메뉴 건너뛰기




Volumn 249, Issue 1, 1997, Pages 239-247

Human and murine serine-palmitoyl-CoA transferase Cloning, expression and characterization of the key enzyme in sphingolipid synthesis

Author keywords

Characterization; Cloning; Overexpression; Serine palmitoyltransferase; Sphingolipid biosynthesis

Indexed keywords

COENZYME A TRANSFERASE; SPHINGOLIPID;

EID: 0030755002     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00239.x     Document Type: Article
Times cited : (166)

References (41)
  • 1
    • 0027514797 scopus 로고
    • The sphingomyelin cycle: A prototypic sphingolipid signaling pathway
    • Hannun, Y. & Bell, R. (1993) The sphingomyelin cycle: a prototypic sphingolipid signaling pathway, Adv. Lipid Res. 25, 27-41.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 27-41
    • Hannun, Y.1    Bell, R.2
  • 2
    • 0026650132 scopus 로고
    • Network of signal transduction pathways involving lipids: Protein kinase C-dependent and -independent pathways
    • Bell, R., Burns, D., Okazaki, T. & Hannun, Y. (1992) Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways, Adv. Exp. Med. Biol. 318, 275-284.
    • (1992) Adv. Exp. Med. Biol. , vol.318 , pp. 275-284
    • Bell, R.1    Burns, D.2    Okazaki, T.3    Hannun, Y.4
  • 3
    • 0027488403 scopus 로고
    • Ceramide: A novel second messenger
    • Mathias, S. & Kolesnick, R. (1993) Ceramide: a novel second messenger, Adv. Lipid Res. 25, 65-90.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 65-90
    • Mathias, S.1    Kolesnick, R.2
  • 4
    • 0027363176 scopus 로고
    • Introduction: Sphingolipids and their metabolites in cell regulation
    • Merrill, A., Hannun, Y. & Bell, R. (1993) Introduction: sphingolipids and their metabolites in cell regulation, Adv. Lipid Res. 25, 1-24.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 1-24
    • Merrill, A.1    Hannun, Y.2    Bell, R.3
  • 5
    • 0028352908 scopus 로고
    • Signal transduction through the sphingomyelin pathway
    • Kolesnick, R. (1994) Signal transduction through the sphingomyelin pathway, Mol. Chem. Neuropathol. 21, 287-297.
    • (1994) Mol. Chem. Neuropathol. , vol.21 , pp. 287-297
    • Kolesnick, R.1
  • 6
    • 0028297068 scopus 로고
    • The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
    • Kolesnick, R. & Golde, D. (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling, Cell 77, 325-328.
    • (1994) Cell , vol.77 , pp. 325-328
    • Kolesnick, R.1    Golde, D.2
  • 7
    • 84941384261 scopus 로고
    • Metabolism of sphingosine bases. Biosynthesis of dihydrosphingosine in vitro
    • Stoffel, W., LeKim, D. & Sticht, G. (1968) Metabolism of sphingosine bases. Biosynthesis of dihydrosphingosine in vitro, Hoppe-Seyler's Z. Physiol. Chem. 349, 664-670.
    • (1968) Hoppe-Seyler's Z. Physiol. Chem. , vol.349 , pp. 664-670
    • Stoffel, W.1    LeKim, D.2    Sticht, G.3
  • 8
    • 0014180402 scopus 로고
    • Metabolism of sphingosine bases. 2-amino-1-hydroxyoctadecane-3-one (3-oxodihydrosphingosine), the common intermediate in the biosynthesis of dihydrosphingosine and sphingosine and in the degradation of dihydrosphingosine
    • Stoffel, W., LeKim, D. & Sticht, G. (1967) Metabolism of sphingosine bases. 2-amino-1-hydroxyoctadecane-3-one (3-oxodihydrosphingosine), the common intermediate in the biosynthesis of dihydrosphingosine and sphingosine and in the degradation of dihydrosphingosine, Hoppe-Seyler's Z. Physiol. Chem. 348, 1570-1574.
    • (1967) Hoppe-Seyler's Z. Physiol. Chem. , vol.348 , pp. 1570-1574
    • Stoffel, W.1    LeKim, D.2    Sticht, G.3
  • 9
    • 0014104159 scopus 로고
    • The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri
    • Braun, P. & Snell, E. (1967) The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri, Proc. Natl Acad. Sci. USA 58, 298-303.
    • (1967) Proc. Natl Acad. Sci. USA , vol.58 , pp. 298-303
    • Braun, P.1    Snell, E.2
  • 10
    • 0026712872 scopus 로고
    • Subcellular localization and membrane topology of serine palmitoyltransferase. 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
    • Mandon, E. C., Ehses, I., Rohter, J., van Echten, G. & Sandhoff, K. (1992) Subcellular localization and membrane topology of serine palmitoyltransferase. 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver, J. Biol. Chem. 267, 11 144-11 148.
    • (1992) J. Biol. Chem. , vol.267 , pp. 11144-11148
    • Mandon, E.C.1    Ehses, I.2    Rohter, J.3    Van Echten, G.4    Sandhoff, K.5
  • 11
    • 84942961893 scopus 로고
    • Metabolism of sphingosine bases. Stereospecificity of the NADPH-dependent reduction reaction of 3-oxodihydrosphingosine (2-amino-1-hydroxyoctadecane-3-one)
    • Stoffel, W., LeKim, D. & Sticht, G. (1968) Metabolism of sphingosine bases. Stereospecificity of the NADPH-dependent reduction reaction of 3-oxodihydrosphingosine (2-amino-1-hydroxyoctadecane-3-one), Hoppe-Seyler's Z. Physiol. Chem. 349, 1637-1644.
    • (1968) Hoppe-Seyler's Z. Physiol. Chem. , vol.349 , pp. 1637-1644
    • Stoffel, W.1    LeKim, D.2    Sticht, G.3
  • 12
    • 0027074149 scopus 로고
    • Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells
    • Rother, J., van Echten, G., Schwarzmann, G. & Sandhoff, K. (1992) Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells, Biochem. Biophys. Res. Commun. 189, 14-20.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 14-20
    • Rother, J.1    Van Echten, G.2    Schwarzmann, G.3    Sandhoff, K.4
  • 13
    • 0016256120 scopus 로고
    • Studies on the desaturation of sphinganine. Ceramide and sphingomyelin metabolism in the rat and BHK21 cells in tissue culture
    • Stoffel, W. & Bister, K. (1974) Studies on the desaturation of sphinganine. Ceramide and sphingomyelin metabolism in the rat and BHK21 cells in tissue culture, Hoppe-Seyler's Z. Physiol. Chem. 355, 911-923.
    • (1974) Hoppe-Seyler's Z. Physiol. Chem. , vol.355 , pp. 911-923
    • Stoffel, W.1    Bister, K.2
  • 14
    • 0015785319 scopus 로고
    • In vivo studies on the introduction of the 4-trans-double bond of the sphingenine moiety of rat brain ceramides
    • Ong, D. E. & Brady, R. N. (1973) In vivo studies on the introduction of the 4-trans-double bond of the sphingenine moiety of rat brain ceramides, J. Biol. Chem. 248, 3884-3888.
    • (1973) J. Biol. Chem. , vol.248 , pp. 3884-3888
    • Ong, D.E.1    Brady, R.N.2
  • 15
    • 0025739993 scopus 로고
    • Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long chain base component of sphingolipids
    • Buede, R., Pinto, W. J., Lester, R. L. & Dickson, R. C. (1991) Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long chain base component of sphingolipids, J. Bacteriol. 173, 4325-4332.
    • (1991) J. Bacteriol. , vol.173 , pp. 4325-4332
    • Buede, R.1    Pinto, W.J.2    Lester, R.L.3    Dickson, R.C.4
  • 16
    • 0027980277 scopus 로고
    • The LCB2 gene of Saccharomyces cerevisiae and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis
    • Nagiec, M. M., Baltisberger, J. A., Wells, G. B., Lester, R. L. & Dickson, R. C. (1994) The LCB2 gene of Saccharomyces cerevisiae and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis, Proc. Natl Acad. Sci. USA 91, 7899-7902.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 7899-7902
    • Nagiec, M.M.1    Baltisberger, J.A.2    Wells, G.B.3    Lester, R.L.4    Dickson, R.C.5
  • 18
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 19
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
    • Smith, D. & Johnson, K. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene 67, 31-40.
    • (1988) Gene , vol.67 , pp. 31-40
    • Smith, D.1    Johnson, K.2
  • 22
    • 0021333971 scopus 로고
    • Enzymology of long-chain base synthesis by liver: Characterization of serine palmitoyltransferase in rat liver microsomes
    • Williams, R., Wang, E. & Merrill, A. (1984) Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes, Arch. Biochem. Biophys. 228, 282-291.
    • (1984) Arch. Biochem. Biophys. , vol.228 , pp. 282-291
    • Williams, R.1    Wang, E.2    Merrill, A.3
  • 23
    • 0023036582 scopus 로고    scopus 로고
    • Biosynthesis of long chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganines
    • Merrill, A. H. & Wang, E. W. (1996) Biosynthesis of long chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganines, J. Biol. Chem. 261, 3764-3769.
    • (1996) J. Biol. Chem. , vol.261 , pp. 3764-3769
    • Merrill, A.H.1    Wang, E.W.2
  • 24
    • 51249193286 scopus 로고
    • Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography
    • Gaver, R. C. & Sweeley, C. C. (1965) Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography, J. Am. Oil Chem. Soc. 42, 295-298.
    • (1965) J. Am. Oil Chem. Soc. , vol.42 , pp. 295-298
    • Gaver, R.C.1    Sweeley, C.C.2
  • 25
    • 0000207681 scopus 로고
    • TMBASE - A database of membrane spanning protein segments
    • Hofmann, K. & Stoffel, W. (1993) TMBASE - A database of membrane spanning protein segments, Biol. Chem. Hoppe-Seyler 374, 166.
    • (1993) Biol. Chem. Hoppe-Seyler , vol.374 , pp. 166
    • Hofmann, K.1    Stoffel, W.2
  • 26
    • 0021814377 scopus 로고
    • Activities of serine palmitoyltransferase (3-ketosphinganine synthetase) in microsomes from different rat tissues
    • Merrill, A. H., Nixon, D. W. & Williams, R. D. (1985) Activities of serine palmitoyltransferase (3-ketosphinganine synthetase) in microsomes from different rat tissues, J. Lipid Res. 26, 617-622.
    • (1985) J. Lipid Res. , vol.26 , pp. 617-622
    • Merrill, A.H.1    Nixon, D.W.2    Williams, R.D.3
  • 27
    • 0023718226 scopus 로고
    • Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by β-chloroalanine
    • Medlock, K. A. & Merrill, A. H. (1988) Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by β-chloroalanine, Biochem. 27, 7079-7084.
    • (1988) Biochem. , vol.27 , pp. 7079-7084
    • Medlock, K.A.1    Merrill, A.H.2
  • 28
    • 0023608494 scopus 로고
    • Inhibition of serine palmitoyltransferase activity in rabbit aorta byl-cycloserine
    • Williams, R. D., Sgoutas, D. S., Zaatari, G. S. & Santoianni, R. A. (1987) Inhibition of serine palmitoyltransferase activity in rabbit aorta byl-cycloserine, J. Lipid Res. 28, 1478-1481.
    • (1987) J. Lipid Res. , vol.28 , pp. 1478-1481
    • Williams, R.D.1    Sgoutas, D.S.2    Zaatari, G.S.3    Santoianni, R.A.4
  • 29
    • 0021349321 scopus 로고
    • Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo
    • Sundaram, K. S. & Lev, M. (1984) Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo, J. Neurochem. 42, 577-581.
    • (1984) J. Neurochem. , vol.42 , pp. 577-581
    • Sundaram, K.S.1    Lev, M.2
  • 30
    • 0021992498 scopus 로고
    • Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine
    • Sundaram, K. S. & Lev, M. (1985) Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine, J. Lipid Res. 26, 473-477.
    • (1985) J. Lipid Res. , vol.26 , pp. 473-477
    • Sundaram, K.S.1    Lev, M.2
  • 32
    • 0029075192 scopus 로고
    • Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
    • Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T. & Kawasaki, T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin, Biochem. Biophys. Res. Commun. 211, 396-403.
    • (1995) Biochem. Biophys. Res. Commun. , vol.211 , pp. 396-403
    • Miyake, Y.1    Kozutsumi, Y.2    Nakamura, S.3    Fujita, T.4    Kawasaki, T.5
  • 34
    • 0011364702 scopus 로고
    • Characterization of a S. cerevisiae mutant defective in inositol sphingolipid synthesis
    • Pinto, W. J., Wells, G. B., Williams, A. C., Anderson, K. A., Teater, E. C. & Lester, R. L. (1986) Characterization of a S. cerevisiae mutant defective in inositol sphingolipid synthesis, Fed. Proc. 45, 1826.
    • (1986) Fed. Proc. , vol.45 , pp. 1826
    • Pinto, W.J.1    Wells, G.B.2    Williams, A.C.3    Anderson, K.A.4    Teater, E.C.5    Lester, R.L.6
  • 35
    • 0026697256 scopus 로고
    • Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: Genetics, physiology, and a method for their selection
    • Pinto, W., Srinivasan, B., Shepherd, S., Schmidt, A., Dickson, R. & Lester, R. (1992) Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection, J. Bacteriol. 174, 2565-2574.
    • (1992) J. Bacteriol. , vol.174 , pp. 2565-2574
    • Pinto, W.1    Srinivasan, B.2    Shepherd, S.3    Schmidt, A.4    Dickson, R.5    Lester, R.6
  • 36
    • 0023014094 scopus 로고
    • Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases
    • Merrill, A. Jr, Sereni, A. M., Stevens, V. L., Hannun, Y. A., Bell, R. M. & Kinkade, J. Jr (1986) Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases, J. Biol. Chem. 261, 12 610-12 615.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12610-12615
    • Merrill Jr., A.1    Sereni, A.M.2    Stevens, V.L.3    Hannun, Y.A.4    Bell, R.M.5    Kinkade Jr., J.6
  • 37
    • 0025796981 scopus 로고
    • Sphingoipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases
    • Mandon, E. C., Van Echten, G., Birk, R., Schmidt, R. R. & Sandhoff, K. (1991) Sphingoipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases, Eur. J. Biochem. 198, 667-674.
    • (1991) Eur. J. Biochem. , vol.198 , pp. 667-674
    • Mandon, E.C.1    Van Echten, G.2    Birk, R.3    Schmidt, R.R.4    Sandhoff, K.5
  • 38
    • 0025186874 scopus 로고
    • 2-Amino-3-ketobutyrate CoA ligase of Escherichia coli:stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme
    • Mukherjee, J. J. & Dekker, E. E. (1990) 2-Amino-3-ketobutyrate CoA ligase of Escherichia coli:stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme, Biochim. Biophys. Acta 1037, 24-29.
    • (1990) Biochim. Biophys. Acta , vol.1037 , pp. 24-29
    • Mukherjee, J.J.1    Dekker, E.E.2
  • 39
    • 0027371956 scopus 로고
    • Heme biosynthesis in mammalian systems: Evidence of a Schiff base linkage between the pyridoxal 5′-phosphate cofactor and a lysine residue in 5-aminolevulinate synthase
    • Ferreira, G. C., Neame, P. J. & Dailey, H. A. (1993) Heme biosynthesis in mammalian systems: evidence of a Schiff base linkage between the pyridoxal 5′-phosphate cofactor and a lysine residue in 5-aminolevulinate synthase, Protein Sci. 2, 1959-1965.
    • (1993) Protein Sci. , vol.2 , pp. 1959-1965
    • Ferreira, G.C.1    Neame, P.J.2    Dailey, H.A.3
  • 40
    • 0028934117 scopus 로고
    • Aminolevulinate synthase: Lysine 313 is not essential for binding the pyridoxal phosphate cofactor but is essential for catalysis
    • Ferreira, G. C., Vajapey, U., Hafez, O., Hunter, G. A. & Barber, M. J. (1995) Aminolevulinate synthase: lysine 313 is not essential for binding the pyridoxal phosphate cofactor but is essential for catalysis, Protein Sci. 4, 1001-1006.
    • (1995) Protein Sci. , vol.4 , pp. 1001-1006
    • Ferreira, G.C.1    Vajapey, U.2    Hafez, O.3    Hunter, G.A.4    Barber, M.J.5
  • 41
    • 0030600475 scopus 로고    scopus 로고
    • Sphingolipid synthesis: Identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase
    • Nagiec, M. M., Lester, R. L. & Dickson, R. C. (1996) Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase, Gene 177, 237-241.
    • (1996) Gene , vol.177 , pp. 237-241
    • Nagiec, M.M.1    Lester, R.L.2    Dickson, R.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.