Milk processing as a tool to reduce cow's milk allergenicity: A mini-review

Dairy Science and Technology

Volumn 93, Issue 3, 2013, Pages 211-223

  Bu, Guanhao ^a   Luo, Yongkang ^b   Chen, Fusheng ^a   Liu, Kunlun ^a   Zhu, Tingwei ^a  

^a HENAN UNIVERSITY OF TECHNOLOGY   (China)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Allergen; Control technologies; Cow's milk protein; Milk processing

Indexed keywords

CONTROL TECHNOLOGIES; GLYCATION REACTION; LACTIC ACID FERMENTATION; MAJOR ALLERGENS; MILK PROCESSING; MILK PROTEIN; PROCESSING CONDITION; PROCESSING TECHNOLOGIES;

ALLERGENS; ALLERGIES; ENZYMATIC HYDROLYSIS; PROTEINS;

DAIRY PRODUCTS;

EID: 84883010738     PISSN: 19585586     EISSN: 19585594     Source Type: Journal    
DOI: 10.1007/s13594-013-0113-x     Document Type: Review

References (89)

1. S1-caseins by proteolytic activity of Lactobacillus helveticus A75. J Food Biochem. doi: 10.11/j.1745-4514.2012.00664.x
2. Babiker E, Hiroyuki A, Matsudomi N, Iwata H, Ogawa T, Bando N, Kato A (1998) Effect of polysaccharide conjugation or transglutaminase treatment on the allergenicity and functional properties of soy protein. J Agric Food Chem 46:866-871
3. Baldo BA (1984) Milk allergies. Aust J Dairy Technol 39:120-128
4. Beran M, Klubal R, Molik P, Strohalm J, Urban M, Klaudyova AA, Prajzlerova K (2009) Influence of high-hydrostatic pressure on tryptic and chymotryptic hydrolysis of milk proteins. High Press Res 29:23-27
5. Bertrand-Harb C, Baday A, Dalgalarrondo M, Chobert J-M, Haertlé T (2002) Thermal modifications of structure and codenaturation of α-lactalbumin and β-lactoglobulin induce changes of solubility and susceptibility to proteases. Nahrung 46:283-289
6. Bertrand-Harb C, Ivanova IV, Dalgalarrondo M, Haertlé T (2003) Evolution of β-lactoglobulin and α-lactalbumin content during yoghurt fermentation. Int Dairy J 13:39-45
7. Blecker U (1997) Role of hydrolyzed formulas in nutritional allergy prevention in infants. South Med J 90:1170-1175
8. Bonomi F, Fiocchi A, Frøkiaer H, Gaiaschi A, Iametti S, Poiesi C, Rasmussen P, Restani P, Rovere P (2003) Reduction of immunoreactivity of bovine beta-lactoglobulin upon combined physical and proteolytic treatment. J Dairy Res 70:51-59
9. Bu GH, Lu J, Zheng Z, Luo YK (2009a) Influence of Maillard reaction conditions on the antigenicity of bovine α-lactalbumin using response surface methodology. J Sci Food Agric 89:2428-2434
10. Bu GH, Luo YK, Zheng Z, Zheng H (2009b) Effect of heat treatment on the antigenicity of bovine α-lactalbumin and β-lactoglobulin in whey protein isolate. Food Agric Immunol 20:195-206
11. Bu GH, Luo YK, Lu J, Zhang Y (2010a) Reduced antigenicity of β-lactoglobulin by conjugation with glucose through controlled Maillard reaction conditions. Food Agric Immunol 21:143-156
12. Bu GH, Luo YK, Zhang Y, Chen FS (2010b) Effects of fermentation by lactic acid bacteria on the antigenicity of bovine whey proteins. J Sci Food Agric 90:2015-2020
13. Businco L, Bruno G, Giampietro PG (1999) Prevention and management of food allergy. Acta Paediatr Suppl 88:104-109
14. Calvo MM, Gómez R (2002) Peptidic profile, molecular mass distribution and immunological properties of commercial hypoallergenic infant formulas. Milchwissenschaft 57:187-190
15. Chan YH, Shek LPC, Aw M, Quak SH, Lee BW (2002) Use of hypoallergenic formula in the prevention of atopic disease among Asian children. J Paediatr Child Health 38:84-88
16. Chicón R, Belloque J, Recio I, López-Fandiño R (2006a) Influence of high hydrostatic pressure on the proteolysis pattern of beta-lactoglobulin A treated with trypsin. J Dairy Res 73:121-128
17. Chicón R, López-Fandiño R, Quirós A, Belloque J (2006b) Changes of chymotrypsin hydrolysis of beta-lactoblobulin A induced by high hydrostatic pressure. J Agric Food Chem 54:2333-2341
18. Chicón R, Belloque J, Alonso E, López-Fandiño R (2008a) Immunoreactivity and digestibility of high-pressure-treated whey proteins. Int Dairy J 18:367-376
19. Chicón R, López-Fandiño R, Alonso E, Belloque J (2008b) Proteolytic pattern, antigenicity, and serum immunoglobulin E binding of β-lactoglobulin hydrolysates obtained by pepsin and high-pressure treatments. J Dairy Sci 91:928-938
20. Cross ML, Stevenson LM, Gill HS (2001) Anti-allergy properties of fermented foods: an important immunoregulatory mechanism of lactic acid bacteria? Int Immunopharmacol 1:891-901
21. Davis PJ, Williams SC (1998) Protein modification by thermal processing. Allergy 53:102-105
22. Davis PJ, Smales CM, James DC (2001) How can thermal processing modify the antigenicity of proteins? Allergy 56:56-60
23. Duan CC, Huo GC, Yang LJ, Ren DX, Chen JL (2012) Comparison of sensitization between β-lactoglobulin and its hydrolysates. Asian Pac J Allergy Immunol 30:32-39
24. Eggesbo M, Botten G, Halvorsen R, Magnus P (2001) The prevalence of allergy to egg: a population-based study in young children. Allergy 56:403-411
25. Ehn BM, Ekstrand B, Bengtsson U, Ahlstedt S (2004) Modification of IgE binding during heat processing of the cow's milk allergen beta-lactoglobulin. J Agric Food Chem 52:1398-1403
26. Ehn BM, Allmere T, Telemo E, Bengtsson U, Ekstrand B (2005) Modification of IgE binding to β-lactoglobulin by fermentation and proteolysis of cow's milk. J Agric Food Chem 53(9):3743-3748
27. El Mecherfi KE, Saidi D, Kheroua O, Boudraa G, Touhami M, Rouaud O, Curet S, Choiset Y, Rabesona H, Chobert JM, Haertlé T (2011) Combined microwave and enzymatic treatments for β-lactoglobulin and bovine whey proteins and their effect on the IgE immunoreactivity. Eur Food Res Technol 233:859-867
28. El-Agamy EI (2007) The challenge of cow milk protein allergy. Small Ruminant Res 68:64-72
29. El-Ghaish S, Ahmadova A, Hadji-Sfaxi I, El Mecherfi KE, Bazukyan I, Choiset Y, Rabesona H, Sitohy M, Popov YG, Kuliev AA, Mozzi F, Chobert J-M, Haertlé T (2011a) Potential use of lactic acid bacteria for reduction of allergenicity and for longer conservation of fermented foods. Trends Food Sci Tech 22:509-516
30. S1- casein. J Dairy Res 78:203-210
31. Ena JM, Van Beresteijn ECH, Robben AJPM, Schmidt DG (1995) Whey protein antigenicity reduction by fungal proteinases and a pepsin/pancreatin combination. J Food Sci 60:104-110
32. Exl BM (2001) A review of recent developments in the use of moderately hydrolyzed whey formulae in infant nutrition. Nutr Res 21:355-379
33. Exl BM, Fritsche R (2001) Cow's milk protein allergy and possible means for its prevention. Nutrition 17:642-651
34. Fiocchi A, Restani P, Riva E, Mirri GP, Santini I, Bernardo L, Galli CL (1998) Heat treatment modifies the allergenicity of beef and bovine serum albumin. Food Technol 53:798-802
35. Fiocchi A, Brozek J, Schünemann H, Bahna SL, von Berg A, Beyer K, Bozzola M, Bradsher J, Compalati E, Ebisawa M, Guzman MA, Li H, Heine RG, Keith P, Lack G, Landi M, Martelli A, Rancé F, Sampson H, Stein A, Terracciano L, Vieths S (2010) World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines. Pediatr Allergy Immunol 21:1-125
36. Fox PF, McSweeney PLH (1998) Dairy chemistry and biochemistry. Blackie Academic & Professional, London
37. Fritsche R (2003) Role for technology in dairy allergy. Aust J Dairy Technol 58:89-91
38. Gauthier SF, Pouliot Y, Saint-Sauveur D (2006) Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. Int Dairy J 16:1315-1323
39. Guo BH (2001) Dairy chemistry. China Light Industry Press, Beijing
40. Haddad ZH, Kalra V, Verma S (1979) IgE antibodies to peptic and peptic-tryptic digest of β-lactoglobulin: significance in food hypersensitivity. Ann Allergy 42:368-371
41. Halmerbauer G, Gartner C, Schier M, Arshad H, Dean T, Koller DY, Karmaus W, Kuehr J, Forster J, Urbanek R, Frischer T, SPACE collaborative study team (2002) Study on the prevention of allergy in children in Europe (SPACE): allergic sensitization in children at 1 year of age in a controlled trial of allergen avoidance from birth. Pediatr Allergy Immunol 13(s15):47-54
42. Hanson LA, Mansson I (1961) Immune electrophoretic studies of bovine milk and milk products. Acta Paediatrica 50:484-490
43. Hattori M, Nagasawa K, Ametani A, Kaminogawa S, Takahashi K (1994) Functional changes in β-lactoglobulin by conjugation with carboxymethyl dextran. J Agric Food Chem 42:2120-2125
44. Hattori M, Nagasawa K, Ohgata K, Sone N, Fukuda A, Matsuda H, Takahashi K (2000a) Reduced immunogenicity of β-lactoglobulin by conjugation with carboxymethyl dextran. Bioconjugate Chem 11:84-93
45. Hattori M, Numamoto K, Kobayashi K, Takahashi K (2000b) Functional changes in β-lactoglobulin by conjugation with cationic saccharides. J Agric Food Chem 48:2050-2056
46. Hattori M, Miyakawa S, Ohama Y, Kawamura H, Yoshida T, To-o K, Kuriki T, Takahashi K (2004) Reduced immunogenicity of β-lactoglobulin by conjugation with acidic oligosaccharides. J Agric Food Chem 52:4546-4553
47. Helm RM, Burks AW (2000) Mechanisms of food allergy. Curr Opin Immunol 12:647-653
48. Heyman M (1999) Evaluation of the impact of food technology on the allergenicity of cow's milk proteins. Proc Nutr Soc 58:587-592
49. Iametti S, Transidico P, Bonomi F, Vecchio G, Pittia P, Rovere P, Dall'Aglio G (1997) Molecular modifications of β-lactoglobulin upon exposure to high pressure. J Agric Food Chem 45:23-29
50. Isolauri E, Turjanmaa K (1996) Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol 97:9-15
51. Izquierdo F, Inteaz A, Varoujan Y, Gomez R (2007) Microwave assisted digestion of β-lactoglobulin by pronase, α-chymotrypsin and pepsin. Int Dairy J 17:465-470
52. Izquierdo F, Penas E, Luisa B, Gomez R (2008) Effects of combined microwave and enzymatic treatments on the hydrolysis and immunoreactivity of dairy whey proteins. Int Dairy J 18:918-922
53. Jedrychowski L, Wroblewska B (1999) Reduction of the antigenicity of whey proteins by lactic acid fermentation. Food Agric Immunol 11:91-99
54. Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361:1869-1871
55. Kleber N, Hinrichs J (2007) Antigenic response of β-lactoglobulin in thermally treated bovine skim milk and sweet whey. Milchwissenschaft 62:121-124
56. Kleber N, Weyrich U, Hinrichs J (2006) Screening for lactic acid bacteria with potential to reduce antigenic response of β-lactoglobulin in bovine skim milk and sweet whey. Innov Food Sci Emerg Technol 7:233-238
57. Kleber N, Maier S, Hinrichs J (2007) Antigenic response of bovine β-lactoglobulin influenced by ultra-high pressure treatment and temperature. Innov Food Sci Emerg Technol 8:39-45
58. Kobayashi K, Hirano A, Ohta A, Yoshida T, Takahashi K, Hattori M (2001) Reduced immunogenicity of β-lactoglobulin by conjugation with carboxymethyl dextran differing in molecular weight. J Agric Food Chem 49:823-831
59. Kobayashi K, Yoshida T, Takahashi K, Hattori M (2003) Modulation of the T cell response to β-Lactoglobulin by conjugation with carboxymethyl dextran. Bioconjug Chem 14:168-176
60. López-Expósito I, Chicón R, Belloque J, López-Fandiño R, Berin MC (2012) In vivo methods for testing allergenicity show that high hydrostatic pressure hydrolysates of β-lactoglobulin are immunologically inert. J Dairy Sci 95:541-548
61. Majamaa H, Isolauri E (1997) Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 99:179-185
62. Nagasawa K, Takahashi K, Hattori M (1996) Improved emulsifying properties of β-lactoglobulin by conjugating with carboxymethyl dextran. Food Hydrocoll 10:63-67
63. Nakamura T, Sado H, Syukunobe Y, Hirota T (1993) Antigenicity of whey protein hydrolysates prepared by combination of two proteases. Milchwissenschaft 48:667-670
64. Nakamura S, Suzuki Y, Ishikawa E, Yakushi T, Jing H, Miyamoto T, Hashizume K (2008) Reduction of in vitro allergenicity of buckwheat Fag e 1 through the Maillard-type glycosylation with polysaccharides. Food Chem 109:538-545
65. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, Sampson HA (2008) Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 122(2):342-347, 347.e1-2
66. Pahud JJ, Monti JC, Jost R (1985) Allergenicity of whey protein: its modification by tryptic in vitro hydrolysis of the protein. J Pediatr Gastroenterol Nutr 4:408-413
67. Peñas E, Préstamo G, Baeza ML, Martínez-Molero MI, Gomez R (2006a) Effects of combined high pressure and enzymatic treatments on the hydrolysis and immunoreactivity of dairy whey proteins. Int Dairy J 16:831-839
68. Peñas E, Restani P, Ballabio C, Préstamo G, Fiocchi A, Gomez R (2006b) Evaluation of the residual antigenicity of dairy whey hydrolysates obtained by combination of enzymatic hydrolysis and high-pressure treatment. J Food Prot 69:1707-1712
69. Peñas E, Snel H, Floris R, Prestamo G, Gomez R (2006c) High pressure can reduce the antigenicity of bovine whey protein hydrolysates. Int Dairy J 16:969-975
70. Pescuma M, Hébert EM, Rabesona H, Drouet M, Choiset Y, Haertlé T, Mozzi F, de Valdez GF, Chobert J-M (2011) Proteolytic action of Lactobacillus delbrueckii subsp. bulgaricus CRL 656 reduces antigenic response to bovine β-lactoglobulin. Food Chem 127:487-492
71. Peyron S, Mouécoucou J, Frémont S, Sanchez C, Gontard N (2006) Effects of heat treatment and pectin addition on beta-lactoglobulin allergenicity. J Agric Food Chem 54:5643-5650
72. Phromraksa P, Nagano H, Boonmars T, Kamboonruang C (2008) Identification of proteolytic bacteria from Thai traditional fermented foods and their allergenic reducing potentials. J Food Sci 73:189-195
73. Prioult G, Pecquet S, Fliss I (2005) Allergenicity of acidic peptides from bovine β-lactoglobulin is reduced by hydrolysis with Bifidobacterium lactis NCC362 enzymes. Int Dairy J 15:439-448
74. Puerta A, Diez-Masa JC, de Frutos M (2006) Immunochromatographic determination of β-lactoglobulin and its antigenic peptides in hypoallergenic formulas. Int Dairy J 16:406-414
75. Rytkönen J, Karttunen TJ, Karttunen R, Valkonen KH, Jenmalm MC, Alatossava T, Björkstén B, Kokkonen J (2002) Effect of heat denaturation on beta-lactoglobulin-induced gastrointestinal sensitization in rats: denatured β-LG induces a more intensive local immunologic response than native β-LG. Pediatr Allergy Immunol 13:269-277
76. Saint-Sauveur D, Gauthier SF, Boutin Y, Montoni A (2008) Immunomodulating properties of a whey protein isolate, its enzymatic digest and peptide fractions. Int Dairy J 18:260-270
77. Schmidt DG, Meijer RJ, Slangen CJ, van Beresteijn EC (1995) Raising the pH of the pepsin-catalyzed hydrolysis of bovine whey proteins increases the antigenicity of the hydrolysates. Clin Exp Allergy 25(10):1007-1017
78. Selo I, Clement G, Bernard H, Chatel JM, Creminon C, Peltre G, Wal JM (1999) Allergy to bovine β-lactoglobulin: specificity of human IgE to tryptic peptides. Clin Exp Allergy 29:1055-1063
79. Sharma S, Kumar P, Betzel C, Singh TP (2001) Structure and function of proteins involved in milk allergies. J Chromatogr B 756:183-187
80. Svenning C, Brynhildsvold J, Molland T, Langsrud T, Vegarud GE (2000) Antigenic response of whey proteins and genetic variants of β- lactoglobulin-the effect of proteolysis and processing. Int Dairy J 10:699-711
81. Terheggen-Lagro SWJ, Khouw IMSL, Schaafsma A, Wauters EAK (2002) Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study. BMC Pediatr 2:10
82. Thomas K, Herouet-Guicheney C, Ladics G, Bannon G, Cockburn A, Crevel R, Fitzpatrick J, Mills C, Privalle L, Vieths S (2007) Evaluating the effect of food processing on the potential human allergenicity of novel proteins: international workshop report. Food Chem Toxicol 45:1116-1122
83. Tzvetkova I, Dalgalarrondo M, Danova S, Iliev I, Ivanova I, Chobert J-M, Haertle T (2007) Hydrolysis of major dairy proteins by lactic acid bacteria from Bulgarian yogurts. J Food Biochem 31:680-702
84. Van Beresteijn ECH, Peeters RA, Kaper J, Meijer RJGM, Robben AJPM, Schmidt DG (1994) Molecular mass distribution, immunological properties and nutritive value of whey protein hydrolysates. J Food Prot 57:619-625
85. van de Lagemaat J, Silvan JM, Moreno FJ, Olano A, del Castillo MD (2007) In vitro glycation and antigenicity of soy proteins. Food Res Int 40:153-160
86. Van Hoeyveld EM, Escalona-Monge M, de Swert LFA, Stevens EAM (1998) Allergenic and antigenic activity of peptide fragments in a whey hydrolysate formula. Clin Exp Allergy 28:1131-1137
87. Wal JM (2001) Structure and function of milk allergens. Allergy 56:35-38
88. Wróblewska B, Karamać M, Amarowicz R, Szymkiewicz A, Troszyńska A, Kubicka E (2004) Immunoreactive properties of peptide fractions of cow whey milk proteins after enzymatic hydrolysis. Int J Food Sci Technol 39:839-850
89. Zheng H, Shen XQ, Bu GH, Luo YK (2008) Effects of pH, temperature and enzyme-to-substrate ratio on the antigenicity of whey protein hydrolysates prepared by alcalase. Int Dairy J 18:1028-1033