Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia

Human Immunology

Volumn 72, Issue 6, 2011, Pages 486-491

  Chen, Zhen ping ^a,b   Gu, Dong sheng ^a,d   Zhou, Ze ping ^a   Chen, Xiao li ^a   Guo, Zhen xing ^a,c   Du, Wei ting ^a   Ge, Jing ^a   Ren, Qian ^a   Yang, Ren chi ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c FIRST HOSPITAL OF TSINGHUA UNIVERSITY   (China)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA deoxymethylcytosine; DNA methylation; Methyl CpG binding domain 2; Methyl CpG binding domain 4; Primary immune thrombocytopenia

Indexed keywords

MESSENGER RNA; METHYL CPG BINDING PROTEIN 2;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA CONTENT; DNA METHYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MBD4 GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMARY IMMUNE THROMBOCYTOPENIA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD;

ACUTE DISEASE; ADULT; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DNA METHYLATION; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RNA;

EID: 79955782511     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.02.006     Document Type: Article

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