Investigation of the biotransformation pathway of verapamil using electrochemistry/liquid chromatography/mass spectrometry - A comparative study with liver cell microsomes

Journal of Chromatography A

Volumn 1218, Issue 51, 2011, Pages 9210-9220

  Jahn, Sandra ^a   Baumann, Anne ^a   Roscher, Jörg ^a   Hense, Katharina ^a   Zazzeroni, Raniero ^b   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Drug metabolism; Electrochemistry; Liquid chromatography; Mass spectrometry; Verapamil

Indexed keywords

ACCURATE MASS; AMPEROMETRIC; BORON DOPED DIAMOND; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY/MASS SPECTROMETRY; COMPARATIVE STUDIES; DRUG DISCOVERY; DRUG METABOLISMS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN LIVER MICROSOMES; IN-VITRO; IN-VIVO; INSTRUMENTAL TECHNIQUES; LIVER CELLS; METABOLIC PRODUCTS; METABOLIC REACTIONS; MS/MS EXPERIMENTS; OXIDATIVE METABOLISM; PHASE I; THIN-LAYER CELLS; VERAPAMIL; WORKING ELECTRODE;

BORON; ELECTROCHEMISTRY; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHYSIOLOGY; SULFONATION;

METABOLISM;

AMINE; BORON; CALCIUM ANTAGONIST; DIAMOND; IMINE; IMINE METHIDE; METHANOLAMINE; NORVERAPAMIL; UNCLASSIFIED DRUG; VERAPAMIL;

AEROBIC METABOLISM; AMPEROMETRY; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEMETHYLATION; DRUG DEVELOPMENT; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; ELECTROCHEMISTRY; ELECTRODE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; ONLINE ANALYSIS; PRIORITY JOURNAL; SIMULATION; TANDEM MASS SPECTROMETRY;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; ELECTROCHEMICAL TECHNIQUES; HUMANS; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VERAPAMIL;

RATTUS;

EID: 82555168199     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.10.052     Document Type: Article

References (60)

1. Singh B.N., Ellrodt G., Peter C.T. Drugs 1978, 15:169.
2. McTavish D., Sorkin E.M. Drugs 1989, 38:19.
3. Brogden R.N., Benfield P. Drugs 1996, 51:792.
4. Eichelbaum M., Ende M., Remberg G., Schomerus M., Dengler H.J. Drug Metab. Dispos. 1979, 7:145.
5. McAllister R.G., Schloemer G.L., Hamann S.R. Am. J. Cardiol. 1986, 57:16D.
6. Remberg G., Ende M., Eichelbaum M., Schomerus M. Arzneimittel-Forsch. 1980, 30:398.
7. McIlhenny H.M. J. Med. Chem. 1971, 14:1178.
8. Nelson W.L., Olsen L.D. Drug Metab. Dispos. 1988, 16:834.
9. Nelson W.L., Olsen L.D., Beitner D.B., Pallow R.J. Drug Metab. Dispos. 1988, 16:184.
10. Cashman J.R. Mol. Pharmacol. 1989, 36:497.
11. Walles M., Thum T., Levsen K., Borlak J. J. Chromatogr. B 2003, 798:265.
12. Borlak J., Walles M., Elend M., Thum T., Preiss A., Levsen K. Xenobiotica 2003, 33:655.
13. Borlak J., Walles M., Levsen K., Thum T. Drug Metab. Dispos. 2003, 31:888.
14. Walles M., Thum T., Levsen K., Borlak J. J. Chromatogr. A 2002, 970:117.
15. Walles M., Thum T., Levsen K., Borlak J. Drug Metab. Dispos. 2001, 29:761.
16. Brandon E.F.A., Raap C.D., Meijernan I., Beijnen J.H., Schellens J.H.M. Toxicol. Appl. Pharmacol. 2003, 189:233.
17. Traylor P.S., Dolphin D., Traylor T.G. J. Chem. Soc. Chem. Commun. 1984, 279.
18. Bernadou J., Meunier B. Adv. Synth. Catal. 2004, 346:171.
19. Feiters M.C., Rowan A.E., Nolte R.J.M. Chem. Soc. Rev. 2000, 29:375.
20. Sun L., Huang H.-H., Liu L., Zhong D.-F. Appl. Environ. Microbiol. 2004, 70:2722.
21. Moody J.D., Zhang D.L., Heinze T.M., Cerniglia C.E. Appl. Environ. Microbiol. 2000, 66:3646.
22. Hezari M., Davis P.J. Drug Metab. Dispos. 1993, 21:259.
23. Baumann A., Karst U. Expert Opin. Drug Metab. Toxicol. 2010, 6:1.
24. Lohmann W., Karst U. Anal. Bioanal. Chem. 2008, 391:79.
25. Shono T., Toda T., Oshino N. Drug Metab. Dispos. 1981, 9:481.
26. Shono T., Toda T., Oshino N. J. Am. Chem. Soc. 1982, 104:2639.
27. Hambitzer G., Heitbaum J. Anal. Chem. 1986, 58:1067.
28. Volk K.J., Lee M.S., Yost R.A., Brajter-Toth A. Anal. Chem. 1986, 60:720.
29. Volk K.J., Yost R.A., Brajter-Toth A. J. Chromatogr. 1989, 474:231.
30. Getek T.A., Korfmacher W.A., McRae T.A., Hinson J.A. J. Chromatogr. 1989, 474:245.
31. Zhou F., Van Berkel G.J. Anal. Chem. 1995, 67:3643.
32. Van Berkel G.J., Zhou F. Anal. Chem. 1995, 67:2916.
33. Deng H., Van Berkel G.J. Anal. Chem. 1999, 71:4284.
34. Deng H., Van Berkel G.J. Electroanalysis 1999, 11:857.
35. Jurva U., Wikström H.V., Bruins A.P. Rapid Commun. Mass Spectrom. 2000, 14:529.
36. Kertesz V., Deng H., Asano K.G., Hettich R.L., Van Berkel G.J. Electroanalysis 2002, 14:1027.
37. Jurva U., Wikström H.V., Weidolf L., Bruins A.P. Rapid Commun. Mass Spectrom. 2003, 17:800.
38. Gamache P.H., Smith R., McCarthy R., Waraska J., Acworth I.N. Spectroscopy 2003, 18:14.
39. Gamache P.H., Meyer D.F., Granger M.C., Acworth I.N. J. Am. Chem. Mass Spectrom. 2004, 15:1717.
40. Madsen K.G., Olsen J., Skonberg C., Hansen S.H., Jurva U. Chem. Res. Toxicol. 2007, 20:821.
41. Tahara K., Yano Y., Kanagawa K., Abe Y., Yamada J., Iijima S., Mochizuki M., Nishikawa T. Chem. Pharm. Bull. 2007, 55:1207.
42. Baumann A., Lohmann W., Rose T., Ahn K.C., Hammock B.D., Karst U., Schebb N.H. Drug Metab. Dispos. 2010, 38:2130.
43. Nouri-Nigjeh E., Bischoff R., Bruins A.P., Permentier H.P. Curr. Drug Metab. 2011, 12:359.
44. Baumann A., Lohmann W., Schubert B., Oberacher H., Karst U. J. Chromatogr. A 2009, 1216:3192.
45. Lohmann W., Karst U. Anal. Bioanal. Chem. 2006, 386:1701.
46. Van Leeuwen S.M., Blankert B., Kauffmann J.M., Karst U. Anal. Bioanal. Chem. 2005, 382:742.
47. Madsen K.G., Skonberg C., Jurva U., Cornett C., Hansen S.H., Johansen T.N., Olsen J. Chem. Res. Toxicol. 2008, 21:1107.
48. Jurva U., Holmén A., Grönberg G., Masimirembwa C., Weidolf L. Chem. Res. Toxicol. 2008, 21:928.
49. Lohmann W., Karst U. Anal. Chem. 2007, 79:6831.
50. Thevis M., Lohmann W., Schrader Y., Kohler M., Bornatsch W., Karst U., Schänzer W. Eur. J. Mass Spectrom. 2008, 14:163.
51. Nissilä T., Sainiemi L., Karikko M.-M., Kemell M., Ritala M., Franssila S., Kostiainen R., Ketola R.A. Lab Chip 2011, 11:1470.
52. Godfraind T. Calcium Modulators 1982, vol. 15:51. Elsevier Biomedical Press, Amsterdam.
53. McAllister R.G., Hamann S.R., Blouin R.A. Am. J. Cardiol. 1985, 55:30B.
54. Johansson T., Weidolf L., Jurva U. Rapid Commun. Mass Spectrom. 2007, 21:2323.
55. Baumann A., Lohmann W., Jahn S., Karst U. Electroanalysis 2010, 22:286.
56. Kraft A. Int. J. Electrochem. Sci. 2007, 2:355.
57. Graham D.G. Mol. Pharmacol. 1978, 14:633.
58. Harrison A.C., Kitteringham N.R., Clarke J.B., Park B.K. Biochem. Pharmacol. 1992, 43:1421.
59. Yan Z., Zhong H.M., Maher N., Torres R., Leo G.C., Caldwell G.M., Huebert N. Drug Metab. Dispos. 2005, 33:1867.
60. Hollenberg P.F. FASEB J. 1992, 6:686.