Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP

Blood

Volumn 103, Issue 4, 2004, Pages 1364-1369

  McMillan, Robert ^a   Wang, Lei ^b   Tomer, Aaron ^b   Nichol, Janet ^b   Pistillo, Jeanne ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIBODY; CD34 ANTIGEN; IMMUNOGLOBULIN G; THROMBOCYTE ANTIBODY;

ADSORPTION; ADULT; ARTICLE; CELL CULTURE; CELL DESTRUCTION; CELL MATURATION; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMOBILIZATION; MEGAKARYOCYTE; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTOPOIESIS;

EID: 0842328846     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-08-2672     Document Type: Article

References (22)

1. Harrington WJ, Sprague CC, Minnich V, Moore CV, Aulvin RC, Dubach R. Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura. Ann Intern Med. 1953;38:433-469.
2. Shulman NR, Marder VJ, Weinrach RS. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura: physiologic, serologic, and isotopic studies. Ann NY Acad Sci. 1965;124:499-542.
3. Heyns AP, Lotter MG, Badenhorst PN, et al. Kinetics and sites of destruction of 111-indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol. 1982;12:167-177.
4. Stoll D, Cines DB, Aster RH, Murphy S. Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia. Blood. 1985;65:584-588.
5. Heyns AP, Badenhorst PN, Lotter MG, Pieters H, Wessels P, Kotze HP. Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 11-In-Labeled and homologous 51-Cr-Labeled platelets differ. Blood. 1986;67:86-92.
6. Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter S. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura: evidence for both impaired platelet production and increased platelet clearance. J Clin Invest. 1987;80:33-40.
7. Vainchenker W, Deschamps JF, Bastin JM, et al. Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients. Blood. 1982;59:514-521.
8. McMillan R, Tani P, Millard F, Berchtold P, Renshaw L, Woods VL. Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood. 1987;70:1040-1045.
9. Kiefel V, Santoso S, Kaufmann E, Mueller-Eckcardt C. Autoantibodies against platelet glycoprotein Ib/Ix: A frequent finding in autoimmune thrombocytopenic purpura. Br J Haematol. 1991;79:256-262.
10. Chang M, Nakagawa PA, Williams SA, et al. Inhibition of megakaryocytopoiesis in vitro by immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies. Blood. In press.
11. Mazur EM, Basilico D, Newton JL, et al. Isolation of large numbers of enriched human megakaryocytes from liquid cultures of normal peripheral blood progenitor cells. Blood. 2003;76:1771-1782.
12. Tomer A. Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia. Blood. 2002;99:1602-1609.
13. Dameshek W, Miller EB. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. Blood. 1946;1:27-52.
14. Diggs LW, Hewlett JS. A study of the bone marrow from thirty-six patients with idiopathic hemorrhagic (thrombopenic) purpura. Blood. 1948;3:1090-1104.
15. Stahl CP, Zucker-Franklin D, McDonald TP. Incomplete antigenic cross-reactivity between platelets and megakaryocytes: relevance to ITP. Blood. 1986;67:421-428.
16. McKenna JL, Pisciotta AV. Fluorescence of megakaryocytes in idiopathic thrombocytopenic purpura (ITP) stained with fluorescent antiglobulin serum. Blood. 1962;19:664-674.
17. McMillan R, Luiken GA, Levy R, Yelenosky R, Longmire RL. Antibody against megakaryocytes in idiopathic thrombocytopenic purpura. JAMA. 1978;239:2460-2462.
18. Bellucci S, Han ZC, Caen JP. Studies of in vitro megakaryocytopoiesis in adult immune thrombocytopenic purpura (ITP). Eur J Haematol. 1991;47:86-90.
19. Houwerzijl EJ, Blom NR, van der Want JJL, et al. Ultrastructural study shows morphological features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Prepublished online September 11, 2003, as Blood First Edition paper. DOI 10.1182/blood-2003-01-0275.
20. Abgrall J, Berthou C, Sensebe L, Le Niger C, Escoffre M. Decreased in vitro megakaryocyte colony formation in chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1993;85:803-804.
21. Hoffman R, Mazur E, Bruno E, Floyd V. Assay of an activity in the serum of patients with disorders of thrombopoiesis that stimulates formation of megakaryocytic colonies. N Engl J Med. 1981;305:533-538.
22. + cells are correlated with different levels of platelet release. Blood. 2002;99:888-897.