Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

Diabetes

Volumn 50, Issue 1, 2001, Pages 123-130

  Dobbins, Robert L ^a,b   Szczepaniak, Lidia S ^a   Bentley, Brandon ^a   Esser, Victoria ^a   Myhill, Jeffrey ^a   Denis McGarry, J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; ENZYME ACTIVITY; FAT INTAKE; FATTY ACID OXIDATION; HYPERLIPIDEMIA; INSULIN RESISTANCE; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

EID: 0035149738     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.1.123     Document Type: Article

References (65)

1. Influence of dietary fat composition on development of insulin resistance in rats: Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipid
2. What if Minkowski had been ageusic? An alternative angle on diabetes
3. Disordered metabolism in diabetes: Have we underemphasized the fat component?
4. Lipid abnormalities in tissues of the KKA mouse: Effects of pioglitazone on malonyl-CoA and diacylglycerol
5. Growth hormone-induced insulin resistance and its relationship to lipid availability in the rat
6. Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
7. Dietary fats and insulin action
8. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
9. Skeletal muscle triglyceride levels are inversely related to insulin action
10. 13C nuclear magnetic resonance study
11. Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients
12. Skeletal muscle triglyceride stores are increased in insulin resistance
13. 1H spectroscopy: Validation in vivo
14. Skeletal muscle triacylglycerol in the rat: Methods for sampling and measurement, and studies of biological variability
15. 1H NMR spectroscopy study
16. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
17. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
18. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
19. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C τ and alterations in the insulin signaling cascade
20. Glucose metabolism of rat skeletal muscle at rest: Effect of starvation, diabetes, ketone bodies, and free fatty acids
21. Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors
22. Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes
23. Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus
24. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus
25. Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM
26. Chronic inhibition of fatty acid oxidation: New model of diastolic dysfunction
27. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues: Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat
28. Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I)
29. Protein measurement with the folin phenol reagent
30. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
31. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
32. Short-term effects of leptin on hepatic gluconeogenisis and in vivo insulin action
33. Leptin selectively decreases visceral adiposity and enhances insulin action
34. Assessment of body composition of poultry by nuclear magnetic resonance imaging and spectroscopy
35. Energy restriction reduces metabolic rate in adult male Fisher-344 rats
36. Use of proton spectroscopy for detection of homozygous fatty ZDF-Drt rats before weaning
37. Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin
38. Dietary obesity in rats: Body weight and body fat accretion in seven strains of rats
39. Quantitation of metabolites in human blood serum by proton magnetic resonance spectroscopy: A comparative study of the use of formate and TSP as concentration standards
40. A simple method for the isolation and purification of total lipids from animal tissues
41. A simple enzymatic quantitative analysis of triglycerides in tissues
42. Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns
43. Direct transesterification of all classes of lipids in a one-step reaction
44. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue
45. 1H-MR-spectroscopy
46. Bulk magnetic susceptibility effects on the assessment of intra- and extra-cellular lipids in vivo
47. Phenylalkyloxirane carboxylic acids, a new class of hypoglycaemic substances: Hypoglycaemic and hyoketoneaemic effects of sodium 2-[5-(4-chlorophenyl)-pentyl]-oxirane-2-carboxylate (B 807-27) in fasted animals
48. Glucose kinetics during acute and chronic treatment of rats with 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, etomoxir
49. The longitudinal effect of inhibiting fatty acid oxidation in diabetic rats fed a high-fat diet
50. Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyltransferase inhibitor etomoxir
51. Defects in substrate oxidation involved in the predisposition to obesity
52. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
53. Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia
54. A gender-related defect in lipid metabolism and glucose hemostasis in peroxisome proliferator-activated receptor α-deficient mice
55. Alterations in the expression and cellular localization of protein kinase C isozymes ε and τ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
56. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect
57. Effects of free fatty acids on glucose transport and IRS1-associated phosphatidylinositol 3-kinase activity
58. Fuel selection in human skeletal muscle in insulin resistance: A reexamination
59. Triacylglycerol synthesis in the different skeletal muscle fiber sections of the rat
60. Functional differences in lipid metabolism in resting skeletal muscle of various fiber types
61. 1H nuclear magnetic resonance spectroscopic study
62. Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
63. Acute reversal of experimental diabetic ketoacidosis in the rat with (+)-decanoylcarnitine
64. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine
65. First clinical trial with etomoxir in patients with chronic congestive heart failure