메뉴 건너뛰기




Volumn , Issue JUL, 2013, Pages

Inflammatory process in Alzheimer's Disease

Author keywords

Alzheimer disease; Amyloid ; Anti inflammatory strategies; Astrocyte; Microglia; Neurodegeneration; Neuroinflammation; Pro inflammatory cytokine

Indexed keywords

AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CELECOXIB; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4D; COMPLEMENT COMPONENT C5B; CORTICOSTERONE; CYCLOOXYGENASE 2; DEXAMETHASONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IBUPROFEN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MEFENAMIC ACID; MONOCYTE CHEMOTACTIC PROTEIN 1; NAPROXEN; PREDNISONE; ROFECOXIB; TAU PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRIFLUSAL;

EID: 84882665749     PISSN: 16625145     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnint.2013.00059     Document Type: Review
Times cited : (320)

References (178)
  • 1
    • 77949725218 scopus 로고    scopus 로고
    • Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease
    • doi: 10.1111/j.1471-4159.2010.06595.x
    • Ager, R. R., Fonseca, M. I., Chu, S. H., Sanderson, S. D., Taylor, S. M., Woodruff, T. M., et al. (2010). Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J. Neurochem. 113, 389-401. doi: 10.1111/j.1471-4159.2010.06595.x
    • (2010) J. Neurochem , vol.113 , pp. 389-401
    • Ager, R.R.1    Fonseca, M.I.2    Chu, S.H.3    Sanderson, S.D.4    Taylor, S.M.5    Woodruff, T.M.6
  • 3
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer's Disease progression. a randomized controlled trial
    • doi:, 10.1001/jama.289.21.2819
    • Aisen, P. S., Schaffer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., et al. (2003). Effects of rofecoxib or naproxen vs placebo on Alzheimer's Disease progression. a randomized controlled trial. JAMA 289, 2819-2826. doi:10.1001/jama.289.21.2819
    • (2003) JAMA , vol.289 , pp. 2819-2826
    • Aisen, P.S.1    Schaffer, K.A.2    Grundman, M.3    Pfeiffer, E.4    Sano, M.5    Davis, K.L.6
  • 4
    • 0032510692 scopus 로고    scopus 로고
    • Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism
    • doi: 10.1073/pnas.95.10.5795
    • Akama, K. T., Albanese, C., Pestell, R. G., and Van Eldik, L. J. (1998). Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 95, 5795-5800. doi: 10.1073/pnas.95.10.5795
    • (1998) Proc. Natl. Acad. Sci. U.S.A , vol.95 , pp. 5795-5800
    • Akama, K.T.1    Albanese, C.2    Pestell, R.G.3    van Eldik, L.J.4
  • 5
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • doi: 10.1016/S0197-4580(00)00124-X
    • Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., et al. (2000). Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421. doi: 10.1016/S0197-4580(00)00124-X
    • (2000) Neurobiol. Aging , vol.21 , pp. 383-421
    • Akiyama, H.1    Barger, S.2    Barnum, S.3    Bradt, B.4    Bauer, J.5    Cole, G.M.6
  • 6
    • 0030598393 scopus 로고    scopus 로고
    • The aminoterminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients
    • doi:, 10.1016/S0304-3940(96)13197-9
    • Akiyama, H., Kondo, H., Mori, H., Kametani, F., Nishimura, T., Ikeda, K., et al. (1996). The aminoterminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients. Neurosci. Lett. 219, 115-118. doi: 10.1016/S0304-3940(96)13197-9
    • (1996) Neurosci. Lett , vol.219 , pp. 115-118
    • Akiyama, H.1    Kondo, H.2    Mori, H.3    Kametani, F.4    Nishimura, T.5    Ikeda, K.6
  • 7
    • 80052621321 scopus 로고    scopus 로고
    • CXCL8 protects human neurons from amyloid-beta-induced neurotoxicity: Relevance to Alzheimer's disease
    • doi:, 10.1016/j.bbrc.2011.07.127
    • Ashutosh, Kou W., Cotter, R., Borgmann, K., Wu, L., Persidsky, R., et al. (2011). CXCL8 protects human neurons from amyloid-beta-induced neurotoxicity: relevance to Alzheimer's disease. Biochem. Biophys. Res. Commun. 412, 565-571. doi: 10.1016/j.bbrc.2011.07.127
    • (2011) Biochem. Biophys. Res. Commun , vol.412 , pp. 565-571
    • Ashutosh, K.W.1    Cotter, R.2    Borgmann, K.3    Wu, L.4    Persidsky, R.5
  • 8
    • 78650712733 scopus 로고    scopus 로고
    • Endothelial nitric oxide modulates expression and processing of amyloid precursor protein
    • doi:, 10.1161/CIRCRESAHA.110.233080
    • Austin, S. A., Santhanam, A. V., and Katusic, Z. S. (2010). Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ. Res. 107, 1498-1502. doi: 10.1161/CIRCRESAHA.110.233080
    • (2010) Circ. Res , vol.107 , pp. 1498-1502
    • Austin, S.A.1    Santhanam, A.V.2    Katusic, Z.S.3
  • 9
    • 0037200076 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs stimulate secretion of on-amyloidogenic precursor protein
    • doi:, 10.1074/jbc.M201308200
    • Avramovich, J., Amit, T., and Youdim, M. B. H. (2002). Non-steroidal anti-inflammatory drugs stimulate secretion of on-amyloidogenic precursor protein. J. Biol. Chem. 277, 31466-31473. doi: 10.1074/jbc.M201308200
    • (2002) J. Biol. Chem , vol.277 , pp. 31466-31473
    • Avramovich, J.1    Amit, T.2    Youdim, M.B.H.3
  • 10
    • 33744477341 scopus 로고    scopus 로고
    • How corticos-teroids control inflammation: Quintiles prize lecture 2005
    • doi: 10.1038/sj.bjp.0706736
    • Barnes, P. J. (2006). How corticos-teroids control inflammation: quintiles prize lecture 2005. Br. J. Pharmacol. 148, 245-254. doi: 10.1038/sj.bjp.0706736
    • (2006) Br. J. Pharmacol , vol.148 , pp. 245-254
    • Barnes, P.J.1
  • 11
    • 0024670986 scopus 로고
    • DNA regulatory elements for steroid hormones
    • doi: 10.1016/0022-4731(89)90521-9
    • Beato, M., Chalepakis, G., Schauer, M., and Slater, E. P. (1989). DNA regulatory elements for steroid hormones. J. Steroid Biochem. 32, 737-747. doi: 10.1016/0022-4731(89)90521-9
    • (1989) J. Steroid Biochem , vol.32 , pp. 737-747
    • Beato, M.1    Chalepakis, G.2    Schauer, M.3    Slater, E.P.4
  • 12
    • 84861182620 scopus 로고    scopus 로고
    • Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
    • doi: 10.1016/j.neurobiolaging.2011.02.011
    • Beeri, M. S., Schmeidler, J., Lesser, G. T., Maroukian, M., West, R., Leung, S., et al. (2012). Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology. Neurobiol. Aging 33, 1258-1264. doi: 10.1016/j.neurobiolaging.2011.02.011
    • (2012) Neurobiol. Aging , vol.33 , pp. 1258-1264
    • Beeri, M.S.1    Schmeidler, J.2    Lesser, G.T.3    Maroukian, M.4    West, R.5    Leung, S.6
  • 14
    • 13244299287 scopus 로고    scopus 로고
    • NO signaling in the CNS: From the physiological to the pathological
    • doi:, 10.1016/j.tox.2004.11.034
    • Bishop, A., and Anderson, J. E. (2005). NO signaling in the CNS: from the physiological to the pathological. Toxicology 208, 193-205. doi: 10.1016/j.tox.2004.11.034
    • (2005) Toxicology , vol.208 , pp. 193-205
    • Bishop, A.1    Anderson, J.E.2
  • 15
    • 13844281550 scopus 로고    scopus 로고
    • How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes
    • doi:, 10.1111/j.1474-9728.2004.00101.x
    • Blasko, I., Stampfer-Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., and Grubeck-Loebenstein, B. (2004). How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 3, 169-176. doi: 10.1111/j.1474-9728.2004.00101.x
    • (2004) Aging Cell , vol.3 , pp. 169-176
    • Blasko, I.1    Stampfer-Kountchev, M.2    Robatscher, P.3    Veerhuis, R.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 16
    • 0034523456 scopus 로고    scopus 로고
    • Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
    • doi:, 10.1006/nbdi.2000.0321
    • Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., and Grubeck-Loebenstein, B. (2000). Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol. Dis. 7, 682-689. doi: 10.1006/nbdi.2000.0321
    • (2000) Neurobiol. Dis , vol.7 , pp. 682-689
    • Blasko, I.1    Veerhuis, R.2    Stampfer-Kountchev, M.3    Saurwein-Teissl, M.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6
  • 17
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • doi: 10.1016/0304-3940(95)12192-7
    • Blum-Degen, D., Muller, T., Kuhn, W., Gerlach, M., Przuntek, H., and Riederer, P. (1995). Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202, 17-20. doi: 10.1016/0304-3940(95)12192-7
    • (1995) Neurosci. Lett , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Muller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 18
    • 77954656871 scopus 로고    scopus 로고
    • Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
    • doi: 10.1016/j.expneurol.2010.05.010
    • Boimel, M., Grigoriadis, N., Lourbopoulos, A., Haber, E., Abramsky, O., and Rosenmann, H. (2010). Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp. Neurol. 224, 472-485. doi: 10.1016/j.expneurol.2010.05.010
    • (2010) Exp. Neurol , vol.224 , pp. 472-485
    • Boimel, M.1    Grigoriadis, N.2    Lourbopoulos, A.3    Haber, E.4    Abramsky, O.5    Rosenmann, H.6
  • 19
    • 78650065372 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
    • doi: 10.1523/JNEUROSCI.4363-10.2010
    • Boutajangout, A., Quartermain, D., and Sigurdsson, E. M. (2010). Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J. Neurosci. 30, 16559-16566. doi: 10.1523/JNEUROSCI.4363-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 16559-16566
    • Boutajangout, A.1    Quartermain, D.2    Sigurdsson, E.M.3
  • 20
    • 0028902109 scopus 로고
    • Characterization of inducible cyclooxygenase in rat brain
    • doi:, 10.1002/cne.903550208
    • Breder, C. D., Dewitt, D., and Kraig, R. P. (1995). Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 355, 296-315. doi: 10.1002/cne.903550208
    • (1995) J. Comp. Neurol , vol.355 , pp. 296-315
    • Breder, C.D.1    Dewitt, D.2    Kraig, R.P.3
  • 21
    • 66649131390 scopus 로고    scopus 로고
    • Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
    • doi:, 10.1212/WNL.0b013e3181a18691
    • Breitner, J. C. S., Haneuse, S. J. P. A., Walker, R., Dublin, S., Crane, P. K., Gray, S. L., et al. (2009). Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology 72, 1899-1905. doi: 10.1212/WNL.0b013e3181a18691
    • (2009) Neurology , vol.72 , pp. 1899-1905
    • Breitner, J.C.S.1    Haneuse, S.J.P.A.2    Walker, R.3    Dublin, S.4    Crane, P.K.5    Gray, S.L.6
  • 22
    • 0033751840 scopus 로고    scopus 로고
    • Anti-inflammatory drugs protect against Alzheimer's Disease at low doses
    • doi:, 10.1001/archneur.57.11.1586
    • Broe, G. A., Grayson, D. A., Creasey, H. M., Waite, L. M., Casey, B. J., Bennett, H. P., et al. (2000). Anti-inflammatory drugs protect against Alzheimer's Disease at low doses. Arch. Neurol. 57, 1586-1591. doi: 10.1001/archneur.57.11.1586
    • (2000) Arch. Neurol , vol.57 , pp. 1586-1591
    • Broe, G.A.1    Grayson, D.A.2    Creasey, H.M.3    Waite, L.M.4    Casey, B.J.5    Bennett, H.P.6
  • 23
    • 0032741786 scopus 로고    scopus 로고
    • The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo
    • doi: 10.1016/S0304-3940(99)00790-9
    • Budas, G., Coughlan, C. M., Seckl, J. R., and Breen, K. C. (1999). The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo. Neurosci. Lett. 276, 61-64. doi: 10.1016/S0304-3940(99)00790-9.
    • (1999) Neurosci. Lett , vol.276 , pp. 61-64
    • Budas, G.1    Coughlan, C.M.2    Seckl, J.R.3    Breen, K.C.4
  • 24
    • 27144511230 scopus 로고    scopus 로고
    • Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
    • doi: 10.1523/JNEUROSCI.1697-05.2005
    • Buttini, M., Masliah, E., Barbour, R., Grajeda, H., Motter, R., Johnson-Wood, K., et al. (2005). Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J. Neurosci. 25, 9096-9101. doi: 10.1523/JNEUROSCI.1697-05.2005
    • (2005) J. Neurosci , vol.25 , pp. 9096-9101
    • Buttini, M.1    Masliah, E.2    Barbour, R.3    Grajeda, H.4    Motter, R.5    Johnson-Wood, K.6
  • 25
    • 34648836983 scopus 로고    scopus 로고
    • Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity
    • doi: 10.1038/nrn2214
    • Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., and Stella, A. M. (2007). Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat. Rev. Neurosci. 8, 766-775. doi: 10.1038/nrn2214
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 766-775
    • Calabrese, V.1    Mancuso, C.2    Calvani, M.3    Rizzarelli, E.4    Butterfield, D.A.5    Stella, A.M.6
  • 26
    • 84861743669 scopus 로고    scopus 로고
    • Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain
    • doi: 10.1016/j.expneurol.2012.05.004
    • Carrero, I., Gonzalo, M. R., Martin, B., Sanz-Anquela, J. M., Arevalo-Serrano, J., and Gonzalo-Ruiz, A. (2012). Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain. Exp. Neurol. 236, 215-227. doi: 10.1016/j.expneurol.2012.05.004
    • (2012) Exp. Neurol , vol.236 , pp. 215-227
    • Carrero, I.1    Gonzalo, M.R.2    Martin, B.3    Sanz-Anquela, J.M.4    Arevalo-Serrano, J.5    Gonzalo-Ruiz, A.6
  • 27
    • 77952545096 scopus 로고    scopus 로고
    • Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease
    • Coma, M., Serenó, L., Da Rocha-Souto, B., Scotton, T. C., España, J., Sánchez, M. B., et al. (2010). Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 38, 482-491.
    • (2010) Neurobiol. Dis , vol.38 , pp. 482-491
    • Coma, M.1    Serenó, L.2    Da Rocha-Souto, B.3    Scotton, T.C.4    España, J.5    Sánchez, M.B.6
  • 28
    • 0035866060 scopus 로고    scopus 로고
    • Beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs, C. K., Karlo, J. C., Kao, S. C., and Landreth, G. E. (2001). beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21, 1179-1188.
    • (2001) J. Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3    Landreth, G.E.4
  • 29
    • 79960594603 scopus 로고    scopus 로고
    • Chemokines in CSF of Alzheimer's disease patients
    • doi: 10.1590/S0004-282X2011000400009
    • Correa, J. D., Starling, D., Teixeira, A. L., Caramelli, P., and Silva, T. A. (2011). Chemokines in CSF of Alzheimer's disease patients. Arq. Neuropsiquiatr. 69, 455-459. doi: 10.1590/S0004-282X2011000400009
    • (2011) Arq. Neuropsiquiatr , vol.69 , pp. 455-459
    • Correa, J.D.1    Starling, D.2    Teixeira, A.L.3    Caramelli, P.4    Silva, T.A.5
  • 30
    • 84860477341 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease
    • doi: 10.1016/j.jalz.2011.03.012
    • Coté, S., Carmichael, P.-H., Verrault, R., Lindsay, J., Lefebvre, J., and Laurin, D. (2012). Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease. Alzheimers Dement. 8, 219-226. doi: 10.1016/j.jalz.2011.03.012
    • (2012) Alzheimers Dement , vol.8 , pp. 219-226
    • Coté, S.1    Carmichael, P.-H.2    Verrault, R.3    Lindsay, J.4    Lefebvre, J.5    Laurin, D.6
  • 31
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • doi: 10.1007/BF02740836
    • Cotman, C., and Anderson, A. (1995). A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10, 19-45. doi: 10.1007/BF02740836
    • (1995) Mol. Neurobiol , vol.10 , pp. 19-45
    • Cotman, C.1    Anderson, A.2
  • 32
    • 0032797272 scopus 로고    scopus 로고
    • Chemokines and cell migration in secondary lymphoid organs
    • doi:, 10.1126/science.286.5447.2098
    • Cyster, J. G. (1999). Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102. doi: 10.1126/science.286.5447.2098
    • (1999) Science , vol.286 , pp. 2098-2102
    • Cyster, J.G.1
  • 33
    • 80053202160 scopus 로고    scopus 로고
    • Passive immunization with anti-tau antibodies in two transgenic models reduction of tau pathology and delay of disease progression
    • doi:, 10.1074/jbc.M111.229633
    • Chai, X., Wu, S., Murray, T. K., Kinley, R., Cella, C. V., Sims, H., et al. (2011). Passive immunization with anti-tau antibodies in two transgenic models reduction of tau pathology and delay of disease progression. J. Biol. Chem. 286, 34457-34467. doi: 10.1074/jbc.M111.229633
    • (2011) J. Biol. Chem , vol.286 , pp. 34457-34467
    • Chai, X.1    Wu, S.2    Murray, T.K.3    Kinley, R.4    Cella, C.V.5    Sims, H.6
  • 34
    • 76149092520 scopus 로고    scopus 로고
    • Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition
    • doi: 10.1096/fj.09-141754
    • Chakrabarty, P., Jansen-West, K., Beccard, A., Ceballos-Diaz, C., Levites, Y., Verbeeck, C., et al. (2010). Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. 24, 548-559. doi: 10.1096/fj.09-141754
    • (2010) FASEB J , vol.24 , pp. 548-559
    • Chakrabarty, P.1    Jansen-West, K.2    Beccard, A.3    Ceballos-Diaz, C.4    Levites, Y.5    Verbeeck, C.6
  • 35
    • 0025861341 scopus 로고
    • Screening for the beta-amyloid precursor protein mutation (APP717: Val-Ile) in extended pedigrees with early onset Alzheimer's disease
    • doi: 10.1016/0304-3940(91)90738-F
    • Chartier-Harlin, M. C., Crawford, F., Hamandi, K., Mullan, M., Goate, A., Hardy, J., et al. (1991). Screening for the beta-amyloid precursor protein mutation (APP717: Val-Ile) in extended pedigrees with early onset Alzheimer's disease. Neurosci. Lett. 129, 134-135. doi: 10.1016/0304-3940(91)90738-F
    • (1991) Neurosci. Lett , vol.129 , pp. 134-135
    • Chartier-Harlin, M.C.1    Crawford, F.2    Hamandi, K.3    Mullan, M.4    Goate, A.5    Hardy, J.6
  • 36
    • 79953277743 scopus 로고    scopus 로고
    • CR1 is associated with amyloid plaque burden and age-related cognitive decline
    • doi: 10.1002/ana.22277
    • Chibnik, L. B., Shulman, J. M., Leurgans, S. E., Schneider, J. A., Wilson, R. S., Tran, D., et al. (2011). CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann. Neurol. 69, 560-569. doi: 10.1002/ana.22277
    • (2011) Ann. Neurol , vol.69 , pp. 560-569
    • Chibnik, L.B.1    Shulman, J.M.2    Leurgans, S.E.3    Schneider, J.A.4    Wilson, R.S.5    Tran, D.6
  • 37
    • 77953953898 scopus 로고    scopus 로고
    • Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    • Choi, S. H., and Bosetti, F. (2009). Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging 1, 234-244.
    • (2009) Aging , vol.1 , pp. 234-244
    • Choi, S.H.1    Bosetti, F.2
  • 38
    • 79851480619 scopus 로고    scopus 로고
    • An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction
    • doi: 10.1002/glia.21131
    • Desai, M. K., Guercio, B. J., Narrow, W. C., and Bowers, W. J. (2011). An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia 59, 627-640. doi: 10.1002/glia.21131
    • (2011) Glia , vol.59 , pp. 627-640
    • Desai, M.K.1    Guercio, B.J.2    Narrow, W.C.3    Bowers, W.J.4
  • 39
    • 0023809230 scopus 로고
    • Alzheimer's disease. a double-labeling immuno-histochemical study of senile plaques
    • Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P., and Yen, S. H. (1988). Alzheimer's disease. a double-labeling immuno-histochemical study of senile plaques. Am. J. Pathol. 132, 86-101.
    • (1988) Am. J. Pathol , vol.132 , pp. 86-101
    • Dickson, D.W.1    Farlo, J.2    Davies, P.3    Crystal, H.4    Fuld, P.5    Yen, S.H.6
  • 40
    • 0026688723 scopus 로고
    • Neuroimmunology of Alzheimer's Disease: A conference report
    • doi: 10.1016/0197-4580(92)90104-6
    • Dickson, D. W., and Rogers, J. (1992). Neuroimmunology of Alzheimer's Disease: a conference report. Neurobiol. Aging 13, 793-798. doi: 10.1016/0197-4580(92)90104-6
    • (1992) Neurobiol. Aging , vol.13 , pp. 793-798
    • Dickson, D.W.1    Rogers, J.2
  • 42
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    • doi:, 10.1038/383710a0
    • Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Perez-Tur, J., et al. (1996). Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713. doi: 10.1038/383710a0
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3    Yu, X.4    Prada, C.M.5    Perez-Tur, J.6
  • 43
    • 0031957224 scopus 로고    scopus 로고
    • Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease
    • doi: 10.1016/S0197-4580(98)00036-0
    • El Khoury, J., Hickman, S. E., Thomas, C. A., Loike, J. D., and Silverstein, S. C. (1998). Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease. Neurobiol. Aging 19, S81-S84. doi: 10.1016/S0197-4580(98)00036-0
    • (1998) Neurobiol. Aging , vol.19
    • El Khoury, J.1    Hickman, S.E.2    Thomas, C.A.3    Loike, J.D.4    Silverstein, S.C.5
  • 44
    • 36849063880 scopus 로고    scopus 로고
    • Induction of complement proteins in a mouse model for cerebral microvascular a beta deposition
    • doi: 10.1186/1742-2094-4-22
    • Fan, R., Defilippis, K., and Van Nostrand, W. E. (2007). Induction of complement proteins in a mouse model for cerebral microvascular a beta deposition. J. Neuroinflammation 4, 22. doi: 10.1186/1742-2094-4-22
    • (2007) J. Neuroinflammation , vol.4 , pp. 22
    • Fan, R.1    Defilippis, K.2    van Nostrand, W.E.3
  • 45
    • 7344246592 scopus 로고    scopus 로고
    • Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model
    • Fiala, M., Zhang, L., Gan, X., Sherry, B., Taub, D., Graves, M. C., et al. (1998). Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol. Med. 4, 480-489.
    • (1998) Mol. Med , vol.4 , pp. 480-489
    • Fiala, M.1    Zhang, L.2    Gan, X.3    Sherry, B.4    Taub, D.5    Graves, M.C.6
  • 46
    • 0025807206 scopus 로고
    • Elevated circulating tumor necrosis factor levels in Alzheimer's disease
    • doi:, 10.1016/0304-3940(91)90490-K
    • Fillit, H., Ding, W., Buee, L., Kalman, J., Alstiel, L., Lawlor, B., et al. (1991). Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci. Lett. 129, 318-320. doi: 10.1016/0304-3940(91)90490-K
    • (1991) Neurosci. Lett , vol.129 , pp. 318-320
    • Fillit, H.1    Ding, W.2    Buee, L.3    Kalman, J.4    Alstiel, L.5    Lawlor, B.6
  • 47
    • 0029046504 scopus 로고
    • Altered expression of transforming growth factor-beta in Alzheimer's disease
    • doi:, 10.1212/WNL.45.8.1561
    • Flanders, K. C., Lippa, C. F., Smith, T. W., Pollen, D. A., and Sporn, M. B. (1995). Altered expression of transforming growth factor-beta in Alzheimer's disease. Neurology 45, 1561-1569. doi: 10.1212/WNL.45.8.1561
    • (1995) Neurology , vol.45 , pp. 1561-1569
    • Flanders, K.C.1    Lippa, C.F.2    Smith, T.W.3    Pollen, D.A.4    Sporn, M.B.5
  • 48
    • 0017162027 scopus 로고
    • Inflammatory effects of prostaglandin D2 in rat and human skin
    • doi: 10.1111/j.1476-5381.1976.tb07446.x
    • Flower, R. J., Harvey, E. A and Kingston, W. P. (1976). Inflammatory effects of prostaglandin D2 in rat and human skin. Br. J. Pharmacol. 56, 229-233. doi: 10.1111/j.1476-5381.1976.tb07446.x
    • (1976) Br. J. Pharmacol , vol.56 , pp. 229-233
    • Flower, R.J.1    Harvey, E.A.2    Kingston, W.P.3
  • 49
    • 69249152289 scopus 로고    scopus 로고
    • Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease
    • doi: 10.4049/jim, munol.0901005
    • Fonseca, M. I., Ager, R. R., Chu, S. H., Yazan, O., Sanderson, S. D., Laferla, F. M., et al. (2009). Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J. Immunol. 183, 1375-1383. doi: 10.4049/jimmunol.0901005
    • (2009) J. Immunol , vol.183 , pp. 1375-1383
    • Fonseca, M.I.1    Ager, R.R.2    Chu, S.H.3    Yazan, O.4    Sanderson, S.D.5    Laferla, F.M.6
  • 50
    • 3242766671 scopus 로고    scopus 로고
    • Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
    • doi: 10.1523/ JNEUROSCI.0901-04.2004
    • Fonseca, M. I., Zhou, J., Botto, M., and Tenner, A. J. (2004). Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J. Neurosci. 24, 6457-6465. doi: 10.1523/ JNEUROSCI.0901-04.2004
    • (2004) J. Neurosci , vol.24 , pp. 6457-6465
    • Fonseca, M.I.1    Zhou, J.2    Botto, M.3    Tenner, A.J.4
  • 51
    • 84862628488 scopus 로고    scopus 로고
    • The modular serine proteases of the complement cascade
    • doi: 10.1016/j.sbi.2012.04.001
    • Forneris, F., Wu, J., and Gros, P. (2012). The modular serine proteases of the complement cascade. Curr. Opin. Struct. Biol. 22, 333-341. doi: 10.1016/j.sbi.2012.04.001
    • (2012) Curr. Opin. Struct. Biol , vol.22 , pp. 333-341
    • Forneris, F.1    Wu, J.2    Gros, P.3
  • 52
    • 0030273697 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and cognitive function in the elderly: Inconclusive results from a population.based cohort study
    • doi: 10.1016/0895-4356(96) 00202-8
    • Fourrier, A., Letenneur, L., Bégaud, B., and Dartigues, J. F. (1996). Nonsteroidal anti-inflammatory drug use and cognitive function in the elderly: inconclusive results from a population.based cohort study. J. Clin. Epidmiol. 49, 1201. doi: 10.1016/0895-4356(96) 00202-8
    • (1996) J. Clin. Epidmiol , vol.49 , pp. 1201
    • Fourrier, A.1    Letenneur, L.2    Bégaud, B.3    Dartigues, J.F.4
  • 53
    • 0026783591 scopus 로고
    • Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
    • doi: 10.1007/BF00227813
    • Frackowiak, J., Wisniewski, H. M., Wegiel, J., Merz, G. S., Iqbal, K., and Wang, K. C. (1992). Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol. 84, 225-233. doi: 10.1007/BF00227813
    • (1992) Acta Neuropathol , vol.84 , pp. 225-233
    • Frackowiak, J.1    Wisniewski, H.M.2    Wegiel, J.3    Merz, G.S.4    Iqbal, K.5    Wang, K.C.6
  • 54
    • 0344687380 scopus 로고    scopus 로고
    • Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients
    • doi: 10.1002/ana.10531
    • Galimberti, D., Schoonenboom, N., Scarpini, E., and Scheltens, P. (2003). Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients. Ann. Neurol. 53, 547-548. doi: 10.1002/ana.10531
    • (2003) Ann. Neurol , vol.53 , pp. 547-548
    • Galimberti, D.1    Schoonenboom, N.2    Scarpini, E.3    Scheltens, P.4
  • 55
    • 77956954550 scopus 로고    scopus 로고
    • Macrophages in Alzheimer's disease: The blood-borne identity
    • doi: 10.1007/s00702-010-0422-7
    • Gate, D., Rezai-Zadeh, K., Jodry, D., Rentsendorj, A., and Town, T. (2010). Macrophages in Alzheimer's disease: the blood-borne identity. J. Neural Transm. 117, 961-970. doi: 10.1007/s00702-010-0422-7
    • (2010) J. Neural Transm , vol.117 , pp. 961-970
    • Gate, D.1    Rezai-Zadeh, K.2    Jodry, D.3    Rentsendorj, A.4    Town, T.5
  • 56
    • 0021572660 scopus 로고
    • The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis
    • Glenner, G. G., Wong, C. W., Quaranta, V., and Eanes, E. D. (1984). The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl. Pathol. 2, 357-369.
    • (1984) Appl. Pathol , vol.2 , pp. 357-369
    • Glenner, G.G.1    Wong, C.W.2    Quaranta, V.3    Eanes, E.D.4
  • 57
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • doi: 10.1038/349704a0
    • Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., et al. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706. doi: 10.1038/349704a0
    • (1991) Nature , vol.349 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6
  • 58
    • 0005775566 scopus 로고
    • Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
    • doi: 10.1073/pnas.86.19.7606
    • Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., Donnelly, R. J., Jacobsen, J. S., et al. (1989). Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 86, 7606-7610. doi: 10.1073/pnas.86.19.7606
    • (1989) Proc. Natl. Acad. Sci. U.S.A , vol.86 , pp. 7606-7610
    • Goldgaber, D.1    Harris, H.W.2    Hla, T.3    Maciag, T.4    Donnelly, R.J.5    Jacobsen, J.S.6
  • 59
    • 0030879929 scopus 로고    scopus 로고
    • Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide
    • doi: 10.1016/S0006-8993(97)00653-7
    • Goodwin, J. L., Kehrli, M. E. Jr., and Uemura, E. (1997). Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide. Brain Res. 768, 279-286. doi: 10.1016/S0006-8993(97)00653-7
    • (1997) Brain Res , vol.768 , pp. 279-286
    • Goodwin, J.L.1    Kehrli Jr., M.E.2    Uemura, E.3
  • 60
    • 33748253471 scopus 로고    scopus 로고
    • Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
    • doi: 10.1523/JNEUROSCI.2797-06.2006
    • Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., and Laferla, F. M. (2006). Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 26, 9047-9056. doi: 10.1523/JNEUROSCI.2797-06.2006
    • (2006) J. Neurosci , vol.26 , pp. 9047-9056
    • Green, K.N.1    Billings, L.M.2    Roozendaal, B.3    McGaugh, J.L.4    Laferla, F.M.5
  • 61
    • 0028926976 scopus 로고
    • Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
    • doi: 10.1097/00005072-199503000-00014
    • Griffin, W. S., Sheng, J. G., Roberts, G. W., and Mrak, R. E. (1995). Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54, 276-281. doi: 10.1097/00005072-199503000-00014
    • (1995) J. Neuropathol. Exp. Neurol , vol.54 , pp. 276-281
    • Griffin, W.S.1    Sheng, J.G.2    Roberts, G.W.3    Mrak, R.E.4
  • 62
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • doi: 10.1073/pnas.86.19.7611
    • Griffin, W. S., Stanley, L. C., Ling, C., White, L., Macleod, V., Perrot, L. J., et al. (1989). Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 86, 7611-7615. doi: 10.1073/pnas.86.19.7611
    • (1989) Proc. Natl. Acad. Sci. U.S.A , vol.86 , pp. 7611-7615
    • Griffin, W.S.1    Stanley, L.C.2    Ling, C.3    White, L.4    Macleod, V.5    Perrot, L.J.6
  • 63
    • 84862307062 scopus 로고    scopus 로고
    • Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
    • doi: 10.1002/emmm.201200243
    • Guix, F. X., Wahle, T., Vennekens, K., Snellinx, A., Chavez-Gutierrez, L., Ill-Raga, G., et al. (2012). Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol. Med. 4, 660-673. doi: 10.1002/emmm.201200243
    • (2012) EMBO Mol. Med , vol.4 , pp. 660-673
    • Guix, F.X.1    Wahle, T.2    Vennekens, K.3    Snellinx, A.4    Chavez-Gutierrez, L.5    Ill-Raga, G.6
  • 64
    • 0027468515 scopus 로고
    • Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells
    • doi:, 10.1016/0006-8993(93)91698-R
    • Haga, S., Ikeda, K., Sato, M., and Ishii, T. (1993). Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601, 88-94. doi: 10.1016/0006-8993(93)91698-R
    • (1993) Brain Res , vol.601 , pp. 88-94
    • Haga, S.1    Ikeda, K.2    Sato, M.3    Ishii, T.4
  • 65
    • 77951929051 scopus 로고    scopus 로고
    • Integrated brain circuits: Astrocytic networks modulate neuronal activity and behavior
    • doi: 10.1146/annurev-physiol-021909-135843
    • Halassa, M. M., and Haydon, P. G. (2010). Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu. Rev. Physiol. 72, 335-355. doi: 10.1146/annurev-physiol-021909-135843
    • (2010) Annu. Rev. Physiol , vol.72 , pp. 335-355
    • Halassa, M.M.1    Haydon, P.G.2
  • 66
    • 74549135360 scopus 로고    scopus 로고
    • Long-term potentiation depends on release of D-serine from astrocytes
    • doi: 10.1038/nature08673
    • Henneberger, C., Papouin, T., Oliet, S. H., and Rusakov, D. A. (2010). Long-term potentiation depends on release of D-serine from astrocytes. Nature 463, 232-236. doi: 10.1038/nature08673
    • (2010) Nature , vol.463 , pp. 232-236
    • Henneberger, C.1    Papouin, T.2    Oliet, S.H.3    Rusakov, D.A.4
  • 67
    • 84856968457 scopus 로고    scopus 로고
    • No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2011.08.006
    • Hillmann, A., Hahn, S., Schilling, S., Hoffmann, T., Demuth, H.-U., Bulic, B., et al. (2012). No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 33, 833.e39-833.e50. doi: 10.1016/j.neurobiolaging.2011.08.006
    • (2012) Neurobiol. Aging , vol.33 , Issue.833
    • Hillmann, A.1    Hahn, S.2    Schilling, S.3    Hoffmann, T.4    Demuth, H.-U.5    Bulic, B.6
  • 68
    • 27144513779 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's ß-amyloid fibrils in vitro
    • doi: 10.1016/j.neuropharm.2005.07.004
    • Hirohata, M., Ono, K., Naiki, H., and Yamada, M. (2005). Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's ß-amyloid fibrils in vitro. Neuropharmacology 49, 1088-1099. doi: 10.1016/j.neuropharm.2005.07.004
    • (2005) Neuropharmacology , vol.49 , pp. 1088-1099
    • Hirohata, M.1    Ono, K.2    Naiki, H.3    Yamada, M.4
  • 69
    • 0035100231 scopus 로고    scopus 로고
    • Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
    • doi: 10.1001/archneur.58.3.487
    • Ho, L., Purohit, D., Haroutunian, V., Luterman, J. D., Willis, F., Naslund, J., et al. (2001). Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch. Neurol. 58, 487-492. doi: 10.1001/archneur.58.3.487
    • (2001) Arch. Neurol , vol.58 , pp. 487-492
    • Ho, L.1    Purohit, D.2    Haroutunian, V.3    Luterman, J.D.4    Willis, F.5    Naslund, J.6
  • 70
    • 0038100154 scopus 로고    scopus 로고
    • Antibodies against ß-amyloid slow cognitive decline in Alzheimer's disease
    • doi: 10.1016/S0896-6273(03)00294-0
    • Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., et al. (2003). Antibodies against ß-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554. doi: 10.1016/S0896-6273(03)00294-0
    • (2003) Neuron , vol.38 , pp. 547-554
    • Hock, C.1    Konietzko, U.2    Streffer, J.R.3    Tracy, J.4    Signorell, A.5    Muller-Tillmanns, B.6
  • 71
    • 28344439699 scopus 로고    scopus 로고
    • Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
    • doi: 10.1186/1742-2094-2-27
    • Hoozemans, J. J., Van Haastert, E. S., Veerhuis, R., Arendt, T., Scheper, W., Eikelenboom, P., et al. (2005). Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J. Neuroinflammation 2, 27. doi: 10.1186/1742-2094-2-27
    • (2005) J. Neuroinflammation , vol.2 , pp. 27
    • Hoozemans, J.J.1    van Haastert, E.S.2    Veerhuis, R.3    Arendt, T.4    Scheper, W.5    Eikelenboom, P.6
  • 72
    • 0034745370 scopus 로고    scopus 로고
    • Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: Implications for Alzheimer's disease
    • doi: 10.1016/S0531-5565(00)00226-6
    • Hoozemans, J. J., Veerhuis, R., Janssen, I., Rozemuller, A. J., and Eikelenboom, P. (2001). Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. Exp. Gerontol. 36, 559-570. doi: 10.1016/S0531-5565(00)00226-6
    • (2001) Exp. Gerontol , vol.36 , pp. 559-570
    • Hoozemans, J.J.1    Veerhuis, R.2    Janssen, I.3    Rozemuller, A.J.4    Eikelenboom, P.5
  • 73
    • 0029986869 scopus 로고    scopus 로고
    • Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
    • doi: 10.1111/j.1749-6632.1996. tb34420.x
    • Hull, M., Berger, M., Volk, B., and Bauer, J. (1996). Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques. Ann. N.Y. Acad. Sci. 777, 205-212. doi: 10.1111/j.1749-6632.1996. tb34420.x
    • (1996) Ann. N.Y. Acad. Sci , vol.777 , pp. 205-212
    • Hull, M.1    Berger, M.2    Volk, B.3    Bauer, J.4
  • 74
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's Disease
    • doi:, 10.1056/NEJMoa010178
    • In'T Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L., Van Duijn, C. M., Stijnen, T., et al. (2001). Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's Disease. N. Eng. J. Med. 345, 1515-1521. doi: 10.1056/NEJMoa010178
    • (2001) N. Eng. J. Med , vol.345 , pp. 1515-1521
    • In'T Veld, B.A.1    Ruitenberg, A.2    Hofman, A.3    Launer, L.4    van Duijn, C.M.5    Stijnen, T.6
  • 75
    • 0030988629 scopus 로고    scopus 로고
    • Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
    • doi: 10.1111/j.1440-1819.1997.tb02375.x
    • Ishizuka, K., Kimura, T., Igata-Yi, R., Katsuragi, S., Takamatsu, J., and Miyakawa, T. (1997). Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci. 51, 135-138. doi: 10.1111/j.1440-1819.1997.tb02375.x
    • (1997) Psychiatry Clin. Neurosci , vol.51 , pp. 135-138
    • Ishizuka, K.1    Kimura, T.2    Igata-Yi, R.3    Katsuragi, S.4    Takamatsu, J.5    Miyakawa, T.6
  • 77
    • 80053484102 scopus 로고    scopus 로고
    • Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    • doi:, 10.1186/1750-1326-6-69
    • Jiang, H., Hampel, H., Prvulovic, D., Wallin, A., Blennow, K., Li, R., et al. (2011). Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol. Neurodegener. 6, 69. doi: 10.1186/1750-1326-6-69
    • (2011) Mol. Neurodegener , vol.6 , pp. 69
    • Jiang, H.1    Hampel, H.2    Prvulovic, D.3    Wallin, A.4    Blennow, K.5    Li, R.6
  • 78
    • 0037411495 scopus 로고    scopus 로고
    • Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study
    • doi: 10.1016/S0197-4580(02)00188-4
    • Jonker, C., Comijs, H. C., and Smit, J. H. (2003). Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study. Neurobiol. Aging 24, 583-588. doi: 10.1016/S0197-4580(02)00188-4
    • (2003) Neurobiol. Aging , vol.24 , pp. 583-588
    • Jonker, C.1    Comijs, H.C.2    Smit, J.H.3
  • 79
    • 30044447532 scopus 로고    scopus 로고
    • Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's Disease models
    • Joo, Y., Kim, H.-S., Woo, R.-S., Park, C. H., Shin, K.-Y., Lee, J.-P., et al. (2006). Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's Disease models. Mol. Pharmacol. 69, 76-84.
    • (2006) Mol. Pharmacol , vol.69 , pp. 76-84
    • Joo, Y.1    Kim, H.-S.2    Woo, R.-S.3    Park, C.H.4    Shin, K.-Y.5    Lee, J.-P.6
  • 80
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • doi: 10.1016/j.cell.2004.12.041
    • Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H., and Karin, M. (2005). Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120, 649-661. doi: 10.1016/j.cell.2004.12.041
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 81
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • doi: 10.1038/325733a0
    • Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., et al. (1987). The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736. doi: 10.1038/325733a0
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5    Grzeschik, K.H.6
  • 82
    • 9644272489 scopus 로고    scopus 로고
    • Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
    • doi: 10.1074/jbc.M405600200
    • Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., et al. (2004). Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J. Biol. Chem. 279, 50310-50320. doi: 10.1074/jbc.M405600200
    • (2004) J. Biol. Chem , vol.279 , pp. 50310-50320
    • Keil, U.1    Bonert, A.2    Marques, C.A.3    Scherping, I.4    Weyermann, J.5    Strosznajder, J.B.6
  • 83
    • 83755183781 scopus 로고    scopus 로고
    • Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model
    • doi:, 10.4049/jimmunol.1100620
    • Kitazawa, M., Cheng, D., Tsukamoto, M. R., Koike, M. A., Wes, P. D., Vasilevko, V., et al. (2011). Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model. J. Immunol. 187, 6539-6549. doi: 10.4049/jimmunol.1100620
    • (2011) J. Immunol , vol.187 , pp. 6539-6549
    • Kitazawa, M.1    Cheng, D.2    Tsukamoto, M.R.3    Koike, M.A.4    Wes, P.D.5    Vasilevko, V.6
  • 84
    • 14944367845 scopus 로고    scopus 로고
    • Microglia as a potential bridge between the amyloid beta-peptide and tau
    • doi:, 10.1196/annals.1332.006
    • Kitazawa, M., Yamasaki, T. R., and Laferla, F. M. (2004). Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann. N.Y. Acad. Sci. 1035, 85-103. doi: 10.1196/annals.1332.006
    • (2004) Ann. N.Y. Acad. Sci , vol.1035 , pp. 85-103
    • Kitazawa, M.1    Yamasaki, T.R.2    Laferla, F.M.3
  • 85
    • 0036278099 scopus 로고    scopus 로고
    • Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease
    • doi: 10.1046/ j.1365-2990.2002.00390.x
    • Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., et al. (2002). Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 28, 238-251. doi: 10.1046/ j.1365-2990.2002.00390.x
    • (2002) Neuropathol. Appl. Neurobiol , vol.28 , pp. 238-251
    • Kobayashi, K.1    Hayashi, M.2    Nakano, H.3    Fukutani, Y.4    Sasaki, K.5    Shimazaki, M.6
  • 86
    • 16844381310 scopus 로고    scopus 로고
    • TGF-{beta}1 activates two distinct type I receptors in neurons: Implications for neuronal NF-{kappa}B signaling
    • doi: 10.1083/jcb.200407027
    • Konig, H. G., Kogel, D., Rami, A., and Prehn, J. H. (2005). TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell Biol. 168, 1077-1086. doi: 10.1083/jcb.200407027
    • (2005) J. Cell Biol , vol.168 , pp. 1077-1086
    • Konig, H.G.1    Kogel, D.2    Rami, A.3    Prehn, J.H.4
  • 87
    • 0036146345 scopus 로고    scopus 로고
    • TGF-beta and the regulation of neuron survival and death
    • doi: 10.1016/ S0928-4257(01)00077-8
    • Krieglstein, K., Strelau, J., Schober, A., Sullivan, A., and Unsicker, K. (2002). TGF-beta and the regulation of neuron survival and death. J. Physiol. Paris 96, 25-30. doi: 10.1016/ S0928-4257(01)00077-8
    • (2002) J. Physiol. Paris , vol.96 , pp. 25-30
    • Krieglstein, K.1    Strelau, J.2    Schober, A.3    Sullivan, A.4    Unsicker, K.5
  • 88
    • 84860704720 scopus 로고    scopus 로고
    • Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice
    • doi:, 10.1007/s11481-011-9339-7
    • Kummer, M. P., Hulsmann, C., Hermes, M., Axt, D., and Heneka, M. T. (2012). Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. J. Neuroimmune Pharmacol. 7, 165-172. doi: 10.1007/s11481-011-9339-7
    • (2012) J. Neuroimmune Pharmacol , vol.7 , pp. 165-172
    • Kummer, M.P.1    Hulsmann, C.2    Hermes, M.3    Axt, D.4    Heneka, M.T.5
  • 89
    • 60649084668 scopus 로고    scopus 로고
    • Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Aβ 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia
    • doi: 10.1007/s00406-008-0838-3
    • Laske, C., Stransky, E., Fritsche, A., Eschweiler, G., and Leyhe, T. (2009). Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Aβ 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia. Eur. Arch. Psychiatry Clin. Neurosci. 259, 80-85. doi: 10.1007/s00406-008-0838-3
    • (2009) Eur. Arch. Psychiatry Clin. Neurosci , vol.259 , pp. 80-85
    • Laske, C.1    Stransky, E.2    Fritsche, A.3    Eschweiler, G.4    Leyhe, T.5
  • 90
    • 0029150716 scopus 로고
    • A familial Alzheimer's disease locus on chromosome 1
    • doi:, 10.1126/science.7638621
    • Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A., Weber, J. L., et al. (1995). A familial Alzheimer's disease locus on chromosome 1. Science 269, 970-973. doi: 10.1126/science.7638621
    • (1995) Science , vol.269 , pp. 970-973
    • Levy-Lahad, E.1    Wijsman, E.M.2    Nemens, E.3    Anderson, L.4    Goddard, K.A.5    Weber, J.L.6
  • 91
    • 0026778840 scopus 로고
    • A case-control study of Alzheimer's disease in China
    • doi:, 10.1212/WNL.42.8.1481
    • Li, G., Shen, Y. C., Li, Y. T., Chen, C. H., Zhau, Y. W., and Silverman, J. M. (1992). A case-control study of Alzheimer's disease in China. Neurology 42, 1481-1488. doi: 10.1212/WNL.42.8.1481
    • (1992) Neurology , vol.42 , pp. 1481-1488
    • Li, G.1    Shen, Y.C.2    Li, Y.T.3    Chen, C.H.4    Zhau, Y.W.5    Silverman, J.M.6
  • 92
    • 73649084740 scopus 로고    scopus 로고
    • Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice
    • doi:, 10.1016/j.ejphar.2009.11.045
    • Li, W.-Z., Li, W.-P., Yao, Y.-Y., Zhang, W., Yin, Y.-Y., Wu, G.-C., et al. (2010). Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice. Eur. J. Pharmacol. 628, 108-115. doi: 10.1016/j.ejphar.2009.11.045
    • (2010) Eur. J. Pharmacol , vol.628 , pp. 108-115
    • Li, W.-Z.1    Li, W.-P.2    Yao, Y.-Y.3    Zhang, W.4    Yin, Y.-Y.5    Wu, G.-C.6
  • 93
    • 0037336701 scopus 로고    scopus 로고
    • Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
    • Li, Y., Liu, L., Barger, S. W., and Griffin, W. S. (2003). Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J. Neurosci. 23, 1605-1611.
    • (2003) J. Neurosci , vol.23 , pp. 1605-1611
    • Li, Y.1    Liu, L.2    Barger, S.W.3    Griffin, W.S.4
  • 94
    • 0031693662 scopus 로고    scopus 로고
    • S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures
    • doi: 10.1046/j.1471-4159.1998.71041421.x
    • Li, Y., Wang, J., Sheng, J. G., Liu, L., Barger, S. W., Jones, R. A., et al. (1998). S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. J. Neurochem. 71, 1421-1428. doi: 10.1046/j.1471-4159.1998.71041421.x
    • (1998) J. Neurochem , vol.71 , pp. 1421-1428
    • Li, Y.1    Wang, J.2    Sheng, J.G.3    Liu, L.4    Barger, S.W.5    Jones, R.A.6
  • 95
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretasemediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • doi:, 10.1074/jbc.M402034200
    • Liao, Y. F., Wang, B. J., Cheng, H. T., Kuo, L. H., and Wolfe, M. S. (2004). Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretasemediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J. Biol. Chem. 279, 49523-49532. doi: 10.1074/jbc.M402034200
    • (2004) J. Biol. Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3    Kuo, L.H.4    Wolfe, M.S.5
  • 96
    • 0036272473 scopus 로고    scopus 로고
    • Role of nitric oxide in inflammation-mediated neurodegeneration
    • doi: 10.1111/j.1749-6632.2002.tb04077.x
    • Liu, B., Gao, H. M., Wang, J. Y., Jeohn, G. H., Cooper, C. L., and Hong, J. S. (2002). Role of nitric oxide in inflammation-mediated neurodegeneration. Ann. N.Y. Acad. Sci. 962, 318-331. doi: 10.1111/j.1749-6632.2002.tb04077.x
    • (2002) Ann. N.Y. Acad. Sci , vol.962 , pp. 318-331
    • Liu, B.1    Gao, H.M.2    Wang, J.Y.3    Jeohn, G.H.4    Cooper, C.L.5    Hong, J.S.6
  • 97
    • 79951563382 scopus 로고    scopus 로고
    • Passive (Amyloid-β Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice
    • Liu, Y., Lee, M. K., James, M. M., Price, D. L., Borchelt, D. R., Troncoso, J. C., et al. (2011). Passive (Amyloid-β Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice. J. Alzheimer's Dis. 23, 271-279.
    • (2011) J. Alzheimer's Dis , vol.23 , pp. 271-279
    • Liu, Y.1    Lee, M.K.2    James, M.M.3    Price, D.L.4    Borchelt, D.R.5    Troncoso, J.C.6
  • 98
    • 0034948192 scopus 로고    scopus 로고
    • Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
    • doi:, 10.1002/glia.1072
    • Lue, L. F., Rydel, R., Brigham, E. F., Yang, L. B., Hampel, H., Murphy, G. M. Jr., et al., (2001). Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35, 72-79. doi: 10.1002/glia.1072
    • (2001) Glia , vol.35 , pp. 72-79
    • Lue, L.F.1    Rydel, R.2    Brigham, E.F.3    Yang, L.B.4    Hampel, H.5    Murphy Jr., G.M.6
  • 99
    • 22044446806 scopus 로고    scopus 로고
    • Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures
    • doi:, 10.1016/j.expneurol.2005.02.021
    • Macpherson, A., Dinkel, K., and Sapolsky, R. (2005). Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures. Exp. Neurol. 194, 376-383. doi: 10.1016/j.expneurol.2005.02.021
    • (2005) Exp. Neurol , vol.194 , pp. 376-383
    • Macpherson, A.1    Dinkel, K.2    Sapolsky, R.3
  • 100
    • 46749087854 scopus 로고    scopus 로고
    • Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
    • doi: 10.1523/JNEUROSCI.0829-08.2008
    • Maier, M., Peng, Y., Jiang, L., Seabrook, T. J., Carroll, M. C., and Lemere, C. A. (2008). Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J. Neurosci. 28, 6333-6341. doi: 10.1523/JNEUROSCI.0829-08.2008
    • (2008) J. Neurosci , vol.28 , pp. 6333-6341
    • Maier, M.1    Peng, Y.2    Jiang, L.3    Seabrook, T.J.4    Carroll, M.C.5    Lemere, C.A.6
  • 101
    • 33847128514 scopus 로고    scopus 로고
    • Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease
    • doi: 10.1016/j., neurobiolaging.2006.02.013
    • Man, S. M., Ma, Y. R., Shang, D. S., Zhao, W. D., Li, B., Guo, D. W., et al. (2007). Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease. Neurobiol. Aging 28, 485-496. doi: 10.1016/j.neurobiolaging.2006.02.013
    • (2007) Neurobiol. Aging , vol.28 , pp. 485-496
    • Man, S.M.1    Ma, Y.R.2    Shang, D.S.3    Zhao, W.D.4    Li, B.5    Guo, D.W.6
  • 102
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • doi: 10.1001/arch-neur.2008.65.7.nct70006
    • Martin, B., Szekely, C., Brandt, J., Piantadosi, S., Breitner, J., Craft, S., et al. (2008). Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 65, 896. doi: 10.1001/arch-neur.2008.65.7.nct70006
    • (2008) Arch. Neurol , vol.65 , pp. 896
    • Martin, B.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.5    Craft, S.6
  • 103
    • 84860751910 scopus 로고    scopus 로고
    • Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration
    • doi:, 10.1007/s11481-011-9331-2
    • Matousek, S. B., Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., and O'Banion, M. K. (2012). Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7, 156-164. doi: 10.1007/s11481-011-9331-2
    • (2012) J. Neuroimmune Pharmacol , vol.7 , pp. 156-164
    • Matousek, S.B.1    Ghosh, S.2    Shaftel, S.S.3    Kyrkanides, S.4    Olschowka, J.A.5    O'Banion, M.K.6
  • 104
    • 62249094525 scopus 로고    scopus 로고
    • Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    • doi: 10.1016/j.nbd.2009.01.006
    • McAlpine, F. E., Lee, J. K., Harms, A. S., Ruhn, K. A., Blurton-Jones, M., Hong, J., et al. (2009). Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol. Dis. 34, 163-177. doi: 10.1016/j.nbd.2009.01.006
    • (2009) Neurobiol. Dis , vol.34 , pp. 163-177
    • McAlpine, F.E.1    Lee, J.K.2    Harms, A.S.3    Ruhn, K.A.4    Blurton-Jones, M.5    Hong, J.6
  • 105
    • 0024317005 scopus 로고
    • Activation of the classical complement pathway in brain tissue of Alzheimer patients
    • doi: 10.1016/0304-3940(89)90843-4
    • McGeer, P. L., Akiyama, H., Itagaki, S., and McGeer, E. G. (1989). Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci. Lett. 107, 341-346. doi: 10.1016/0304-3940(89)90843-4
    • (1989) Neurosci. Lett , vol.107 , pp. 341-346
    • McGeer, P.L.1    Akiyama, H.2    Itagaki, S.3    McGeer, E.G.4
  • 106
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • doi: 10.1007/BF00689592
    • McGeer, P. L., Itagaki, S., and McGeer, E. G. (1988). Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 76, 550-557. doi: 10.1007/BF00689592
    • (1988) Acta Neuropathol , vol.76 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 107
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • doi:, 10.1016/0165-0173(95)00011-9
    • McGeer, P. L., and McGeer, E. G. (1995). The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21, 195-218. doi: 10.1016/0165-0173(95)00011-9
    • (1995) Brain Res. Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 108
    • 0032891880 scopus 로고    scopus 로고
    • Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]
    • doi:, 10.1016/S0165-5728(98)00188-X
    • Meda, L., Baron, P., Prat, E., Scarpini, E., Scarlato, G., Cassatella, M. A., et al. (1999). Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. J. Neuroimmunol. 93, 45-52. doi: 10.1016/S0165-5728(98)00188-X
    • (1999) J. Neuroimmunol , vol.93 , pp. 45-52
    • Meda, L.1    Baron, P.2    Prat, E.3    Scarpini, E.4    Scarlato, G.5    Cassatella, M.A.6
  • 109
    • 84868252916 scopus 로고    scopus 로고
    • Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
    • doi:, 10.1016/j.expneurol.2012.10.007
    • Medeiros, R., and Laferla, F. M. (2013). Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp. Neurol. 239, 133-138. doi: 10.1016/j.expneurol.2012.10.007
    • (2013) Exp. Neurol , vol.239 , pp. 133-138
    • Medeiros, R.1    Laferla, F.M.2
  • 110
    • 80053268668 scopus 로고    scopus 로고
    • Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: Implications for chronic pan-TNF-alpha suppressive therapeutic strategies in the brain
    • . doi: 10.1016/j.ajpath.2011.07.001
    • Montgomery, S. L., Mastrangelo, M. A., Habib, D., Narrow, W. C., Knowlden, S. A., Wright, T. W., et al. (2011). Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-alpha suppressive therapeutic strategies in the brain. Am. J. Pathol. 179, 2053-2070. doi: 10.1016/j.ajpath.2011.07.001
    • (2011) Am. J. Pathol , vol.179 , pp. 2053-2070
    • Montgomery, S.L.1    Mastrangelo, M.A.2    Habib, D.3    Narrow, W.C.4    Knowlden, S.A.5    Wright, T.W.6
  • 111
    • 24944566030 scopus 로고    scopus 로고
    • The interleukin-1 signalling pathway in astrocytes: A key contributor to inflammation in the brain
    • doi:, 10.1111/j.1469-7580.2005.00445.x
    • Moynagh, P. N. (2005). The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain. J. Anat. 207, 265-269. doi: 10.1111/j.1469-7580.2005.00445.x
    • (2005) J. Anat , vol.207 , pp. 265-269
    • Moynagh, P.N.1
  • 112
    • 84862322566 scopus 로고    scopus 로고
    • Microglia in Alzheimer brain: A neuropathological perspective
    • doi: 10.1155/2012/165021
    • Mrak, R. E. (2012). Microglia in Alzheimer brain: a neuropathological perspective. Int. J. Alzheimers Dis. 2012, 165021. doi: 10.1155/2012/165021
    • (2012) Int. J. Alzheimers Dis , vol.2012 , pp. 165021
    • Mrak, R.E.1
  • 113
    • 33645082486 scopus 로고    scopus 로고
    • Potential inflammatory biomarkers in Alzheimer's disease
    • Mrak, R. E., and Griffin, W. S. (2005). Potential inflammatory biomarkers in Alzheimer's disease. J. Alzheimers Dis. 8, 369-375.
    • (2005) J. Alzheimers Dis , vol.8 , pp. 369-375
    • Mrak, R.E.1    Griffin, W.S.2
  • 114
    • 0029670066 scopus 로고    scopus 로고
    • Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease
    • doi: 10.1097/00005072-199603000-00002
    • Mrak, R. E., Sheng, J. G., and Griffin, W. S. (1996). Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease. J. Neuropathol. Exp. Neurol. 55, 273-279. doi: 10.1097/00005072-199603000-00002
    • (1996) J. Neuropathol. Exp. Neurol , vol.55 , pp. 273-279
    • Mrak, R.E.1    Sheng, J.G.2    Griffin, W.S.3
  • 115
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
    • doi:, 10.1126/science.1925564
    • Murrell, J., Farlow, M., Ghetti, B., and Benson, M. D. (1991). A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99. doi: 10.1126/science.1925564
    • (1991) Science , vol.254 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 116
    • 77956393132 scopus 로고    scopus 로고
    • Involvement of Fc receptors in disorders of the central nervous system
    • doi: 10.1007/s12017-009-8099-5
    • Okun, E., Mattson, M. P., and Arumugam, T. V. (2010). Involvement of Fc receptors in disorders of the central nervous system. Neuromol. Med. 12, 164-178. doi: 10.1007/s12017-009-8099-5
    • (2010) Neuromol. Med , vol.12 , pp. 164-178
    • Okun, E.1    Mattson, M.P.2    Arumugam, T.V.3
  • 117
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
    • doi: 10.1212/01.WNL.0000073623.84147.A8
    • Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L., et al. (2003). Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 61, 46-54. doi: 10.1212/01.WNL.0000073623.84147.A8
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.-M.1    Gilman, S.2    Dartigues, J.-F.3    Laurent, B.4    Puel, M.5    Kirby, L.6
  • 118
    • 18144410635 scopus 로고    scopus 로고
    • Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
    • doi: 10.1186/1742-2094-2-9
    • Patel, N. S., Paris, D., Mathura, V., Quadros, A. N., Crawford, F. C., and Mullan, M. J. (2005). Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J. Neuroinflammation 2, 9. doi: 10.1186/1742-2094-2-9
    • (2005) J. Neuroinflammation , vol.2 , pp. 9
    • Patel, N.S.1    Paris, D.2    Mathura, V.3    Quadros, A.N.4    Crawford, F.C.5    Mullan, M.J.6
  • 119
    • 79955546564 scopus 로고    scopus 로고
    • A functional complement system is required for normal T helper cell differentiation
    • doi: 10.1016/j.imbio.2010.10.004
    • Pekkarinen, P. T., Vaali, K., Junnikkala, S., Rossi, L. H., Tuovinen, H., Meri, S., et al. (2011). A functional complement system is required for normal T helper cell differentiation. Immunobiology 216, 737-743. doi: 10.1016/j.imbio.2010.10.004
    • (2011) Immunobiology , vol.216 , pp. 737-743
    • Pekkarinen, P.T.1    Vaali, K.2    Junnikkala, S.3    Rossi, L.H.4    Tuovinen, H.5    Meri, S.6
  • 120
    • 1642420308 scopus 로고    scopus 로고
    • Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
    • doi:, 10.1016/j.yexcr.2004.01.002
    • Quintanilla, R. A., Orellana, D. I., Gonzalez-Billault, C., and Maccioni, R. B. (2004). Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp. Cell Res. 295, 245-257. doi: 10.1016/j.yexcr.2004.01.002
    • (2004) Exp. Cell Res , vol.295 , pp. 245-257
    • Quintanilla, R.A.1    Orellana, D.I.2    Gonzalez-Billault, C.3    Maccioni, R.B.4
  • 121
    • 0030183050 scopus 로고    scopus 로고
    • Chemokines in immune-mediated inflammation of the central nervous system
    • doi:, 10.1016/1359-6101(96)00003-2
    • Ransohoff, R. M., Glabinski, A., and Tani, M. (1996). Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev. 7, 35-46. doi: 10.1016/1359-6101(96)00003-2
    • (1996) Cytokine Growth Factor Rev , vol.7 , pp. 35-46
    • Ransohoff, R.M.1    Glabinski, A.2    Tani, M.3
  • 122
    • 70449534695 scopus 로고    scopus 로고
    • CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease
    • doi:, 10.1007/s11481-009-9166-2
    • Rezai-Zadeh, K., Gate, D., and Town, T. (2009). CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J. Neuroimmune Pharmacol. 4, 462-475. doi: 10.1007/s11481-009-9166-2
    • (2009) J. Neuroimmune Pharmacol , vol.4 , pp. 462-475
    • Rezai-Zadeh, K.1    Gate, D.2    Town, T.3
  • 123
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • doi: 10.1038/ni.1923
    • Ricklin, D., Hajishengallis, G., Yang, K., and Lambris, J. D. (2010). Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797. doi: 10.1038/ni.1923
    • (2010) Nat. Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 124
    • 84866042262 scopus 로고    scopus 로고
    • Nitric oxide synthase and breast cancer: Role of TIMP-1 in NO-mediated Akt activation
    • doi: 10.1371/journal.pone.0044081
    • Ridnour, L. A., Barasch, K. M., Windhausen, A. N., Dorsey, T. H., Lizardo, M. M., Yfantis, H. G., et al. (2012). Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. PLoS ONE 7:e44081. doi: 10.1371/journal.pone.0044081
    • (2012) PLoS ONE , vol.7
    • Ridnour, L.A.1    Barasch, K.M.2    Windhausen, A.N.3    Dorsey, T.H.4    Lizardo, M.M.5    Yfantis, H.G.6
  • 125
    • 34447618051 scopus 로고    scopus 로고
    • Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
    • doi: 10.1093/brain/awm102
    • Ringman, J. M., O'Neill, J., Geschwind, D., Medina, L., Apostolova, L. G., Rodriguez, Y., et al. (2007). Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain 130, 1767-1776. doi: 10.1093/brain/awm102
    • (2007) Brain , vol.130 , pp. 1767-1776
    • Ringman, J.M.1    O'Neill, J.2    Geschwind, D.3    Medina, L.4    Apostolova, L.G.5    Rodriguez, Y.6
  • 126
    • 0032579752 scopus 로고    scopus 로고
    • Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex
    • doi: 10.1016/S0169-328X(97)00356-2
    • Ringheim, G. E., Szczepanik, A. M., Petko, W., Burgher, K. L., Zhu, S. Z., and Chao, C. C. (1998). Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex. Brain Res. Mol. Brain Res. 55, 35-44. doi: 10.1016/S0169-328X(97)00356-2
    • (1998) Brain Res. Mol. Brain Res , vol.55 , pp. 35-44
    • Ringheim, G.E.1    Szczepanik, A.M.2    Petko, W.3    Burgher, K.L.4    Zhu, S.Z.5    Chao, C.C.6
  • 128
    • 0030583248 scopus 로고    scopus 로고
    • Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes
    • doi:, 10.1006/bbrc.1996.1197
    • Rossi, F., and Bianchini, E. (1996). Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes. Biochem. Biophys. Res. Commun. 225, 474-478. doi: 10.1006/bbrc.1996.1197
    • (1996) Biochem. Biophys. Res. Commun , vol.225 , pp. 474-478
    • Rossi, F.1    Bianchini, E.2
  • 129
    • 33646050649 scopus 로고    scopus 로고
    • Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
    • doi: 10.4067/S0716-97602005000400011
    • Roth, A. D., Ramirez, G., Alarcon, R., and Von Bernhardi, R. (2005). Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biol. Res. 38, 381-387. doi: 10.4067/S0716-97602005000400011
    • (2005) Biol. Res , vol.38 , pp. 381-387
    • Roth, A.D.1    Ramirez, G.2    Alarcon, R.3    von Bernhardi, R.4
  • 130
    • 0022504686 scopus 로고
    • Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study
    • doi: 10.1007/BF02899034
    • Rozemuller, J. M., Eikelenboom, P., and Stam, F. C. (1986). Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 51, 247-254. doi: 10.1007/BF02899034
    • (1986) Virchows Arch. B Cell Pathol. Incl. Mol. Pathol , vol.51 , pp. 247-254
    • Rozemuller, J.M.1    Eikelenboom, P.2    Stam, F.C.3
  • 131
    • 67649427845 scopus 로고    scopus 로고
    • A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model
    • doi: 10.1016/j.brainres.2009.05.045
    • Rozkalne, A., Spires-Jones, T. L., Stern, E. A., and Hyman, B. T. (2009). A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model. Brain Res. 1280, 178-185. doi: 10.1016/j.brainres.2009.05.045
    • (2009) Brain Res , vol.1280 , pp. 178-185
    • Rozkalne, A.1    Spires-Jones, T.L.2    Stern, E.A.3    Hyman, B.T.4
  • 132
    • 34548857335 scopus 로고    scopus 로고
    • Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
    • doi: 10.1016/j.it.2007.08.004
    • Rubartelli, A., and Lotze, M. T. (2007). Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol. 28, 429-436. doi: 10.1016/j.it.2007.08.004
    • (2007) Trends Immunol , vol.28 , pp. 429-436
    • Rubartelli, A.1    Lotze, M.T.2
  • 133
    • 4043058045 scopus 로고    scopus 로고
    • Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons
    • Saez, T. E., Pehar, M., Vargas, M., Barbeito, L., and Maccioni, R. B. (2004). Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In Vivo 18, 275-280.
    • (2004) In Vivo , vol.18 , pp. 275-280
    • Saez, T.E.1    Pehar, M.2    Vargas, M.3    Barbeito, L.4    Maccioni, R.B.5
  • 134
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • doi: 10.1212/WNL.0b013e3181c67808
    • Salloway, S., Sperling, R., Gilman, S., Fox, N., Blennow, K., Raskind, M., et al. (2009). A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73, 2061-2070. doi: 10.1212/WNL.0b013e3181c67808
    • (2009) Neurology , vol.73 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3    Fox, N.4    Blennow, K.5    Raskind, M.6
  • 135
    • 31044445398 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs repress -secretase gene promoter activity by the activation of PPAR
    • Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., et al. (2006). Nonsteroidal anti-inflammatory drugs repress -secretase gene promoter activity by the activation of PPAR. Proc. Natl. Acad. Sci. U.S.A. 103, 443-448.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 443-448
    • Sastre, M.1    Dewachter, I.2    Rossner, S.3    Bogdanovic, N.4    Rosen, E.5    Borghgraef, P.6
  • 136
    • 0034042595 scopus 로고    scopus 로고
    • Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
    • doi: 10.1006/exnr.2000.7393
    • Sheng, J. G., Zhu, S. G., Jones, R. A., Griffin, W. S., and Mrak, R. E. (2000). Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp. Neurol. 163, 388-391. doi: 10.1006/exnr.2000.7393
    • (2000) Exp. Neurol , vol.163 , pp. 388-391
    • Sheng, J.G.1    Zhu, S.G.2    Jones, R.A.3    Griffin, W.S.4    Mrak, R.E.5
  • 137
    • 0033362096 scopus 로고    scopus 로고
    • Function and dysfunction of the presenilins
    • doi:, 10.1086/302475
    • Sisodia, S. S., Kim, S. H., and Thinakaran, G. (1999). Function and dysfunction of the presenilins. Am. J. Hum. Genet. 65, 7-12. doi: 10.1086/302475
    • (1999) Am. J. Hum. Genet , vol.65 , pp. 7-12
    • Sisodia, S.S.1    Kim, S.H.2    Thinakaran, G.3
  • 138
    • 0028169558 scopus 로고
    • Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state
    • doi: 10.1016/0197-4580(94)00055-7
    • Smyth, M. D., Cribbs, D. H., Tenner, A. J., Shankle, W. R., Dick, M., Kesslak, J. P., et al. (1994). Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol. Aging 15, 609-614. doi: 10.1016/0197-4580(94)00055-7
    • (1994) Neurobiol. Aging , vol.15 , pp. 609-614
    • Smyth, M.D.1    Cribbs, D.H.2    Tenner, A.J.3    Shankle, W.R.4    Dick, M.5    Kesslak, J.P.6
  • 139
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: Biology and pathology
    • doi: 10.1007/s00401-009-0619-8
    • Sofroniew, M. V., and Vinters, H. V. (2010). Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35. doi: 10.1007/s00401-009-0619-8
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 140
    • 58149490804 scopus 로고    scopus 로고
    • Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
    • doi: 10.1016/j.nbd. 2008.10.011
    • Spires-Jones, T. L., Mielke, M. L., Rozkalne, A., Meyer-Luehmann, M., De Calignon, A., Bacskai, B. J., et al. (2009). Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol. Dis. 33, 213-220. doi: 10.1016/j.nbd. 2008.10.011
    • (2009) Neurobiol. Dis , vol.33 , pp. 213-220
    • Spires-Jones, T.L.1    Mielke, M.L.2    Rozkalne, A.3    Meyer-Luehmann, M.4    de Calignon, A.5    Bacskai, B.J.6
  • 141
    • 33748952272 scopus 로고    scopus 로고
    • Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia
    • doi:, 10.1016/j.jneuroim.2006.06.009
    • Sterka, D. Jr., and Marriott, I. (2006). Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia. J. Neuroimmunol. 179, 65-75. doi: 10.1016/j.jneuroim.2006.06.009
    • (2006) J. Neuroimmunol , vol.179 , pp. 65-75
    • Sterka Jr., D.1    Marriott, I.2
  • 142
    • 9644275598 scopus 로고    scopus 로고
    • Modulation of nuclear factor-κb activity by indomethacin influences aβ levels but not aβ precursor protein metabolism in a model of alzheimer's disease
    • doi: 10.1016/ S0002-9440(10)63269-5
    • Sung, S., Yang, H., Uryu, K., Lee, E. B., Zhao, L., Shineman, D., et al. (2004). Modulation of nuclear factor-κb activity by indomethacin influences aβ levels but not aβ precursor protein metabolism in a model of alzheimer's disease. Am. J. Pathol. 165, 2197-2206. doi: 10.1016/ S0002-9440(10)63269-5
    • (2004) Am. J. Pathol , vol.165 , pp. 2197-2206
    • Sung, S.1    Yang, H.2    Uryu, K.3    Lee, E.B.4    Zhao, L.5    Shineman, D.6
  • 143
    • 0028584381 scopus 로고
    • Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid
    • doi: 10.1111/j.1365-2826.1994.tb00635.x
    • Swaab, D. F., Raadsheer, F. C., Endert, E., Hofman, M. A., Kamphorst, W., and Ravid, R. (1994). Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid. J. Neuroendocrinol. 6, 681-687. doi: 10.1111/j.1365-2826.1994.tb00635.x
    • (1994) J. Neuroendocrinol , vol.6 , pp. 681-687
    • Swaab, D.F.1    Raadsheer, F.C.2    Endert, E.3    Hofman, M.A.4    Kamphorst, W.5    Ravid, R.6
  • 144
    • 46049108790 scopus 로고    scopus 로고
    • No advantage of "Aβ42-lowering" NSAIDs for prevention of AD insix pooled cohort studies
    • doi: 10.1212/01.wnl.0000313933.17796.f6
    • Szekely, C. A., Green, R. C., Breitner, J. C. S., Ostbye, T., Beiser, A. S., Corrada, M. M., et al. (2008). No advantage of "Aβ42-lowering" NSAIDs for prevention of AD insix pooled cohort studies. Neurology 70, 2291-2298. doi: 10.1212/01.wnl.0000313933.17796.f6
    • (2008) Neurology , vol.70 , pp. 2291-2298
    • Szekely, C.A.1    Green, R.C.2    Breitner, J.C.S.3    Ostbye, T.4    Beiser, A.S.5    Corrada, M.M.6
  • 145
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • doi: 10.1074/jbc.M600504200
    • Takeuchi, H., Jin, S., Wang, J., Zhang, G., Kawanokuchi, J., Kuno, R., et al. (2006). Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 281, 21362-21368. doi: 10.1074/jbc.M600504200
    • (2006) J. Biol. Chem , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6
  • 146
    • 0033579382 scopus 로고    scopus 로고
    • Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    • doi:, 10.1126/science.286.5448.2352
    • Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., et al. (1999). Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286, 2352-2355. doi: 10.1126/science.286.5448.2352
    • (1999) Science , vol.286 , pp. 2352-2355
    • Tan, J.1    Town, T.2    Paris, D.3    Mori, T.4    Suo, Z.5    Crawford, F.6
  • 147
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
    • doi: 10.1016/S0197-4580(01)00285-8
    • Tarkowski, E., Issa, R., Sjogren, M., Wallin, A., Blennow, K., Tarkowski, A., et al. (2002). Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol. Aging 23, 237-243. doi: 10.1016/S0197-4580(01)00285-8.
    • (2002) Neurobiol. Aging , vol.23 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjogren, M.3    Wallin, A.4    Blennow, K.5    Tarkowski, A.6
  • 148
    • 33750591957 scopus 로고    scopus 로고
    • Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
    • doi: 10.1172/JCI27341
    • Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J.V., et al. (2006). Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J. Clin. Invest. 116, 3060-3069. doi: 10.1172/JCI27341
    • (2006) J. Clin. Invest , vol.116 , pp. 3060-3069
    • Tesseur, I.1    Zou, K.2    Esposito, L.3    Bard, F.4    Berber, E.5    Can, J.V.6
  • 149
    • 21144447586 scopus 로고    scopus 로고
    • A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
    • doi: 10.1038/sj.npp. 1300690
    • Thal, L. J., Ferris, S. H., Kirby, L., Block, G. A., Lines, C. R., Yuen, E., et al. (2005). A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 30, 1204-1215. doi: 10.1038/sj.npp. 1300690
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1204-1215
    • Thal, L.J.1    Ferris, S.H.2    Kirby, L.3    Block, G.A.4    Lines, C.R.5    Yuen, E.6
  • 150
    • 0032825876 scopus 로고    scopus 로고
    • Neurodegenerative disorders: The role of peroxynitrite
    • doi:, 10.1016/S0165-0173(99)00014-4
    • Torreilles, F., Salman-Tabcheh, S., Guerin, M., and Torreilles, J. (1999). Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Brain Res. Rev. 30, 153-163. doi: 10.1016/S0165-0173(99)00014-4
    • (1999) Brain Res. Brain Res. Rev , vol.30 , pp. 153-163
    • Torreilles, F.1    Salman-Tabcheh, S.2    Guerin, M.3    Torreilles, J.4
  • 151
    • 27744464859 scopus 로고    scopus 로고
    • The microglial activation continuum: From innate to adaptive responses
    • doi: 10.1186/1742-2094-2-24
    • Town, T., Nikolic, V., and Tan, J. (2005). The microglial activation continuum: from innate to adaptive responses. J. Neuroinflammation 2, 24. doi: 10.1186/1742-2094-2-24
    • (2005) J. Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 152
    • 77953060906 scopus 로고    scopus 로고
    • Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model
    • doi: 10.1177/0269881108097630
    • Van Dam, D., Coen, K., and De Deyn, P. P. (2010). Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. J. Psychopharmacol. 24, 383-388. doi: 10.1177/0269881108097630
    • (2010) J. Psychopharmacol , vol.24 , pp. 383-388
    • van Dam, D.1    Coen, K.2    de Deyn, P.P.3
  • 153
    • 0023571572 scopus 로고
    • Inflammation and the mechanism of action of anti-inflammmatory drugs
    • Vane, J., and Botting, R. (1987). Inflammation and the mechanism of action of anti-inflammmatory drugs. FASEB J. 1, 89-96.
    • (1987) FASEB J , vol.1 , pp. 89-96
    • Vane, J.1    Botting, R.2
  • 154
    • 64549152492 scopus 로고    scopus 로고
    • Long-term follow-up of patients immunized with AN1792: Reduced functional decline in antibody responders
    • doi: 10.2174/156720509787602852
    • Vellas, B., Black, R., Thal, L. J., Fox, N. C., Daniels, M., McLennan, G., et al. (2009). Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr. Alzheimer Res. 6, 144. doi: 10.2174/156720509787602852
    • (2009) Curr. Alzheimer Res , vol.6 , pp. 144
    • Vellas, B.1    Black, R.2    Thal, L.J.3    Fox, N.C.4    Daniels, M.5    McLennan, G.6
  • 155
    • 0037276438 scopus 로고    scopus 로고
    • Tumor necrosis factor signaling
    • doi:, 10.1038/sj.cdd.4401189
    • Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death Differ. 10, 45-65. doi: 10.1038/sj.cdd.4401189
    • (2003) Cell Death Differ , vol.10 , pp. 45-65
    • Wajant, H.1    Pfizenmaier, K.2    Scheurich, P.3
  • 156
    • 0028923898 scopus 로고
    • Complement and cytokine gene expression in cultured microglial derived from postmortem human brains
    • doi: 10.1002/jnr.490400407
    • Walker, D. G., Kim, S. U., and McGeer, P. L. (1995). Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J. Neurosci. Res. 40, 478-493. doi: 10.1002/jnr.490400407
    • (1995) J. Neurosci. Res , vol.40 , pp. 478-493
    • Walker, D.G.1    Kim, S.U.2    McGeer, P.L.3
  • 157
    • 25444505871 scopus 로고    scopus 로고
    • Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
    • doi:, 10.1002/jnr.20484
    • Walker, D. G., and Lue, L. F. (2005). Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. J. Neurosci. Res. 81, 412-425. doi: 10.1002/jnr.20484
    • (2005) J. Neurosci. Res , vol.81 , pp. 412-425
    • Walker, D.G.1    Lue, L.F.2
  • 158
    • 0031127418 scopus 로고    scopus 로고
    • Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
    • doi: 10.1006/exnr.1996.6373
    • Wallace, M. N., Geddes, J. G., Farquhar, D. A., and Masson, M. R. (1997). Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques. Exp. Neurol. 144, 266-272. doi: 10.1006/exnr.1996.6373
    • (1997) Exp. Neurol , vol.144 , pp. 266-272
    • Wallace, M.N.1    Geddes, J.G.2    Farquhar, D.A.3    Masson, M.R.4
  • 159
    • 0034050540 scopus 로고    scopus 로고
    • Complement component C1q modulates the phagocytosis of Abeta by microglia
    • doi:, 10.1006/exnr.1999.7260
    • Webster, S. D., Yang, A. J., Margol, L., Garzon-Rodriguez, W., Glabe, C. G., and Tenner, A. J. (2000). Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp. Neurol. 161, 127-138. doi: 10.1006/exnr.1999.7260
    • (2000) Exp. Neurol , vol.161 , pp. 127-138
    • Webster, S.D.1    Yang, A.J.2    Margol, L.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 160
    • 0031694532 scopus 로고    scopus 로고
    • Definition, function and pathophysiological significance of chemokine receptors
    • doi: 10.1016/S0165-6147(98)01247-4
    • Wells, T. N., Power, C. A., and Proudfoot, A. E. (1998). Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol. Sci. 19, 376-380. doi: 10.1016/S0165-6147(98)01247-4
    • (1998) Trends Pharmacol. Sci , vol.19 , pp. 376-380
    • Wells, T.N.1    Power, C.A.2    Proudfoot, A.E.3
  • 161
    • 84856383137 scopus 로고    scopus 로고
    • CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
    • doi: 10.1371/jour, nal.pone.0030525
    • Westin, K., Buchhave, P., Nielsen, H., Minthon, L., Janciauskiene, S., and Hansson, O. (2012). CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease. PLoS ONE 7:e30525. doi: 10.1371/journal.pone.0030525
    • (2012) PLoS ONE , vol.7
    • Westin, K.1    Buchhave, P.2    Nielsen, H.3    Minthon, L.4    Janciauskiene, S.5    Hansson, O.6
  • 162
    • 79959670013 scopus 로고    scopus 로고
    • The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
    • doi: 10.1523/ JNEUROSCI.0293-11.2011
    • Wiessner, C., Wiederhold, K. H., Tissot, A. C., Frey, P., Danner, S., Jacobson, L. H., et al. (2011). The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J. Neurosci. 31, 9323-9331. doi: 10.1523/ JNEUROSCI.0293-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 9323-9331
    • Wiessner, C.1    Wiederhold, K.H.2    Tissot, A.C.3    Frey, P.4    Danner, S.5    Jacobson, L.H.6
  • 163
    • 0017886417 scopus 로고
    • The role of prostaglandins in inflammation
    • Williams, T. J. (1978). The role of prostaglandins in inflammation. Ann. R. Coll. Surg. Engl. 60, 198-201.
    • (1978) Ann. R. Coll. Surg. Engl , vol.60 , pp. 198-201
    • Williams, T.J.1
  • 164
    • 0025752360 scopus 로고
    • Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques
    • doi:, 10.1007/BF00310142
    • Wisniewski, H. M., Barcikowska, M., and Kida, E. (1991). Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques. Acta Neuropathol. 81, 588-590. doi: 10.1007/BF00310142
    • (1991) Acta Neuropathol , vol.81 , pp. 588-590
    • Wisniewski, H.M.1    Barcikowska, M.2    Kida, E.3
  • 165
    • 0034744296 scopus 로고    scopus 로고
    • TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    • doi: 10.1038/87945
    • Wyss-Coray, T., Lin, C., Yan, F., Yu, G. Q., Rohde, M., McConlogue, L., et al. (2001). TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 7, 612-618. doi: 10.1038/87945
    • (2001) Nat. Med , vol.7 , pp. 612-618
    • Wyss-Coray, T.1    Lin, C.2    Yan, F.3    Yu, G.Q.4    Rohde, M.5    McConlogue, L.6
  • 166
    • 0037394788 scopus 로고    scopus 로고
    • Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
    • doi:, 10.1038/nm838
    • Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., et al. (2003). Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat. Med. 9, 453-457. doi: 10.1038/nm838
    • (2003) Nat. Med , vol.9 , pp. 453-457
    • Wyss-Coray, T.1    Loike, J.D.2    Brionne, T.C.3    Lu, E.4    Anankov, R.5    Yan, F.6
  • 167
    • 0030764732 scopus 로고    scopus 로고
    • Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
    • doi: 10.1038/39321
    • Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., et al. (1997). Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 389, 603-606. doi: 10.1038/39321
    • (1997) Nature , vol.389 , pp. 603-606
    • Wyss-Coray, T.1    Masliah, E.2    Mallory, M.3    McConlogue, L.4    Johnson-Wood, K.5    Lin, C.6
  • 168
    • 0036679142 scopus 로고    scopus 로고
    • Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
    • doi: 10.1073/pnas.162350199
    • Wyss-Coray, T., Yan, F., Lin, A. H., Lambris, J. D., Alexander, J. J., Quigg, R. J., et al. (2002). Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc. Natl. Acad. Sci. U.S.A. 99, 10837-10842. doi: 10.1073/pnas.162350199
    • (2002) Proc. Natl. Acad. Sci. U.S.A , vol.99 , pp. 10837-10842
    • Wyss-Coray, T.1    Yan, F.2    Lin, A.H.3    Lambris, J.D.4    Alexander, J.J.5    Quigg, R.J.6
  • 169
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • doi:, 10.1016/S0002-9440(10)65542-3
    • Xia, M. Q., Qin, S. X., Wu, L. J., Mackay, C. R., and Hyman, B. T. (1998). Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153, 31-37. doi: 10.1016/S0002-9440(10)65542-3
    • (1998) Am. J. Pathol , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 170
    • 0036227488 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
    • doi: 10.1016/S0197-4580(01)00282-2
    • Xiang, Z., Ho, L., Valdellon, J., Borchelt, D., Kelley, K., Spielman, L., et al. (2002a). Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging 23, 327-334. doi: 10.1016/S0197-4580(01)00282-2
    • (2002) Neurobiol. Aging , vol.23 , pp. 327-334
    • Xiang, Z.1    Ho, L.2    Valdellon, J.3    Borchelt, D.4    Kelley, K.5    Spielman, L.6
  • 171
    • 0036424134 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    • Xiang, Z., Ho, L., Yemul, S., Zhao, Z., Qing, W., Pompl, P., et al. (2002b). Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expr. 10, 271-278.
    • (2002) Gene Expr , vol.10 , pp. 271-278
    • Xiang, Z.1    Ho, L.2    Yemul, S.3    Zhao, Z.4    Qing, W.5    Pompl, P.6
  • 172
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
    • doi: 10.1016/0896-6273(93)90192-T
    • Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., and Worley, P. F. (1993). Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11, 371-386. doi: 10.1016/0896-6273(93)90192-T
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 173
    • 17844375420 scopus 로고    scopus 로고
    • Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition
    • doi: 10.1016/S0002-9440(10)62364-4
    • Yamamoto, M., Horiba, M., Buescher, J. L., Huang, D., Gendelman, H. E., Ransohoff, R. M., et al. (2005). Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am. J. Pathol. 166, 1475-1485. doi: 10.1016/S0002-9440(10)62364-4
    • (2005) Am. J. Pathol , vol.166 , pp. 1475-1485
    • Yamamoto, M.1    Horiba, M.2    Buescher, J.L.3    Huang, D.4    Gendelman, H.E.5    Ransohoff, R.M.6
  • 174
    • 33947512432 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
    • doi: 10.2353/ajpath.2007.060378
    • Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., et al. (2007). Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am. J. Pathol. 170, 680-692. doi: 10.2353/ajpath.2007.060378
    • (2007) Am. J. Pathol , vol.170 , pp. 680-692
    • Yamamoto, M.1    Kiyota, T.2    Horiba, M.3    Buescher, J.L.4    Walsh, S.M.5    Gendelman, H.E.6
  • 175
    • 34848832897 scopus 로고    scopus 로고
    • Memory and learning impairment induced by dexamethasone in senescent but not young mice
    • doi: 10.1016/j.ejphar.2007.07.021
    • Yao, Y.-Y., Liu, D.-M., Xu, D.-F., and Li, W.-P. (2007). Memory and learning impairment induced by dexamethasone in senescent but not young mice. Eur. J. Pharmacol. 574, 20-28. doi: 10.1016/j.ejphar.2007.07.021
    • (2007) Eur. J. Pharmacol , vol.574 , pp. 20-28
    • Yao, Y.-Y.1    Liu, D.-M.2    Xu, D.-F.3    Li, W.-P.4
  • 176
    • 0032725481 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
    • doi: 10.1097/00005072-199911000-00003
    • Yermakova, A. V., Rollins, J., Callahan, L. M., Rogers, J., and O'Banion, M. K. (1999). Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J. Neuropathol. Exp. Neurol. 58, 1135-1146. doi: 10.1097/00005072-199911000-00003
    • (1999) J. Neuropathol. Exp. Neurol , vol.58 , pp. 1135-1146
    • Yermakova, A.V.1    Rollins, J.2    Callahan, L.M.3    Rogers, J.4    O'Banion, M.K.5
  • 177
    • 14544306103 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: The MIRAGE Study
    • doi: 10.1186/1471-2318-5-2
    • Yip, A. G., Green, R. C., Huyck, M., Cupples, L. A., and Farrer, L. A. (2005). Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr. 5:2. doi: 10.1186/1471-2318-5-2
    • (2005) BMC Geriatr , vol.5 , pp. 2
    • Yip, A.G.1    Green, R.C.2    Huyck, M.3    Cupples, L.A.4    Farrer, L.A.5
  • 178
    • 84857770581 scopus 로고    scopus 로고
    • Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
    • doi: 10.1186/1742-2094-9-47
    • Zilka, N., Kazmerova, Z., Jadhav, S., Neradil, P., Madari, A., Obetkova, D., et al. (2012). Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. J. Neuroinflammation 9, 47. doi: 10.1186/1742-2094-9-47
    • (2012) J. Neuroinflammation , vol.9 , pp. 47
    • Zilka, N.1    Kazmerova, Z.2    Jadhav, S.3    Neradil, P.4    Madari, A.5    Obetkova, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.