Simulation of the oxidative metabolism of diclofenac by electrochemistry/(liquid chromatography/)mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 2, 2012, Pages 345-354

  Faber, Helene ^a   Melles, Daniel ^a   Brauckmann, Christine ^a   Wehe, Christoph Alexander ^a   Wentker, Kristina ^a   Karst, Uwe ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Diclofenac; Electrochemistry; Glutathione adducts; High resolution mass spectrometry; Phase I metabolism; Protein adducts

Indexed keywords

ACCURATE MASS; BORON DOPED DIAMOND; DICLOFENAC; GLUTATHIONES; HEPATOTOXICITY; HIGH RESOLUTION MASS SPECTROMETRY; INSTRUMENTAL APPROACH; LACTOGLOBULIN; MODEL PROTEINS; OXIDATION PRODUCTS; OXIDATIVE METABOLISM; OXIDATIVE PATHWAYS; PHASE I; QUINONE-IMINES; REACTIVE METABOLITES; THIN-LAYER CELLS; TRYPTIC DIGESTS; WORKING ELECTRODE;

ELECTROCHEMISTRY; METABOLISM; NITROGEN COMPOUNDS; PEPTIDES; PHYSIOLOGY;

MASS SPECTROMETRY;

DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROCHEMISTRY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; OXIDATION REDUCTION REACTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; ELECTROCHEMISTRY; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION;

EID: 84860444400     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5665-0     Document Type: Article

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