Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 300, Issue 3, 2011, Pages

  Drosatos, Konstantinos ^a   Bharadwaj, Kalyani G ^a   Lymperopoulos, Anastasios ^b,d   Ikeda, Shota ^a   Khan, Raffay ^a   Hu, Yunying ^a   Agarwal, Rajiv ^a   Yu, Shuiqing ^a   Jiang, Hongfeng ^a   Steinberg, Susan F ^c   Blaner, William S ^a   Koch, Walter J ^b   Goldberg, Ira J ^a  

^a Columbia University ^*  (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c New York Presbyterian Columbia University Medical Center   (United States)

^d NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

Fatty acids; Heart; Lipotoxicity

Indexed keywords

BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CERAMIDE; CYCLIC AMP; DIACYLGLYCEROL; FATTY ACID; ISOPRENALINE; LIPID; LIPOPROTEIN LIPASE; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE C; PROTEIN KINASE C DELTA;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATECHOLAMINE RELEASE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE EXPRESSION; GENETIC TRANSFECTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID DIET; LIPID TRANSPORT; LIPOTOXICITY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CERAMIDES; CYCLIC AMP; DIET; DIETARY FATS; DIGLYCERIDES; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; IMMUNOPRECIPITATION; LIPIDS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC; PROTEIN KINASE C; RECEPTORS, ADRENERGIC, BETA; RNA; RNA, SMALL INTERFERING;

EID: 79952175806     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00569.2010     Document Type: Article

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