Peroxisome proliferator-activated receptor δ activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes

Biochemical and Biophysical Research Communications

Volumn 313, Issue 2, 2004, Pages 277-286

  Cheng, Lihong ^a   Ding, Guoliang ^a   Qin, Qianhong ^a   Xiao, Yan ^a   Woods, David ^a   Chen, Yuqing E ^a   Yang, Qinglin ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiomyocytes; Energy metabolisms; Fatty acid oxidation; Peroxisome proliferator activated receptor ; Peroxisome proliferator activated receptor

Indexed keywords

CARBOXYL GROUP; FATTY ACID; GW 0742; HORMONE RECEPTOR AFFECTING AGENT; LIGAND; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA SELECTIVE LIGAND; PIRINIXIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE OVEREXPRESSION; HEART MUSCLE CELL; KNOCKOUT MOUSE; LIGAND BINDING; MOUSE; MUTATOR GENE; NEWBORN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE;

EID: 0345735302     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.11.127     Document Type: Article

References (27)

1. Davila-Roman V.G., Vedala G., Herrero P., de las Fuentes L., Rogers J.G., Kelly D.P., Gropler R.J. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 40:2002;271-277.
2. Olpin S.E., Allen J., Bonham J.R., Clark S., Clayton P.T., Calvin J., Downing M., Ives K., Jones S., Manning N.J., Pollitt R.J., Standing S.J., Tanner M.S. Features of carnitine palmitoyltransferase type I deficiency. J. Inherit. Metab. Dis. 24:2001;35-42.
3. Henry C.G., Strauss A.W., Keating J.P., Hillman R.E. Congestive cardiomyopathy associated with beta-ketothiolase deficiency. J. Pediatr. 99:1981;754-757.
4. Kliewer S.A., Xu H.E., Lambert M.H., Willson T.M. Peroxisome proliferator-activated receptors: from genes to physiology. Recent Prog. Horm. Res. 56:2001;239-263.
5. Chen Y.E., Fu M., Zhang J., Zhu X., Lin Y., Akinbami M.A., Song Q. Peroxisome proliferator-activated receptors and the cardiovascular system. Vitam. Horm. 66:2003;157-188.
6. Gilde A.J., van der Lee K.A., Willemsen P.H., Chinetti G., van der Leij F.R., van der Vusse G.J., Staels B., van Bilsen M. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Circ. Res. 92:2003;518-524.
7. Barger P.M., Kelly D.P. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc. Med. 10:2000;238-245.
8. Asakawa M., Takano H., Nagai T., Uozumi H., Hasegawa H., Kubota N., Saito T., Masuda Y., Kadowaki T., Komuro I. Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation. 105:2002;1240-1246.
9. Wayman N.S., Ellis B.L., Thiemermann C. Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size. Med. Sci. Monit. 8:2002;BR243-BR247.
10. Wayman N.S., Hattori Y., McDonald M.C., Mota-Filipe H., Cuzzocrea S., Pisano B., Chatterjee P.K., Thiemermann C. Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J. 16:2002;1027-1040.
11. Khandoudi N., Delerive P., Berrebi-Bertrand I., Buckingham R.E., Staels B., Bril A. Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury. Diabetes. 51:2002;1507-1514.
12. Yue T.L., Chen J., Bao W., Narayanan P.K., Bril A., Jiang W., Lysko P.G., Gu J.L., Boyce R., Zimmerman D.M., Hart T.K., Buckingham R.E., Ohlstein E.H. In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation. 104:2001;2588-2594.
13. Barak Y., Liao D., He W., Ong E.S., Nelson M.C., Olefsky J.M., Boland R., Evans R.M. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc. Natl. Acad. Sci. USA. 99:2002;303-308.
14. Wang Y.X., Lee C.H., Tiep S., Yu R.T., Ham J., Kang H., Evans R.M. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 113:2003;159-170.
15. Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., Fernandez-Salguero P.M., Westphal H., Gonzalez F.J. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15:1995;3012-3022.
16. Fu M., Zhu X., Wang Q., Zhang J., Song Q., Zheng H., Ogawa W., Du J., Chen Y.E. Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway. Circ. Res. 89:2001;1058-1064.
17. Gulick T., Cresci S., Caira T., Moore D.D., Kelly D.P. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA. 91:1994;11012-11016.
18. Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U., Mangelsdorf D.J., Umesono K., Evans R.M. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA. 91:1994;7355-7359.
19. Muoio D.M., MacLean P.S., Lang D.B., Li S., Houmard J.A., Way J.M., Winegar D.A., Corton J.C., Dohm G.L., Kraus W.E. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. J. Biol. Chem. 277:2002;26089-26097.
20. Peters J.M., Lee S.S., Li W., Ward J.M., Gavrilova O., Everett C., Reitman M.L., Hudson L.D., Gonzalez F.J. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol. 20:2000;5119-5128.
21. ′ -AMP-activated protein kinase inhibition of acetyl-CoA carboxylase J. Biol. Chem. 270:1995;17513-17520.
22. Brown N.F., Weis B.C., Husti J.E., Foster D.W., McGarry J.D. Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart. J. Biol. Chem. 270:1995;8952-8957.
23. Unger R.H. The physiology of cellular liporegulation. Annu. Rev. Physiol. 2002.
24. Razeghi P., Young M.E., Alcorn J.L., Moravec C.S., Frazier O.H., Taegtmeyer H. Metabolic gene expression in fetal and failing human heart. Circulation. 104:2001;2923-2931.
25. Weis B.C., Esser V., Foster D.W., McGarry J.D. Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme. J. Biol. Chem. 269:1994;18712-18715.
26. Brown N.F., Weis B.C., Husti J.E., Foster D.W., McGarry J.D. Mitochondrial carnitine palmitoyltransferase I isoform switching in the developing rat heart. J. Biol. Chem. 270:1995;8952-8957.
27. Watanabe K., Fujii H., Takahashi T., Kodama M., Aizawa Y., Ohta Y., Ono T., Hasegawa G., Naito M., Nakajima T., Kamijo Y., Gonzalez F.J., Aoyama T. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J. Biol. Chem. 275:2000;22293-22299.