Lipotoxic heart disease in obese rats: Implications for human obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 4, 2000, Pages 1784-1789

  Zhou, Yan Ting ^a   Grayburn, Paul ^a,b   Karim, Asad ^a,b   Shimabukuro, Michio ^a,c   Higa, Moritake ^a   Baetens, Dany ^d   Orci, Lelio ^d   Unger, Roger H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Veterans Affairs North Texas Health Care System   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRIACYLGLYCEROL; TROGLITAZONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART DILATATION; HEART DISEASE; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; RAT; STEATOSIS;

AGE FACTORS; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; CHROMANS; DNA FRAGMENTATION; ECHOCARDIOGRAPHY; HEART DISEASES; HUMANS; INSULIN; LIPID METABOLISM; MALE; MICROSCOPY, ELECTRON; MYOCARDIUM; OBESITY; ORGAN SIZE; RATS; RATS, ZUCKER; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES;

ANIMALIA;

EID: 0034652225     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.4.1784     Document Type: Article

References (21)

1. Mokdad, A. H., Serdula, M. K., Dietz, W. H., Bowman, B. A., Marks, J. S. & Koplan, J. P. (1999) J. Am. Med. Assoc. 282, 1519-1522.
2. Yip, J., Facchini, F. S. & Reaven, G. M. (1998) J. Clin. Endocrinol. Metab. 83, 2773-2776.
3. Unger, R. H., Zhou, Y. T. & Orci, L. (1999) Proc. Natl. Acad. Sci. USA 96, 2327-2332.
4. Alpert, M. A., Terry, B. E., Mulekar, M., Cohen, M., Massey, C. V., Fan, T. M., Panayiotou, H. & Mukerji, V. (1997) Am. J. Cardiol. 80, 736-740.
5. Iida, M., Murakami, T., Ishida, K., Mizuno, A., Kuwajima, M. & Shima, K. (1996) Biochem. Biophys. Res. Commun. 224, 597-604.
6. Phillips, M. S., Liu, A., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. J. & Hess, J. F. (1996) Nat. Genet. 13, 18-19.
7. Zhou, Y. T., Shimabukuro, M., Wang, M. Y., Lee, Y., Higa, M., Milburn, J., Newgard, C. B. & Unger, R. H. (1998) Proc. Natl. Acad. Sci. USA 95, 8898-8903.
8. Zhou, Y. T., Wang, Z. W., Higa, M., Newgard, C. B. & Unger, R. H. (1999) Proc. Natl. Acad. Sci. USA 96, 2391-2395.
9. Duke, R. C. & Sellins, C. B. (1989) in Cellular Basis of Immune Modulation, ed. Kaplan, J. C. (Liss, New York), pp. 311-314.
10. Shimabukura, M., Zhou, Y. T., Levi, M. & Unger, R. H. (1998) Proc. Natl. Acad. Sci. USA 95, 2498-2502.
11. Perry, D. K. & Hannun, Y. A. (1999) Trends Biochem. Sci. 24, 266-267.
12. Danno, H. Y., Jinko, Y., Budiyanto, S., Furikawa, Y. & Kimura, S. A. (1992) J. Nutr. Sci. Vitaminol. 38, 517-521.
13. Tandler, B. (1990) J. Electron Microsc. Tech. 16, 81-82.
14. Weibel, E. R. (1973) in Principles and Techniques of Electron Microscopy Biological Application, ed. Hayat, M. A. (Van Nostrand Reinhold, New York), pp. 237-296.
15. Lee, Y., Hirose, H., Ohneda, M., Johnson, J. W., McGarry, J. D. & Unger, R. H. (1994) Proc. Natl. Acad. Sci. USA 91, 10878-10882.
16. Zhou, Y. T., Shimabukuro, M., Lee, Y., Koyama, K., Higa, M., Ferguson, T. & Unger, R. H. (1998) Diabetes 47, 1904-1908.
17. Keller, H., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K. & Wahli, W. (1993) Proc. Natl. Acad. Sci. USA 90, 2160-2164.
18. Shimabukuro, M., Zhou, Y. T., Levi, M. & Unger, R. H. (1998) Proc. Natl. Acad. Sci. USA 95, 2498-2502.
19. Shimabukuro, M., Ohneda, M., Lee, Y. H. & Unger, R. H. (1997) J. Clin. Invest. 100, 290-295.
20. Higa, M., Zhou, Y. T., Ravazzola, M., Baetens, D., Orci, L. & Unger, R. H. (1999) Proc. Natl, Acad. Sci. USA 96, 11513-11518.
21. Bielawska, A. E., Shapiro, J. P., Jiang, L., Melkonyan, H. S., Piot, C., Wolfe, C. L., Tomei, L. D., Hannun, Y. A. & Umansky, S. R. (1997) Am. J. Pathol. 151, 1257-1263.