Bmi-1 regulates autoreactive CD4 + T cell survival in immune thrombocytopenia patients

Journal of Clinical Immunology

Volumn 32, Issue 3, 2012, Pages 505-513

  Ma, Li ^a   Zhou, Zeping ^a,b   Zhang, Donglei ^a   Wang, Hongmei ^a   Li, Huiyuan ^a   Xue, Feng ^a   Yang, Renchi ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Bmi 1; CD4 + T cells; ITP; platelets; proliferation

Indexed keywords

BMI1 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 4; LENTIVIRUS VECTOR; MESSENGER RNA; SHORT HAIRPIN RNA;

ADULT; ANIMAL CELL; APOPTOSIS; APOPTOTIC RESISTANCE CAPACITY; ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; BMI 1 GENE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; CELLULAR PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MALE; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; TH1 TH2 BALANCE; THROMBOCYTE COUNT;

ADULT; APOPTOSIS; BLOOD PLATELETS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REPRESSOR PROTEINS; RNA, MESSENGER;

EID: 84862823554     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-011-9643-2     Document Type: Article

References (31)

1. Cooper N, Bussel J. The pathogenesis of immune thrombocytopaenic purpura. Br J Haematol. 2006;133:364-74.
2. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346:995-1008.
3. Yang R, Han ZC. Pathogenesis and management of chronic idiopathic thrombocytopenic purpura: an update. Int J Hematol. 2000;71:18-24.
4. Zhou B, Zhao H, Yang RC, Han ZC. Multi-dysfunctional pathophysiology in ITP. Crit Rev Oncol Hematol. 2005;54:107-16. (Pubitemid 40544948)
5. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. J Clin Invest. 1998;102:1393-402. (Pubitemid 28467568)
6. Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991;78:2619-25.
7. Semple JW, Milev Y, Cosgrave D, ModyM, Hornstein A, Blanchette V, Freedman J. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996;87:4245-54. (Pubitemid 26152268)
8. Craft J, Fatenejad S. Self antigens and epitope spreading in systemic autoimmunity. Arthritis Rheum. 1997;40:1374-82. (Pubitemid 27430946)
9. Olsson B, Andersson PO, Jacobsson S, Carlsson L, Wadenvik H. Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost. 2005;93:139-44. (Pubitemid 40124268)
10. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423:255-60. (Pubitemid 40852690)
11. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5. (Pubitemid 40852701)
12. Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003;425:962-7. (Pubitemid 37376927)
13. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der ValkM, Deschamps J, Sofroniew M, van Lohuizen M, et al. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 1994;8:757-69.
14. Nakayama T, Yamashita M. Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory. Semin Immunol. 2009;21:78-83.
15. Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med. 2008;205:1109-20. (Pubitemid 351679686)
16. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, SanzMA, Tarantino M,Watson S, Young J, Kuter DJ. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2009;115:168-86.
17. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kuhne T, Ruggeri M, George JN. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113:2386-93.
18. Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S. shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell. 2007;1:87-99. (Pubitemid 46865801)
19. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986. J Immunol. 2005;175:5-14.
20. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 1991;254:279-82. (Pubitemid 21917341)
21. Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, Han ZC. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica. 2005;90:914-23. (Pubitemid 41020294)
22. Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T. Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. J Immunol. 2006;177:7656-64. (Pubitemid 44846280)
23. Heffner M, Fearon DT. Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte. Proc Natl Acad Sci U S A. 2007;104:13414-9. (Pubitemid 47293959)
24. Murphy KM, Heimberger AB, Loh DY. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 1990;250:1720-3. (Pubitemid 120031881)
25. Filion MC, Bradley AJ, Devine DV, Decary F, Chartrand P. Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy. Eur J Immunol. 1995;25:3123-7.
26. M.A. Schaller, H. Logue, S. Mukherjee, D.M. Lindell, A.L. Coelho, P. Lincoln, W.F.t. Carson, T. Ito, K.A. Cavassani, S.W. Chensue, C.M. Hogaboam, N.W. Lukacs, and S.L. Kunkel, Deltalike 4 differentially regulates murine CD4 T cell expansion via BMI1. PLoS One 5 e12172.
27. Ogawara H, Handa H, Morita K, Hayakawa M, Kojima J, Amagai H, Tsumita Y, Kaneko Y, Tsukamoto N, Nojima Y, Murakami H. High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;71:283-8. (Pubitemid 37174699)
28. Panitsas FP, Theodoropoulou M, Kouraklis A, Karakantza M, Theodorou GL, Zoumbos NC, Maniatis A, Mouzaki A. Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood. 2004;103:2645-7. (Pubitemid 38393019)
29. Webber NP, Mascarenhas JO, Crow MK, Bussel J, Schattner EJ. Functional properties of lymphocytes in idiopathic thrombocytopenic purpura. Hum Immunol. 2001;62:1346-55. (Pubitemid 33116972)
30. Glimcher LH, Murphy KM. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 2000;14:1693-711. (Pubitemid 30602989)
31. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol. 2002;2:933-44. (Pubitemid 37323214)