Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells

Journal of Biological Chemistry

Volumn 280, Issue 28, 2005, Pages 26415-26424

  Wang, Guanghu ^a   Silva, Jeane ^a   Krishnamurthy, Kannan ^a   Tran, Eric ^a   Condie, Brian G ^a,b   Bieberich, Erhard ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of Georgia ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; ENZYMES; LIPIDS; LIQUID CHROMATOGRAPHY; PROTEINS;

CERAMIDES; INHIBITOR PROTEINS; LIPID VESICLE-MEDIATED AFFINITY CHROMATOGRAPHY; PROTEIN KINASE;

CELL CULTURE;

CERAMIDE; CERAMIDE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PHOSPHOPROTEIN; PROTEIN KINASE C ZETA; PROTEINASE ACTIVATED RECEPTOR 4;

AFFINITY CHROMATOGRAPHY; APOPTOSIS; ARTICLE; BIOASSAY; CELL DIFFERENTIATION; CELL SURVIVAL; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; LIPID VESICLE; LUCIFERASE REPORTER ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ACTINS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CERAMIDES; CHROMATOGRAPHY; DNA, COMPLEMENTARY; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, REPORTER; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID METABOLISM; LIPIDS; LUCIFERASES; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NF-KAPPA B; PHOSPHATIDYLSERINES; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; STEM CELLS; TIME FACTORS; TRANSFECTION;

EID: 22544468543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501492200     Document Type: Article

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