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Volumn 10, Issue 2, 2013, Pages 109-121

Cardiac lipotoxicity: Molecular pathways and therapeutic implications

Author keywords

Apoptosis; Ceramide; Diacylglycerol; Endoplasmic reticulum stress; Fatty acid oxidation; Heart failure; Insulin signaling; Lipotoxicity; MAPK; PPAR; Protein kinase C

Indexed keywords

ACYL COENZYME A; ALBUMIN; CARNITINE PALMITOYLTRANSFERASE; CERAMIDE; CHYLOMICRON; COENZYME A; FATTY ACID; FATTY ACID TRANSPORTER; GLUCOSE TRANSPORTER 4; GLYCEROL; INSULIN; MALONYL COENZYME A; MITOGEN ACTIVATED PROTEIN KINASE; OCTANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOLIPID; PROTEIN KINASE C; SPHINGOMYELIN PHOSPHODIESTERASE; TRIACYLGLYCEROL;

EID: 84883054064     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-013-0133-0     Document Type: Article
Times cited : (161)

References (165)
  • 1
    • 33646832738 scopus 로고    scopus 로고
    • Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction
    • 16410253 1:CAS:528:DC%2BD28XivVCns78%3D 10.1074/jbc.M509890200
    • Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, et al. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem. 2006;281:8716-23.
    • (2006) J Biol Chem , vol.281 , pp. 8716-8723
    • Augustus, A.S.1    Buchanan, J.2    Park, T.S.3    Hirata, K.4    Noh, H.L.5    Sun, J.6
  • 2
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part i: General concepts
    • 11940554 1:CAS:528:DC%2BD38Xjs12nsL4%3D 10.1161/01.CIR.0000012466.50373. E8
    • Taegtmeyer H, McNulty P, Young ME. Adaptation and maladaptation of the heart in diabetes: Part i: General concepts. Circulation. 2002;105:1727-33.
    • (2002) Circulation , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 3
    • 0031036553 scopus 로고    scopus 로고
    • Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions
    • 9074687 1:CAS:528:DyaK2sXhvVSmsL0%3D 10.1016/S0008-6363(96)00245-3
    • Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res. 1997;33:243-57.
    • (1997) Cardiovasc Res , vol.33 , pp. 243-257
    • Stanley, W.C.1    Lopaschuk, G.D.2    Hall, J.L.3    McCormack, J.G.4
  • 4
    • 0001042845 scopus 로고
    • Myocardial metabolism of fatty acids
    • 13796251 1:CAS:528:DyaF3MXhsVantw%3D%3D 10.1172/JCI104088
    • Ballard FB, Danforth WH, Naegle S, Bing RJ. Myocardial metabolism of fatty acids. J Clin Invest. 1960;39:717-23.
    • (1960) J Clin Invest , vol.39 , pp. 717-723
    • Ballard, F.B.1    Danforth, W.H.2    Naegle, S.3    Bing, R.J.4
  • 5
    • 0020692538 scopus 로고
    • Comparative metabolism of free and esterified fatty acids by the perfused rat heart and rat cardiac myocytes
    • 6860691 1:CAS:528:DyaL3sXhslKkt7g%3D 10.1016/0005-2760(83)90046-2
    • Tamboli A, O'Looney P, Vander Maten M, Vahouny GV. Comparative metabolism of free and esterified fatty acids by the perfused rat heart and rat cardiac myocytes. Biochim Biophys Acta. 1983;750:404-10.
    • (1983) Biochim Biophys Acta , vol.750 , pp. 404-410
    • Tamboli, A.1    O'Looney, P.2    Vander Maten, M.3    Vahouny, G.V.4
  • 6
    • 8844226709 scopus 로고    scopus 로고
    • Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    • 15550674 1:CAS:528:DC%2BD2cXpvVektLw%3D 10.1126/science.1100747
    • Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004;306:1383-6.
    • (2004) Science , vol.306 , pp. 1383-1386
    • Zimmermann, R.1    Strauss, J.G.2    Haemmerle, G.3    Schoiswohl, G.4    Birner-Gruenberger, R.5    Riederer, M.6
  • 7
    • 8744297386 scopus 로고    scopus 로고
    • Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
    • 15337759 1:CAS:528:DC%2BD2cXptFejsLc%3D 10.1074/jbc.M403855200
    • Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 2004;279:47066-75.
    • (2004) J Biol Chem , vol.279 , pp. 47066-47075
    • Villena, J.A.1    Roy, S.2    Sarkadi-Nagy, E.3    Kim, K.H.4    Sul, H.S.5
  • 8
    • 77955176286 scopus 로고    scopus 로고
    • Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor pparalpha
    • 20522803 1:CAS:528:DC%2BC3cXpt1KqsrY%3D 10.1161/CIRCRESAHA.110.221713 This is a paper that sheds light on an important aspect of cardiac metabolism, which pertains to whether fatty acids that are used for cardiac ATP production are obtained from intracellular store of triglycerides or not
    • • Banke NH, Wende AR, Leone TC, O'Donnell JM, Abel ED, Kelly DP, et al. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor pparalpha. Circ Res. 2010;107:233-41. This is a paper that sheds light on an important aspect of cardiac metabolism, which pertains to whether fatty acids that are used for cardiac ATP production are obtained from intracellular store of triglycerides or not.
    • (2010) Circ Res , vol.107 , pp. 233-241
    • Banke, N.H.1    Wende, A.R.2    Leone, T.C.3    O'Donnell, J.M.4    Abel, E.D.5    Kelly, D.P.6
  • 9
    • 84856807853 scopus 로고    scopus 로고
    • Myocardial atgl overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction
    • 22158969 1:CAS:528:DC%2BC38XjtFaqsbY%3D 10.1128/MCB.06470-11
    • Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, et al. Myocardial atgl overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012;32:740-50.
    • (2012) Mol Cell Biol , vol.32 , pp. 740-750
    • Kienesberger, P.C.1    Pulinilkunnil, T.2    Sung, M.M.3    Nagendran, J.4    Haemmerle, G.5    Kershaw, E.E.6
  • 10
    • 0029920693 scopus 로고    scopus 로고
    • Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
    • 8732771 1:CAS:528:DyaK28XivVOmsr0%3D
    • Goldberg IJ. Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37:693-707.
    • (1996) J Lipid Res , vol.37 , pp. 693-707
    • Goldberg, I.J.1
  • 11
    • 0033021140 scopus 로고    scopus 로고
    • Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels
    • 10077655 1:CAS:528:DyaK1MXhvFyktLw%3D 10.1073/pnas.96.6.3165
    • Levak-Frank S, Hofmann W, Weinstock PH, Radner H, Sattler W, Breslow JL, et al. Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. Proc Natl Acad Sci U S A. 1999;96:3165-70.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3165-3170
    • Levak-Frank, S.1    Hofmann, W.2    Weinstock, P.H.3    Radner, H.4    Sattler, W.5    Breslow, J.L.6
  • 12
    • 0017616690 scopus 로고
    • Pre- and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues
    • 857810 1:CAS:528:DyaE2sXktF2lsrw%3D 10.1016/0021-9150(77)90122-8
    • Chajek T, Stein O, Stein Y. Pre- and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues. Atherosclerosis. 1977;26:549-61.
    • (1977) Atherosclerosis , vol.26 , pp. 549-561
    • Chajek, T.1    Stein, O.2    Stein, Y.3
  • 13
    • 0028131210 scopus 로고
    • Transcriptional regulation of lipoprotein lipase in the heart during development in the rat
    • 8048956 1:CAS:528:DyaK2cXltlSktbY%3D 10.1006/bbrc.1994.2006
    • Singh-Bist A, Komaromy MC, Kraemer FB. Transcriptional regulation of lipoprotein lipase in the heart during development in the rat. Biochem Biophys Res Commun. 1994;202:838-43.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 838-843
    • Singh-Bist, A.1    Komaromy, M.C.2    Kraemer, F.B.3
  • 14
    • 0024551698 scopus 로고
    • Lipoprotein lipase and hepatic lipase mrna tissue specific expression, developmental regulation, and evolution
    • 2723548 1:CAS:528:DyaK3cXhslehtro%3D
    • Semenkovich CF, Chen SH, Wims M, Luo CC, Li WH, Chan L. Lipoprotein lipase and hepatic lipase mrna tissue specific expression, developmental regulation, and evolution. J Lipid Res. 1989;30:423-31.
    • (1989) J Lipid Res , vol.30 , pp. 423-431
    • Semenkovich, C.F.1    Chen, S.H.2    Wims, M.3    Luo, C.C.4    Li, W.H.5    Chan, L.6
  • 15
    • 0344845288 scopus 로고    scopus 로고
    • Nutritional regulation of lipoprotein lipase in mice
    • 14643896 1:CAS:528:DC%2BD3sXpt1Sqtrk%3D 10.1016/S1357-2725(03)00256-5
    • Ruge T, Wu G, Olivecrona T, Olivecrona G. Nutritional regulation of lipoprotein lipase in mice. Int J Biochem Cell Biol. 2004;36:320-9.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 320-329
    • Ruge, T.1    Wu, G.2    Olivecrona, T.3    Olivecrona, G.4
  • 16
    • 10744224120 scopus 로고    scopus 로고
    • Evidence for rapid metabolic switching through lipoprotein lipase occupation of endothelial-binding sites
    • 12967632 1:CAS:528:DC%2BD3sXmvVOrsbw%3D 10.1016/S0022-2828(03)00205-0
    • Pulinilkunnil T, Abrahani A, Varghese J, Chan N, Tang I, Ghosh S, et al. Evidence for rapid metabolic switching through lipoprotein lipase occupation of endothelial-binding sites. J Mol Cell Cardiol. 2003;35:1093-103.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1093-1103
    • Pulinilkunnil, T.1    Abrahani, A.2    Varghese, J.3    Chan, N.4    Tang, I.5    Ghosh, S.6
  • 18
    • 0028652720 scopus 로고
    • Regulation of myocardial lipoprotein lipase activity by diabetes and thyroid hormones
    • 7767864 1:CAS:528:DyaK2MXjsl2hsbk%3D 10.1139/y94-180
    • Liu L, Severson DL. Regulation of myocardial lipoprotein lipase activity by diabetes and thyroid hormones. Can J Physiol Pharmacol. 1994;72:1259-64.
    • (1994) Can J Physiol Pharmacol , vol.72 , pp. 1259-1264
    • Liu, L.1    Severson, D.L.2
  • 19
    • 0030060017 scopus 로고    scopus 로고
    • Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart
    • 8603509 1:CAS:528:DyaK28XltVKh 10.1161/01.RES.78.1.8
    • Masuzaki H, Jingami H, Matsuoka N, Nakagawa O, Ogawa Y, Mizuno M, et al. Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart. Circ Res. 1996;78:8-14.
    • (1996) Circ Res , vol.78 , pp. 8-14
    • Masuzaki, H.1    Jingami, H.2    Matsuoka, N.3    Nakagawa, O.4    Ogawa, Y.5    Mizuno, M.6
  • 20
    • 2942616538 scopus 로고    scopus 로고
    • Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression
    • 15028738 1:CAS:528:DC%2BD2cXksFyhtbc%3D 10.1074/jbc.M401028200
    • Augustus A, Yagyu H, Haemmerle G, Bensadoun A, Vikramadithyan RK, Park SY, et al. Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem. 2004;279:25050-7.
    • (2004) J Biol Chem , vol.279 , pp. 25050-25057
    • Augustus, A.1    Yagyu, H.2    Haemmerle, G.3    Bensadoun, A.4    Vikramadithyan, R.K.5    Park, S.Y.6
  • 21
    • 0037316670 scopus 로고    scopus 로고
    • Lipoprotein lipase (lpl) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy
    • 12569168
    • Yagyu H, Chen G, Yokoyama M, Hirata K, Augustus A, Kako Y, et al. Lipoprotein lipase (lpl) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest. 2003;111:419-26.
    • (2003) J Clin Invest , vol.111 , pp. 419-426
    • Yagyu, H.1    Chen, G.2    Yokoyama, M.3    Hirata, K.4    Augustus, A.5    Kako, Y.6
  • 22
    • 0034693232 scopus 로고    scopus 로고
    • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of cd36 knockout mice
    • 10913136 1:CAS:528:DC%2BD3cXnslOitrY%3D 10.1074/jbc.M003826200
    • Coburn CT, Knapp Jr FF, Febbraio M, Beets AL, Silverstein RL, Abumrad NA. Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of cd36 knockout mice. J Biol Chem. 2000;275:32523-9.
    • (2000) J Biol Chem , vol.275 , pp. 32523-32529
    • Coburn, C.T.1    Knapp, Jr.F.F.2    Febbraio, M.3    Beets, A.L.4    Silverstein, R.L.5    Abumrad, N.A.6
  • 23
    • 0031921236 scopus 로고    scopus 로고
    • Fatty acid transport: Difficult or easy?
    • 9548581 1:CAS:528:DyaK1cXit1Kmsbk%3D
    • Hamilton JA. Fatty acid transport: Difficult or easy? J Lipid Res. 1998;39:467-81.
    • (1998) J Lipid Res , vol.39 , pp. 467-481
    • Hamilton, J.A.1
  • 24
    • 0033014527 scopus 로고    scopus 로고
    • Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (cd36 deficiency)
    • 10025829 1:STN:280:DyaK1M7kvVKqtA%3D%3D
    • Fukuchi K, Nozaki S, Yoshizumi T, Hasegawa S, Uehara T, Nakagawa T, et al. Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (cd36 deficiency). J Nucl Med. 1999;40:239-43.
    • (1999) J Nucl Med , vol.40 , pp. 239-243
    • Fukuchi, K.1    Nozaki, S.2    Yoshizumi, T.3    Hasegawa, S.4    Uehara, T.5    Nakagawa, T.6
  • 25
    • 34248640285 scopus 로고    scopus 로고
    • Physiological and pathological roles of a multi-ligand receptor cd36 in atherogenesis; Insights from cd36-deficient patients
    • 16670819 1:CAS:528:DC%2BD2sXltFSrtro%3D 10.1007/s11010-005-9031-4
    • Yamashita S, Hirano K, Kuwasako T, Janabi M, Toyama Y, Ishigami M, et al. Physiological and pathological roles of a multi-ligand receptor cd36 in atherogenesis; insights from cd36-deficient patients. Mol Cell Biochem. 2007;299:19-22.
    • (2007) Mol Cell Biochem , vol.299 , pp. 19-22
    • Yamashita, S.1    Hirano, K.2    Kuwasako, T.3    Janabi, M.4    Toyama, Y.5    Ishigami, M.6
  • 26
    • 1842538563 scopus 로고    scopus 로고
    • Fatty acid translocase/cd36 deficiency does not energetically or functionally compromise hearts before or after ischemia
    • 15023869 1:CAS:528:DC%2BD2cXisVGmsbw%3D 10.1161/01.CIR.0000121730.41801. 12
    • Kuang M, Febbraio M, Wagg C, Lopaschuk GD, Dyck JR. Fatty acid translocase/cd36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation. 2004;109:1550-7.
    • (2004) Circulation , vol.109 , pp. 1550-1557
    • Kuang, M.1    Febbraio, M.2    Wagg, C.3    Lopaschuk, G.D.4    Dyck, J.R.5
  • 27
    • 0038312010 scopus 로고    scopus 로고
    • Myocardial recovery from ischemia is impaired in cd36-null mice and restored by myocyte cd36 expression or medium-chain fatty acids
    • 12746501 1:CAS:528:DC%2BD3sXktlygtr8%3D 10.1073/pnas.1132094100
    • Irie H, Krukenkamp IB, Brinkmann JF, Gaudette GR, Saltman AE, Jou W, et al. Myocardial recovery from ischemia is impaired in cd36-null mice and restored by myocyte cd36 expression or medium-chain fatty acids. Proc Natl Acad Sci U S A. 2003;100:6819-24.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6819-6824
    • Irie, H.1    Krukenkamp, I.B.2    Brinkmann, J.F.3    Gaudette, G.R.4    Saltman, A.E.5    Jou, W.6
  • 28
    • 78649658552 scopus 로고    scopus 로고
    • Chylomicron- and vldl-derived lipids enter the heart through different pathways: In vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    • 20852327 1:CAS:528:DC%2BC3cXhsVOku77N 10.1074/jbc.M110.174458
    • Bharadwaj KG, Hiyama Y, Hu Y, Huggins LA, Ramakrishnan R, Abumrad NA, et al. Chylomicron- and vldl-derived lipids enter the heart through different pathways: In vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. J Biol Chem. 2010;285:37976-86.
    • (2010) J Biol Chem , vol.285 , pp. 37976-37986
    • Bharadwaj, K.G.1    Hiyama, Y.2    Hu, Y.3    Huggins, L.A.4    Ramakrishnan, R.5    Abumrad, N.A.6
  • 29
    • 34247626856 scopus 로고    scopus 로고
    • Cd36 deficiency rescues lipotoxic cardiomyopathy
    • 17363697 1:CAS:528:DC%2BD2sXktlOhs7s%3D 10.1161/01.RES.0000264104.25265. b6
    • Yang J, Sambandam N, Han X, Gross RW, Courtois M, Kovacs A, et al. Cd36 deficiency rescues lipotoxic cardiomyopathy. Circ Res. 2007;100:1208-17.
    • (2007) Circ Res , vol.100 , pp. 1208-1217
    • Yang, J.1    Sambandam, N.2    Han, X.3    Gross, R.W.4    Courtois, M.5    Kovacs, A.6
  • 30
    • 11144355563 scopus 로고    scopus 로고
    • Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle
    • 14991074 1:CAS:528:DC%2BD2cXhvFOksL0%3D
    • Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, Punreddy S, et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest. 2004;113:756-63.
    • (2004) J Clin Invest , vol.113 , pp. 756-763
    • Kim, J.K.1    Gimeno, R.E.2    Higashimori, T.3    Kim, H.J.4    Choi, H.5    Punreddy, S.6
  • 31
    • 0037806023 scopus 로고    scopus 로고
    • Characterization of a heart-specific fatty acid transport protein
    • 12556534 1:CAS:528:DC%2BD3sXksVymsb0%3D 10.1074/jbc.M211412200
    • Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, et al. Characterization of a heart-specific fatty acid transport protein. J Biol Chem. 2003;278:16039-44.
    • (2003) J Biol Chem , vol.278 , pp. 16039-16044
    • Gimeno, R.E.1    Ortegon, A.M.2    Patel, S.3    Punreddy, S.4    Ge, P.5    Sun, Y.6
  • 32
    • 79952175806 scopus 로고    scopus 로고
    • Cardiomyocyte lipids impair beta-adrenergic receptor function via pkc activation
    • 21139071 1:CAS:528:DC%2BC3MXjs1GrsLk%3D 10.1152/ajpendo.00569.2010
    • Drosatos K, Bharadwaj KG, Lymperopoulos A, Ikeda S, Khan R, Hu Y, et al. Cardiomyocyte lipids impair beta-adrenergic receptor function via pkc activation. Am J Physiol Endocrinol Metab. 2011;300:E489-99.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Drosatos, K.1    Bharadwaj, K.G.2    Lymperopoulos, A.3    Ikeda, S.4    Khan, R.5    Hu, Y.6
  • 33
    • 0037453056 scopus 로고    scopus 로고
    • Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    • 12629214 1:CAS:528:DC%2BD3sXisVCnsLs%3D 10.1073/pnas.0630588100
    • Listenberger LL, Han X, Lewis SE, Cases S, Farese Jr RV, Ory DS, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A. 2003;100:3077-82.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 3077-3082
    • Listenberger, L.L.1    Han, X.2    Lewis, S.E.3    Cases, S.4    Farese, Jr.R.V.5    Ory, D.S.6
  • 34
    • 33745712681 scopus 로고    scopus 로고
    • Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin
    • 16443671 1:CAS:528:DC%2BD28XntFGhs7g%3D 10.1152/ajpheart.01295.2005
    • Okere IC, Chandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, et al. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. Am J Physiol Heart Circ Physiol. 2006;291:H38-44.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Okere, I.C.1    Chandler, M.P.2    McElfresh, T.A.3    Rennison, J.H.4    Sharov, V.5    Sabbah, H.N.6
  • 35
    • 54249093047 scopus 로고    scopus 로고
    • Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    • 18515784 1:CAS:528:DC%2BD1cXhtF2jt7bO 10.1194/jlr.M800147-JLR200
    • Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, et al. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res. 2008;49:2101-12.
    • (2008) J Lipid Res , vol.49 , pp. 2101-2112
    • Park, T.S.1    Hu, Y.2    Noh, H.L.3    Drosatos, K.4    Okajima, K.5    Buchanan, J.6
  • 36
    • 0026489335 scopus 로고
    • Preferential elevation of protein kinase c isoform beta ii and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
    • 1438315 1:CAS:528:DyaK3sXjslShuw%3D%3D 10.1073/pnas.89.22.11059
    • Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase c isoform beta ii and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992;89:11059-63.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11059-11063
    • Inoguchi, T.1    Battan, R.2    Handler, E.3    Sportsman, J.R.4    Heath, W.5    King, G.L.6
  • 37
    • 0032555778 scopus 로고    scopus 로고
    • Protein kinase c: A paradigm for regulation of protein function by two membrane-targeting modules
    • 9748550 1:CAS:528:DyaK1cXlsFertbk%3D 10.1016/S0304-4157(98)00003-3
    • Newton AC, Johnson JE. Protein kinase c: A paradigm for regulation of protein function by two membrane-targeting modules. Biochim Biophys Acta. 1998;1376:155-72.
    • (1998) Biochim Biophys Acta , vol.1376 , pp. 155-172
    • Newton, A.C.1    Johnson, J.E.2
  • 38
    • 0026451081 scopus 로고
    • Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase c
    • 1411571 1:CAS:528:DyaK38XmsVyqsbo%3D 10.1126/science.1411571
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase c. Science. 1992;258:607-14.
    • (1992) Science , vol.258 , pp. 607-614
    • Nishizuka, Y.1
  • 39
    • 0035503969 scopus 로고    scopus 로고
    • Human acyl-coa:Diacylglycerol acyltransferase is a tetrameric protein
    • 11672446 1:CAS:528:DC%2BD3MXovVSisbc%3D 10.1042/0264-6021:3590707
    • Cheng D, Meegalla RL, He B, Cromley DA, Billheimer JT, Young PR. Human acyl-coa:Diacylglycerol acyltransferase is a tetrameric protein. Biochem J. 2001;359:707-14.
    • (2001) Biochem J , vol.359 , pp. 707-714
    • Cheng, D.1    Meegalla, R.L.2    He, B.3    Cromley, D.A.4    Billheimer, J.T.5    Young, P.R.6
  • 40
    • 0035914356 scopus 로고    scopus 로고
    • Cloning of dgat2, a second mammalian diacylglycerol acyltransferase, and related family members
    • 11481335 1:CAS:528:DC%2BD3MXnvVenur8%3D 10.1074/jbc.M106219200
    • Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, et al. Cloning of dgat2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001;276:38870-6.
    • (2001) J Biol Chem , vol.276 , pp. 38870-38876
    • Cases, S.1    Stone, S.J.2    Zhou, P.3    Yen, E.4    Tow, B.5    Lardizabal, K.D.6
  • 41
    • 73649094432 scopus 로고    scopus 로고
    • Dgat1 expression increases heart triglyceride content but ameliorates lipotoxicity
    • 19778901 1:CAS:528:DC%2BD1MXhsFyiurvI 10.1074/jbc.M109.049817
    • Liu L, Shi X, Bharadwaj KG, Ikeda S, Yamashita H, Yagyu H, et al. Dgat1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem. 2009;284:36312-23.
    • (2009) J Biol Chem , vol.284 , pp. 36312-36323
    • Liu, L.1    Shi, X.2    Bharadwaj, K.G.3    Ikeda, S.4    Yamashita, H.5    Yagyu, H.6
  • 42
    • 0037067721 scopus 로고    scopus 로고
    • Dgat1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis
    • 11959864 1:CAS:528:DC%2BD38XlsVWhsL4%3D 10.1074/jbc.M202013200
    • Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp Jr FF, et al. Dgat1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J Biol Chem. 2002;277:25474-9.
    • (2002) J Biol Chem , vol.277 , pp. 25474-25479
    • Buhman, K.K.1    Smith, S.J.2    Stone, S.J.3    Repa, J.J.4    Wong, J.S.5    Knapp, Jr.F.F.6
  • 43
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat
    • 10802663 1:CAS:528:DC%2BD3cXjtFSlt78%3D 10.1038/75651
    • Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat. Nat Genet. 2000;25:87-90.
    • (2000) Nat Genet , vol.25 , pp. 87-90
    • Smith, S.J.1    Cases, S.2    Jensen, D.R.3    Chen, H.C.4    Sande, E.5    Tow, B.6
  • 44
    • 0035064965 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome
    • 11307864 1:STN:280:DC%2BD3M3jvVSrsw%3D%3D 10.1097/00000441-200104000- 00003
    • Alpert MA. Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome. Am J Med Sci. 2001;321:225-36.
    • (2001) Am J Med Sci , vol.321 , pp. 225-236
    • Alpert, M.A.1
  • 45
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • 17592090 10.1161/CIRCULATIONAHA.106.679597
    • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation. 2007;115:3213-23.
    • (2007) Circulation , vol.115 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 46
    • 7744234747 scopus 로고    scopus 로고
    • Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
    • 15522914 1:CAS:528:DC%2BD2cXpslGrsrc%3D 10.1096/fj.04-2263com
    • Sharma S, Adrogue JV, Golfman L, Uray I, Lemm J, Youker K, et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J. 2004;18:1692-700.
    • (2004) FASEB J , vol.18 , pp. 1692-1700
    • Sharma, S.1    Adrogue, J.V.2    Golfman, L.3    Uray, I.4    Lemm, J.5    Youker, K.6
  • 47
    • 31644445201 scopus 로고    scopus 로고
    • Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus
    • 16458143 1:CAS:528:DC%2BD28XhtVGjsLg%3D 10.1016/j.jacc.2005.09.030
    • Herrero P, Peterson LR, McGill JB, Matthew S, Lesniak D, Dence C, et al. Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. J Am Coll Cardiol. 2006;47:598-604.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 598-604
    • Herrero, P.1    Peterson, L.R.2    McGill, J.B.3    Matthew, S.4    Lesniak, D.5    Dence, C.6
  • 48
    • 34548385838 scopus 로고    scopus 로고
    • Cardiac steatosis in diabetes mellitus: A 1 h-magnetic resonance spectroscopy study
    • 17698735 10.1161/CIRCULATIONAHA.106.645614
    • McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, et al. Cardiac steatosis in diabetes mellitus: A 1 h-magnetic resonance spectroscopy study. Circulation. 2007;116:1170-5.
    • (2007) Circulation , vol.116 , pp. 1170-1175
    • McGavock, J.M.1    Lingvay, I.2    Zib, I.3    Tillery, T.4    Salas, N.5    Unger, R.6
  • 49
    • 39149097521 scopus 로고    scopus 로고
    • The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover
    • 18155232 10.1016/j.yjmcc.2007.11.006 1:CAS:528:DC%2BD1cXitVehsLw%3D
    • O'Donnell JM, Fields AD, Sorokina N, Lewandowski ED. The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover. J Mol Cell Cardiol. 2008;44:315-22.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 315-322
    • O'Donnell, J.M.1    Fields, A.D.2    Sorokina, N.3    Lewandowski, E.D.4
  • 50
    • 84867073668 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity
    • 22932257 1:CAS:528:DC%2BC38XhsVGiu7jJ 10.1161/CIRCULATIONAHA.111.075978 This paper shows the importance of fatty acid oxidation in preventing cardiac hypertrophy driven by severe pressure overload and indicates caution that the clinical use of fatty acid oxidation inhibitors should be applied with
    • • He L, Kim T, Long Q, Liu J, Wang P, Zhou Y, et al. Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation. 2012;126:1705-16. This paper shows the importance of fatty acid oxidation in preventing cardiac hypertrophy driven by severe pressure overload and indicates caution that the clinical use of fatty acid oxidation inhibitors should be applied with.
    • (2012) Circulation , vol.126 , pp. 1705-1716
    • He, L.1    Kim, T.2    Long, Q.3    Liu, J.4    Wang, P.5    Zhou, Y.6
  • 51
    • 84865863479 scopus 로고    scopus 로고
    • Cardiac-specific deletion of acetyl coa carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy
    • 22730442 1:CAS:528:DC%2BC38Xht1OgtL7O 10.1161/CIRCRESAHA.112.268128 This paper shows that ablation of the ACC2 enzyme that regulates the formation of a fatty acid oxidation inhibitor, malonyl-CoA, improves fatty acid oxidation in pressure-overload hearts and leads to attenuation of cardiac hypertrophy with a significant reduction in fibrosis
    • • Kolwicz Jr SC, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R. Cardiac-specific deletion of acetyl coa carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res. 2012;111:728-38. This paper shows that ablation of the ACC2 enzyme that regulates the formation of a fatty acid oxidation inhibitor, malonyl-CoA, improves fatty acid oxidation in pressure-overload hearts and leads to attenuation of cardiac hypertrophy with a significant reduction in fibrosis.
    • (2012) Circ Res , vol.111 , pp. 728-738
    • Kolwicz, Jr.S.C.1    Olson, D.P.2    Marney, L.C.3    Garcia-Menendez, L.4    Synovec, R.E.5    Tian, R.6
  • 52
    • 49849093637 scopus 로고    scopus 로고
    • Reduced heart size and increased myocardial fuel substrate oxidation in acc2 mutant mice
    • 18487439 1:CAS:528:DC%2BD1cXoslygu7o%3D 10.1152/ajpheart.91489.2007
    • Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, et al. Reduced heart size and increased myocardial fuel substrate oxidation in acc2 mutant mice. Am J Physiol Heart Circ Physiol. 2008;295:H256-65.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Essop, M.F.1    Camp, H.S.2    Choi, C.S.3    Sharma, S.4    Fryer, R.M.5    Reinhart, G.A.6
  • 53
    • 0026746428 scopus 로고
    • Metabolically-modulated growth and phenotype of the rat heart
    • 1396861 1:CAS:528:DyaK3sXpvFeksw%3D%3D 10.1093/eurheartj/13.suppl-D.56
    • Rupp H, Jacob R. Metabolically-modulated growth and phenotype of the rat heart. Eur Heart J. 1992;13(Suppl D):56-61.
    • (1992) Eur Heart J , vol.13 , Issue.SUPPL. D , pp. 56-61
    • Rupp, H.1    Jacob, R.2
  • 54
    • 0034638797 scopus 로고    scopus 로고
    • Etomoxir: A new approach to treatment of chronic heart failure
    • 11089814 1:STN:280:DC%2BD3M%2FltlOltg%3D%3D 10.1016/S0140-6736(00)03149-4
    • Bristow M. Etomoxir: A new approach to treatment of chronic heart failure. Lancet. 2000;356:1621-2.
    • (2000) Lancet , vol.356 , pp. 1621-1622
    • Bristow, M.1
  • 55
    • 0035149738 scopus 로고    scopus 로고
    • Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    • 11147777 1:CAS:528:DC%2BD3MXis1Omsw%3D%3D 10.2337/diabetes.50.1.123
    • Dobbins RL, Szczepaniak LS, Bentley B, Esser V, Myhill J, McGarry JD. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes. 2001;50:123-30.
    • (2001) Diabetes , vol.50 , pp. 123-130
    • Dobbins, R.L.1    Szczepaniak, L.S.2    Bentley, B.3    Esser, V.4    Myhill, J.5    McGarry, J.D.6
  • 56
    • 0034652225 scopus 로고    scopus 로고
    • Lipotoxic heart disease in obese rats: Implications for human obesity
    • 10677535 1:CAS:528:DC%2BD3cXhsFCrt7Y%3D 10.1073/pnas.97.4.1784
    • Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, et al. Lipotoxic heart disease in obese rats: Implications for human obesity. Proc Natl Acad Sci U S A. 2000;97:1784-9.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1784-1789
    • Zhou, Y.T.1    Grayburn, P.2    Karim, A.3    Shimabukuro, M.4    Higa, M.5    Baetens, D.6
  • 57
    • 18044389144 scopus 로고    scopus 로고
    • Impact of altered substrate utilization on cardiac function in isolated hearts from zucker diabetic fatty rats
    • 15615844 1:CAS:528:DC%2BD2MXktlShtr0%3D 10.1152/ajpheart.00935.2004
    • Wang P, Lloyd SG, Zeng H, Bonen A, Chatham JC. Impact of altered substrate utilization on cardiac function in isolated hearts from zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol. 2005;288:H2102-10.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Wang, P.1    Lloyd, S.G.2    Zeng, H.3    Bonen, A.4    Chatham, J.C.5
  • 58
    • 27844457564 scopus 로고    scopus 로고
    • Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
    • 16141388 1:CAS:528:DC%2BD2MXht1OgurrI 10.1210/en.2005-0938
    • Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, et al. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology. 2005;146:5341-9.
    • (2005) Endocrinology , vol.146 , pp. 5341-5349
    • Buchanan, J.1    Mazumder, P.K.2    Hu, P.3    Chakrabarti, G.4    Roberts, M.W.5    Yun, U.J.6
  • 59
    • 35848965708 scopus 로고    scopus 로고
    • Cd36 expression contributes to age-induced cardiomyopathy in mice
    • 17967771 1:CAS:528:DC%2BD2sXht1elsrnM 10.1161/CIRCULATIONAHA.107.712901
    • Koonen DP, Febbraio M, Bonnet S, Nagendran J, Young ME, Michelakis ED, et al. Cd36 expression contributes to age-induced cardiomyopathy in mice. Circulation. 2007;116:2139-47.
    • (2007) Circulation , vol.116 , pp. 2139-2147
    • Koonen, D.P.1    Febbraio, M.2    Bonnet, S.3    Nagendran, J.4    Young, M.E.5    Michelakis, E.D.6
  • 60
    • 0035061419 scopus 로고    scopus 로고
    • A novel mouse model of lipotoxic cardiomyopathy
    • 11285300 1:CAS:528:DC%2BD3MXisFWhsbc%3D 10.1172/JCI10947
    • Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, et al. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001;107:813-22.
    • (2001) J Clin Invest , vol.107 , pp. 813-822
    • Chiu, H.C.1    Kovacs, A.2    Ford, D.A.3    Hsu, F.F.4    Garcia, R.5    Herrero, P.6
  • 61
    • 13444268937 scopus 로고    scopus 로고
    • Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    • 15618539 1:CAS:528:DC%2BD2MXnt1ensQ%3D%3D 10.1161/01.RES.0000154079. 20681.B9
    • Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res. 2005;96:225-33.
    • (2005) Circ Res , vol.96 , pp. 225-233
    • Chiu, H.C.1    Kovacs, A.2    Blanton, R.M.3    Han, X.4    Courtois, M.5    Weinheimer, C.J.6
  • 62
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by pparalpha overexpression mimics that caused by diabetes mellitus
    • 11781357 1:CAS:528:DC%2BD38XjtlarsQ%3D%3D
    • Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, et al. The cardiac phenotype induced by pparalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002;109:121-30.
    • (2002) J Clin Invest , vol.109 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3    Welch, M.J.4    Bennett, M.J.5    Kovacs, A.6
  • 63
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for pparalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • 12552126 1:CAS:528:DC%2BD3sXhtF2gtbw%3D 10.1073/pnas.0336724100
    • Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, et al. A critical role for pparalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content. Proc Natl Acad Sci U S A. 2003;100:1226-31.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6
  • 64
    • 76649123086 scopus 로고    scopus 로고
    • Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators
    • 20065164 1:CAS:528:DC%2BC3cXlvFajsA%3D%3D 10.1161/CIRCULATIONAHA.109. 888735
    • Duncan JG, Bharadwaj KG, Fong JL, Mitra R, Sambandam N, Courtois MR, et al. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010;121:426-35.
    • (2010) Circulation , vol.121 , pp. 426-435
    • Duncan, J.G.1    Bharadwaj, K.G.2    Fong, J.L.3    Mitra, R.4    Sambandam, N.5    Courtois, M.R.6
  • 65
    • 34948910262 scopus 로고    scopus 로고
    • Cardiomyocyte expression of ppargamma leads to cardiac dysfunction in mice
    • 17823655 1:CAS:528:DC%2BD2sXhtFCnt73P 10.1172/JCI30335
    • Son NH, Park TS, Yamashita H, Yokoyama M, Huggins LA, Okajima K, et al. Cardiomyocyte expression of ppargamma leads to cardiac dysfunction in mice. J Clin Invest. 2007;117:2791-801.
    • (2007) J Clin Invest , vol.117 , pp. 2791-2801
    • Son, N.H.1    Park, T.S.2    Yamashita, H.3    Yokoyama, M.4    Huggins, L.A.5    Okajima, K.6
  • 66
    • 77957846150 scopus 로고    scopus 로고
    • Ppargamma-induced cardiolipotoxicity in mice is ameliorated by pparalpha deficiency despite increases in fatty acid oxidation
    • 20852389 1:CAS:528:DC%2BC3cXht1GgtLbO 10.1172/JCI40905
    • Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, et al. Ppargamma-induced cardiolipotoxicity in mice is ameliorated by pparalpha deficiency despite increases in fatty acid oxidation. J Clin Invest. 2010;120:3443-54.
    • (2010) J Clin Invest , vol.120 , pp. 3443-3454
    • Son, N.H.1    Yu, S.2    Tuinei, J.3    Arai, K.4    Hamai, H.5    Homma, S.6
  • 67
    • 0033512660 scopus 로고    scopus 로고
    • Fatty acid oxidation in the reperfused ischemic heart
    • 10408755 1:STN:280:DyaK1MzjsFansg%3D%3D 10.1097/00000441-199907000-00002
    • Kantor PF, Dyck JR, Lopaschuk GD. Fatty acid oxidation in the reperfused ischemic heart. Am J Med Sci. 1999;318:3-14.
    • (1999) Am J Med Sci , vol.318 , pp. 3-14
    • Kantor, P.F.1    Dyck, J.R.2    Lopaschuk, G.D.3
  • 68
    • 0037324942 scopus 로고    scopus 로고
    • Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle
    • 12594240
    • Nohammer C, Brunner F, Wolkart G, Staber PB, Steyrer E, Gonzalez FJ, et al. Myocardial dysfunction and male mortality in peroxisome proliferator- activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle. Lab Invest. 2003;83:259-69.
    • (2003) Lab Invest , vol.83 , pp. 259-269
    • Nohammer, C.1    Brunner, F.2    Wolkart, G.3    Staber, P.B.4    Steyrer, E.5    Gonzalez, F.J.6
  • 69
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • 15475963 1:CAS:528:DC%2BD2cXptVOgsbo%3D 10.1038/nm1116
    • Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004;10:1245-50.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5    He, N.6
  • 70
    • 36849068108 scopus 로고    scopus 로고
    • Nuclear receptors pparbeta/delta and pparalpha direct distinct metabolic regulatory programs in the mouse heart
    • 18037994 1:CAS:528:DC%2BD2sXhsValsLzM
    • Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, et al. Nuclear receptors pparbeta/delta and pparalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007;117:3930-9.
    • (2007) J Clin Invest , vol.117 , pp. 3930-3939
    • Burkart, E.M.1    Sambandam, N.2    Han, X.3    Gross, R.W.4    Courtois, M.5    Gierasch, C.M.6
  • 71
    • 77953810264 scopus 로고    scopus 로고
    • Induction of cardiac angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    • 20378851 1:CAS:528:DC%2BC3cXnt1yrtrY%3D 10.1161/CIRCRESAHA.110.217380
    • Georgiadi A, Lichtenstein L, Degenhardt T, Boekschoten MV, van Bilsen M, Desvergne B, et al. Induction of cardiac angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. Circ Res. 2010;106:1712-21.
    • (2010) Circ Res , vol.106 , pp. 1712-1721
    • Georgiadi, A.1    Lichtenstein, L.2    Degenhardt, T.3    Boekschoten, M.V.4    Van Bilsen, M.5    Desvergne, B.6
  • 72
    • 80052454265 scopus 로고    scopus 로고
    • Atgl-mediated fat catabolism regulates cardiac mitochondrial function via ppar-alpha and pgc-1
    • 21857651 1:CAS:528:DC%2BC3MXhtVGksr%2FP 10.1038/nm.2439 This paper shows that fatty acids that are released via ATGL-mediated lipolysis of cardiac triglycerides are essential for PPARα activation and fatty acid oxidation
    • •• Haemmerle G, Moustafa T, Woelkart G, Buttner S, Schmidt A, van de Weijer T, et al. Atgl-mediated fat catabolism regulates cardiac mitochondrial function via ppar-alpha and pgc-1. Nat Med. 2011;17:1076-85. This paper shows that fatty acids that are released via ATGL-mediated lipolysis of cardiac triglycerides are essential for PPARα activation and fatty acid oxidation.
    • (2011) Nat Med , vol.17 , pp. 1076-1085
    • Haemmerle, G.1    Moustafa, T.2    Woelkart, G.3    Buttner, S.4    Schmidt, A.5    Van De Weijer, T.6
  • 73
    • 12944335303 scopus 로고    scopus 로고
    • Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
    • 10639158 1:CAS:528:DC%2BD3cXot1ansQ%3D%3D 10.1073/pnas.97.2.787
    • Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, et al. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci U S A. 2000;97:787-92.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 787-792
    • Osuga, J.1    Ishibashi, S.2    Oka, T.3    Yagyu, H.4    Tozawa, R.5    Fujimoto, A.6
  • 74
  • 75
    • 0033840188 scopus 로고    scopus 로고
    • Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes
    • 10731449 1:CAS:528:DC%2BD3cXhvFWnt70%3D 10.1006/jmcc.1999.1098
    • Hickson-Bick DL, Buja ML, McMillin JB. Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes. J Mol Cell Cardiol. 2000;32:511-9.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 511-519
    • Hickson-Bick, D.L.1    Buja, M.L.2    McMillin, J.B.3
  • 77
    • 0030755002 scopus 로고    scopus 로고
    • Human and murine serine-palmitoyl-coa transferase-cloning, expression and characterization of the key enzyme in sphingolipid synthesis
    • 9363775 1:CAS:528:DyaK2sXmvVKnurs%3D 10.1111/j.1432-1033.1997.00239.x
    • Weiss B, Stoffel W. Human and murine serine-palmitoyl-coa transferase-cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem. 1997;249:239-47.
    • (1997) Eur J Biochem , vol.249 , pp. 239-247
    • Weiss, B.1    Stoffel, W.2
  • 78
    • 0032484132 scopus 로고    scopus 로고
    • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
    • 9829981 1:CAS:528:DyaK1cXnvFOntrs%3D 10.1074/jbc.273.49.32487
    • Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem. 1998;273:32487-90.
    • (1998) J Biol Chem , vol.273 , pp. 32487-32490
    • Shimabukuro, M.1    Higa, M.2    Zhou, Y.T.3    Wang, M.Y.4    Newgard, C.B.5    Unger, R.H.6
  • 79
    • 0037135536 scopus 로고    scopus 로고
    • De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway
    • 12011104 1:CAS:528:DC%2BD38XlsFKrsrc%3D 10.1074/jbc.R200009200
    • Merrill Jr AH. De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway. J Biol Chem. 2002;277:25843-6.
    • (2002) J Biol Chem , vol.277 , pp. 25843-25846
    • Merrill, Jr.A.H.1
  • 80
    • 0028287960 scopus 로고
    • Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
    • 8046331 1:CAS:528:DyaK2cXltVeit70%3D 10.1084/jem.180.2.525
    • Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med. 1994;180:525-35.
    • (1994) J Exp Med , vol.180 , pp. 525-535
    • Haimovitz-Friedman, A.1    Kan, C.C.2    Ehleiter, D.3    Persaud, R.S.4    McLoughlin, M.5    Fuks, Z.6
  • 81
    • 0031717105 scopus 로고    scopus 로고
    • The amp-activated/snf1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • 9759505 1:CAS:528:DyaK1cXlsFOmtr4%3D 10.1146/annurev.biochem.67.1.821
    • Hardie DG, Carling D, Carlson M. The amp-activated/snf1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu Rev Biochem. 1998;67:821-55.
    • (1998) Annu Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 82
    • 33745717084 scopus 로고    scopus 로고
    • Prolonged ampk activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
    • 16710744 1:CAS:528:DC%2BD28XptVegtL4%3D 10.1007/s11010-006-9140-8
    • Chabowski A, Momken I, Coort SL, Calles-Escandon J, Tandon NN, Glatz JF, et al. Prolonged ampk activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. Mol Cell Biochem. 2006;288:201-12.
    • (2006) Mol Cell Biochem , vol.288 , pp. 201-212
    • Chabowski, A.1    Momken, I.2    Coort, S.L.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.6
  • 83
    • 33847029897 scopus 로고    scopus 로고
    • Ampk-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal cd36
    • 17292863 1:CAS:528:DC%2BD2sXitFOmtb4%3D 10.1016/j.bbrc.2007.01.141
    • Habets DD, Coumans WA, Voshol PJ, den Boer MA, Febbraio M, Bonen A, et al. Ampk-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal cd36. Biochem Biophys Res Commun. 2007;355:204-10.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 204-210
    • Habets, D.D.1    Coumans, W.A.2    Voshol, P.J.3    Den Boer, M.A.4    Febbraio, M.5    Bonen, A.6
  • 84
    • 15444367538 scopus 로고    scopus 로고
    • Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoe-deficient mice
    • 15590644 1:CAS:528:DC%2BD2MXit1eku7k%3D 10.1074/jbc.M412348200
    • Hojjati MR, Li Z, Zhou H, Tang S, Huan C, Ooi E, et al. Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoe-deficient mice. J Biol Chem. 2005;280:10284-9.
    • (2005) J Biol Chem , vol.280 , pp. 10284-10289
    • Hojjati, M.R.1    Li, Z.2    Zhou, H.3    Tang, S.4    Huan, C.5    Ooi, E.6
  • 85
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • 11278654 1:CAS:528:DC%2BD3MXjs1Orsro%3D 10.1074/jbc.M010286200
    • Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem. 2001;276:14890-5.
    • (2001) J Biol Chem , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 86
    • 0036081875 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ros
    • 11788415 1:CAS:528:DC%2BD38XhtFCqt7s%3D
    • Hickson-Bick DL, Sparagna GC, Buja LM, McMillin JB. Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ros. Am J Physiol Heart Circ Physiol. 2002;282:H656-64.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Hickson-Bick, D.L.1    Sparagna, G.C.2    Buja, L.M.3    McMillin, J.B.4
  • 87
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and enos activities by increasing endothelial fatty acid oxidation
    • 16528409 1:CAS:528:DC%2BD28XjsVWnuro%3D 10.1172/JCI23354
    • Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and enos activities by increasing endothelial fatty acid oxidation. J Clin Invest. 2006;116:1071-80.
    • (2006) J Clin Invest , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3    Higham, N.4    Zou, M.H.5    Brownlee, M.6
  • 88
    • 33644672230 scopus 로고    scopus 로고
    • Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in c57bl/6 mice
    • 16306372 1:CAS:528:DC%2BD2MXht12gsL%2FM 10.2337/diabetes.54.12.3530
    • Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, et al. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in c57bl/6 mice. Diabetes. 2005;54:3530-40.
    • (2005) Diabetes , vol.54 , pp. 3530-3540
    • Park, S.Y.1    Cho, Y.R.2    Kim, H.J.3    Higashimori, T.4    Danton, C.5    Lee, M.K.6
  • 89
    • 0036788287 scopus 로고    scopus 로고
    • Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance
    • 12351442 1:CAS:528:DC%2BD38XnslGhs7c%3D 10.2337/diabetes.51.10.3020
    • Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG. Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. Diabetes. 2002;51:3020-4.
    • (2002) Diabetes , vol.51 , pp. 3020-3024
    • Iozzo, P.1    Chareonthaitawee, P.2    Dutka, D.3    Betteridge, D.J.4    Ferrannini, E.5    Camici, P.G.6
  • 90
    • 4344601004 scopus 로고    scopus 로고
    • Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts
    • 15331547 1:CAS:528:DC%2BD2cXns1Shs7g%3D 10.2337/diabetes.53.9.2366
    • Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, et al. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes. 2004;53:2366-74.
    • (2004) Diabetes , vol.53 , pp. 2366-2374
    • Mazumder, P.K.1    O'Neill, B.T.2    Roberts, M.W.3    Buchanan, J.4    Yun, U.J.5    Cooksey, R.C.6
  • 91
    • 0036326045 scopus 로고    scopus 로고
    • Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese zucker rat heart
    • 12145175 1:CAS:528:DC%2BD38XlvFKhsrY%3D 10.2337/diabetes.51.8.2587
    • Young ME, Guthrie PH, Razeghi P, Leighton B, Abbasi S, Patil S, et al. Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese zucker rat heart. Diabetes. 2002;51:2587-95.
    • (2002) Diabetes , vol.51 , pp. 2587-2595
    • Young, M.E.1    Guthrie, P.H.2    Razeghi, P.3    Leighton, B.4    Abbasi, S.5    Patil, S.6
  • 92
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • 16443782 1:CAS:528:DC%2BD28XhsFajsL0%3D 10.2337/diabetes.55.02.06.db05- 1164
    • How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes. 2006;55:466-73.
    • (2006) Diabetes , vol.55 , pp. 466-473
    • How, O.J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.4    Essop, M.F.5    Larsen, T.S.6
  • 93
    • 0033662461 scopus 로고    scopus 로고
    • Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice
    • 11052966 1:CAS:528:DC%2BD3cXotFaqsL4%3D
    • Belke DD, Larsen TS, Gibbs EM, Severson DL. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. Am J Physiol Endocrinol Metab. 2000;279:E1104-13.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Belke, D.D.1    Larsen, T.S.2    Gibbs, E.M.3    Severson, D.L.4
  • 94
    • 0036192939 scopus 로고    scopus 로고
    • Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
    • 11877471 1:CAS:528:DC%2BD38XitVeqtLs%3D
    • Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest. 2002;109:629-39.
    • (2002) J Clin Invest , vol.109 , pp. 629-639
    • Belke, D.D.1    Betuing, S.2    Tuttle, M.J.3    Graveleau, C.4    Young, M.E.5    Pham, M.6
  • 95
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • 16612386 1:CAS:528:DC%2BD28XjsVWktbw%3D 10.1038/nature04634
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 2006;440:944-8.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 96
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • 17339025 1:CAS:528:DC%2BD2sXjsF2qtL8%3D 10.1016/j.cmet.2007.01.002
    • Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007;5:167-79.
    • (2007) Cell Metab , vol.5 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3    Hawkins, E.D.4    Sargent, K.M.5    Liu, Y.6
  • 97
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter glut4 translocation and akt kinase activity by ceramide
    • 9710629 1:CAS:528:DyaK1cXls1Sgurg%3D
    • Summers SA, Garza LA, Zhou H, Birnbaum MJ. Regulation of insulin-stimulated glucose transporter glut4 translocation and akt kinase activity by ceramide. Mol Cell Biol. 1998;18:5457-64.
    • (1998) Mol Cell Biol , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 98
    • 0035133331 scopus 로고    scopus 로고
    • Ceramide impairs the insulin-dependent membrane recruitment of protein kinase b leading to a loss in downstream signalling in l6 skeletal muscle cells
    • 11270673 1:CAS:528:DC%2BD3MXntlSltQ%3D%3D 10.1007/s001250051596
    • Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, et al. Ceramide impairs the insulin-dependent membrane recruitment of protein kinase b leading to a loss in downstream signalling in l6 skeletal muscle cells. Diabetologia. 2001;44:173-83.
    • (2001) Diabetologia , vol.44 , pp. 173-183
    • Hajduch, E.1    Balendran, A.2    Batty, I.H.3    Litherland, G.J.4    Blair, A.S.5    Downes, C.P.6
  • 99
    • 0035513703 scopus 로고    scopus 로고
    • Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining akt in an inactive dephosphorylated state
    • 11679435 1:CAS:528:DC%2BD3MXotFGis7s%3D 10.2337/diabetes.50.11.2563
    • Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining akt in an inactive dephosphorylated state. Diabetes. 2001;50:2563-71.
    • (2001) Diabetes , vol.50 , pp. 2563-2571
    • Teruel, T.1    Hernandez, R.2    Lorenzo, M.3
  • 100
    • 4344614649 scopus 로고    scopus 로고
    • Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of akt/protein kinase b
    • 15220355 1:CAS:528:DC%2BD2cXmvFCms78%3D 10.1074/jbc.M406499200
    • Stratford S, Hoehn KL, Liu F, Summers SA. Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of akt/protein kinase b. J Biol Chem. 2004;279:36608-15.
    • (2004) J Biol Chem , vol.279 , pp. 36608-36615
    • Stratford, S.1    Hoehn, K.L.2    Liu, F.3    Summers, S.A.4
  • 101
    • 21244442275 scopus 로고    scopus 로고
    • Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
    • 15774472 1:CAS:528:DC%2BD2MXktFyksr8%3D 10.1074/jbc.M412769200
    • Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA. Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem. 2005;280:20148-53.
    • (2005) J Biol Chem , vol.280 , pp. 20148-20153
    • Chavez, J.A.1    Holland, W.L.2    Bar, J.3    Sandhoff, K.4    Summers, S.A.5
  • 102
    • 0031809427 scopus 로고    scopus 로고
    • Protein kinase c isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (hek 293 cells)
    • 9686926 1:CAS:528:DyaK1cXktFKkurs%3D 10.1007/s001250050995
    • Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Haring HU. Protein kinase c isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (hek 293 cells). Diabetologia. 1998;41:833-8.
    • (1998) Diabetologia , vol.41 , pp. 833-838
    • Kellerer, M.1    Mushack, J.2    Seffer, E.3    Mischak, H.4    Ullrich, A.5    Haring, H.U.6
  • 105
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (irs-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • 12006582 1:CAS:528:DC%2BD38Xps12gu7s%3D 10.1074/jbc.M200958200
    • Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (irs-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002;277:50230-6.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3    Zhang, D.4    Zong, H.5    Wang, Y.6
  • 106
    • 34547663520 scopus 로고    scopus 로고
    • Muscle-specific knockout of pkc-lambda impairs glucose transport and induces metabolic and diabetic syndromes
    • 17641777 1:CAS:528:DC%2BD2sXoslOnsL8%3D 10.1172/JCI31408
    • Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower Jr WR, et al. Muscle-specific knockout of pkc-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest. 2007;117:2289-301.
    • (2007) J Clin Invest , vol.117 , pp. 2289-2301
    • Farese, R.V.1    Sajan, M.P.2    Yang, H.3    Li, P.4    Mastorides, S.5    Gower, Jr.W.R.6
  • 107
    • 84862137804 scopus 로고    scopus 로고
    • Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
    • 22586279 1:CAS:528:DC%2BC38XosVGrsbo%3D 10.1161/CIRCULATIONAHA.111.060889
    • Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, et al. Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. Circulation. 2012;125:2844-53.
    • (2012) Circulation , vol.125 , pp. 2844-2853
    • Chokshi, A.1    Drosatos, K.2    Cheema, F.H.3    Ji, R.4    Khawaja, T.5    Yu, S.6
  • 108
    • 0036787393 scopus 로고    scopus 로고
    • Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of fat/cd36
    • 12351456 1:CAS:528:DC%2BD38XnslGhsb0%3D 10.2337/diabetes.51.10.3113
    • Luiken JJ, Koonen DP, Willems J, Zorzano A, Becker C, Fischer Y, et al. Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of fat/cd36. Diabetes. 2002;51:3113-9.
    • (2002) Diabetes , vol.51 , pp. 3113-3119
    • Luiken, J.J.1    Koonen, D.P.2    Willems, J.3    Zorzano, A.4    Becker, C.5    Fischer, Y.6
  • 109
    • 17144428529 scopus 로고    scopus 로고
    • Foxo1 stimulates fatty acid uptake and oxidation in muscle cells through cd36-dependent and -independent mechanisms
    • 15691844 1:CAS:528:DC%2BD2MXivV2rsbw%3D 10.1074/jbc.M413625200
    • Bastie CC, Nahle Z, McLoughlin T, Esser K, Zhang W, Unterman T, et al. Foxo1 stimulates fatty acid uptake and oxidation in muscle cells through cd36-dependent and -independent mechanisms. J Biol Chem. 2005;280:14222-9.
    • (2005) J Biol Chem , vol.280 , pp. 14222-14229
    • Bastie, C.C.1    Nahle, Z.2    McLoughlin, T.3    Esser, K.4    Zhang, W.5    Unterman, T.6
  • 110
    • 0029060391 scopus 로고
    • Protein kinase c and lipid signaling for sustained cellular responses
    • 7737456 1:CAS:528:DyaK2MXlsVOqurk%3D
    • Nishizuka Y. Protein kinase c and lipid signaling for sustained cellular responses. FASEB J. 1995;9:484-96.
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 111
    • 0141918802 scopus 로고    scopus 로고
    • Ceramide induces translocation of protein kinase c-alpha to the golgi compartment of human embryonic kidney cells by interacting with the c2 domain
    • 14563411 1:CAS:528:DC%2BD3sXotVCmtbo%3D 10.1016/j.bbalip.2003.08.004
    • Aschrafi A, Franzen R, Shabahang S, Fabbro D, Pfeilschifter J, Huwiler A. Ceramide induces translocation of protein kinase c-alpha to the golgi compartment of human embryonic kidney cells by interacting with the c2 domain. Biochim Biophys Acta. 2003;1634:30-9.
    • (2003) Biochim Biophys Acta , vol.1634 , pp. 30-39
    • Aschrafi, A.1    Franzen, R.2    Shabahang, S.3    Fabbro, D.4    Pfeilschifter, J.5    Huwiler, A.6
  • 112
    • 0034634596 scopus 로고    scopus 로고
    • Ceramide directly activates protein kinase c zeta to regulate a stress-activated protein kinase signaling complex
    • 10962008 1:CAS:528:DC%2BD3cXotFehsrY%3D 10.1074/jbc.M007346200
    • Bourbon NA, Yun J, Kester M. Ceramide directly activates protein kinase c zeta to regulate a stress-activated protein kinase signaling complex. J Biol Chem. 2000;275:35617-23.
    • (2000) J Biol Chem , vol.275 , pp. 35617-35623
    • Bourbon, N.A.1    Yun, J.2    Kester, M.3
  • 113
    • 34250344614 scopus 로고    scopus 로고
    • Ceramide recruits and activates protein kinase c zeta (pkc zeta) within structured membrane microdomains
    • 17308302 1:CAS:528:DC%2BD2sXksVSjtbw%3D 10.1074/jbc.M700082200
    • Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, et al. Ceramide recruits and activates protein kinase c zeta (pkc zeta) within structured membrane microdomains. J Biol Chem. 2007;282:12450-7.
    • (2007) J Biol Chem , vol.282 , pp. 12450-12457
    • Fox, T.E.1    Houck, K.L.2    O'Neill, S.M.3    Nagarajan, M.4    Stover, T.C.5    Pomianowski, P.T.6
  • 114
    • 0030846622 scopus 로고    scopus 로고
    • Ceramide-induced translocation of protein kinase c zeta in primary cultures of astrocytes
    • 9357981 1:CAS:528:DyaK2sXmsVKlt78%3D 10.1016/S0014-5793(97)00985-X
    • Galve-Roperh I, Haro A, Diaz-Laviada I. Ceramide-induced translocation of protein kinase c zeta in primary cultures of astrocytes. FEBS Lett. 1997;415:271-4.
    • (1997) FEBS Lett , vol.415 , pp. 271-274
    • Galve-Roperh, I.1    Haro, A.2    Diaz-Laviada, I.3
  • 115
    • 0032817224 scopus 로고    scopus 로고
    • Ceramides modulate protein kinase c activity and perturb the structure of phosphatidylcholine/phosphatidylserine bilayers
    • 10465759 1:CAS:528:DyaK1MXmtVamsrk%3D 10.1016/S0006-3495(99)76996-1
    • Huang HW, Goldberg EM, Zidovetzki R. Ceramides modulate protein kinase c activity and perturb the structure of phosphatidylcholine/phosphatidylserine bilayers. Biophys J. 1999;77:1489-97.
    • (1999) Biophys J , vol.77 , pp. 1489-1497
    • Huang, H.W.1    Goldberg, E.M.2    Zidovetzki, R.3
  • 116
    • 0032514649 scopus 로고    scopus 로고
    • Selective ceramide binding to protein kinase c-alpha and -delta isoenzymes in renal mesangial cells
    • 9772184 1:CAS:528:DyaK1cXmtF2hurc%3D 10.1021/bi981401i
    • Huwiler A, Fabbro D, Pfeilschifter J. Selective ceramide binding to protein kinase c-alpha and -delta isoenzymes in renal mesangial cells. Biochemistry. 1998;37:14556-62.
    • (1998) Biochemistry , vol.37 , pp. 14556-14562
    • Huwiler, A.1    Fabbro, D.2    Pfeilschifter, J.3
  • 117
    • 0035131424 scopus 로고    scopus 로고
    • Subtype-specific translocation of the delta subtype of protein kinase c and its activation by tyrosine phosphorylation induced by ceramide in hela cells
    • 11238914 1:CAS:528:DC%2BD3MXhtlGhsbg%3D 10.1128/MCB.21.5.1769-1783.2001
    • Kajimoto T, Ohmori S, Shirai Y, Sakai N, Saito N. Subtype-specific translocation of the delta subtype of protein kinase c and its activation by tyrosine phosphorylation induced by ceramide in hela cells. Mol Cell Biol. 2001;21:1769-83.
    • (2001) Mol Cell Biol , vol.21 , pp. 1769-1783
    • Kajimoto, T.1    Ohmori, S.2    Shirai, Y.3    Sakai, N.4    Saito, N.5
  • 118
    • 1842582001 scopus 로고    scopus 로고
    • Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase cdelta in the golgi complex
    • 14715667 1:CAS:528:DC%2BD2cXitl2gtrc%3D 10.1074/jbc.M312350200
    • Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, et al. Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase cdelta in the golgi complex. J Biol Chem. 2004;279:12668-76.
    • (2004) J Biol Chem , vol.279 , pp. 12668-12676
    • Kajimoto, T.1    Shirai, Y.2    Sakai, N.3    Yamamoto, T.4    Matsuzaki, H.5    Kikkawa, U.6
  • 119
    • 0142091454 scopus 로고    scopus 로고
    • Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase b (pkb)/akt by a pkczeta-dependent mechanism
    • 14560023 1:CAS:528:DC%2BD3sXosFOgt7k%3D 10.1128/MCB.23.21.7794-7808.2003
    • Powell DJ, Hajduch E, Kular G, Hundal HS. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase b (pkb)/akt by a pkczeta-dependent mechanism. Mol Cell Biol. 2003;23:7794-808.
    • (2003) Mol Cell Biol , vol.23 , pp. 7794-7808
    • Powell, D.J.1    Hajduch, E.2    Kular, G.3    Hundal, H.S.4
  • 120
    • 67649827252 scopus 로고    scopus 로고
    • The carboxyl-terminal domain of atypical protein kinase czeta binds to ceramide and regulates junction formation in epithelial cells
    • 19304661 1:CAS:528:DC%2BD1MXlvV2isrs%3D 10.1074/jbc.M808909200
    • Wang G, Krishnamurthy K, Umapathy NS, Verin AD, Bieberich E. The carboxyl-terminal domain of atypical protein kinase czeta binds to ceramide and regulates junction formation in epithelial cells. J Biol Chem. 2009;284:14469-75.
    • (2009) J Biol Chem , vol.284 , pp. 14469-14475
    • Wang, G.1    Krishnamurthy, K.2    Umapathy, N.S.3    Verin, A.D.4    Bieberich, E.5
  • 121
    • 22544468543 scopus 로고    scopus 로고
    • Direct binding to ceramide activates protein kinase czeta before the formation of a pro-apoptotic complex with par-4 in differentiating stem cells
    • 15901738 1:CAS:528:DC%2BD2MXlvFymur4%3D 10.1074/jbc.M501492200
    • Wang G, Silva J, Krishnamurthy K, Tran E, Condie BG, Bieberich E. Direct binding to ceramide activates protein kinase czeta before the formation of a pro-apoptotic complex with par-4 in differentiating stem cells. J Biol Chem. 2005;280:26415-24.
    • (2005) J Biol Chem , vol.280 , pp. 26415-26424
    • Wang, G.1    Silva, J.2    Krishnamurthy, K.3    Tran, E.4    Condie, B.G.5    Bieberich, E.6
  • 122
    • 0030875166 scopus 로고    scopus 로고
    • Targeted overexpression of protein kinase c beta2 isoform in myocardium causes cardiomyopathy
    • 9256480 1:CAS:528:DyaK2sXls1Klsb0%3D 10.1073/pnas.94.17.9320
    • Wakasaki H, Koya D, Schoen FJ, Jirousek MR, Ways DK, Hoit BD, et al. Targeted overexpression of protein kinase c beta2 isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A. 1997;94:9320-5.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9320-9325
    • Wakasaki, H.1    Koya, D.2    Schoen, F.J.3    Jirousek, M.R.4    Ways, D.K.5    Hoit, B.D.6
  • 123
    • 0037312560 scopus 로고    scopus 로고
    • Increased translocation of cardiac protein kinase c beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat
    • 12566467 1:CAS:528:DC%2BD3sXhtV2ntL8%3D
    • Jalili T, Manning J, Kim S. Increased translocation of cardiac protein kinase c beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat. J Nutr. 2003;133:358-61.
    • (2003) J Nutr , vol.133 , pp. 358-361
    • Jalili, T.1    Manning, J.2    Kim, S.3
  • 124
    • 0038104862 scopus 로고    scopus 로고
    • Increased expression of protein kinase c isoforms in heart failure due to myocardial infarction
    • 12742831 1:CAS:528:DC%2BD3sXltVehsb4%3D
    • Wang J, Liu X, Sentex E, Takeda N, Dhalla NS. Increased expression of protein kinase c isoforms in heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol. 2003;284:H2277-87.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Wang, J.1    Liu, X.2    Sentex, E.3    Takeda, N.4    Dhalla, N.S.5
  • 125
    • 34547578672 scopus 로고    scopus 로고
    • Augmented protein kinase c-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure
    • 17556659 1:CAS:528:DC%2BD2sXns1Cmsb0%3D 10.1161/CIRCRESAHA.107.148288
    • Belin RJ, Sumandea MP, Allen EJ, Schoenfelt K, Wang H, Solaro RJ, et al. Augmented protein kinase c-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res. 2007;101:195-204.
    • (2007) Circ Res , vol.101 , pp. 195-204
    • Belin, R.J.1    Sumandea, M.P.2    Allen, E.J.3    Schoenfelt, K.4    Wang, H.5    Solaro, R.J.6
  • 126
    • 0032061108 scopus 로고    scopus 로고
    • Adenosine a1 receptor stimulation antagonizes the negative inotropic effects of the pkc activator dioctanoylglycerol
    • 9618232 1:CAS:528:DyaK1cXjslOmtbY%3D 10.1006/jmcc.1998.0648
    • Narayan P, Valdivia HH, Mentzer Jr RM, Lasley RD. Adenosine a1 receptor stimulation antagonizes the negative inotropic effects of the pkc activator dioctanoylglycerol. J Mol Cell Cardiol. 1998;30:913-21.
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 913-921
    • Narayan, P.1    Valdivia, H.H.2    Mentzer, Jr.R.M.3    Lasley, R.D.4
  • 127
    • 77953654365 scopus 로고    scopus 로고
    • Inhibition of protein kinase c-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy
    • 19808328 1:CAS:528:DC%2BD1MXivVelt70%3D 10.1161/CIRCHEARTFAILURE.108. 765750
    • Connelly KA, Kelly DJ, Zhang Y, Prior DL, Advani A, Cox AJ, et al. Inhibition of protein kinase c-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy. Circ Heart Fail. 2009;2:129-37.
    • (2009) Circ Heart Fail , vol.2 , pp. 129-137
    • Connelly, K.A.1    Kelly, D.J.2    Zhang, Y.3    Prior, D.L.4    Advani, A.5    Cox, A.J.6
  • 128
    • 68049086486 scopus 로고    scopus 로고
    • Protein kinase c{alpha}, but not pkc{beta} or pkc{gamma}, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach
    • 19556521 1:CAS:528:DC%2BD1MXot1ektLg%3D 10.1161/CIRCRESAHA.109.195313
    • Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, et al. Protein kinase c{alpha}, but not pkc{beta} or pkc{gamma}, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach. Circ Res. 2009;105:194-200.
    • (2009) Circ Res , vol.105 , pp. 194-200
    • Liu, Q.1    Chen, X.2    Macdonnell, S.M.3    Kranias, E.G.4    Lorenz, J.N.5    Leitges, M.6
  • 129
    • 1642388834 scopus 로고    scopus 로고
    • Pkc-alpha regulates cardiac contractility and propensity toward heart failure
    • 14966518 1:CAS:528:DC%2BD2cXhs1Wntbk%3D 10.1038/nm1000
    • Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, et al. Pkc-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004;10:248-54.
    • (2004) Nat Med , vol.10 , pp. 248-254
    • Braz, J.C.1    Gregory, K.2    Pathak, A.3    Zhao, W.4    Sahin, B.5    Klevitsky, R.6
  • 130
    • 33746799599 scopus 로고    scopus 로고
    • Pharmacological- and gene therapy-based inhibition of protein kinase calpha/beta enhances cardiac contractility and attenuates heart failure
    • 16880328 1:CAS:528:DC%2BD28Xns1Snu78%3D 10.1161/CIRCULATIONAHA.105.592550
    • Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, et al. Pharmacological- and gene therapy-based inhibition of protein kinase calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation. 2006;114:574-82.
    • (2006) Circulation , vol.114 , pp. 574-582
    • Hambleton, M.1    Hahn, H.2    Pleger, S.T.3    Kuhn, M.C.4    Klevitsky, R.5    Carr, A.N.6
  • 131
    • 22244487289 scopus 로고    scopus 로고
    • Inhibition of protein kinase c reduces left ventricular fibrosis and dysfunction following myocardial infarction
    • 15878171 1:CAS:528:DC%2BD2MXmsVOrtrk%3D 10.1016/j.yjmcc.2005.03.008
    • Boyle AJ, Kelly DJ, Zhang Y, Cox AJ, Gow RM, Way K, et al. Inhibition of protein kinase c reduces left ventricular fibrosis and dysfunction following myocardial infarction. J Mol Cell Cardiol. 2005;39:213-21.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 213-221
    • Boyle, A.J.1    Kelly, D.J.2    Zhang, Y.3    Cox, A.J.4    Gow, R.M.5    Way, K.6
  • 132
    • 0030815973 scopus 로고    scopus 로고
    • Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese zucker rats
    • 9252480 1:CAS:528:DyaK2sXlt1SrsLw%3D
    • Kolter T, Uphues I, Eckel J. Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese zucker rats. Am J Physiol. 1997;273:E59-67.
    • (1997) Am J Physiol , vol.273
    • Kolter, T.1    Uphues, I.2    Eckel, J.3
  • 133
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • 15486293 10.1126/science.1103160 1:CAS:528:DC%2BD2cXotlCkt7Y%3D
    • Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004;306:457-61.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 134
    • 78751632066 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin a/c gene
    • 21173351 1:CAS:528:DC%2BC3MXhs1yjuw%3D%3D 10.1161/CIRCULATIONAHA.110. 970673
    • Wu W, Muchir A, Shan J, Bonne G, Worman HJ. Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin a/c gene. Circulation. 2011;123:53-61.
    • (2011) Circulation , vol.123 , pp. 53-61
    • Wu, W.1    Muchir, A.2    Shan, J.3    Bonne, G.4    Worman, H.J.5
  • 135
    • 0037423550 scopus 로고    scopus 로고
    • Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-jun nh2-terminal kinase-dependent activation of the mitochondrial pathway
    • 12574140 1:CAS:528:DC%2BD3sXot1Khsw%3D%3D 10.1161/01.RES.0000054624. 03539.B4
    • Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, et al. Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-jun nh2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res. 2003;92:136-8.
    • (2003) Circ Res , vol.92 , pp. 136-138
    • Remondino, A.1    Kwon, S.H.2    Communal, C.3    Pimentel, D.R.4    Sawyer, D.B.5    Singh, K.6
  • 136
    • 0037155837 scopus 로고    scopus 로고
    • Direct activation of mitochondrial apoptosis machinery by c-jun n-terminal kinase in adult cardiac myocytes
    • 11786558 1:CAS:528:DC%2BD38XisVyltbs%3D 10.1074/jbc.M112355200
    • Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, Matsuzaki M, et al. Direct activation of mitochondrial apoptosis machinery by c-jun n-terminal kinase in adult cardiac myocytes. J Biol Chem. 2002;277:10244-50.
    • (2002) J Biol Chem , vol.277 , pp. 10244-10250
    • Aoki, H.1    Kang, P.M.2    Hampe, J.3    Yoshimura, K.4    Noma, T.5    Matsuzaki, M.6
  • 138
    • 0035065271 scopus 로고    scopus 로고
    • Inhibition of c-jun n-terminal kinase 1, but not c-jun n-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes
    • 11259632 1:CAS:528:DC%2BD3MXisVSqs7k%3D
    • Hreniuk D, Garay M, Gaarde W, Monia BP, McKay RA, Cioffi CL. Inhibition of c-jun n-terminal kinase 1, but not c-jun n-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol. 2001;59:867-74.
    • (2001) Mol Pharmacol , vol.59 , pp. 867-874
    • Hreniuk, D.1    Garay, M.2    Gaarde, W.3    Monia, B.P.4    McKay, R.A.5    Cioffi, C.L.6
  • 139
    • 80054694121 scopus 로고    scopus 로고
    • Inhibition of c-jun-n-terminal kinase increases cardiac ppar{alpha} expression and fatty acid oxidation and prevents lps-induced heart dysfunction
    • 21873422 1:CAS:528:DC%2BC3MXhtlSqt7fK 10.1074/jbc.M111.272146
    • Drosatos K, Drosatos-Tampakaki Z, Khan R, Homma S, Schulze PC, Zannis VI, et al. Inhibition of c-jun-n-terminal kinase increases cardiac ppar{alpha} expression and fatty acid oxidation and prevents lps-induced heart dysfunction. J Biol Chem. 2011;286:36331-9.
    • (2011) J Biol Chem , vol.286 , pp. 36331-36339
    • Drosatos, K.1    Drosatos-Tampakaki, Z.2    Khan, R.3    Homma, S.4    Schulze, P.C.5    Zannis, V.I.6
  • 140
    • 52649094346 scopus 로고    scopus 로고
    • Reduction of jnk1 expression with antisense oligonucleotide improves adiposity in obese mice
    • 18523126 1:CAS:528:DC%2BD1cXhtVaktrvJ 10.1152/ajpendo.00629.2007
    • Yu XX, Murray SF, Watts L, Booten SL, Tokorcheck J, Monia BP, et al. Reduction of jnk1 expression with antisense oligonucleotide improves adiposity in obese mice. Am J Physiol Endocrinol Metab. 2008;295:E436-45.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Yu, X.X.1    Murray, S.F.2    Watts, L.3    Booten, S.L.4    Tokorcheck, J.5    Monia, B.P.6
  • 141
    • 31944439780 scopus 로고    scopus 로고
    • A critical role for eukaryotic elongation factor 1a-1 in lipotoxic cell death
    • 16319173 1:CAS:528:DC%2BD28XhtlWru7w%3D 10.1091/mbc.E05-08-0742
    • Borradaile NM, Buhman KK, Listenberger LL, Magee CJ, Morimoto ET, Ory DS, et al. A critical role for eukaryotic elongation factor 1a-1 in lipotoxic cell death. Mol Biol Cell. 2006;17:770-8.
    • (2006) Mol Biol Cell , vol.17 , pp. 770-778
    • Borradaile, N.M.1    Buhman, K.K.2    Listenberger, L.L.3    Magee, C.J.4    Morimoto, E.T.5    Ory, D.S.6
  • 142
    • 33845575826 scopus 로고    scopus 로고
    • Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    • 16960261 1:CAS:528:DC%2BD28XhtlSit7fE 10.1194/jlr.M600299-JLR200
    • Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res. 2006;47:2726-37.
    • (2006) J Lipid Res , vol.47 , pp. 2726-2737
    • Borradaile, N.M.1    Han, X.2    Harp, J.D.3    Gale, S.E.4    Ory, D.S.5    Schaffer, J.E.6
  • 143
    • 3242772953 scopus 로고    scopus 로고
    • Fatty acyl coa-mediated inhibition of endoplasmic reticulum assembly
    • 15276319 1:CAS:528:DC%2BD2cXmtVSqtbo%3D 10.1016/j.bbamcr.2004.05.002
    • Turner MD. Fatty acyl coa-mediated inhibition of endoplasmic reticulum assembly. Biochim Biophys Acta. 2004;1693:1-4.
    • (2004) Biochim Biophys Acta , vol.1693 , pp. 1-4
    • Turner, M.D.1
  • 144
    • 80054732357 scopus 로고    scopus 로고
    • Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating er stress response
    • 21960749 10.7150/ijms.8.564
    • Song XJ, Yang CY, Liu B, Wei Q, Korkor MT, Liu JY, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating er stress response. Int J Med Sci. 2011;8:564-72.
    • (2011) Int J Med Sci , vol.8 , pp. 564-572
    • Song, X.J.1    Yang, C.Y.2    Liu, B.3    Wei, Q.4    Korkor, M.T.5    Liu, J.Y.6
  • 145
    • 22544462381 scopus 로고    scopus 로고
    • A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes
    • 16054054 1:CAS:528:DC%2BD2MXit12rtbs%3D 10.1016/j.cmet.2005.01.006
    • Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, et al. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. Cell Metab. 2005;1:133-44.
    • (2005) Cell Metab , vol.1 , pp. 133-144
    • Finck, B.N.1    Bernal-Mizrachi, C.2    Han, D.H.3    Coleman, T.4    Sambandam, N.5    Lariviere, L.L.6
  • 146
    • 0345735302 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    • 14684157 1:CAS:528:DC%2BD3sXpvVWmt7k%3D 10.1016/j.bbrc.2003.11.127
    • Cheng L, Ding G, Qin Q, Xiao Y, Woods D, Chen YE, et al. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun. 2004;313:277-86.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 277-286
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Xiao, Y.4    Woods, D.5    Chen, Y.E.6
  • 147
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by ppar gamma 2, a lipid-activated transcription factor
    • 8001151 1:STN:280:DyaK2M%2FpsVaqsg%3D%3D 10.1016/0092-8674(94)90006-X
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by ppar gamma 2, a lipid-activated transcription factor. Cell. 1994;79:1147-56.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 148
    • 21044433343 scopus 로고    scopus 로고
    • Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by ppargamma agonists
    • 15727952 1:CAS:528:DC%2BD2MXmvVeru78%3D 10.1152/ajpendo.00141.2004
    • Cha BS, Ciaraldi TP, Park KS, Carter L, Mudaliar SR, Henry RR. Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by ppargamma agonists. Am J Physiol Endocrinol Metab. 2005;289:E151-9.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Cha, B.S.1    Ciaraldi, T.P.2    Park, K.S.3    Carter, L.4    Mudaliar, S.R.5    Henry, R.R.6
  • 149
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator pgc-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • 10669761 1:CAS:528:DC%2BD3cXhtF2ntb8%3D 10.1128/MCB.20.5.1868-1876.2000
    • Vega RB, Huss JM, Kelly DP. The coactivator pgc-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000;20:1868-76.
    • (2000) Mol Cell Biol , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 150
    • 0038637806 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart
    • 12655356 1:CAS:528:DC%2BD3sXjvVegtLo%3D
    • Karbowska J, Kochan Z, Smolenski RT. Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart. Cell Mol Biol Lett. 2003;8:49-53.
    • (2003) Cell Mol Biol Lett , vol.8 , pp. 49-53
    • Karbowska, J.1    Kochan, Z.2    Smolenski, R.T.3
  • 151
    • 0346264792 scopus 로고    scopus 로고
    • Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction
    • 19641651 1:CAS:528:DC%2BD2cXks12gsg%3D%3D
    • Masamura K, Tanaka N, Yoshida M, Kato M, Kawai Y, Oida K, et al. Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction. Exp Clin Cardiol. 2003;8:61-6.
    • (2003) Exp Clin Cardiol , vol.8 , pp. 61-66
    • Masamura, K.1    Tanaka, N.2    Yoshida, M.3    Kato, M.4    Kawai, Y.5    Oida, K.6
  • 152
    • 0035877163 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia
    • 11390509 1:CAS:528:DC%2BD3MXksVOms7c%3D
    • Narravula S, Colgan SP. Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol. 2001;166:7543-8.
    • (2001) J Immunol , vol.166 , pp. 7543-7548
    • Narravula, S.1    Colgan, S.P.2
  • 153
    • 0035860177 scopus 로고    scopus 로고
    • Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart
    • 11549245 1:CAS:528:DC%2BD3MXms1anu78%3D 10.1006/bbrc.2001.5541
    • Razeghi P, Young ME, Abbasi S, Taegtmeyer H. Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun. 2001;287:5-10.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 5-10
    • Razeghi, P.1    Young, M.E.2    Abbasi, S.3    Taegtmeyer, H.4
  • 154
    • 0030827807 scopus 로고    scopus 로고
    • Regulation of cyp4a1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes
    • 9354589 1:CAS:528:DyaK2sXmsVGqs70%3D 10.1016/S0006-2952(97)00256-6
    • Parmentier JH, Schohn H, Bronner M, Ferrari L, Batt AM, Dauca M, et al. Regulation of cyp4a1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes. Biochem Pharmacol. 1997;54:889-98.
    • (1997) Biochem Pharmacol , vol.54 , pp. 889-898
    • Parmentier, J.H.1    Schohn, H.2    Bronner, M.3    Ferrari, L.4    Batt, A.M.5    Dauca, M.6
  • 155
    • 0037155907 scopus 로고    scopus 로고
    • Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in c2c12 skeletal muscle cells
    • 11792699 1:CAS:528:DC%2BD38XisVylt7g%3D 10.1074/jbc.M110321200
    • Cabrero A, Alegret M, Sanchez RM, Adzet T, Laguna JC, Carrera MV. Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in c2c12 skeletal muscle cells. J Biol Chem. 2002;277:10100-7.
    • (2002) J Biol Chem , vol.277 , pp. 10100-10107
    • Cabrero, A.1    Alegret, M.2    Sanchez, R.M.3    Adzet, T.4    Laguna, J.C.5    Carrera, M.V.6
  • 156
    • 4744371376 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    • 15456881 1:CAS:528:DC%2BD2cXotl2mur8%3D 10.1128/MCB.24.20.9079-9091.2004
    • Huss JM, Torra IP, Staels B, Giguere V, Kelly DP. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol. 2004;24:9079-91.
    • (2004) Mol Cell Biol , vol.24 , pp. 9079-9091
    • Huss, J.M.1    Torra, I.P.2    Staels, B.3    Giguere, V.4    Kelly, D.P.5
  • 157
    • 0038660688 scopus 로고    scopus 로고
    • The transcriptional coactivator pgc-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (erralpha)
    • 12522104 1:CAS:528:DC%2BD3sXhvVyqtbk%3D 10.1074/jbc.M212923200
    • Schreiber SN, Knutti D, Brogli K, Uhlmann T, Kralli A. The transcriptional coactivator pgc-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (erralpha). J Biol Chem. 2003;278:9013-8.
    • (2003) J Biol Chem , vol.278 , pp. 9013-9018
    • Schreiber, S.N.1    Knutti, D.2    Brogli, K.3    Uhlmann, T.4    Kralli, A.5
  • 158
    • 29244436681 scopus 로고    scopus 로고
    • Ampk activation increases fatty acid oxidation in skeletal muscle by activating pparalpha and pgc-1
    • 16364253 1:CAS:528:DC%2BD2MXhtlCqtbfP 10.1016/j.bbrc.2005.12.011
    • Lee WJ, Kim M, Park HS, Kim HS, Jeon MJ, Oh KS, et al. Ampk activation increases fatty acid oxidation in skeletal muscle by activating pparalpha and pgc-1. Biochem Biophys Res Commun. 2006;340:291-5.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 291-295
    • Lee, W.J.1    Kim, M.2    Park, H.S.3    Kim, H.S.4    Jeon, M.J.5    Oh, K.S.6
  • 159
    • 70349085322 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway
    • 19699196 1:CAS:528:DC%2BD1MXhtFGlt73F 10.1016/j.ejphar.2009.08.024
    • Meng RS, Pei ZH, Yin R, Zhang CX, Chen BL, Zhang Y, et al. Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway. Eur J Pharmacol. 2009;620:63-70.
    • (2009) Eur J Pharmacol , vol.620 , pp. 63-70
    • Meng, R.S.1    Pei, Z.H.2    Yin, R.3    Zhang, C.X.4    Chen, B.L.5    Zhang, Y.6
  • 160
    • 33646142778 scopus 로고    scopus 로고
    • Glucose-induced repression of pparalpha gene expression in pancreatic beta-cells involves pp 2a activation and ampk inactivation
    • 16595700 1:CAS:528:DC%2BD28Xkslequ78%3D 10.1677/jme.1.01965
    • Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S. Glucose-induced repression of pparalpha gene expression in pancreatic beta-cells involves pp 2a activation and ampk inactivation. J Mol Endocrinol. 2006;36:289-99.
    • (2006) J Mol Endocrinol , vol.36 , pp. 289-299
    • Ravnskjaer, K.1    Boergesen, M.2    Dalgaard, L.T.3    Mandrup, S.4
  • 161
    • 0030938190 scopus 로고    scopus 로고
    • Upregulation of 5'-amp-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit
    • 9118478 1:CAS:528:DyaK2sXhvFyrurw%3D 10.1161/01.RES.80.4.482
    • Makinde AO, Gamble J, Lopaschuk GD. Upregulation of 5'-amp-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. Circ Res. 1997;80:482-9.
    • (1997) Circ Res , vol.80 , pp. 482-489
    • Makinde, A.O.1    Gamble, J.2    Lopaschuk, G.D.3
  • 162
    • 0037058977 scopus 로고    scopus 로고
    • Amp kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • 12444247 1:CAS:528:DC%2BD38Xps1egu7s%3D 10.1073/pnas.252625599
    • Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, et al. Amp kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A. 2002;99:15983-7.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3    Pypaert, M.4    Mu, J.5    Birnbaum, M.J.6
  • 163
    • 27744536355 scopus 로고    scopus 로고
    • Role of amp-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle
    • 16237515 1:CAS:528:DC%2BD2MXht1Skt7jN 10.1007/s00125-005-1962-5
    • Long YC, Barnes BR, Mahlapuu M, Steiler TL, Martinsson S, Leng Y, et al. Role of amp-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle. Diabetologia. 2005;48:2354-64.
    • (2005) Diabetologia , vol.48 , pp. 2354-2364
    • Long, Y.C.1    Barnes, B.R.2    Mahlapuu, M.3    Steiler, T.L.4    Martinsson, S.5    Leng, Y.6
  • 164
    • 33644701630 scopus 로고    scopus 로고
    • Changes in exercise-induced gene expression in 5'-amp-activated protein kinase gamma3-null and gamma3 r225q transgenic mice
    • 16306365 1:CAS:528:DC%2BD2MXht12gsL7P 10.2337/diabetes.54.12.3484
    • Barnes BR, Long YC, Steiler TL, Leng Y, Galuska D, Wojtaszewski JF, et al. Changes in exercise-induced gene expression in 5'-amp-activated protein kinase gamma3-null and gamma3 r225q transgenic mice. Diabetes. 2005;54:3484-9.
    • (2005) Diabetes , vol.54 , pp. 3484-3489
    • Barnes, B.R.1    Long, Y.C.2    Steiler, T.L.3    Leng, Y.4    Galuska, D.5    Wojtaszewski, J.F.6
  • 165
    • 58149099037 scopus 로고    scopus 로고
    • Gain-of-function r225q mutation in amp-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle
    • 18838377 1:CAS:528:DC%2BD1cXhsVylsrnO 10.1074/jbc.M805078200
    • Garcia-Roves PM, Osler ME, Holmstrom MH, Zierath JR. Gain-of-function r225q mutation in amp-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle. J Biol Chem. 2008;283:35724-34.
    • (2008) J Biol Chem , vol.283 , pp. 35724-35734
    • Garcia-Roves, P.M.1    Osler, M.E.2    Holmstrom, M.H.3    Zierath, J.R.4


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