CD16+ monocytes control T-cell subset development in immune thrombocytopenia

Blood

Volumn 120, Issue 16, 2012, Pages 3226-3235

  Zhong, Hui ^a   Bao, Weili ^a   Li, Xiaojuan ^a,b   Miller, Allison ^c   Seery, Caroline ^c   Haq, Naznin ^c   Bussel, James ^c   Yazdanbakhsh, Karina ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3; FC RECEPTOR;

ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; COHORT ANALYSIS; HUMAN; HUMAN CELL; IMMUNE THROMBOCYTOPENIA; LYMPHOCYTE PROLIFERATION; MONOCYTE; POLARIZATION; PRIORITY JOURNAL; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; TH17 CELL; CASE CONTROL STUDY; CELL CULTURE; COMPARATIVE STUDY; FLOW CYTOMETRY; HELPER CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE SUBPOPULATION;

CASE-CONTROL STUDIES; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE ACTIVATION; MONOCYTES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, IGG; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84868135867     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-06-434605     Document Type: Article

References (50)

1. Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8(5):337-348. (Pubitemid 351595217)
2. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu Rev Immunol. 2009;27:485-517.
3. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10(7):490-500.
4. Serbina NV, Jia T, Hohl TM, Pamer EG. Monocyte-mediated defense against microbial pathogens. Annu Rev Immunol. 2008;26:421-452. (Pubitemid 351600381)
5. Evans HG, Gullick NJ, Kelly S, et al. In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci U S A. 2009;106(15):6232-6237.
6. Movahedi K, Guilliams M, Van den Bossche J, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 2008;111(8):4233-4244.
7. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol. 2009;27:669-692.
8. Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116(16):e74-e80.
9. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007;81(3):584-592. (Pubitemid 46393535)
10. Mobley JL, Leininger M, Madore S, Baginski TJ, Renkiewicz R. Genetic evidence of a functional monocyte dichotomy. Inflammation. 2007;30(6):189-197. (Pubitemid 350264453)
11. Gernsheimer T. Chronic idiopathic thrombocytopenic purpura: mechanisms of pathogenesis. Oncologist. 2009;14(1):12-21.
12. Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991;78(10):2619-2625.
13. Ogawara H, Handa H, Morita K, et al. High Th1 Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;71(4):283-288. (Pubitemid 37174699)
14. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura: role in production of antiplatelet autoantibody. J Clin Invest. 1998;102(7):1393-1402. (Pubitemid 28467568)
15. Sakakura M, Wada H, Tawara I, et al. Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res. 2007;120(2):187-193. (Pubitemid 46754414)
16. Liu B, Zhao H, Poon MC, et al. Abnormality of CD4 (+) CD25 (+) regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol. 2007;78(2):139-143. (Pubitemid 46058876)
17. Ling Y, Cao X, Yu Z, Ruan C. Circulating dendritic cells subsets and CD4+Foxp3+regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. Eur J Haematol. 2007;79(4):310-316. (Pubitemid 47390130)
18. Stasi R, Cooper N, Del Poeta G, et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B celldepleting therapy with rituximab. Blood. 2008;112(4):1147-1150.
19. Yu J, Heck S, Patel V, et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood. 2008;112(4):1325-1328.
20. Audia S, Samson M, Guy J, et al. Immunologic effects of rituximab on the human spleen in immune thrombocytopenia. Blood. 2011;118(16):4394-4400.
21. Liu XG, Ma SH, Sun JZ, et al. High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fcgamma receptors on monocytes in patients with primary immune thrombocytopenia. Blood. 2011;117(6):2061-2069.
22. Rocha AM, Souza C, Rocha GA, et al. The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia. Haematologica. 2011;96(10):1560-1564.
23. Zhang J, Ma D, Zhu X, et al. Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica. 2009;94(9):1326-1329.
24. Wang JD, Chang TK, Lin HK, et al. Reduced expression of transforming growth factor-beta1 and correlated elevation of interleukin-17 and interferon-gamma in pediatric patients with chronic primary immune thrombocytopenia (ITP). Pediatr Blood Cancer. 2011;57(4):636-640.
25. Sollazzo D, Trabanelli S, Curti A, et al. Circulating CD4+CD161+CD196+ Th17 cells are not increased in immune thrombocytopenia. Haematologica. 2011;96(4):632-634.
26. Cao J, Chen C, Li L, et al. Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia. J Clin Immunol. 2012;32(3):523-529.
27. Bussel JB, Kuter DJ. New thrombopoietic agents: introduction. Semin Hematol. 2010;47(3):211.
28. Bao W, Bussel JB, Heck S, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood. 2010;116(22):4639-4645.
29. Gavin MA, Torgerson TR, Houston E, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006;103(17):6659-6664.
30. Liu H, Rohowsky-Kochan C. Regulation of IL-17 in human CCR6+ effector memory T cells. J Immunol. 2008;180(12):7948-7957.
31. Hoeve MA, Savage ND, de Boer T, et al. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol. 2006;36(3):661-670.
32. Nakae S, Iwakura Y, Suto H, Galli SJ. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81(5):1258-1268. (Pubitemid 46702045)
33. Kwissa M, Nakaya HI, Oluoch H, Pulendran B. Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Blood. 2012;119(9):2044-2055.
34. Yang Q, Wang B, Yu H, et al. TLR7 promotes Th1 polarization in immune thrombocytopenia. Thromb Res. 2011;128(3):237-242.
35. Bradshaw EM, Raddassi K, Elyaman W, et al. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009;183(7):4432-4439.
36. Panzer S, Hocker L, Vormittag R, et al. Flow cytometric evaluation of platelet activation in chronic autoimmune thrombocytopenia. Pediatr Blood Cancer. 2006;47(5 Suppl):694-696. (Pubitemid 44360032)
37. Landsman L, Bar-On L, Zernecke A, et al. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009;113(4):963-972.
38. Olsson B, Ridell B, Carlsson L, Jacobsson S, Wadenvik H. Recruitment of T-cells into bone marrow of ITP patients possibly due to elevated expression VLA-4 and CX3CR1. Blood. 2008;112(4):1078-1084.
39. Biburger M, Aschermann S, Schwab I, et al. Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo. Immunity. 2011;35(6):932-944.
40. Rissoan MC, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 1999;283(5405):1183-1186.
41. Aliahmadi E, Gramlich R, Grutzkau A, et al. TLR2-activated human Langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol. 2009;39(5):1221-1230.
42. Sanchez-Torres C, Garcia-Romo GS, Cornejo-Cortes MA, Rivas-Carvalho A, Sanchez-Schmitz G. CD16+ and CD16-human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells. Int Immunol. 2001;13(12):1571-1581. (Pubitemid 33133884)
43. Cao X, Leonard K, Collins LI, et al. Interleukin 12 stimulates IFN-γamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res. 2009;69(22):8700-8709.
44. Evans HG, Suddason T, Jackson I, Taams LS, Lord GM. Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A. 2007;104(43):17034-17039. (Pubitemid 350210986)
45. Snijders A, Kalinski P, Hilkens CM, Kapsenberg ML. High-level IL-12 production by human dendritic cells requires two signals. Int Immunol. 1998;10(11):1593-1598. (Pubitemid 28502373)
46. Wesa A, Galy A. Increased production of proinflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand. BMC Immunol. 2002;3:14.
47. Taams LS, van Amelsfort JM, Tiemessen MM, et al. Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells. Hum Immunol. 2005;66(3):222-230. (Pubitemid 40395242)
48. Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204(8):1849-1861. (Pubitemid 47240944)
49. Nistala K, Adams S, Cambrook H, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci U S A. 2010;107(33):14751-14756.
50. Voo KS, Wang YH, Santori FR, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009;106(12):4793-4798.