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Volumn 163, Issue 1, 2013, Pages 10-23

Cellular immune dysfunction in immune thrombocytopenia (ITP)

Author keywords

Antigen presenting cells; Autoimmunity; B cells; Immune thrombocytopenia (ITP); T cells

Indexed keywords

GLUCOCORTICOID; IMMUNOGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RITUXIMAB;

EID: 84884152225     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12480     Document Type: Review
Times cited : (155)

References (191)
  • 1
    • 79959896863 scopus 로고    scopus 로고
    • B cell activating factor gene polymorphisms in patients with risk of idiopathic thrombocytopenic purpura
    • Abdel-Hamid, S.M. & Al-Lithy, H.N. (2011) B cell activating factor gene polymorphisms in patients with risk of idiopathic thrombocytopenic purpura. American Journal of the Medical Sciences, 1, 9-14.
    • (2011) American Journal of the Medical Sciences , vol.1 , pp. 9-14
    • Abdel-Hamid, S.M.1    Al-Lithy, H.N.2
  • 4
    • 33847667225 scopus 로고    scopus 로고
    • The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    • Afzali, B., Lombardi, G., Lechler, R.I. & Lord, G.M. (2007) The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clinical and Experimental Immunology, 1, 32-46.
    • (2007) Clinical and Experimental Immunology , vol.1 , pp. 32-46
    • Afzali, B.1    Lombardi, G.2    Lechler, R.I.3    Lord, G.M.4
  • 5
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Akira, S. & Hemmi, H. (2003) Recognition of pathogen-associated molecular patterns by TLR family. Immunology Letters, 2, 85-95.
    • (2003) Immunology Letters , vol.2 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 6
    • 84872175112 scopus 로고    scopus 로고
    • Dendritic cells a double-edge sword in autoimmune responses
    • Amodio, G. & Gregori, S. (2012) Dendritic cells a double-edge sword in autoimmune responses. Frontiers in Immunology, 3, 233.
    • (2012) Frontiers in Immunology , vol.3 , pp. 233
    • Amodio, G.1    Gregori, S.2
  • 8
    • 65649133976 scopus 로고    scopus 로고
    • Surveillance of antigen-presenting cells by CD4 +  CD25 +  regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications
    • André, S., Tough, D.F., Lacroix-Desmazes, S., Kaveri, S.V. & Bayry, J. (2009) Surveillance of antigen-presenting cells by CD4 +  CD25 +  regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. American Journal of Pathology, 5, 1575-1587.
    • (2009) American Journal of Pathology , vol.5 , pp. 1575-1587
    • André, S.1    Tough, D.F.2    Lacroix-Desmazes, S.3    Kaveri, S.V.4    Bayry, J.5
  • 10
    • 70449636017 scopus 로고    scopus 로고
    • Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome
    • Arkfeld, D.G. & Weitz, I.C. (2009) Immune thrombocytopenia in patients with connective tissue disorders and the antiphospholipid antibody syndrome. Hematology/Oncology Clinics of North America, 6, 1239-1249.
    • (2009) Hematology/Oncology Clinics of North America , vol.6 , pp. 1239-1249
    • Arkfeld, D.G.1    Weitz, I.C.2
  • 11
    • 30444436765 scopus 로고    scopus 로고
    • Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo
    • Aslam, R., Speck, E.R., Kim, M., Crow, A.R., Bang, K.W., Nestel, F.P., Ni, H., Lazarus, A.H., Freedman, J. & Semple, J.W. (2006) Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood, 2, 637-641.
    • (2006) Blood , vol.2 , pp. 637-641
    • Aslam, R.1    Speck, E.R.2    Kim, M.3    Crow, A.R.4    Bang, K.W.5    Nestel, F.P.6    Ni, H.7    Lazarus, A.H.8    Freedman, J.9    Semple, J.W.10
  • 12
    • 84866177904 scopus 로고    scopus 로고
    • Thymic retention of CD4 + CD25 + FoxP3 +  T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia
    • Aslam, R., Hu, Y., Gebremeskel, S., Segel, G.B., Speck, E.R., Guo, L., Kim, M., Ni, H., Freedman, J. & Semple, J.W. (2012) Thymic retention of CD4 + CD25 + FoxP3 +  T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood, 10, 2127-2132.
    • (2012) Blood , vol.10 , pp. 2127-2132
    • Aslam, R.1    Hu, Y.2    Gebremeskel, S.3    Segel, G.B.4    Speck, E.R.5    Guo, L.6    Kim, M.7    Ni, H.8    Freedman, J.9    Semple, J.W.10
  • 16
    • 78649486228 scopus 로고    scopus 로고
    • Improved regulatory T cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents
    • Bao, W., Bussel, J.B., Heck, S., He, W., Karpoff, M., Boulad, N. & Yazdanbakhsh, K. (2010) Improved regulatory T cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood, 22, 4639-4645.
    • (2010) Blood , vol.22 , pp. 4639-4645
    • Bao, W.1    Bussel, J.B.2    Heck, S.3    He, W.4    Karpoff, M.5    Boulad, N.6    Yazdanbakhsh, K.7
  • 17
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., Oukka, M., Weiner, H.L. & Kuchroo, V.K. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 7090, 235-238.
    • (2006) Nature , vol.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 18
    • 74649083783 scopus 로고    scopus 로고
    • CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    • Blair, P.A., Noreña, L.Y., Flores-Borja, F., Rawlings, D.J., Isenberg, D.A., Ehrenstein, M.R. & Mauri, C. (2010) CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity, 1, 129-140.
    • (2010) Immunity , vol.1 , pp. 129-140
    • Blair, P.A.1    Noreña, L.Y.2    Flores-Borja, F.3    Rawlings, D.J.4    Isenberg, D.A.5    Ehrenstein, M.R.6    Mauri, C.7
  • 21
    • 79959597551 scopus 로고    scopus 로고
    • Management of immune thrombocytopenic purpura in children: potential role of novel agents
    • Bredlau, A.L., Semple, J.W. & Segel, G.B. (2011) Management of immune thrombocytopenic purpura in children: potential role of novel agents. Paediatric Drugs, 4, 213-223.
    • (2011) Paediatric Drugs , vol.4 , pp. 213-223
    • Bredlau, A.L.1    Semple, J.W.2    Segel, G.B.3
  • 23
    • 33748485816 scopus 로고    scopus 로고
    • Current challenges in the management of children with idiopathic thrombocytopenic purpura
    • Buchanan, G.R. & Adix, L. (2006) Current challenges in the management of children with idiopathic thrombocytopenic purpura. Pediatric Blood & Cancer, 5, 681-684.
    • (2006) Pediatric Blood & Cancer , vol.5 , pp. 681-684
    • Buchanan, G.R.1    Adix, L.2
  • 24
    • 80053132093 scopus 로고    scopus 로고
    • Elevated plasma IL-22 levels correlated with Th1 and Th22 cells in patients with immune thrombocytopenia
    • Cao, J., Chen, C., Zeng, L., Li, L., Li, X., Li, Z. & Xu, K. (2011a) Elevated plasma IL-22 levels correlated with Th1 and Th22 cells in patients with immune thrombocytopenia. Clinical Immunology, 1, 121-123.
    • (2011) Clinical Immunology , vol.1 , pp. 121-123
    • Cao, J.1    Chen, C.2    Zeng, L.3    Li, L.4    Li, X.5    Li, Z.6    Xu, K.7
  • 26
    • 84862787633 scopus 로고    scopus 로고
    • Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia
    • Cao, J., Chen, C., Li, L., Ling-yu, Z., Zhen-yu, L., Zhi-ling, Y., Wei, C., Hai, C., Sang, W. & Kai-lin, X. (2012) Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia. Journal of Clinical Immunology, 3, 523-529.
    • (2012) Journal of Clinical Immunology , vol.3 , pp. 523-529
    • Cao, J.1    Chen, C.2    Li, L.3    Ling-yu, Z.4    Zhen-yu, L.5    Zhi-ling, Y.6    Wei, C.7    Hai, C.8    Sang, W.9    Kai-lin, X.10
  • 29
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
    • Chang, M., Nakagawa, P.A., Williams, S.A., Schwartz, M.R., Imfeld, K.L., Buzby, J.S. & Nugent, D.J. (2003) Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood, 3, 887-895.
    • (2003) Blood , vol.3 , pp. 887-895
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3    Schwartz, M.R.4    Imfeld, K.L.5    Buzby, J.S.6    Nugent, D.J.7
  • 32
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 +  regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., Jin, W., Hardegen, N., Lei, K.J., Li, L., Marinos, N., McGrady, G. & Wahl, S.M. (2003) Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25 +  regulatory T cells by TGF-beta induction of transcription factor Foxp3. Journal of Experimental Medicine, 12, 1875-1886.
    • (2003) Journal of Experimental Medicine , vol.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 33
    • 79955782511 scopus 로고    scopus 로고
    • Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia
    • Chen, Z.P., Gu, D.S., Zhou, Z.P., Chen, X.L., Guo, Z.X., Du, W.T., Ge, J., Ren, Q. & Yang, R.C. (2011) Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia. Human Immunology, 6, 486-491.
    • (2011) Human Immunology , vol.6 , pp. 486-491
    • Chen, Z.P.1    Gu, D.S.2    Zhou, Z.P.3    Chen, X.L.4    Guo, Z.X.5    Du, W.T.6    Ge, J.7    Ren, Q.8    Yang, R.C.9
  • 34
    • 84866057080 scopus 로고    scopus 로고
    • The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia
    • Chen, J.F., Yang, L.H., Chang, L.X., Feng, J.J. & Liu, J.Q. (2012) The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia. Hematology, 5, 283-290.
    • (2012) Hematology , vol.5 , pp. 283-290
    • Chen, J.F.1    Yang, L.H.2    Chang, L.X.3    Feng, J.J.4    Liu, J.Q.5
  • 35
  • 36
    • 69249240344 scopus 로고    scopus 로고
    • The ITP syndrome: pathogenic and clinical diversity
    • Cines, D.B., Bussel, J.B., Liebman, H.A. & Luning Prak, E.T. (2009) The ITP syndrome: pathogenic and clinical diversity. Blood, 26, 6511-6521.
    • (2009) Blood , vol.26 , pp. 6511-6521
    • Cines, D.B.1    Bussel, J.B.2    Liebman, H.A.3    Luning Prak, E.T.4
  • 38
    • 0038494827 scopus 로고    scopus 로고
    • IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity
    • Crow, A.R., Song, S., Freedman, J., Helgason, C.D., Humphries, R.K., Siminovitch, K.A. & Lazarus, A.H. (2003) IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Blood, 2, 558-560.
    • (2003) Blood , vol.2 , pp. 558-560
    • Crow, A.R.1    Song, S.2    Freedman, J.3    Helgason, C.D.4    Humphries, R.K.5    Siminovitch, K.A.6    Lazarus, A.H.7
  • 39
    • 33845976292 scopus 로고    scopus 로고
    • A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
    • Crow, A.R., Song, S., Semple, J.W., Freedman, J. & Lazarus, A.H. (2007) A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood, 1, 155-158.
    • (2007) Blood , vol.1 , pp. 155-158
    • Crow, A.R.1    Song, S.2    Semple, J.W.3    Freedman, J.4    Lazarus, A.H.5
  • 40
    • 83455195478 scopus 로고    scopus 로고
    • The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia
    • Crow, A.R., Suppa, S.J., Chen, X., Mott, P.J. & Lazarus, A.H. (2011) The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood, 24, 6403-6406.
    • (2011) Blood , vol.24 , pp. 6403-6406
    • Crow, A.R.1    Suppa, S.J.2    Chen, X.3    Mott, P.J.4    Lazarus, A.H.5
  • 42
    • 84870996379 scopus 로고    scopus 로고
    • Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia
    • Daridon, C., Loddenkemper, C., Spieckermann, S., Kühl, A.A., Salama, A., Burmester, G.R., Lipsky, P.E. & Dörner, T. (2012) Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia. Blood, 25, 5021-5031.
    • (2012) Blood , vol.25 , pp. 5021-5031
    • Daridon, C.1    Loddenkemper, C.2    Spieckermann, S.3    Kühl, A.A.4    Salama, A.5    Burmester, G.R.6    Lipsky, P.E.7    Dörner, T.8
  • 43
    • 63149121183 scopus 로고    scopus 로고
    • Regulatory T cells: fine-tuning TReg cells
    • David, R. (2009) Regulatory T cells: fine-tuning TReg cells. Nature Reviews Immunology, 9, 226-227.
    • (2009) Nature Reviews Immunology , vol.9 , pp. 226-227
    • David, R.1
  • 44
    • 44649144463 scopus 로고    scopus 로고
    • Autoantigen-specific TGFbeta-induced Foxp3 + regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells
    • DiPaolo, R.J., Brinster, C., Davidson, T.S., Andersson, J., Glass, D. & Shevach, E.M. (2007) Autoantigen-specific TGFbeta-induced Foxp3 + regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells. Journal of Immunology, 7, 4685-4693.
    • (2007) Journal of Immunology , vol.7 , pp. 4685-4693
    • DiPaolo, R.J.1    Brinster, C.2    Davidson, T.S.3    Andersson, J.4    Glass, D.5    Shevach, E.M.6
  • 45
    • 84884138223 scopus 로고    scopus 로고
    • Expressions of th17 cells and interleukin 17 in patients with primary immune thrombocytopenia and their clinical significance
    • Duan, X.J., Yang, L.H., Zhang, L., Ren, F.G., Zhang, R.J., Chen, J.F., Qin, X.Y. & Liang, H.Z. (2012) Expressions of th17 cells and interleukin 17 in patients with primary immune thrombocytopenia and their clinical significance. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 5, 1154-1157.
    • (2012) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.5 , pp. 1154-1157
    • Duan, X.J.1    Yang, L.H.2    Zhang, L.3    Ren, F.G.4    Zhang, R.J.5    Chen, J.F.6    Qin, X.Y.7    Liang, H.Z.8
  • 50
    • 38449090586 scopus 로고    scopus 로고
    • Functional role of CD4 + CD25 +  regulatory T cells and transforming growth factor-beta1 in childhood immune thrombocytopenic purpura
    • Fahim, N.M. & Monir, E. (2006) Functional role of CD4 + CD25 +  regulatory T cells and transforming growth factor-beta1 in childhood immune thrombocytopenic purpura. The Egyptian Journal of Immunology, 1, 173-187.
    • (2006) The Egyptian Journal of Immunology , vol.1 , pp. 173-187
    • Fahim, N.M.1    Monir, E.2
  • 52
    • 0028882422 scopus 로고
    • Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy
    • Filion, M.C., Bradley, A.J., Devine, D.V., Décary, F. & Chartrand, P. (1995) Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy. European Journal of Immunology, 11, 3123-3127.
    • (1995) European Journal of Immunology , vol.11 , pp. 3123-3127
    • Filion, M.C.1    Bradley, A.J.2    Devine, D.V.3    Décary, F.4    Chartrand, P.5
  • 53
    • 0027283589 scopus 로고
    • Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56 +  CD3- natural killer cells subset
    • Garcia-Suarez, J., Prieto, A., Reyes, E., Manzano, L., Merino, J.L. & Alvarez-Mon, M. (1993) Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56 +  CD3- natural killer cells subset. Blood, 5, 1538-1545.
    • (1993) Blood , vol.5 , pp. 1538-1545
    • Garcia-Suarez, J.1    Prieto, A.2    Reyes, E.3    Manzano, L.4    Merino, J.L.5    Alvarez-Mon, M.6
  • 54
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet, M., Cao, W. & Liu, Y.J. (2008) Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nature Reviews Immunology, 8, 594-606.
    • (2008) Nature Reviews Immunology , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 57
    • 0141813574 scopus 로고    scopus 로고
    • Rituximab-mediated antibody-dependent cellular cytotoxicity against neoplastic B cells is stimulated strongly by interleukin-2
    • Golay, J., Manganini, M., Facchinetti, V., Gramigna, R., Broady, R., Borleri, G., Rambaldi, A. & Introna, M. (2003) Rituximab-mediated antibody-dependent cellular cytotoxicity against neoplastic B cells is stimulated strongly by interleukin-2. Haematologica, 9, 1002-1012.
    • (2003) Haematologica , vol.9 , pp. 1002-1012
    • Golay, J.1    Manganini, M.2    Facchinetti, V.3    Gramigna, R.4    Broady, R.5    Borleri, G.6    Rambaldi, A.7    Introna, M.8
  • 58
    • 84979821592 scopus 로고    scopus 로고
    • Expression of regulatory T cells and Th17 cells in idiopathic thrombocytopenic purpura and its significance
    • Guo, N.H., Shi, Q.Z., Hua, J.Y., Li, Z.J., Li, J., He, W.F. & Wu, Q. (2010) Expression of regulatory T cells and Th17 cells in idiopathic thrombocytopenic purpura and its significance. Zhonghua Xue Ye Xue Za Zhi, 9, 610-612.
    • (2010) Zhonghua Xue Ye Xue Za Zhi , vol.9 , pp. 610-612
    • Guo, N.H.1    Shi, Q.Z.2    Hua, J.Y.3    Li, Z.J.4    Li, J.5    He, W.F.6    Wu, Q.7
  • 59
    • 84876075349 scopus 로고    scopus 로고
    • Detection and clinical significance of Th1/Th2 cytokines in patients with idiopathic thrombocytopenic purpura
    • Guo, X.H., Zhao, F., Shi, W., Ma, X.M., Xu, Q., A-Bu-Li-Zi, P. & Ya-Sen, H. (2012) Detection and clinical significance of Th1/Th2 cytokines in patients with idiopathic thrombocytopenic purpura. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 11, 1185-1187.
    • (2012) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.11 , pp. 1185-1187
    • Guo, X.H.1    Zhao, F.2    Shi, W.3    Ma, X.M.4    Xu, Q.5    A-Bu-Li-Zi, P.6    Ya-Sen, H.7
  • 61
    • 0036918050 scopus 로고    scopus 로고
    • Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor
    • Hansen, R.J. & Balthasar, J.P. (2002) Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor. Thrombosis and Haemostasis, 6, 898-899.
    • (2002) Thrombosis and Haemostasis , vol.6 , pp. 898-899
    • Hansen, R.J.1    Balthasar, J.P.2
  • 63
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4 +  effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L.E., Hatton, R.D., Mangan, P.R., Turner, H., Murphy, T.L., Murphy, K.M. & Weaver, C.T. (2005) Interleukin 17-producing CD4 +  effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunology, 11, 1123-1132.
    • (2005) Nature Immunology , vol.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 65
    • 80055053680 scopus 로고    scopus 로고
    • Increased number of Tc17 and correlation with Th17 cells in patients with immune thrombocytopenia
    • Hu, Y., Ma, D.X., Shan, N.N., Zhu, Y.Y., Liu, X.G., Zhang, L., Yu, S., Ji, C.Y. & Hou, M. (2011) Increased number of Tc17 and correlation with Th17 cells in patients with immune thrombocytopenia. PLoS ONE, 10, e26522.
    • (2011) PLoS ONE , vol.10
    • Hu, Y.1    Ma, D.X.2    Shan, N.N.3    Zhu, Y.Y.4    Liu, X.G.5    Zhang, L.6    Yu, S.7    Ji, C.Y.8    Hou, M.9
  • 66
    • 84861775491 scopus 로고    scopus 로고
    • Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia
    • Hu, Y., Li, H., Zhang, L., Shan, B., Xu, X., Li, H., Liu, X., Xu, S., Yu, S., Ma, D., Peng, J. & Hou, M. (2012) Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia. Human Immunology, 6, 629-635.
    • (2012) Human Immunology , vol.6 , pp. 629-635
    • Hu, Y.1    Li, H.2    Zhang, L.3    Shan, B.4    Xu, X.5    Li, H.6    Liu, X.7    Xu, S.8    Yu, S.9    Ma, D.10    Peng, J.11    Hou, M.12
  • 71
    • 0026791975 scopus 로고
    • The immune system evolved to discriminate infectious nonself from noninfectious self
    • Janeway, C.A. Jr (1992) The immune system evolved to discriminate infectious nonself from noninfectious self. Immunology Today, 1, 11-16.
    • (1992) Immunology Today , vol.1 , pp. 11-16
    • Janeway Jr., C.A.1
  • 73
    • 84870662738 scopus 로고    scopus 로고
    • The ratio of treg/th17 cells correlates with the disease activity of primary immune thrombocytopenia
    • Ji, L., Zhan, Y., Hua, F., Li, F., Zou, S., Wang, W., Song, D., Min, Z., Chen, H. & Cheng, Y. (2012) The ratio of treg/th17 cells correlates with the disease activity of primary immune thrombocytopenia. PLoS ONE, 12, e50909.
    • (2012) PLoS ONE , vol.12
    • Ji, L.1    Zhan, Y.2    Hua, F.3    Li, F.4    Zou, S.5    Wang, W.6    Song, D.7    Min, Z.8    Chen, H.9    Cheng, Y.10
  • 75
    • 31044439372 scopus 로고    scopus 로고
    • The molecular mechanisms that control thrombopoiesis
    • Kaushansky, K. (2005) The molecular mechanisms that control thrombopoiesis. The Journal of Clinical Investigation, 12, 3339-3347.
    • (2005) The Journal of Clinical Investigation , vol.12 , pp. 3339-3347
    • Kaushansky, K.1
  • 77
  • 78
    • 13944266299 scopus 로고    scopus 로고
    • The role of autoreactive T cells in the pathogenesis of idiopathic thrombocytopenic purpura
    • Kuwana, M. & Ikeda, Y. (2005) The role of autoreactive T cells in the pathogenesis of idiopathic thrombocytopenic purpura. International Journal of Hematology, 2, 106-112.
    • (2005) International Journal of Hematology , vol.2 , pp. 106-112
    • Kuwana, M.1    Ikeda, Y.2
  • 79
    • 0025240576 scopus 로고
    • Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T cells
    • Lanzavecchia, A. (1990) Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T cells. Annual Review of Immunology, 8, 773-793.
    • (1990) Annual Review of Immunology , vol.8 , pp. 773-793
    • Lanzavecchia, A.1
  • 80
    • 36549043931 scopus 로고    scopus 로고
    • Anti-platelet antibodies in a natural animal model of sulphonamide-associated thrombocytopaenia
    • Lavergne, S.N. & Trepanier, L.A. (2007) Anti-platelet antibodies in a natural animal model of sulphonamide-associated thrombocytopaenia. Platelets, 8, 595-604.
    • (2007) Platelets , vol.8 , pp. 595-604
    • Lavergne, S.N.1    Trepanier, L.A.2
  • 81
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M. & Hoffmann, J.A. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 6, 973-983.
    • (1996) Cell , vol.6 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 83
    • 84859567130 scopus 로고    scopus 로고
    • Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD
    • Léon, C., Evert, K., Dombrowski, F., Pertuy, F., Eckly, A., Laeuffer, P., Gachet, C. & Greinacher, A. (2012) Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD. Blood, 14, 3333-3341.
    • (2012) Blood , vol.14 , pp. 3333-3341
    • Léon, C.1    Evert, K.2    Dombrowski, F.3    Pertuy, F.4    Eckly, A.5    Laeuffer, P.6    Gachet, C.7    Greinacher, A.8
  • 84
    • 84865030107 scopus 로고    scopus 로고
    • Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin
    • Leontyev, D., Katsman, Y., Ma, X.Z., Miescher, S., Käsermann, F. & Branch, D.R. (2012) Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin. Transfusion, 8, 1799-1805.
    • (2012) Transfusion , vol.8 , pp. 1799-1805
    • Leontyev, D.1    Katsman, Y.2    Ma, X.Z.3    Miescher, S.4    Käsermann, F.5    Branch, D.R.6
  • 86
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li, J., Yang, C., Xia, Y., Bertino, A., Glaspy, J., Roberts, M. & Kuter, D.J. (2001) Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood, 12, 3241-3248.
    • (2001) Blood , vol.12 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3    Bertino, A.4    Glaspy, J.5    Roberts, M.6    Kuter, D.J.7
  • 87
    • 78651517265 scopus 로고    scopus 로고
    • Association of cytotoxic T cell antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population
    • Li, H., Ge, J., Zhao, H., Du, W., Xu, J., Sui, T., Ma, L., Zhou, Z., Qi, A. & Yang, R. (2011a) Association of cytotoxic T cell antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population. Platelets, 1, 39-44.
    • (2011) Platelets , vol.1 , pp. 39-44
    • Li, H.1    Ge, J.2    Zhao, H.3    Du, W.4    Xu, J.5    Sui, T.6    Ma, L.7    Zhou, Z.8    Qi, A.9    Yang, R.10
  • 88
    • 78751580375 scopus 로고    scopus 로고
    • Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia
    • Li, Z., Mou, W., Lu, G., Cao, J., He, X., Pan, X. & Xu, K. (2011b) Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia. International Journal of Hematology, 1, 91-98.
    • (2011) International Journal of Hematology , vol.1 , pp. 91-98
    • Li, Z.1    Mou, W.2    Lu, G.3    Cao, J.4    He, X.5    Pan, X.6    Xu, K.7
  • 90
    • 77956901240 scopus 로고    scopus 로고
    • Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG
    • Liang, S.X., Pinkevych, M., Khachigian, L.M., Parish, C.R., Davenport, M.P. & Chong, B.H. (2010) Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG. Blood, 11, 1958-1960.
    • (2010) Blood , vol.11 , pp. 1958-1960
    • Liang, S.X.1    Pinkevych, M.2    Khachigian, L.M.3    Parish, C.R.4    Davenport, M.P.5    Chong, B.H.6
  • 91
    • 0017619985 scopus 로고
    • Histocompatibility antigen-activated cytotoxic T cells. II. Estimates of the frequency and specificity of precursors
    • Lindahl, K.F. & Wilson, D.B. (1977) Histocompatibility antigen-activated cytotoxic T cells. II. Estimates of the frequency and specificity of precursors. Journal of Experimental Medicine, 3, 508-522.
    • (1977) Journal of Experimental Medicine , vol.3 , pp. 508-522
    • Lindahl, K.F.1    Wilson, D.B.2
  • 92
    • 47249085788 scopus 로고    scopus 로고
    • Alterations of CD4 +  CD25 +  regulatory T cells in patients with idiopathic thrombocytopenic purpura
    • Ling, Y., Cao, X.S., Yu, Z.Q., Luo, G.H., Bai, X., Su, J., Dai, L. & Ruan, C.G. (2007a) Alterations of CD4 +  CD25 +  regulatory T cells in patients with idiopathic thrombocytopenic purpura. Zhong-hua Xue Ye Xue Za Zhi, 3, 184-188.
    • (2007) Zhong-hua Xue Ye Xue Za Zhi , vol.3 , pp. 184-188
    • Ling, Y.1    Cao, X.S.2    Yu, Z.Q.3    Luo, G.H.4    Bai, X.5    Su, J.6    Dai, L.7    Ruan, C.G.8
  • 93
    • 34548595302 scopus 로고    scopus 로고
    • Circulating dendritic cells subsets and CD4 + Foxp3 +  regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome
    • Ling, Y., Cao, X., Yu, Z. & Ruan, C. (2007b) Circulating dendritic cells subsets and CD4 + Foxp3 +  regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. European Journal of Haematology, 4, 310-316.
    • (2007) European Journal of Haematology , vol.4 , pp. 310-316
    • Ling, Y.1    Cao, X.2    Yu, Z.3    Ruan, C.4
  • 97
  • 99
    • 53549107469 scopus 로고    scopus 로고
    • Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura
    • Ma, D., Zhu, X., Zhao, P., Zhao, C., Li, X., Zhu, Y., Li, L., Sun, J., Peng, J., Ji, C. & Hou, M. (2008) Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Annals of Hematology, 11, 899-904.
    • (2008) Annals of Hematology , vol.11 , pp. 899-904
    • Ma, D.1    Zhu, X.2    Zhao, P.3    Zhao, C.4    Li, X.5    Zhu, Y.6    Li, L.7    Sun, J.8    Peng, J.9    Ji, C.10    Hou, M.11
  • 101
    • 79957803679 scopus 로고    scopus 로고
    • Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP
    • Ma, L., Zhou, Z., Wang, H., Zhou, H., Zhang, D., Li, H., Qi, A. & Yang, R. (2011b) Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP. Molecular Immunology, 12-13, 1525-1531.
    • (2011) Molecular Immunology , vol.12-13 , pp. 1525-1531
    • Ma, L.1    Zhou, Z.2    Wang, H.3    Zhou, H.4    Zhang, D.5    Li, H.6    Qi, A.7    Yang, R.8
  • 102
    • 84862823554 scopus 로고    scopus 로고
    • Bmi-1 regulates autoreactive CD4 +  T cell survival in immune thrombocytopenia patients
    • Ma, L., Zhou, Z., Zhang, D., Wang, H., Li, H., Xue, F. & Yang, R. (2012) Bmi-1 regulates autoreactive CD4 +  T cell survival in immune thrombocytopenia patients. Journal of Clinical Immunology, 3, 505-513.
    • (2012) Journal of Clinical Immunology , vol.3 , pp. 505-513
    • Ma, L.1    Zhou, Z.2    Zhang, D.3    Wang, H.4    Li, H.5    Xue, F.6    Yang, R.7
  • 103
    • 84859385739 scopus 로고    scopus 로고
    • Immune regulatory function of B cells
    • Mauri, C. & Bosma, A. (2012) Immune regulatory function of B cells. Annual Review of Immunology, 30, 221-241.
    • (2012) Annual Review of Immunology , vol.30 , pp. 221-241
    • Mauri, C.1    Bosma, A.2
  • 104
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    • McMillan, R., Wang, L., Tomer, A., Nichol, J. & Pistillo, J. (2004) Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood, 4, 1364-1369.
    • (2004) Blood , vol.4 , pp. 1364-1369
    • McMillan, R.1    Wang, L.2    Tomer, A.3    Nichol, J.4    Pistillo, J.5
  • 105
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A. Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 6640, 394-397.
    • (1997) Nature , vol.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 106
    • 77953591720 scopus 로고    scopus 로고
    • New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents
    • Metjian, A. & Abrams, C.S. (2009) New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents. Biologics: Targets & Therapy, 3, 499-513.
    • (2009) Biologics: Targets & Therapy , vol.3 , pp. 499-513
    • Metjian, A.1    Abrams, C.S.2
  • 107
    • 0027328669 scopus 로고
    • Development and characterization of monoclonal antiplatelet autoantibodies from autoimmune thrombocytopenic purpura-prone (NZW x BXSB) F1 mice
    • Mizutani, H., Engelman, R.W., Kurata, Y., Ikehara, S. & Good, R.A. (1993) Development and characterization of monoclonal antiplatelet autoantibodies from autoimmune thrombocytopenic purpura-prone (NZW x BXSB) F1 mice. Blood, 3, 837-844.
    • (1993) Blood , vol.3 , pp. 837-844
    • Mizutani, H.1    Engelman, R.W.2    Kurata, Y.3    Ikehara, S.4    Good, R.A.5
  • 108
    • 77953499777 scopus 로고    scopus 로고
    • Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside
    • Molineux, G. & Newland, A. (2010) Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside. British Journal of Haematology, 1, 9-20.
    • (2010) British Journal of Haematology , vol.1 , pp. 9-20
    • Molineux, G.1    Newland, A.2
  • 110
    • 33645531319 scopus 로고    scopus 로고
    • A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy
    • Ni, H., Chen, P., Spring, C.M., Sayeh, E., Semple, J.W., Lazarus, A.H., Hynes, R.O. & Freedman, J. (2006) A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood, 7, 2976-2983.
    • (2006) Blood , vol.7 , pp. 2976-2983
    • Ni, H.1    Chen, P.2    Spring, C.M.3    Sayeh, E.4    Semple, J.W.5    Lazarus, A.H.6    Hynes, R.O.7    Freedman, J.8
  • 111
    • 84858340684 scopus 로고    scopus 로고
    • Critical role of CD4(+)CD25(+) regulatory T cells in preventing murine autoantibody-mediated thrombocytopenia
    • Nishimoto, T., Satoh, T., Takeuchi, T., Ikeda, Y. & Kuwana, M. (2012) Critical role of CD4(+)CD25(+) regulatory T cells in preventing murine autoantibody-mediated thrombocytopenia. Experimental Hematology, 4, 279-289.
    • (2012) Experimental Hematology , vol.4 , pp. 279-289
    • Nishimoto, T.1    Satoh, T.2    Takeuchi, T.3    Ikeda, Y.4    Kuwana, M.5
  • 114
    • 51649128648 scopus 로고    scopus 로고
    • Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1
    • Olsson, B., Ridell, B., Carlsson, L., Jacobsson, S. & Wadenvik, H. (2008) Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood, 4, 1078-1084.
    • (2008) Blood , vol.4 , pp. 1078-1084
    • Olsson, B.1    Ridell, B.2    Carlsson, L.3    Jacobsson, S.4    Wadenvik, H.5
  • 115
    • 84857373395 scopus 로고    scopus 로고
    • Increased number of B cells in the red pulp of the spleen in ITP
    • Olsson, B., Ridell, B., Jernås, M. & Wadenvik, H. (2012) Increased number of B cells in the red pulp of the spleen in ITP. Annals of Hematology, 2, 271-277.
    • (2012) Annals of Hematology , vol.2 , pp. 271-277
    • Olsson, B.1    Ridell, B.2    Jernås, M.3    Wadenvik, H.4
  • 116
    • 77952903274 scopus 로고    scopus 로고
    • Regulatory T cells in systemic lupus erythematosus-associated thrombocytopenia: a comparison with idiopathic thrombocytopenic purpura
    • Park, S.H., Kim, J.Y., Kim, S.K., Choe, J.Y., Kim, S.G. & Ryoo, H.M. (2010) Regulatory T cells in systemic lupus erythematosus-associated thrombocytopenia: a comparison with idiopathic thrombocytopenic purpura. Lupus, 7, 888-889.
    • (2010) Lupus , vol.7 , pp. 888-889
    • Park, S.H.1    Kim, J.Y.2    Kim, S.K.3    Choe, J.Y.4    Kim, S.G.5    Ryoo, H.M.6
  • 117
    • 80455144994 scopus 로고    scopus 로고
    • Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
    • Pehlivan, M., Okan, V., Sever, T., Balci, S.O., Yilmaz, M., Babacan, T. & Pehlivan, S. (2011) Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura. Platelets, 8, 588-595.
    • (2011) Platelets , vol.8 , pp. 588-595
    • Pehlivan, M.1    Okan, V.2    Sever, T.3    Balci, S.O.4    Yilmaz, M.5    Babacan, T.6    Pehlivan, S.7
  • 118
    • 75749148783 scopus 로고    scopus 로고
    • CD20-depleting therapy in autoimmune diseases: from basic research to the clinic
    • Perosa, F., Prete, M., Racanelli, V. & Dammacco, F. (2010) CD20-depleting therapy in autoimmune diseases: from basic research to the clinic. Journal of Internal Medicine, 3, 260-277.
    • (2010) Journal of Internal Medicine , vol.3 , pp. 260-277
    • Perosa, F.1    Prete, M.2    Racanelli, V.3    Dammacco, F.4
  • 119
    • 84867350040 scopus 로고    scopus 로고
    • DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia
    • doi:10.1155/2012/352059.
    • Pesmatzoglou, M., Lourou, M., Goulielmos, G.N. & Stiakaki, E. (2012) DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia. Clinical & Developmental Immunology, doi:10.1155/2012/352059.
    • (2012) Clinical & Developmental Immunology
    • Pesmatzoglou, M.1    Lourou, M.2    Goulielmos, G.N.3    Stiakaki, E.4
  • 121
    • 41149091775 scopus 로고    scopus 로고
    • CTLA-4 x Ig converts naive CD4 + CD25- T cells into CD4 + CD25 +  regulatory T cells
    • Razmara, M., Hilliard, B., Ziarani, A.K., Chen, Y.H. & Tykocinski, M.L. (2008) CTLA-4 x Ig converts naive CD4 + CD25- T cells into CD4 + CD25 +  regulatory T cells. International Immunology, 4, 471-483.
    • (2008) International Immunology , vol.4 , pp. 471-483
    • Razmara, M.1    Hilliard, B.2    Ziarani, A.K.3    Chen, Y.H.4    Tykocinski, M.L.5
  • 123
    • 0021209335 scopus 로고
    • Antigen presentation by haptenspecific B cells. I. Role of surface immunoglobulin receptors
    • Rock, K.L., Benacerraf, B. & Abbas, A.K. (1984) Antigen presentation by haptenspecific B cells. I. Role of surface immunoglobulin receptors. Journal of Experimental Medicine, 160, 1102-1113.
    • (1984) Journal of Experimental Medicine , vol.160 , pp. 1102-1113
    • Rock, K.L.1    Benacerraf, B.2    Abbas, A.K.3
  • 125
  • 127
    • 84881073251 scopus 로고    scopus 로고
    • Rituximab causes a polarisation of B cells which augments its therapeutic function in NK cell-mediated antibody-dependent cellular cytotoxicity
    • Rudnicka, D., Oszmiana, A., Finch, D.K., Strickland, I., Schofield, D.J., Lowe, D.C., Sleeman, M.A. & Davis, D.M. (2013) Rituximab causes a polarisation of B cells which augments its therapeutic function in NK cell-mediated antibody-dependent cellular cytotoxicity. Blood, 121, 4694-4702.
    • (2013) Blood , vol.121 , pp. 4694-4702
    • Rudnicka, D.1    Oszmiana, A.2    Finch, D.K.3    Strickland, I.4    Schofield, D.J.5    Lowe, D.C.6    Sleeman, M.A.7    Davis, D.M.8
  • 130
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4_ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S. (2004) Naturally arising CD4_ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annual Review of Immunology, 22, 531-562.
    • (2004) Annual Review of Immunology , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 133
    • 0024431412 scopus 로고
    • Monocyte-platelet interaction in immune and nonimmune thrombocytopenia
    • Saleh, M.N., Moore, D.L., Lee, J.Y. & LoBuglio, A.F. (1989) Monocyte-platelet interaction in immune and nonimmune thrombocytopenia. Blood, 4, 1328-1331.
    • (1989) Blood , vol.4 , pp. 1328-1331
    • Saleh, M.N.1    Moore, D.L.2    Lee, J.Y.3    LoBuglio, A.F.4
  • 134
    • 0035910392 scopus 로고    scopus 로고
    • Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor
    • Samuelsson, A., Towers, T.L. & Ravetch, J.V. (2001) Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science, 5503, 484-486.
    • (2001) Science , vol.5503 , pp. 484-486
    • Samuelsson, A.1    Towers, T.L.2    Ravetch, J.V.3
  • 135
    • 79960139310 scopus 로고    scopus 로고
    • Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults
    • Sarpatwari, A., Bussel, J.B., Ahmed, M., Erqou, S., Semple, J.W., Newland, A.C., Bennett, D., Pharoah, P. & Provan, D. (2011) Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults. Hematology, 4, 243-248.
    • (2011) Hematology , vol.4 , pp. 243-248
    • Sarpatwari, A.1    Bussel, J.B.2    Ahmed, M.3    Erqou, S.4    Semple, J.W.5    Newland, A.C.6    Bennett, D.7    Pharoah, P.8    Provan, D.9
  • 136
    • 84871276532 scopus 로고    scopus 로고
    • B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo
    • Schwab, I., Seeling, M., Biburger, M., Aschermann, S., Nitschke, L. & Nimmerjahn, F. (2012a) B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo. European Journal of Immunology, 12, 3302-3309.
    • (2012) European Journal of Immunology , vol.12 , pp. 3302-3309
    • Schwab, I.1    Seeling, M.2    Biburger, M.3    Aschermann, S.4    Nitschke, L.5    Nimmerjahn, F.6
  • 139
    • 67651225663 scopus 로고    scopus 로고
    • Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura
    • Segel, G.B. & Feig, S.A. (2009) Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura. Pediatric Blood & Cancer, 3, 318-324.
    • (2009) Pediatric Blood & Cancer , vol.3 , pp. 318-324
    • Segel, G.B.1    Feig, S.A.2
  • 140
    • 70449650486 scopus 로고    scopus 로고
    • Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia
    • Semple, J.W. (2009) Infections, antigen-presenting cells, T cells, and immune tolerance: their role in the pathogenesis of immune thrombocytopenia. Hematology/oncology Clinics of North America, 6, 1177-1192.
    • (2009) Hematology/oncology Clinics of North America , vol.6 , pp. 1177-1192
    • Semple, J.W.1
  • 141
    • 77955657769 scopus 로고    scopus 로고
    • Animal models of immune thrombocytopenia (ITP)
    • Semple, J.W. (2010) Animal models of immune thrombocytopenia (ITP). Annals of Hematology, 1, 37-44.
    • (2010) Annals of Hematology , vol.1 , pp. 37-44
    • Semple, J.W.1
  • 142
    • 84868089049 scopus 로고    scopus 로고
    • Bregging rights in ITP
    • Semple, J.W. (2012) Bregging rights in ITP. Blood, 16, 3169.
    • (2012) Blood , vol.16 , pp. 3169
    • Semple, J.W.1
  • 143
    • 0025876206 scopus 로고
    • Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia
    • Semple, J.W. & Freedman, J. (1991) Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood, 10, 2619-2625.
    • (1991) Blood , vol.10 , pp. 2619-2625
    • Semple, J.W.1    Freedman, J.2
  • 144
    • 84865435670 scopus 로고    scopus 로고
    • The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage
    • Semple, J.W. & Provan, D. (2012) The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage. Current Opinion in Hematology, 5, 357-362.
    • (2012) Current Opinion in Hematology , vol.5 , pp. 357-362
    • Semple, J.W.1    Provan, D.2
  • 145
    • 0025816682 scopus 로고
    • Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura
    • Semple, J.W., Bruce, S. & Freedman, J. (1991) Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura. American Journal of Hematology, 4, 258-262.
    • (1991) American Journal of Hematology , vol.4 , pp. 258-262
    • Semple, J.W.1    Bruce, S.2    Freedman, J.3
  • 146
    • 0029964421 scopus 로고    scopus 로고
    • Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T cell reactivity
    • Semple, J.W., Milev, Y., Cosgrave, D., Mody, M., Hornstein, A., Blanchette, V. & Freedman, J. (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T cell reactivity. Blood, 10, 4245-4254.
    • (1996) Blood , vol.10 , pp. 4245-4254
    • Semple, J.W.1    Milev, Y.2    Cosgrave, D.3    Mody, M.4    Hornstein, A.5    Blanchette, V.6    Freedman, J.7
  • 147
    • 34249310057 scopus 로고    scopus 로고
    • Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets
    • Semple, J.W., Aslam, R., Kim, M., Speck, E.R. & Freedman, J. (2007) Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets. Blood, 11, 4803-4805.
    • (2007) Blood , vol.11 , pp. 4803-4805
    • Semple, J.W.1    Aslam, R.2    Kim, M.3    Speck, E.R.4    Freedman, J.5
  • 148
    • 78049291385 scopus 로고    scopus 로고
    • Recent progress in understanding the pathogenesis of immune thrombocytopenia
    • Semple, J.W., Provan, D., Garvey, M.B. & Freedman, J. (2010) Recent progress in understanding the pathogenesis of immune thrombocytopenia. Current Opinion in Hematology, 6, 590-595.
    • (2010) Current Opinion in Hematology , vol.6 , pp. 590-595
    • Semple, J.W.1    Provan, D.2    Garvey, M.B.3    Freedman, J.4
  • 151
    • 33744989699 scopus 로고    scopus 로고
    • Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells
    • Siragam, V., Crow, A.R., Brinc, D., Song, S., Freedman, J. & Lazarus, A.H. (2006) Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells. Nature Medicine, 6, 688-692.
    • (2006) Nature Medicine , vol.6 , pp. 688-692
    • Siragam, V.1    Crow, A.R.2    Brinc, D.3    Song, S.4    Freedman, J.5    Lazarus, A.H.6
  • 153
    • 79953882332 scopus 로고    scopus 로고
    • Circulating CD4 + CD161 + CD196 +  Th17 cells are not increased in immune thrombocytopenia
    • Sollazzo, D., Trabanelli, S., Curti, A., Vianelli, N., Lemoli, R.M. & Catani, L. (2011) Circulating CD4 + CD161 + CD196 +  Th17 cells are not increased in immune thrombocytopenia. Haematologica, 4, 632-634.
    • (2011) Haematologica , vol.4 , pp. 632-634
    • Sollazzo, D.1    Trabanelli, S.2    Curti, A.3    Vianelli, N.4    Lemoli, R.M.5    Catani, L.6
  • 155
    • 77950327120 scopus 로고    scopus 로고
    • Rituximab in autoimmune hematologic diseases: not just a matter of B cells
    • Stasi, R. (2010) Rituximab in autoimmune hematologic diseases: not just a matter of B cells. Seminars in Hematology, 2, 170-179.
    • (2010) Seminars in Hematology , vol.2 , pp. 170-179
    • Stasi, R.1
  • 156
    • 35548960551 scopus 로고    scopus 로고
    • Response to B cell depleting therapy with rituximab reverts the abnormalities of T cell subsets in patients with idiopathic thrombocytopenic purpura
    • Stasi, R., Del Poeta, G., Stipa, E., Evangelista, M.L., Trawinska, M.M., Cooper, N. & Amadori, S. (2007) Response to B cell depleting therapy with rituximab reverts the abnormalities of T cell subsets in patients with idiopathic thrombocytopenic purpura. Blood, 8, 2924-2930.
    • (2007) Blood , vol.8 , pp. 2924-2930
    • Stasi, R.1    Del Poeta, G.2    Stipa, E.3    Evangelista, M.L.4    Trawinska, M.M.5    Cooper, N.6    Amadori, S.7
  • 157
    • 51649091745 scopus 로고    scopus 로고
    • Analysis of regulatory T cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab
    • Stasi, R., Cooper, N., Del Poeta, G., Stipa, E., Laura Evangelista, M., Abruzzese, E. & Amadori, S. (2008a) Analysis of regulatory T cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood, 4, 1147-1150.
    • (2008) Blood , vol.4 , pp. 1147-1150
    • Stasi, R.1    Cooper, N.2    Del Poeta, G.3    Stipa, E.4    Laura Evangelista, M.5    Abruzzese, E.6    Amadori, S.7
  • 163
    • 34848818791 scopus 로고    scopus 로고
    • Picogram doses of lipopolysaccharide exacerbate antibody-mediated thrombocytopenia and reduce the therapeutic efficacy of intravenous immunoglobulin in mice
    • Tremblay, T., Aubin, E., Lemieux, R. & Bazin, R. (2007) Picogram doses of lipopolysaccharide exacerbate antibody-mediated thrombocytopenia and reduce the therapeutic efficacy of intravenous immunoglobulin in mice. British Journal of Haematology, 2, 297-302.
    • (2007) British Journal of Haematology , vol.2 , pp. 297-302
    • Tremblay, T.1    Aubin, E.2    Lemieux, R.3    Bazin, R.4
  • 166
    • 0021550018 scopus 로고
    • Antigen-presenting function of the macrophage
    • Unanue, E.R. (1984) Antigen-presenting function of the macrophage. Annual Review of Immunology, 2, 395-428.
    • (1984) Annual Review of Immunology , vol.2 , pp. 395-428
    • Unanue, E.R.1
  • 167
    • 77955660270 scopus 로고
    • Experimental study of Immune Thrombocytopenia induced by quinidine
    • Wakisaka, G., Yasunaga, K., Kuramoto, A., Okuma, M. & Furukawa, H. (1964) Experimental study of Immune Thrombocytopenia induced by quinidine. Arerugi, 13, 686-689.
    • (1964) Arerugi , vol.13 , pp. 686-689
    • Wakisaka, G.1    Yasunaga, K.2    Kuramoto, A.3    Okuma, M.4    Furukawa, H.5
  • 168
    • 79955798431 scopus 로고    scopus 로고
    • Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura
    • Wang, X.P., Qiu, Y.S., Hao, G.P. & Zhu, L. (2011) Levels of regulatory T cells in peripheral blood of children with idiopathic thrombocytopenic purpura. Zhongguo Dang Dai Er Ke Za Zhi, 4, 282-284.
    • (2011) Zhongguo Dang Dai Er Ke Za Zhi , vol.4 , pp. 282-284
    • Wang, X.P.1    Qiu, Y.S.2    Hao, G.P.3    Zhu, L.4
  • 169
    • 0027434990 scopus 로고
    • Phenotypic and clonal analysis of T cells in childhood immune thrombocytopenic purpura
    • Ware, R.E. & Howard, T.A. (1993) Phenotypic and clonal analysis of T cells in childhood immune thrombocytopenic purpura. Blood, 7, 2137-2142.
    • (1993) Blood , vol.7 , pp. 2137-2142
    • Ware, R.E.1    Howard, T.A.2
  • 170
    • 0026548541 scopus 로고
    • Autoimmune thrombocytopenia: clinical aspects
    • Waters, A.H. (1992) Autoimmune thrombocytopenia: clinical aspects. Seminars in Hematology, 1, 18-25.
    • (1992) Seminars in Hematology , vol.1 , pp. 18-25
    • Waters, A.H.1
  • 171
    • 0030937833 scopus 로고    scopus 로고
    • Capture and processing of exogenous antigens for presentation on MHC molecules
    • Watts, C. (1997) Capture and processing of exogenous antigens for presentation on MHC molecules. Annual Review of Immunology, 15, 821-850.
    • (1997) Annual Review of Immunology , vol.15 , pp. 821-850
    • Watts, C.1
  • 172
    • 72949106340 scopus 로고    scopus 로고
    • Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
    • Weaver, C.T. & Hatton, R.D. (2009) Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nature Reviews Immunology, 12, 883-889.
    • (2009) Nature Reviews Immunology , vol.12 , pp. 883-889
    • Weaver, C.T.1    Hatton, R.D.2
  • 173
    • 33746638332 scopus 로고    scopus 로고
    • Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies
    • Webster, M.L., Sayeh, E., Crow, M., Chen, P., Nieswandt, B., Freedman, J. & Ni, H. (2006) Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Blood, 3, 943-946.
    • (2006) Blood , vol.3 , pp. 943-946
    • Webster, M.L.1    Sayeh, E.2    Crow, M.3    Chen, P.4    Nieswandt, B.5    Freedman, J.6    Ni, H.7
  • 178
    • 77955865780 scopus 로고    scopus 로고
    • An FcgammaRIIb transmembrane polymorphism in Chinese ITP patients
    • Xu, J., Huang, Y., Tao, J., Zhou, Z., Chen, Z., Ge, J. & Yang, R. (2010) An FcgammaRIIb transmembrane polymorphism in Chinese ITP patients. Platelets, 6, 479-485.
    • (2010) Platelets , vol.6 , pp. 479-485
    • Xu, J.1    Huang, Y.2    Tao, J.3    Zhou, Z.4    Chen, Z.5    Ge, J.6    Yang, R.7
  • 179
    • 84877660658 scopus 로고    scopus 로고
    • Childhood immune thrombocytopenia-who will spontaneously recover?
    • Yacobovich, J., Revel-Vilk, S. & Tamary, H. (2013) Childhood immune thrombocytopenia-who will spontaneously recover? Seminars in Hematology, 50, S71-S74.
    • (2013) Seminars in Hematology , vol.50
    • Yacobovich, J.1    Revel-Vilk, S.2    Tamary, H.3
  • 181
    • 79960784716 scopus 로고    scopus 로고
    • Pathway of Toll-like receptor 7/B cell activating factor/B cell activating factor receptor plays a role in immune thrombocytopenia in vivo
    • Yang, Q., Xu, S., Li, X., Wang, B., Wang, X., Ma, D., Yang, L., Peng, J. & Hou, M. (2011) Pathway of Toll-like receptor 7/B cell activating factor/B cell activating factor receptor plays a role in immune thrombocytopenia in vivo. PLoS ONE, 7, e22708.
    • (2011) PLoS ONE , vol.7
    • Yang, Q.1    Xu, S.2    Li, X.3    Wang, B.4    Wang, X.5    Ma, D.6    Yang, L.7    Peng, J.8    Hou, M.9
  • 183
    • 51649127854 scopus 로고    scopus 로고
    • Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
    • Yu, J., Heck, S., Patel, V., Levan, J., Yu, Y., Bussel, J.B. & Yazdanbakhsh, K. (2008) Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood, 4, 1325-1328.
    • (2008) Blood , vol.4 , pp. 1325-1328
    • Yu, J.1    Heck, S.2    Patel, V.3    Levan, J.4    Yu, Y.5    Bussel, J.B.6    Yazdanbakhsh, K.7
  • 184
    • 78650103795 scopus 로고    scopus 로고
    • TLR7 regulates dendritic cell-dependent B cell responses through BlyS in immune thrombocytopenic purpura
    • Yu, H., Liu, Y., Han, J., Yang, Z., Sheng, W., Dai, H., Wang, Y., Xia, T. & Hou, M. (2011) TLR7 regulates dendritic cell-dependent B cell responses through BlyS in immune thrombocytopenic purpura. European Journal of Haematology, 1, 67-74.
    • (2011) European Journal of Haematology , vol.1 , pp. 67-74
    • Yu, H.1    Liu, Y.2    Han, J.3    Yang, Z.4    Sheng, W.5    Dai, H.6    Wang, Y.7    Xia, T.8    Hou, M.9
  • 185
    • 70349098114 scopus 로고    scopus 로고
    • Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura
    • Zhang, J., Ma, D., Zhu, X., Qu, X., Ji, C. & Hou, M. (2009a) Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica, 9, 1326-1329.
    • (2009) Haematologica , vol.9 , pp. 1326-1329
    • Zhang, J.1    Ma, D.2    Zhu, X.3    Qu, X.4    Ji, C.5    Hou, M.6
  • 186
    • 63849181603 scopus 로고    scopus 로고
    • De novo induction of platelet-specific CD4(+)CD25(+) regulatory T cells from CD4(+)CD25(-) cells in patients with idiopathic thrombocytopenic purpura
    • Zhang, X.L., Peng, J., Sun, J.Z., Liu, J.J., Guo, C.S., Wang, Z.G., Yu, Y., Shi, Y., Qin, P., Li, S.G., Zhang, L.N. & Hou, M. (2009b) De novo induction of platelet-specific CD4(+)CD25(+) regulatory T cells from CD4(+)CD25(-) cells in patients with idiopathic thrombocytopenic purpura. Blood, 11, 2568-2577.
    • (2009) Blood , vol.11 , pp. 2568-2577
    • Zhang, X.L.1    Peng, J.2    Sun, J.Z.3    Liu, J.J.4    Guo, C.S.5    Wang, Z.G.6    Yu, Y.7    Shi, Y.8    Qin, P.9    Li, S.G.10    Zhang, L.N.11    Hou, M.12
  • 188
    • 84868135867 scopus 로고    scopus 로고
    • CD16 +  monocytes control T cell subset development in immune thrombocytopenia
    • Zhong, H., Bao, W., Li, X., Miller, A., Seery, C., Haq, N., Bussel, J. & Yazdanbakhsh, K. (2012) CD16 +  monocytes control T cell subset development in immune thrombocytopenia. Blood, 16, 3326-3335.
    • (2012) Blood , vol.16 , pp. 3326-3335
    • Zhong, H.1    Bao, W.2    Li, X.3    Miller, A.4    Seery, C.5    Haq, N.6    Bussel, J.7    Yazdanbakhsh, K.8
  • 189
    • 84979819307 scopus 로고    scopus 로고
    • The role of B cell-activating factor secreted by peripheral blood monocyte-derived dendritic cell in chronic idiopathic thrombocytopenic purpura
    • Zhou, Z.H., Zhuang, L., Li, X.Y., Li, J. & Luo, S.K. (2010) The role of B cell-activating factor secreted by peripheral blood monocyte-derived dendritic cell in chronic idiopathic thrombocytopenic purpura. Zhonghua Xue Ye Xue Za Zhi, 9, 599-602.
    • (2010) Zhonghua Xue Ye Xue Za Zhi , vol.9 , pp. 599-602
    • Zhou, Z.H.1    Zhuang, L.2    Li, X.Y.3    Li, J.4    Luo, S.K.5
  • 191
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • Zou, W. & Restifo, N.P. (2010) T(H)17 cells in tumour immunity and immunotherapy. Nature Reviews Immunology, 4, 248-256.
    • (2010) Nature Reviews Immunology , vol.4 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2


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