Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 2, 2000, Pages 787-792

  Osuga, Jun Ichi ^a   Ishibashi, Shun ^a   Oka, Teruaki ^a   Yagyu, Hiroaki ^a   Tozawa, Ryuichi ^a   Fujimoto, Akihisa ^b   Shionoiri, Futoshi ^a   Yahagi, Naoya ^a   Kraemer, Frederic B ^c   Tsutsumi, Osamu ^b   Yamada, Nobuhiro ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTERASE; CORTICOSTERONE; DNA; FATTY ACID; FOLLITROPIN; LUTEINIZING HORMONE; RNA; TESTOSTERONE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; KNOCKOUT MOUSE; LIPOLYSIS; MALE; MALE STERILITY; MOUSE; NONHUMAN; OBESITY; OLIGOSPERMIA; OXYGEN CONSUMPTION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SPERMATOGENESIS; SPERMATOZOON MOTILITY; STEROIDOGENESIS; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; CHOLESTEROL; CHOLESTEROL ESTERASE; CHOLESTEROL ESTERS; DNA; FEMALE; GENOTYPE; HYPERTROPHY; INFERTILITY, MALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; OBESITY; SPERMATIDS; SPERMATOCYTES; TESTIS; TRIGLYCERIDES;

ANIMALIA;

EID: 12944335303     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.2.787     Document Type: Article

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