountchev, M.3    Saurwein-Teissl, M.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 36
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • Sastre M, Dewachter I, Landreth GE, Willson TM, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci 2003, 23:9796-804.
    • (2003) J Neurosci , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    van Leuven, F.6    Heneka, M.T.7
  • 37
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • 10.1126/science.274.5284.99, 8810256
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102. 10.1126/science.274.5284.99, 8810256.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 38
    • 0037767814 scopus 로고    scopus 로고
    • Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes
    • 10.1016/S0006-291X(03)01270-1, 12878199
    • Hong HS, Hwang EM, Sim HJ, Cho HJ, Boo JH, Oh SS, Kim SU, Mook-Jung I. Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes. Biochem Biophys Res Commun 2003, 307:922-7. 10.1016/S0006-291X(03)01270-1, 12878199.
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 922-927
    • Hong, H.S.1    Hwang, E.M.2    Sim, H.J.3    Cho, H.J.4    Boo, J.H.5    Oh, S.S.6    Kim, S.U.7    Mook-Jung, I.8
  • 39
    • 33846852617 scopus 로고    scopus 로고
    • IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes
    • 10.1002/glia.20451, 17091494
    • Cho HJ, Kim SK, Jin SM, Hwang EM, Kim YS, Huh K, Mook-Jung I. IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes. Glia 2007, 55:253-62. 10.1002/glia.20451, 17091494.
    • (2007) Glia , vol.55 , pp. 253-262
    • Cho, H.J.1    Kim, S.K.2    Jin, S.M.3    Hwang, E.M.4    Kim, Y.S.5    Huh, K.6    Mook-Jung, I.7
  • 40
    • 33947512432 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
    • 10.2353/ajpath.2007.060378, 1851864, 17255335
    • Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 2007, 170:680-92. 10.2353/ajpath.2007.060378, 1851864, 17255335.
    • (2007) Am J Pathol , vol.170 , pp. 680-692
    • Yamamoto, M.1    Kiyota, T.2    Horiba, M.3    Buescher, J.L.4    Walsh, S.M.5    Gendelman, H.E.6    Ikezu, T.7
  • 41
    • 34548316575 scopus 로고    scopus 로고
    • Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice
    • 10.1083/jcb.200705042, 2064547, 17724122
    • He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y. Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol 2007, 178:829-41. 10.1083/jcb.200705042, 2064547, 17724122.
    • (2007) J Cell Biol , vol.178 , pp. 829-841
    • He, P.1    Zhong, Z.2    Lindholm, K.3    Berning, L.4    Lee, W.5    Lemere, C.6    Staufenbiel, M.7    Li, R.8    Shen, Y.9
  • 42
    • 0032473596 scopus 로고    scopus 로고
    • Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
    • 10.1016/S0006-8993(97)01318-8, 9518610
    • Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res 1998, 785:195-206. 10.1016/S0006-8993(97)01318-8, 9518610.
    • (1998) Brain Res , vol.785 , pp. 195-206
    • Hu, J.1    Akama, K.T.2    Krafft, G.A.3    Chromy, B.A.4    Van Eldik, L.J.5
  • 43
    • 14744283139 scopus 로고    scopus 로고
    • Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation
    • 10.1016/j.nbd.2004.12.013, 15755672
    • White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ. Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis 2005, 18:459-65. 10.1016/j.nbd.2004.12.013, 15755672.
    • (2005) Neurobiol Dis , vol.18 , pp. 459-465
    • White, J.A.1    Manelli, A.M.2    Holmberg, K.H.3    Van Eldik, L.J.4    Ladu, M.J.5
  • 44
    • 0034678024 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism
    • 10.1074/jbc.275.11.7918, 10713108
    • Akama KT, Van Eldik LJ. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. J Biol Chem 2000, 275:7918-24. 10.1074/jbc.275.11.7918, 10713108.
    • (2000) J Biol Chem , vol.275 , pp. 7918-7924
    • Akama, K.T.1    Van Eldik, L.J.2
  • 45
    • 4644316149 scopus 로고    scopus 로고
    • Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo
    • 10.1016/j.neurobiolaging.2004.01.006, 15465624
    • Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging 2004, 25:1283-92. 10.1016/j.neurobiolaging.2004.01.006, 15465624.
    • (2004) Neurobiol Aging , vol.25 , pp. 1283-1292
    • Craft, J.M.1    Watterson, D.M.2    Frautschy, S.A.3    Van Eldik, L.J.4
  • 46
    • 67049159505 scopus 로고    scopus 로고
    • Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid
    • 10.1515/REVNEURO.2009.20.1.1, 19526730
    • Nimmrich V, Ebert U. Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid. Rev Neurosci 2009, 20:1-12. 10.1515/REVNEURO.2009.20.1.1, 19526730.
    • (2009) Rev Neurosci , vol.20 , pp. 1-12
    • Nimmrich, V.1    Ebert, U.2
  • 47
    • 0029671449 scopus 로고    scopus 로고
    • S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes
    • 10.1074/jbc.271.5.2543, 8576219
    • Hu J, Castets F, Guevara JL, Van Eldik LJ. S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes. J Biol Chem 1996, 271:2543-7. 10.1074/jbc.271.5.2543, 8576219.
    • (1996) J Biol Chem , vol.271 , pp. 2543-2547
    • Hu, J.1    Castets, F.2    Guevara, J.L.3    Van Eldik, L.J.4
  • 48
    • 84934439037 scopus 로고    scopus 로고
    • Preparing synthetic Aβ in different aggregation states
    • Stine WB, Jungbauer L, Yu C, LaDu MJ. Preparing synthetic Aβ in different aggregation states. Methods Mol Biol 2011, 670:13-32.
    • (2011) Methods Mol Biol , vol.670 , pp. 13-32
    • Stine, W.B.1    Jungbauer, L.2    Yu, C.3    LaDu, M.J.4
  • 49
    • 28044458281 scopus 로고    scopus 로고
    • Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis
    • 10.1523/JNEUROSCI.2350-05.2005, 16306400
    • Velliquette RA, O'Connor T, Vassar R. Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. J Neurosci 2005, 25:10874-83. 10.1523/JNEUROSCI.2350-05.2005, 16306400.
    • (2005) J Neurosci , vol.25 , pp. 10874-10883
    • Velliquette, R.A.1    O'Connor, T.2    Vassar, R.3
  • 51
    • 34248178463 scopus 로고    scopus 로고
    • Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides
    • 10.1002/jnr.21252, 17385716
    • Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR. Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides. J Neurosci Res 2007, 85:1194-204. 10.1002/jnr.21252, 17385716.
    • (2007) J Neurosci Res , vol.85 , pp. 1194-1204
    • Bourne, K.Z.1    Ferrari, D.C.2    Lange-Dohna, C.3    Rossner, S.4    Wood, T.G.5    Perez-Polo, J.R.6
  • 52
    • 0026745610 scopus 로고
    • Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
    • 10.1038/360672a0, 1465129
    • Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 1992, 360:672-4. 10.1038/360672a0, 1465129.
    • (1992) Nature , vol.360 , pp. 672-674
    • Citron, M.1    Oltersdorf, T.2    Haass, C.3    McConlogue, L.4    Hung, A.Y.5    Seubert, P.6    Vigo-Pelfrey, C.7    Lieberburg, I.8    Selkoe, D.J.9
  • 54
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • 10.1172/JCI31450, 1878531, 17549256
    • Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 2007, 117:1595-604. 10.1172/JCI31450, 1878531, 17549256.
    • (2007) J Clin Invest , vol.117 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5    O'Banion, M.K.6
  • 55
    • 0033525735 scopus 로고    scopus 로고
    • Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences
    • 10.1074/jbc.274.10.6421, 10037734
    • Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. J Biol Chem 1999, 274:6421-31. 10.1074/jbc.274.10.6421, 10037734.
    • (1999) J Biol Chem , vol.274 , pp. 6421-6431
    • Rogers, J.T.1    Leiter, L.M.2    McPhee, J.3    Cahill, C.M.4    Zhan, S.S.5    Potter, H.6    Nilsson, L.N.7
  • 58
    • 76949084622 scopus 로고    scopus 로고
    • TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion
    • 10.1038/sj.bjc.6605530, 2837572, 20087353
    • Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion. Br J Cancer 2010, 102:639-44. 10.1038/sj.bjc.6605530, 2837572, 20087353.
    • (2010) Br J Cancer , vol.102 , pp. 639-644
    • Wu, Y.1    Zhou, B.P.2
  • 59
    • 77049092286 scopus 로고    scopus 로고
    • Gene modulation and immunoregulatory roles of interferon gamma
    • 10.1016/j.cyto.2009.11.021, 20036577
    • Saha B, Jyothi Prasanna S, Chandrasekar B, Nandi D. Gene modulation and immunoregulatory roles of interferon gamma. Cytokine 2010, 50:1-14. 10.1016/j.cyto.2009.11.021, 20036577.
    • (2010) Cytokine , vol.50 , pp. 1-14
    • Saha, B.1    Jyothi Prasanna, S.2    Chandrasekar, B.3    Nandi, D.4
  • 61
    • 0030610645 scopus 로고    scopus 로고
    • Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
    • 10.1038/42257, 9278049
    • Barger SW, Harmon AD. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 1997, 388:878-81. 10.1038/42257, 9278049.
    • (1997) Nature , vol.388 , pp. 878-881
    • Barger, S.W.1    Harmon, A.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.