-
1
-
-
33744984785
-
Th17: An effector CD4 T cell lineage with regulatory T cell ties
-
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M. & Murphy, K. M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24, 677-688 (2006).
-
(2006)
Immunity
, vol.24
, pp. 677-688
-
-
Weaver, C.T.1
Harrington, L.E.2
Mangan, P.R.3
Gavrieli, M.4
Murphy, K.M.5
-
2
-
-
33645318217
-
Diversification of T-helper-cell lineages: Finding the family root of IL-17-producing cells
-
Dong, C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nature Rev. Immunol. 6, 329-333 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 329-333
-
-
Dong, C.1
-
4
-
-
27544490377
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunol. 6, 1123-1132 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
-
5
-
-
33745873727
-
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
-
Sutton, C., Brereton, C., Keogh, B., Mills, K. H. & Lavelle, E. C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1685-1691
-
-
Sutton, C.1
Brereton, C.2
Keogh, B.3
Mills, K.H.4
Lavelle, E.C.5
-
6
-
-
33745321276
-
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
-
Komiyama, Y. et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566-573 (2006).
-
(2006)
J. Immunol.
, vol.177
, pp. 566-573
-
-
Komiyama, Y.1
-
7
-
-
33646545068
-
Immunology: What does it mean to be just 17?
-
Tato, C. M. & O'Shea, J. J. Immunology: what does it mean to be just 17? Nature 441, 166-168 (2006).
-
(2006)
Nature
, vol.441
, pp. 166-168
-
-
Tato, C.M.1
O'Shea, J.J.2
-
8
-
-
41549135632
-
The biological functions of T helper 17 cell effector cytokines in inflammation
-
Ouyang, W., Kolls, J. K. & Zheng, Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467 (2008).
-
(2008)
Immunity
, vol.28
, pp. 454-467
-
-
Ouyang, W.1
Kolls, J.K.2
Zheng, Y.3
-
9
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls, J. K. & Linden, A. Interleukin-17 family members and inflammation. Immunity 21, 467-476 (2004).
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
10
-
-
72949106340
-
Reg cell lineages: A (co-)evolutionary perspective
-
Reg cell lineages: a (co-)evolutionary perspective. Nature Rev. Immunol. 9, 883-889 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 883-889
-
-
Weaver, C.T.1
Hatton, R.D.2
-
11
-
-
55149090692
-
Th17 cytokines and mucosal immunity
-
Dubin, P. J. & Kolls, J. K. Th17 cytokines and mucosal immunity. Immunol. Rev. 226, 160-171 (2008).
-
(2008)
Immunol. Rev.
, vol.226
, pp. 160-171
-
-
Dubin, P.J.1
Kolls, J.K.2
-
12
-
-
58049194071
-
Emergence of the Th17 pathway and its role in host defense
-
O'Quinn, D. B., Palmer, M. T., Lee, Y. K. & Weaver, C. T. Emergence of the Th17 pathway and its role in host defense. Adv. Immunol. 99, 115-163 (2008).
-
(2008)
Adv. Immunol.
, vol.99
, pp. 115-163
-
-
O'Quinn, D.B.1
Palmer, M.T.2
Lee, Y.K.3
Weaver, C.T.4
-
13
-
-
34249806717
-
Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumour microenvironment
-
Kryczek, I. et al. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumour microenvironment. J. Immunol. 178, 6730-6733 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 6730-6733
-
-
Kryczek, I.1
-
14
-
-
69849107597
-
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumour environments
-
Kryczek, I. et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumour environments. Blood 11 4, 1141-1149 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 1141-1149
-
-
Kryczek, I.1
-
15
-
-
47649122633
-
Tumour-specific Th17-polarized cells eradicate large established melanoma
-
Muranski, P. et al. Tumour-specific Th17-polarized cells eradicate large established melanoma. Blood 11 2, 362-373 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 362-373
-
-
Muranski, P.1
-
16
-
-
58149316658
-
+ T cell trafficking and development by IFN-γ: Mechanism and pathological relevance in psoriasis
-
+ T cell trafficking and development by IFN-γ: mechanism and pathological relevance in psoriasis. J. Immunol. 181, 4733-4741 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 4733-4741
-
-
Kryczek, I.1
-
17
-
-
70449530422
-
T helper 17 cells promote cytotoxic T cell activation in tumour immunity
-
Martin-Orozco, N. et al. T helper 17 cells promote cytotoxic T cell activation in tumour immunity. Immunity 31, 787-798 (2009).
-
(2009)
Immunity
, vol.31
, pp. 787-798
-
-
Martin-Orozco, N.1
-
18
-
-
0035658072
-
Stromal-derived factor-1 in human tumours recruits and alters the function of plasmacytoid precursor dendritic cells
-
Zou, W. et al. Stromal-derived factor-1 in human tumours recruits and alters the function of plasmacytoid precursor dendritic cells. Nature Med. 7, 1339-1346 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 1339-1346
-
-
Zou, W.1
-
19
-
-
19944431949
-
CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers
-
Kryczek, I. et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res. 65, 465-472 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 465-472
-
-
Kryczek, I.1
-
20
-
-
0033571785
-
In breast carcinoma tissue, immature dendritic cells reside within the tumour, whereas mature dendritic cells are located in peritumoral areas
-
Bell, D. et al. In breast carcinoma tissue, immature dendritic cells reside within the tumour, whereas mature dendritic cells are located in peritumoral areas. J. Exp. Med. 190, 1417-1426 (1999).
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1417-1426
-
-
Bell, D.1
-
21
-
-
34249079176
-
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
-
Acosta-Rodriguez, E. V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nature Immunol. 8, 639-646 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 639-646
-
-
Acosta-Rodriguez, E.V.1
-
22
-
-
34547734621
-
Phenotypic and functional features of human Th17 cells
-
Annunziato, F. et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204, 1849-1861 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1849-1861
-
-
Annunziato, F.1
-
23
-
-
70149106667
-
+ T cells display enhanced anti-tumour immunity
-
+ T cells display enhanced anti-tumour immunity. Blood 11 4, 596-599 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 596-599
-
-
Hinrichs, C.S.1
-
24
-
-
34250327922
-
+T cell responses
-
+T cell responses. J. Exp. Med. 204, 1405-1416 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1405-1416
-
-
Precopio, M.L.1
-
25
-
-
34948906159
-
+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover
-
+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204, 2473-2485 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2473-2485
-
-
Almeida, J.R.1
-
26
-
-
58749098605
-
Cutting edge: IFN-γ enables APC to promote memory Th17 and abate Th1 cell development
-
Kryczek, I. et al. Cutting edge: IFN-γ enables APC to promote memory Th17 and abate Th1 cell development. J. Immunol. 181, 5842-5846 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 5842-5846
-
-
Kryczek, I.1
-
27
-
-
33645853780
-
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
-
Kryczek, I. et al. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 203, 871-881 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 871-881
-
-
Kryczek, I.1
-
28
-
-
55749098500
-
+ IL-17-producing T cells in ovarian cancer
-
+ IL-17-producing T cells in ovarian cancer. Proc. Natl Acad. Sci. USA 105, 15505-15510 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 15505-15510
-
-
Miyahara, Y.1
-
29
-
-
47549112840
-
H17 cells
-
H17 cells. Nature 454, 350-352 (2008).
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
-
30
-
-
44049104564
-
H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
-
H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nature Immunol. 9, 641-649 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 641-649
-
-
Manel, N.1
Unutmaz, D.2
Littman, D.R.3
-
31
-
-
44049102724
-
H-17 responses
-
H-17 responses. Nature Immunol. 9, 650-657 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 650-657
-
-
Volpe, E.1
-
32
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17-producing helper T cells
-
Wilson, N. J. et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nature Immunol. 8, 950-957 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
-
33
-
-
34548125305
-
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
-
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A. & Sallusto, F. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nature Immunol. 8, 639-646 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 639-646
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavecchia, A.3
Sallusto, F.4
-
34
-
-
16844379997
-
Immunosuppressive networks in the tumour environment and their therapeutic relevance
-
Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nature Rev. Cancer 5, 263-274 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 263-274
-
-
Zou, W.1
-
35
-
-
34548651152
-
+ T cell pool IL-1 subverts IL-2-mediated suppression
-
+ T cell pool IL-1 subverts IL-2-mediated suppression. J. Immunol. 179, 1423-1426 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 1423-1426
-
-
Kryczek, I.1
-
36
-
-
64049089798
-
Critical regulation of early Th17 cell differentiation by interleukin-1 signalling
-
Chung, Y. et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signalling. Immunity 30, 576-587 (2009).
-
(2009)
Immunity
, vol.30
, pp. 576-587
-
-
Chung, Y.1
-
37
-
-
74649086985
-
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
-
Gulen, M. F. et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32, 54-66 (2010).
-
(2010)
Immunity
, vol.32
, pp. 54-66
-
-
Gulen, M.F.1
-
38
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
-
39
-
-
34447503805
-
H17 and regulatory T cell differentiation mediated by retinoic acid
-
H17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
-
40
-
-
33646577466
-
H17 and regulatory T cells
-
H17 and regulatory T cells. Nature 441, 235-238 (2006).
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
41
-
-
65549088243
-
IL-17-producing human peripheral regulatory T cells retain suppressive function
-
Beriou, G. et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 11 3, 4240-4249 (2009).
-
(2009)
Blood
, vol.11
, Issue.3
, pp. 4240-4249
-
-
Beriou, G.1
-
42
-
-
63849183918
-
+ regulatory T cells in humans
-
+ regulatory T cells in humans. Proc. Natl Acad. Sci. USA 106, 4793-4798 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4793-4798
-
-
Voo, K.S.1
-
43
-
-
0033973947
-
IL-6 production in ovarian carcinoma is associated with histiotype and biological characteristics of the tumour and influences local immunity
-
Kryczek, I., Grybos, M., Karabon, L., Klimczak, A. & Lange, A. IL-6 production in ovarian carcinoma is associated with histiotype and biological characteristics of the tumour and influences local immunity. Br. J. Cancer 82, 621-628 (2000).
-
(2000)
Br. J. Cancer
, vol.82
, pp. 621-628
-
-
Kryczek, I.1
Grybos, M.2
Karabon, L.3
Klimczak, A.4
Lange, A.5
-
44
-
-
34250351459
-
Adenosine generation catalysed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio, S. et al. Adenosine generation catalysed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
-
45
-
-
34547098277
-
+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
-
+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 11 0, 1225-1232 (2007).
-
(2007)
Blood
, vol.11
, Issue.0
, pp. 1225-1232
-
-
Borsellino, G.1
-
46
-
-
77249095912
-
Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
-
Kao, J. Y. et al. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology 138, 1046-1054 (2010).
-
(2010)
Gastroenterology
, vol.138
, pp. 1046-1054
-
-
Kao, J.Y.1
-
47
-
-
70049113279
-
H17 responses in a Stat3-dependent manner
-
H17 responses in a Stat3-dependent manner. Science 326, 986-991 (2009).
-
(2009)
Science
, vol.326
, pp. 986-991
-
-
Chaudhry, A.1
-
49
-
-
58149251898
-
Late developmental plasticity in the T helper 17 lineage
-
Lee, Y. K. et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30, 92-107 (2009).
-
(2009)
Immunity
, vol.30
, pp. 92-107
-
-
Lee, Y.K.1
-
50
-
-
73349101421
-
Tc17 CD8 T cells: Functional plasticity and subset diversity
-
Yen, H. R. et al. Tc17 CD8 T cells: functional plasticity and subset diversity. J. Immunol. 183, 7161-7168 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 7161-7168
-
-
Yen, H.R.1
-
51
-
-
67650650890
-
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/ SCID recipient mice
-
Bending, D. et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/ SCID recipient mice. J. Clin. Invest. 11 9, 565-572 (2009).
-
(2009)
J. Clin. Invest.
, vol.11
, Issue.9
, pp. 565-572
-
-
Bending, D.1
-
52
-
-
60549086638
-
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
-
Martin-Orozco, N., Chung, Y., Chang, S. H., Wang, Y. H. & Dong, C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 39, 216-224 (2009).
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 216-224
-
-
Martin-Orozco, N.1
Chung, Y.2
Chang, S.H.3
Wang, Y.H.4
Dong, C.5
-
53
-
-
64849103287
-
Cutting edge: In vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts
-
Nurieva, R., Yang, X. O., Chung, Y. & Dong, C. Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J. Immunol. 182, 2565-2568 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 2565-2568
-
-
Nurieva, R.1
Yang, X.O.2
Chung, Y.3
Dong, C.4
-
54
-
-
42249084849
-
Either a Th17 or a Th1 effector response can drive autoimmunity: Conditions of disease induction affect dominant effector category
-
Luger, D. et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205, 799-810 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 799-810
-
-
Luger, D.1
-
55
-
-
65749091607
-
A protective function for interleukin 17A in T cell-mediated intestinal inflammation
-
O'Connor, W. Jr et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunol. 10, 603-609 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 603-609
-
-
Jr, O.W.1
-
56
-
-
70449585536
-
Does IL-17 promote tumour growth?
-
Muranski, P. & Restifo, N. P. Does IL-17 promote tumour growth? Blood 11 4, 231-232 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 231-232
-
-
Muranski, P.1
Restifo, N.P.2
-
57
-
-
70449472445
-
Th17 cells in ovarian cancer
-
Munn, D. H. Th17 cells in ovarian cancer. Blood 11 4, 1134-1135 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 1134-1135
-
-
Munn, D.H.1
-
58
-
-
55149114870
-
Th17 and cancer: Friends or foes?
-
Bronte, V. Th17 and cancer: friends or foes? Blood 11 2, 214 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 214
-
-
Bronte, V.1
-
59
-
-
67651094058
-
Endogenous IL-17 contributes to reduced tumour growth and metastasis
-
Kryczek, I., Wei, S., Szeliga, W., Vatan, L. & Zou, W. Endogenous IL-17 contributes to reduced tumour growth and metastasis. Blood 11 4, 357-359 (2009).
-
(2009)
Blood
, vol.11
, Issue.4
, pp. 357-359
-
-
Kryczek, I.1
Wei, S.2
Szeliga, W.3
Vatan, L.4
Zou, W.5
-
60
-
-
0034909080
-
Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumour-specific immunity in mice
-
Hirahara, N. et al. Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumour-specific immunity in mice. Oncology 61, 79-89 (2001).
-
(2001)
Oncology
, vol.61
, pp. 79-89
-
-
Hirahara, N.1
-
61
-
-
0037085768
-
Interleukin-17 inhibits tumour cell growth by means of a T-cell-dependent mechanism
-
Benchetrit, F. et al. Interleukin-17 inhibits tumour cell growth by means of a T-cell-dependent mechanism. Blood 99, 2114-2121 (2002).
-
(2002)
Blood
, vol.99
, pp. 2114-2121
-
-
Benchetrit, F.1
-
62
-
-
85046915755
-
Endogenous IL-17, tumour growth and metastasis
-
the press
-
Wei, S., Kryczek, I., Namm, J., Szeliga, W., Vatan, L., Chang, A. E. & Zou, W. Endogenous IL-17, tumour growth and metastasis. Blood (in the press).
-
Blood
-
-
Wei, S.1
Kryczek, I.2
Namm, J.3
Szeliga, W.4
Vatan, L.5
Chang, A.E.6
Zou, W.7
-
63
-
-
67650351923
-
+ Tregs to TH17-like cells in tumour-draining lymph nodes
-
+ Tregs to TH17-like cells in tumour-draining lymph nodes. Blood 11 3, 6102-6111(2009).
-
(2009)
Blood
, vol.11
, Issue.3
, pp. 6102-6111
-
-
Sharma, M.D.1
-
64
-
-
67349193717
-
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies
-
Pellegrini, M. et al. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nature Med. 15, 528-536 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 528-536
-
-
Pellegrini, M.1
-
65
-
-
37549008775
-
Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer
-
Kottke, T. et al. Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res. 67, 11970-11979 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 11970-11979
-
-
Kottke, T.1
-
66
-
-
48849103649
-
H17 and Treg skewing
-
H17 and Treg skewing. Clin. Cancer Res. 14, 3254-3261 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3254-3261
-
-
Sfanos, K.S.1
-
67
-
-
67649268353
-
CTLA4 blockade increases Th17 cells in patients with metastatic melanoma
-
von Euw, E. et al. CTLA4 blockade increases Th17 cells in patients with metastatic melanoma. J. Transl. Med. 7, 35 (2009).
-
(2009)
J. Transl. Med.
, vol.7
, pp. 35
-
-
Von Euw, E.1
-
68
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumours predict clinical outcome
-
Galon, J. et al. Type, density, and location of immune cells within human colorectal tumours predict clinical outcome. Science 313, 1960-1964 (2006).
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
-
69
-
-
0037448353
-
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
-
Zhang, L. et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203-213 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 203-213
-
-
Zhang, L.1
-
70
-
-
29444442811
-
+/regulatory T cell ratio are associated with favourable prognosis in ovarian cancer
-
+/regulatory T cell ratio are associated with favourable prognosis in ovarian cancer. Proc. Natl Acad. Sci. USA 102, 18538-18543 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18538-18543
-
-
Sato, E.1
-
71
-
-
17444401702
-
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumours in nude mice
-
Tartour, E. et al. Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumours in nude mice. Cancer Res. 59, 3698-3704 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3698-3704
-
-
Tartour, E.1
-
72
-
-
27144449330
-
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
-
Numasaki, M. et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol. 175, 6177-6189 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 6177-6189
-
-
Numasaki, M.1
-
73
-
-
0037849915
-
Interleukin-17 promotes angiogenesis and tumour growth
-
Numasaki, M. et al. Interleukin-17 promotes angiogenesis and tumour growth. Blood 101, 2620-2627 (2003).
-
(2003)
Blood
, vol.101
, pp. 2620-2627
-
-
Numasaki, M.1
-
74
-
-
69949120571
-
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
-
Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature Med. 15, 1016-1022 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 1016-1022
-
-
Wu, S.1
-
75
-
-
67650495415
-
IL-17 can promote tumour growth through an IL-6-Stat3 signalling pathway
-
Wang, L. et al. IL-17 can promote tumour growth through an IL-6-Stat3 signalling pathway. J. Exp. Med. 206, 1457-1464 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1457-1464
-
-
Wang, L.1
-
76
-
-
67449110988
-
Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum
-
Kawakami, Y. et al. Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J. Exp. Med. 206, 1219-1225 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1219-1225
-
-
Kawakami, Y.1
-
77
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski, J. L. et al. IL-23 promotes tumour incidence and growth. Nature 442, 461-465 (2006).
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
-
78
-
-
33749032429
-
Induction of potent antitumour immunity by intratumoral injection of interleukin 23-transduced dendritic cells
-
Hu, J. et al. Induction of potent antitumour immunity by intratumoral injection of interleukin 23-transduced dendritic cells. Cancer Res. 66, 8887-8896 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 8887-8896
-
-
Hu, J.1
-
79
-
-
33645095181
-
Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumour activity against intracranial glioma
-
Yuan, X., Hu, J., Belladonna, M. L., Black, K. L. & Yu, J. S. Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumour activity against intracranial glioma. Cancer Res. 66, 2630-2638 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 2630-2638
-
-
Yuan, X.1
Hu, J.2
Belladonna, M.L.3
Black, K.L.4
Yu, J.S.5
-
80
-
-
33645972617
-
Immunological and antitumour effects of IL-23 as a cancer vaccine adjuvant
-
Overwijk, W. W. et al. Immunological and antitumour effects of IL-23 as a cancer vaccine adjuvant. J. Immunol. 176, 5213-5222 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 5213-5222
-
-
Overwijk, W.W.1
-
81
-
-
33745685864
-
Interleukin-23 and interleukin-27 exert quite different antitumour and vaccine effects on poorly immunogenic melanoma
-
Oniki, S. et al. Interleukin-23 and interleukin-27 exert quite different antitumour and vaccine effects on poorly immunogenic melanoma. Cancer Res. 66, 6395-6404 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 6395-6404
-
-
Oniki, S.1
-
82
-
-
34250164929
-
Systemic administration of IL-23 induces potent antitumour immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12
-
Kaiga, T. et al. Systemic administration of IL-23 induces potent antitumour immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12. J. Immunol. 178, 7571-7580 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 7571-7580
-
-
Kaiga, T.1
-
83
-
-
33646356996
-
Adoptive immunotherapy for cancer: Building on success
-
Gattinoni, L., Powell, D. J. Jr, Rosenberg, S. A. & Restifo, N. P. Adoptive immunotherapy for cancer: building on success. Nature Rev. Immunol. 6, 383-393 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 383-393
-
-
Gattinoni, L.1
Powell Jr., D.P.2
Rosenberg, S.A.3
Restifo, N.P.4
-
85
-
-
20044363610
-
+ T helper cells and hindered by naturally occurring T regulatory cells
-
+ T helper cells and hindered by naturally occurring T regulatory cells. J. Immunol. 174, 2591-2601 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 2591-2601
-
-
Antony, P.A.1
-
86
-
-
33645286546
-
Regulatory T cells, tumour immunity and immunotherapy
-
Zou, W. Regulatory T cells, tumour immunity and immunotherapy. Nature Rev. Immunol. 6, 295-307 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 295-307
-
-
Zou, W.1
-
87
-
-
5044220930
-
IDO expression by dendritic cells: Tolerance and tryptophan catabolism
-
Mellor, A. L. & Munn, D. H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nature Rev. Immunol. 4, 762-774 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 762-774
-
-
Mellor, A.L.1
Munn, D.H.2
-
88
-
-
10244279184
-
Mechanisms and functional significance of tumour-induced dendritic-cell defects
-
Gabrilovich, D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nature Rev. Immunol. 4, 941-952 (2004).
-
(2004)
Nature Rev. Immunol.
, vol.4
, pp. 941-952
-
-
Gabrilovich, D.1
-
89
-
-
23444456772
-
Regulation of immune responses by l-arginine metabolism
-
Bronte, V. & Zanovello, P. Regulation of immune responses by l-arginine metabolism. Nature Rev. Immunol. 5, 641-654 (2005).
-
(2005)
Nature Rev. Immunol.
, vol.5
, pp. 641-654
-
-
Bronte, V.1
Zanovello, P.2
-
90
-
-
33748987908
-
Cancer despite immunosurveillance: Immunoselection and immunosubversion
-
Zitvogel, L., Tesniere, A. & Kroemer, G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nature Rev. Immunol. 6, 715-727 (2006).
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 715-727
-
-
Zitvogel, L.1
Tesniere, A.2
Kroemer, G.3
-
91
-
-
45549099784
-
+ T cells against NY-ESO-1
-
+ T cells against NY-ESO-1. N. Engl. J. Med. 358, 2698-2703 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2698-2703
-
-
Hunder, N.N.1
-
92
-
-
69349093225
-
Interleukin-17 and type 17 helper T cells
-
Miossec, P., Korn, T. & Kuchroo, V. K. Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361, 888-898 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 888-898
-
-
Miossec, P.1
Korn, T.2
Kuchroo, V.K.3
-
93
-
-
41149097574
-
Adoptive cell transfer: A clinical path to effective cancer immunotherapy
-
Rosenberg, S. A., Restifo, N. P., Yang, J. C., Morgan, R. A. & Dudley, M. E. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nature Rev. Cancer 8, 299-308 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 299-308
-
-
Rosenberg, S.A.1
Restifo, N.P.2
Yang, J.C.3
Morgan, R.A.4
Dudley, M.E.5
-
95
-
-
63949083529
-
+ T-cell axis in patients with breast cancer
-
+ T-cell axis in patients with breast cancer. Br. J. Cancer 100, 1061-1067 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, pp. 1061-1067
-
-
Horlock, C.1
-
96
-
-
48849101281
-
The prevalence of Th17 cells in patients with gastric cancer
-
Zhang, B. et al. The prevalence of Th17 cells in patients with gastric cancer. Biochem. Biophys. Res. Commun. 374, 533-537 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.374
, pp. 533-537
-
-
Zhang, B.1
-
97
-
-
64549108462
-
Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
-
Zhang, J. P. et al. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol 50, 980-989 (2009).
-
(2009)
J. Hepatol
, vol.50
, pp. 980-989
-
-
Zhang, J.P.1
-
98
-
-
58149332682
-
Effects of high-dose IFNα2b on regional lymph node metastases of human melanoma: Modulation of STAT5 FOXP3, and IL-17
-
Wang, W. et al. Effects of high-dose IFNα2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clin. Cancer Res. 14, 8314-8320 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 8314-8320
-
-
Wang, W.1
-
99
-
-
53449089919
-
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
-
Dhodapkar, K. M. et al. Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 11 2, 2878-2885 (2008).
-
(2008)
Blood
, vol.11
, Issue.2
, pp. 2878-2885
-
-
Dhodapkar, K.M.1
-
100
-
-
70349668946
-
The tumour-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans
-
Charles, K. A. et al. The tumour-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J. Clin. Invest. 11 9, 3011-3023 (2009).
-
(2009)
J. Clin. Invest.
, vol.11
, Issue.9
, pp. 3011-3023
-
-
Charles, K.A.1
-
101
-
-
68249133652
-
+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
-
+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Int. J. Cancer 125, 1372-1379 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 1372-1379
-
-
Derhovanessian, E.1
-
102
-
-
63649112073
-
IL-17 secreted by tumour reactive T cells induces IL-8 release by human renal cancer cells
-
Inozume, T., Hanada, K., Wang, Q. J. & Yang, J. C. IL-17 secreted by tumour reactive T cells induces IL-8 release by human renal cancer cells. J. Immunother. 32, 109-117 (2009).
-
(2009)
J. Immunother.
, vol.32
, pp. 109-117
-
-
Inozume, T.1
Hanada, K.2
Wang, Q.J.3
Yang, J.C.4
-
103
-
-
58149234402
-
+ regulatory T cells in small cell lung cancer reflects disease stage
-
+ regulatory T cells in small cell lung cancer reflects disease stage. Clin. Cancer Res. 14, 6770-6779 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6770-6779
-
-
Koyama, K.1
-
104
-
-
38049072274
-
Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion
-
Coury, F. et al. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nature Med. 14, 81-87 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 81-87
-
-
Coury, F.1
-
105
-
-
36248965294
-
H-17 cell mediated pathology
-
H-17 cell mediated pathology. Nature Immunol. 8, 1390-1397 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 1390-1397
-
-
McGeachy, M.J.1
-
106
-
-
36248970702
-
Suppression of autoimmune inflammation of central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
-
Fitzgerald, D. C. et al. Suppression of autoimmune inflammation of central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nature Immunol. 8, 1372-1379 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 1372-1379
-
-
Fitzgerald, D.C.1
-
107
-
-
36248951161
-
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
-
Stumhofer, J. S. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nature Immunol. 8, 1363-1371 (2007).
-
(2007)
Nature Immunol.
, vol.8
, pp. 1363-1371
-
-
Stumhofer, J.S.1
|