Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor α expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction

Journal of Biological Chemistry

Volumn 286, Issue 42, 2011, Pages 36331-36339

  Drosatos, Konstantinos ^a   Drosatos Tampakaki, Zoi ^a   Khan, Raffay ^a   Homma, Shunichi ^a   Schulze, P Christian ^a   Zannis, Vassilis I ^b   Goldberg, Ira J ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE RESPONSE; BACTERIAL INFECTIONS; C57BL/6 MICE; CARDIOMYOCYTES; CELL LINES; DOWN-REGULATION; ENERGY DEPLETION; ENERGY PRODUCTIONS; FATTY ACID OXIDATION; HEART DYSFUNCTION; HEART FAILURE; JNK ACTIVATION; JNK INHIBITION; LPS TREATMENT; MICRORNAS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; SEPTIC SHOCKS;

CARDIOLOGY; CELL CULTURE; GLUCOSE; HEART; MAMMALS; OXIDATION; PATHOLOGY; TISSUE;

FATTY ACIDS;

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUCOSE; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MICRORNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ALPHAMHC GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETAMHC GENE; CONTROLLED STUDY; FATTY ACID OXIDATION; FEMALE; GENE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SEPSIS;

ANIMALS; ANTHRACENES; CELL LINE; FATTY ACIDS; GENE EXPRESSION REGULATION; HEART DISEASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; PPAR ALPHA;

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); MUS;

EID: 80054694121     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.272146     Document Type: Article

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