CTLA-4·Ig converts naive CD4+ CD25- T cells into CD4+CD25+ regulatory T cells

International Immunology

Volumn 20, Issue 4, 2008, Pages 471-483

  Razmara, Marjaneh ^a   Hilliard, Brendan ^a   Ziarani, Azadeh K ^a   Chen, Youhai H ^a   Tykocinski, Mark L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Co stimulation; CTLA 4 Ig; Regulatory T cells

Indexed keywords

ABATACEPT; CD3 ANTIBODY; CD4 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; IMMUNOGLOBULIN; LEUKOCYTE ANTIGEN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CLONAL ANERGY; CONTROLLED STUDY; DRUG MECHANISM; EFFECTOR CELL; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE COUNT; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; ANIMAL; ANTIGEN ANTIBODY REACTION; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECT; GENETICS; IMMUNOLOGY; METHODOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, CD; ANTIGENS, CD4; CELL PROLIFERATION; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOGLOBULINS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

EID: 41149091775     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn007     Document Type: Article

References (48)

1. Piccirillo, C. A. and Shevach, E. M. 2004. Naturally-occurring CD4+CD25+ immunoregulatory T cells: Central players in the arena of peripheral tolerance. Semin. Immunol. 16:81.
2. Randolph, D. A. and Fathman, C. G. 2006. Cd4+Cd25+ regulatory T cells and their therapeutic potential. Annu. Rev. Med. 57:381.
3. Sakaguchi, S., Ono, M., Setoguchi, R. et al. 2006. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212:8.
4. Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330.
5. Hori, S., Takahashi, T. and Sakaguchi, S. 2003. Control of autoimmunity by naturally arising regulatory CD4+ T cells. Adv. Immunol. 81:331.
6. Ziegler, S. F. 2006. FOXP3: Of mice and men. Annu. Rev. Immunol. 24:209.
7. Fu, S., Zhang, N., Yopp, A. C. et al. 2004. TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25-precursors. Am. J. Transplant. 4:1614.
8. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875.
9. Levings, M. K. and Roncarolo, M. G. 2005. Phenotypic and functional differences between human CD4+CD25+ and type 1 regulatory T cells. Curr. Top. Microbiol. Immunol. 293:303.
10. Lohr, J., Knoechel, B., Kahn, E. C. and Abbas, A. K. 2004. Role of B7 in T cell tolerance. J. Immunol. 173:5028.
11. Penna, G., Giarratana, N., Amuchastegui, S., Mariani, R., Daniel, K. C. and Adorini, L. 2005. Manipulating dendritic cells to induce regulatory T cells. Microbes Infect 7:1033.
12. Barrat, F. J., Cua, D. J., Boonstra, A. et al. 002. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195:603.
13. Wakkach, A., Fournier, N., Brun, V., Breittmayer, J. P., Cottrez, F. and Groux, H. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18:605.
14. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151.
15. Dieckmann, D., Plottner, H., Berchtold, S., Berger, T and Schuler, G. 2001. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 193:1303.
16. Bluestone, J. A., St Clair, E. W. and Turka, L. A. 2006. CTLA4lg: bridging the basic immunology with clinical application. Immunity 24:233.
17. Dall'Era, M. and Davis, J. 2004. CTLA4lg: A novel inhibitor of costimulation. Lupus 13:372.
18. Bluestone, J. A. 2005. CTLA-4lg is finally making it: A personal perspective. Am. J. Transplant. 5:423.
19. Szot, G. L., Zhou, P., Sharpe, A. H. et al. 2000. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival. Transplantation 69:904.
20. Salomon, B., Lenschow, D. J., Rhee, L. et al. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431.
21. Benigni, A., Tomasoni, S., Turka, L. A. et al. 2006. Adeno-associated virus-mediated CTLA4lg gene transfer protects MHC-mismatched renal allografts from chronic rejection. J. Am. Soc. Nephrol. 17:1665.
22. Miao, G., Ito, T. Uchikoshi, F. et al. 2004. Development of donor-specific immunoregulatory T-cells after local CTLA4lg gene transfer to pancreatic allograft. Transplantation 78:59.
23. Zhang, G., Gao, X., Song, Y. K. et al. 2004. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther. 11:675.
24. Tarbell, K. V., Yamazaki, S. and Steinman, R. M. 2006. The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity. Semin. Immunol. 18:93.
25. Grohmann, U., Orabona, C., Fallarino, F. et al. 2002. CTLA-4-lg regulates tryptophan catabolism in vivo. Nat. Immunol. 3:1097.
26. Wang, S. and Chen, L. 2004. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes Infect. 6:759.
27. Tai, X., Cowan, M., Feigenbaum, L. and Singer, A. 2005. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6:152.
28. D'Cruz, L. M. and Klein, L. 2005. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol. 6:1152.
29. Setoguchi, R., Hori, S., Takahashi, T. and Sakaguchi, S. 2005. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723.
30. Bingaman, A. W., Ha, J., Durham, M. M. et al. 2001. Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4+ T cells in vivo. Transplantation 72:1286.
31. Battaglia, M., Stabilini, A., Migliavacca, B., Horejs-Hoeck, J., Kaupper, T and Roncarolo, M. G. 2006. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 177:8338.
32. Skapenko, A., Kalden, J. R., Lipsky, P. E. and Schulze-Koops, H. 2005. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. J. Immunol. 175:6107.
33. Zheng, S. G., Gray, J. D., Ohtsuka, K., Yamagiwa, S. and Horwitz, D. A. 2002. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J. Immunol. 169:4183.
34. van Maurik, A., Herber, M., Wood, K. J. and Jones, N. D. 2002. Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: Implications for anti-CD154 immunotherapy. J. Immunol. 169:5401.
35. Bluestone, J. A. and Abbas, A. K. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253.
36. Wing, K., Fehervari, Z. and Sakaguchi, S. 2006. Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18:991.
37. Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6:1142.
38. Bour-Jordan, H., Thompson, H. L. and Bluestone, J. A. 2005. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. J. Immunol. 175:5649.
39. Lohr, J., Knoechel, B. and Abbas, A. K. 2006. Regulatory T cells in the periphery. Immunol. Rev. 212:149.
40. Knoechel, B., Lohr, J., Kahn, E., Bluestone, J. A. and Abbas, A. K. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202:1375.
41. Fallarino, F., Grohmann, U., You, S. et al. 2006. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor (zeta)-chain and induce a regulatory phenotype in naive T cells. J. Immunol. 176:6752.
42. Watanabe, N., Wang, Y. H., Lee, H. K. et al. 2005. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436:1181.
43. Yamazaki, S., Iyoda, T., Tarbell, K. et al. 2003. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235.
44. Zhu, X. Y., Zhou, Y. H., Wang, M. Y., Jin, L. P., Yuan, M. M. and Li, D. J. 2005. Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4+CD25+ regulatory T cells to rescue abortion-prone fetuses. Biol. Reprod. 72:338.
45. Fehervari, Z. and Sakaguchi, S. 2004. Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells. Int. Immunol. 16:1769.
46. Bhatia, S., Edidin, M., Almo, S. C. and Nathenson, S. G. 2006. B7-1 and B7-2: Similar costimulatory ligands with different biochemical, oligomeric and signaling properties. Immunol. Lett. 104:70.
47. Sansom, D. M. and Walker, L. S. 2006. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol. Rev. 212:131.
48. Montagnoli, C., Bacci, A., Bozza, S. et al. 2002. B7/ CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J. Immunol. 169:6298.