Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 1030-1036

  Tahara, Kayoko ^a   Nishikawa, Takashi ^b   Hattori, Yutaka ^a   Iijima, Shiro ^a   Kouno, Yukiko ^a   Abe, Yoshihiro ^a  

^a KEIO UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Electrochemical oxidation; LC MS; Nonaqueous medium; Reactive drug metabolite; Troglitazone

Indexed keywords

ACETONITRILE; DRUG METABOLITE; ESTER DERIVATIVE; QUINONE DERIVATIVE; TROGLITAZONE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL MODIFICATION; DRUG DETERMINATION; DRUG SAFETY; DRUG STABILITY; ELECTROCHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; LIVER TOXICITY; OXIDATION; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ACETONITRILES; BIOTRANSFORMATION; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMERIZATION; ELECTROCHEMISTRY; HUMANS; MICROSOMES, LIVER; MODELS, CHEMICAL; OXYGEN; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE; THIAZOLIDINEDIONES; TIME FACTORS;

EID: 70349172996     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.06.002     Document Type: Article

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