Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1

Blood

Volumn 112, Issue 4, 2008, Pages 1078-1084

  Olsson, Bob ^a,b   Ridell, Börje ^a   Carlsson, Lena ^a   Jacobsson, Stefan ^a   Wadenvik, Hans ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; FAS ANTIGEN; VERY LATE ACTIVATION ANTIGEN 4; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CD25+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL HOMING; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ADOLESCENT; BONE MARROW; CELL MOTION; GENE EXPRESSION PROFILING; GENETICS; IMMUNITY; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; UPREGULATION;

ADOLESCENT; ADULT; AGED; BONE MARROW; CELL MOVEMENT; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY; INTEGRIN ALPHA4BETA1; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; UP-REGULATION;

EID: 51649128648     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-02-139402     Document Type: Article

References (43)

1. Harrington WJ. Minnich V, Hollingsworth JW, Moore GV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med. 1951 ;38:1-10.
2. Dixon RH, RosseWF. Platelet antibody in autoimmune thrombocytopenia. Br J Haematol. 1975; 31:129-134.
3. McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1981;304:1135-1147.
4. van Leeuwen EF. van der Ven JT, Engelfriet CP, von dem Borne AE. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood. 1982;59:23-26.
5. Semple JW, Freedman J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood. 1991;78:2619-2625.
6. Ware RE, Howard TA. Phenotypic and clonal analysis of T lymphocytes in childhood immune
7. thrombocytopenic purpura. Blood. 1993;82:2137-2142.
8. Shimomura T, Fujimura K. Takafuta T. et al. Oligo-clonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytopenic purpura. Br J Haematol. 1996;95:732-737.
9. Kuwana M, Kaburaki J, Ikeda Y. Autoreactive T cells to platelet GPIIb-llla in immune thrombocytopenic purpura: role in production of antiplatelet autoantibody. J Clin Invest. 1998;102:1393-1402.
10. Sukati H, Watson HG, Urbaniak SJ; Barker RN. Mapping helper T-cell epitopes on platelet membrane glycoprotein IlIa in chronic autoimmune thrombocytopenic purpura. Blood. 2007;109: 4528-4538.
11. Olsson B, Andersson PO, Jernas M. et al. T-cell- mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9:1123-1124.
12. Olsson B, Andersson PO, Jacobsson S, Carlsson L, Wadenvik H. Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost. 2005;93:139-144.
13. Zhang F, Chu X, Wang L, et al. Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 2006;76:427-431.
14. Semple JW, Milev Y, Cosgrave D, et al. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996;87:4245-4254.
15. Mouzaki A, Theodoropoulou M, Gianakopoulos I, Vlaha V, Kyrtsonis MC, Maniatis A. Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis. Blood. 2002;100:1774-1779.
16. Andersson PO; Stockelberg D, Jacobsson S, Wadenvik H. A transforming growth factor-betal - mediated bystander immune suppression could be associated with remission of chronic idiopathic thrombocytopenic purpura. Ann Hematol. 2000; 79:507-513.
17. Alizadeh A, Eisen M, Botstein D, Brown PO, Staudt LM. Probing lymphocyte biology by genomic-scale gene expression analysis. J Clin Immunol. 1998;18:373-379.
18. Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt G. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood. 1987;70:1722-1726.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
20. Affymetrix. Affymetrix Gene Chip Expression Analysis manual, https://www.affymetrix.com/site/login/login.affx.
21. Olsson B, Bohlooly YM, Brusehed O, et al. Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes. Am J Physiol Endocrinol Metab. 2003; 285:E504-E511.
22. Brazma A, Hingamp P, Quackenbush J, et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001 ;29:365-371.
23. National Center for Biotechnology Information. Gene Expression Omnibus, http://www.ncbi.nlm.nih.gov/geo/.
24. Heydtmann M, Hardie D. Shields PL et al. Detailed analysis of intrahepatic CD8 T cells in the normal and hepatitis C-infected liver reveals differences in specific populations of memory cells with distinct horning phenotypes. J Immunol. 2006;177:729-738.
25. Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, Flavell RA. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med. 2001 ;193: 741-754.
26. Berlin-Rutenach C, Otto F, Mathies M, et al. Lymphocyte migration in lymphocyte function- associated antigen (LFA)-1 -deficient mice. J Exp Med. 1999;189:1467-1478.
27. Di Rosa F Pabst R. The bone marrow: a nest for migratory memory T cells. Trends Immunol. 2005; 26:360-366.
28. Polman CH; O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natali-zumab for relapsing multiple sclerosis. N Engl J Med. 2006;354:899-910.
29. Targan SR; Feagan BG; Fedorak RN, et al. Na- talizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology. 2007;132:1672-1683.
30. Umehara H, Bloom ET Okazaki T, Nagano Y Yoshie O. Imai T. Fractalkine in vascular biology: from basic research to clinical disease. ArteriosclerThromb Vase Biol. 2004;24:34-40.
31. Nishimura M, Umehara H, Nakayama T et al. Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression. J Immunol. 2002;168:6173-6180.
32. Mazo IB, Honczarenko M, Leung H, et al. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity. 2005;22:259-270.
33. Combadiere B, Faure S, Autran B, Debre R Combadiere C. The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CDS
34. effector-memory T lymphocytes in HIV-infected patients. Al DS. 2003; 17:1279-1290.
35. Imai T, Hieshima K, Haskell C. et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 1997;91:521-530.
36. Fong AM, Robinson LA, Steeber DA, et al. Fractalkine and GX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med. 1998;188: 1413-1419.
37. Chow L, Ni H, Kim M, et al. A new murine model of immune thrombocytopenia: evidence of both antibody- and CD8+ T cell-mediated platelet destruction. Blood. 2007;110.
38. Liu B, Zhao H, Poon MC, et al. Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol. 2007;78:139-143.
39. Sakakura M, Wada H, Tawara I, et al. Reduced Cd4+Cd25+ T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res. 2007; 120:187-193.
40. Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007;26:579-591.
41. Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor- beta 1 gene results in multifocal inflammatory disease. Nature. 1992;359:693-699.
42. McMillan R, Wang L, Tomer A, Nichol J, Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood. 2004;103:1364-1369.
43. Ju ST, Panka DJ, Cui H, et al. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature. 1995;373:444-448.