-
1
-
-
77949725218
-
Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease
-
doi: 10.1111/j.1471-4159.2010.06595.x
-
Ager, R. R., Fonseca, M. I., Chu, S. H., Sanderson, S. D., Taylor, S. M., Woodruff, T. M., et al. (2010). Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J. Neurochem. 113, 389-401. doi: 10.1111/j.1471-4159.2010.06595.x
-
(2010)
J. Neurochem
, vol.113
, pp. 389-401
-
-
Ager, R.R.1
Fonseca, M.I.2
Chu, S.H.3
Sanderson, S.D.4
Taylor, S.M.5
Woodruff, T.M.6
-
2
-
-
0034620538
-
A randomized controlled trial of prednisone in Alzheimer's disease
-
doi: 10.1212/WNL.54.3.588
-
Aisen, P. S., Davis, K. L., Berg, J. D., Schafer, K., Campbell, K., Thomas, R. G., et al. (2000). A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology 54, 588-593. doi: 10.1212/WNL.54.3.588
-
(2000)
Alzheimer's Disease Cooperative Study. Neurology
, vol.54
, pp. 588-593
-
-
Aisen, P.S.1
Davis, K.L.2
Berg, J.D.3
Schafer, K.4
Campbell, K.5
Thomas, R.G.6
-
3
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer's Disease progression. a randomized controlled trial
-
doi:, 10.1001/jama.289.21.2819
-
Aisen, P. S., Schaffer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., et al. (2003). Effects of rofecoxib or naproxen vs placebo on Alzheimer's Disease progression. a randomized controlled trial. JAMA 289, 2819-2826. doi:10.1001/jama.289.21.2819
-
(2003)
JAMA
, vol.289
, pp. 2819-2826
-
-
Aisen, P.S.1
Schaffer, K.A.2
Grundman, M.3
Pfeiffer, E.4
Sano, M.5
Davis, K.L.6
-
4
-
-
0032510692
-
Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism
-
doi: 10.1073/pnas.95.10.5795
-
Akama, K. T., Albanese, C., Pestell, R. G., and Van Eldik, L. J. (1998). Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 95, 5795-5800. doi: 10.1073/pnas.95.10.5795
-
(1998)
Proc. Natl. Acad. Sci. U.S.A
, vol.95
, pp. 5795-5800
-
-
Akama, K.T.1
Albanese, C.2
Pestell, R.G.3
van Eldik, L.J.4
-
5
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
doi: 10.1016/S0197-4580(00)00124-X
-
Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., et al. (2000). Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421. doi: 10.1016/S0197-4580(00)00124-X
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
-
6
-
-
0030598393
-
The aminoterminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients
-
doi:, 10.1016/S0304-3940(96)13197-9
-
Akiyama, H., Kondo, H., Mori, H., Kametani, F., Nishimura, T., Ikeda, K., et al. (1996). The aminoterminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients. Neurosci. Lett. 219, 115-118. doi: 10.1016/S0304-3940(96)13197-9
-
(1996)
Neurosci. Lett
, vol.219
, pp. 115-118
-
-
Akiyama, H.1
Kondo, H.2
Mori, H.3
Kametani, F.4
Nishimura, T.5
Ikeda, K.6
-
7
-
-
80052621321
-
CXCL8 protects human neurons from amyloid-beta-induced neurotoxicity: Relevance to Alzheimer's disease
-
doi:, 10.1016/j.bbrc.2011.07.127
-
Ashutosh, Kou W., Cotter, R., Borgmann, K., Wu, L., Persidsky, R., et al. (2011). CXCL8 protects human neurons from amyloid-beta-induced neurotoxicity: relevance to Alzheimer's disease. Biochem. Biophys. Res. Commun. 412, 565-571. doi: 10.1016/j.bbrc.2011.07.127
-
(2011)
Biochem. Biophys. Res. Commun
, vol.412
, pp. 565-571
-
-
Ashutosh, K.W.1
Cotter, R.2
Borgmann, K.3
Wu, L.4
Persidsky, R.5
-
8
-
-
78650712733
-
Endothelial nitric oxide modulates expression and processing of amyloid precursor protein
-
doi:, 10.1161/CIRCRESAHA.110.233080
-
Austin, S. A., Santhanam, A. V., and Katusic, Z. S. (2010). Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ. Res. 107, 1498-1502. doi: 10.1161/CIRCRESAHA.110.233080
-
(2010)
Circ. Res
, vol.107
, pp. 1498-1502
-
-
Austin, S.A.1
Santhanam, A.V.2
Katusic, Z.S.3
-
9
-
-
0037200076
-
Non-steroidal anti-inflammatory drugs stimulate secretion of on-amyloidogenic precursor protein
-
doi:, 10.1074/jbc.M201308200
-
Avramovich, J., Amit, T., and Youdim, M. B. H. (2002). Non-steroidal anti-inflammatory drugs stimulate secretion of on-amyloidogenic precursor protein. J. Biol. Chem. 277, 31466-31473. doi: 10.1074/jbc.M201308200
-
(2002)
J. Biol. Chem
, vol.277
, pp. 31466-31473
-
-
Avramovich, J.1
Amit, T.2
Youdim, M.B.H.3
-
10
-
-
33744477341
-
How corticos-teroids control inflammation: Quintiles prize lecture 2005
-
doi: 10.1038/sj.bjp.0706736
-
Barnes, P. J. (2006). How corticos-teroids control inflammation: quintiles prize lecture 2005. Br. J. Pharmacol. 148, 245-254. doi: 10.1038/sj.bjp.0706736
-
(2006)
Br. J. Pharmacol
, vol.148
, pp. 245-254
-
-
Barnes, P.J.1
-
11
-
-
0024670986
-
DNA regulatory elements for steroid hormones
-
doi: 10.1016/0022-4731(89)90521-9
-
Beato, M., Chalepakis, G., Schauer, M., and Slater, E. P. (1989). DNA regulatory elements for steroid hormones. J. Steroid Biochem. 32, 737-747. doi: 10.1016/0022-4731(89)90521-9
-
(1989)
J. Steroid Biochem
, vol.32
, pp. 737-747
-
-
Beato, M.1
Chalepakis, G.2
Schauer, M.3
Slater, E.P.4
-
12
-
-
84861182620
-
Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
-
doi: 10.1016/j.neurobiolaging.2011.02.011
-
Beeri, M. S., Schmeidler, J., Lesser, G. T., Maroukian, M., West, R., Leung, S., et al. (2012). Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology. Neurobiol. Aging 33, 1258-1264. doi: 10.1016/j.neurobiolaging.2011.02.011
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 1258-1264
-
-
Beeri, M.S.1
Schmeidler, J.2
Lesser, G.T.3
Maroukian, M.4
West, R.5
Leung, S.6
-
13
-
-
84859110180
-
NSAIDs may protect against agerelated brain atrophy
-
doi:, 10.3389/fnagi.2010.00035
-
Bendlin, B. B., Newman, L. M., Ries, M. L., Puglielli, L., Carlsson, C. M., Sager, M. A., et al. (2010). NSAIDs may protect against agerelated brain atrophy. Front. Aging Neurosci. 2, 1-8. doi: 10.3389/fnagi.2010.00035
-
(2010)
Front. Aging Neurosci
, vol.2
, pp. 1-8
-
-
Bendlin, B.B.1
Newman, L.M.2
Ries, M.L.3
Puglielli, L.4
Carlsson, C.M.5
Sager, M.A.6
-
14
-
-
13244299287
-
NO signaling in the CNS: From the physiological to the pathological
-
doi:, 10.1016/j.tox.2004.11.034
-
Bishop, A., and Anderson, J. E. (2005). NO signaling in the CNS: from the physiological to the pathological. Toxicology 208, 193-205. doi: 10.1016/j.tox.2004.11.034
-
(2005)
Toxicology
, vol.208
, pp. 193-205
-
-
Bishop, A.1
Anderson, J.E.2
-
15
-
-
13844281550
-
How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes
-
doi:, 10.1111/j.1474-9728.2004.00101.x
-
Blasko, I., Stampfer-Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., and Grubeck-Loebenstein, B. (2004). How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 3, 169-176. doi: 10.1111/j.1474-9728.2004.00101.x
-
(2004)
Aging Cell
, vol.3
, pp. 169-176
-
-
Blasko, I.1
Stampfer-Kountchev, M.2
Robatscher, P.3
Veerhuis, R.4
Eikelenboom, P.5
Grubeck-Loebenstein, B.6
-
16
-
-
0034523456
-
Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
-
doi:, 10.1006/nbdi.2000.0321
-
Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., and Grubeck-Loebenstein, B. (2000). Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol. Dis. 7, 682-689. doi: 10.1006/nbdi.2000.0321
-
(2000)
Neurobiol. Dis
, vol.7
, pp. 682-689
-
-
Blasko, I.1
Veerhuis, R.2
Stampfer-Kountchev, M.3
Saurwein-Teissl, M.4
Eikelenboom, P.5
Grubeck-Loebenstein, B.6
-
17
-
-
0029417080
-
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
-
doi: 10.1016/0304-3940(95)12192-7
-
Blum-Degen, D., Muller, T., Kuhn, W., Gerlach, M., Przuntek, H., and Riederer, P. (1995). Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202, 17-20. doi: 10.1016/0304-3940(95)12192-7
-
(1995)
Neurosci. Lett
, vol.202
, pp. 17-20
-
-
Blum-Degen, D.1
Muller, T.2
Kuhn, W.3
Gerlach, M.4
Przuntek, H.5
Riederer, P.6
-
18
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
-
doi: 10.1016/j.expneurol.2010.05.010
-
Boimel, M., Grigoriadis, N., Lourbopoulos, A., Haber, E., Abramsky, O., and Rosenmann, H. (2010). Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp. Neurol. 224, 472-485. doi: 10.1016/j.expneurol.2010.05.010
-
(2010)
Exp. Neurol
, vol.224
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
19
-
-
78650065372
-
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
-
doi: 10.1523/JNEUROSCI.4363-10.2010
-
Boutajangout, A., Quartermain, D., and Sigurdsson, E. M. (2010). Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J. Neurosci. 30, 16559-16566. doi: 10.1523/JNEUROSCI.4363-10.2010
-
(2010)
J. Neurosci
, vol.30
, pp. 16559-16566
-
-
Boutajangout, A.1
Quartermain, D.2
Sigurdsson, E.M.3
-
20
-
-
0028902109
-
Characterization of inducible cyclooxygenase in rat brain
-
doi:, 10.1002/cne.903550208
-
Breder, C. D., Dewitt, D., and Kraig, R. P. (1995). Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 355, 296-315. doi: 10.1002/cne.903550208
-
(1995)
J. Comp. Neurol
, vol.355
, pp. 296-315
-
-
Breder, C.D.1
Dewitt, D.2
Kraig, R.P.3
-
21
-
-
66649131390
-
Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort
-
doi:, 10.1212/WNL.0b013e3181a18691
-
Breitner, J. C. S., Haneuse, S. J. P. A., Walker, R., Dublin, S., Crane, P. K., Gray, S. L., et al. (2009). Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. Neurology 72, 1899-1905. doi: 10.1212/WNL.0b013e3181a18691
-
(2009)
Neurology
, vol.72
, pp. 1899-1905
-
-
Breitner, J.C.S.1
Haneuse, S.J.P.A.2
Walker, R.3
Dublin, S.4
Crane, P.K.5
Gray, S.L.6
-
22
-
-
0033751840
-
Anti-inflammatory drugs protect against Alzheimer's Disease at low doses
-
doi:, 10.1001/archneur.57.11.1586
-
Broe, G. A., Grayson, D. A., Creasey, H. M., Waite, L. M., Casey, B. J., Bennett, H. P., et al. (2000). Anti-inflammatory drugs protect against Alzheimer's Disease at low doses. Arch. Neurol. 57, 1586-1591. doi: 10.1001/archneur.57.11.1586
-
(2000)
Arch. Neurol
, vol.57
, pp. 1586-1591
-
-
Broe, G.A.1
Grayson, D.A.2
Creasey, H.M.3
Waite, L.M.4
Casey, B.J.5
Bennett, H.P.6
-
23
-
-
0032741786
-
The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo
-
doi: 10.1016/S0304-3940(99)00790-9
-
Budas, G., Coughlan, C. M., Seckl, J. R., and Breen, K. C. (1999). The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo. Neurosci. Lett. 276, 61-64. doi: 10.1016/S0304-3940(99)00790-9.
-
(1999)
Neurosci. Lett
, vol.276
, pp. 61-64
-
-
Budas, G.1
Coughlan, C.M.2
Seckl, J.R.3
Breen, K.C.4
-
24
-
-
27144511230
-
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease
-
doi: 10.1523/JNEUROSCI.1697-05.2005
-
Buttini, M., Masliah, E., Barbour, R., Grajeda, H., Motter, R., Johnson-Wood, K., et al. (2005). Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease. J. Neurosci. 25, 9096-9101. doi: 10.1523/JNEUROSCI.1697-05.2005
-
(2005)
J. Neurosci
, vol.25
, pp. 9096-9101
-
-
Buttini, M.1
Masliah, E.2
Barbour, R.3
Grajeda, H.4
Motter, R.5
Johnson-Wood, K.6
-
25
-
-
34648836983
-
Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity
-
doi: 10.1038/nrn2214
-
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., and Stella, A. M. (2007). Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity. Nat. Rev. Neurosci. 8, 766-775. doi: 10.1038/nrn2214
-
(2007)
Nat. Rev. Neurosci
, vol.8
, pp. 766-775
-
-
Calabrese, V.1
Mancuso, C.2
Calvani, M.3
Rizzarelli, E.4
Butterfield, D.A.5
Stella, A.M.6
-
26
-
-
84861743669
-
Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain
-
doi: 10.1016/j.expneurol.2012.05.004
-
Carrero, I., Gonzalo, M. R., Martin, B., Sanz-Anquela, J. M., Arevalo-Serrano, J., and Gonzalo-Ruiz, A. (2012). Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain. Exp. Neurol. 236, 215-227. doi: 10.1016/j.expneurol.2012.05.004
-
(2012)
Exp. Neurol
, vol.236
, pp. 215-227
-
-
Carrero, I.1
Gonzalo, M.R.2
Martin, B.3
Sanz-Anquela, J.M.4
Arevalo-Serrano, J.5
Gonzalo-Ruiz, A.6
-
27
-
-
77952545096
-
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease
-
Coma, M., Serenó, L., Da Rocha-Souto, B., Scotton, T. C., España, J., Sánchez, M. B., et al. (2010). Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 38, 482-491.
-
(2010)
Neurobiol. Dis
, vol.38
, pp. 482-491
-
-
Coma, M.1
Serenó, L.2
Da Rocha-Souto, B.3
Scotton, T.C.4
España, J.5
Sánchez, M.B.6
-
28
-
-
0035866060
-
Beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
-
Combs, C. K., Karlo, J. C., Kao, S. C., and Landreth, G. E. (2001). beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21, 1179-1188.
-
(2001)
J. Neurosci
, vol.21
, pp. 1179-1188
-
-
Combs, C.K.1
Karlo, J.C.2
Kao, S.C.3
Landreth, G.E.4
-
29
-
-
79960594603
-
Chemokines in CSF of Alzheimer's disease patients
-
doi: 10.1590/S0004-282X2011000400009
-
Correa, J. D., Starling, D., Teixeira, A. L., Caramelli, P., and Silva, T. A. (2011). Chemokines in CSF of Alzheimer's disease patients. Arq. Neuropsiquiatr. 69, 455-459. doi: 10.1590/S0004-282X2011000400009
-
(2011)
Arq. Neuropsiquiatr
, vol.69
, pp. 455-459
-
-
Correa, J.D.1
Starling, D.2
Teixeira, A.L.3
Caramelli, P.4
Silva, T.A.5
-
30
-
-
84860477341
-
Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease
-
doi: 10.1016/j.jalz.2011.03.012
-
Coté, S., Carmichael, P.-H., Verrault, R., Lindsay, J., Lefebvre, J., and Laurin, D. (2012). Nonsteroidal anti-inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease. Alzheimers Dement. 8, 219-226. doi: 10.1016/j.jalz.2011.03.012
-
(2012)
Alzheimers Dement
, vol.8
, pp. 219-226
-
-
Coté, S.1
Carmichael, P.-H.2
Verrault, R.3
Lindsay, J.4
Lefebvre, J.5
Laurin, D.6
-
31
-
-
0029245289
-
A potential role for apoptosis in neurodegeneration and Alzheimer's disease
-
doi: 10.1007/BF02740836
-
Cotman, C., and Anderson, A. (1995). A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10, 19-45. doi: 10.1007/BF02740836
-
(1995)
Mol. Neurobiol
, vol.10
, pp. 19-45
-
-
Cotman, C.1
Anderson, A.2
-
32
-
-
0032797272
-
Chemokines and cell migration in secondary lymphoid organs
-
doi:, 10.1126/science.286.5447.2098
-
Cyster, J. G. (1999). Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102. doi: 10.1126/science.286.5447.2098
-
(1999)
Science
, vol.286
, pp. 2098-2102
-
-
Cyster, J.G.1
-
33
-
-
80053202160
-
Passive immunization with anti-tau antibodies in two transgenic models reduction of tau pathology and delay of disease progression
-
doi:, 10.1074/jbc.M111.229633
-
Chai, X., Wu, S., Murray, T. K., Kinley, R., Cella, C. V., Sims, H., et al. (2011). Passive immunization with anti-tau antibodies in two transgenic models reduction of tau pathology and delay of disease progression. J. Biol. Chem. 286, 34457-34467. doi: 10.1074/jbc.M111.229633
-
(2011)
J. Biol. Chem
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
Kinley, R.4
Cella, C.V.5
Sims, H.6
-
34
-
-
76149092520
-
Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition
-
doi: 10.1096/fj.09-141754
-
Chakrabarty, P., Jansen-West, K., Beccard, A., Ceballos-Diaz, C., Levites, Y., Verbeeck, C., et al. (2010). Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. 24, 548-559. doi: 10.1096/fj.09-141754
-
(2010)
FASEB J
, vol.24
, pp. 548-559
-
-
Chakrabarty, P.1
Jansen-West, K.2
Beccard, A.3
Ceballos-Diaz, C.4
Levites, Y.5
Verbeeck, C.6
-
35
-
-
0025861341
-
Screening for the beta-amyloid precursor protein mutation (APP717: Val-Ile) in extended pedigrees with early onset Alzheimer's disease
-
doi: 10.1016/0304-3940(91)90738-F
-
Chartier-Harlin, M. C., Crawford, F., Hamandi, K., Mullan, M., Goate, A., Hardy, J., et al. (1991). Screening for the beta-amyloid precursor protein mutation (APP717: Val-Ile) in extended pedigrees with early onset Alzheimer's disease. Neurosci. Lett. 129, 134-135. doi: 10.1016/0304-3940(91)90738-F
-
(1991)
Neurosci. Lett
, vol.129
, pp. 134-135
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Hamandi, K.3
Mullan, M.4
Goate, A.5
Hardy, J.6
-
36
-
-
79953277743
-
CR1 is associated with amyloid plaque burden and age-related cognitive decline
-
doi: 10.1002/ana.22277
-
Chibnik, L. B., Shulman, J. M., Leurgans, S. E., Schneider, J. A., Wilson, R. S., Tran, D., et al. (2011). CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann. Neurol. 69, 560-569. doi: 10.1002/ana.22277
-
(2011)
Ann. Neurol
, vol.69
, pp. 560-569
-
-
Chibnik, L.B.1
Shulman, J.M.2
Leurgans, S.E.3
Schneider, J.A.4
Wilson, R.S.5
Tran, D.6
-
37
-
-
77953953898
-
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
-
Choi, S. H., and Bosetti, F. (2009). Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging 1, 234-244.
-
(2009)
Aging
, vol.1
, pp. 234-244
-
-
Choi, S.H.1
Bosetti, F.2
-
38
-
-
79851480619
-
An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction
-
doi: 10.1002/glia.21131
-
Desai, M. K., Guercio, B. J., Narrow, W. C., and Bowers, W. J. (2011). An Alzheimer's disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia 59, 627-640. doi: 10.1002/glia.21131
-
(2011)
Glia
, vol.59
, pp. 627-640
-
-
Desai, M.K.1
Guercio, B.J.2
Narrow, W.C.3
Bowers, W.J.4
-
39
-
-
0023809230
-
Alzheimer's disease. a double-labeling immuno-histochemical study of senile plaques
-
Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P., and Yen, S. H. (1988). Alzheimer's disease. a double-labeling immuno-histochemical study of senile plaques. Am. J. Pathol. 132, 86-101.
-
(1988)
Am. J. Pathol
, vol.132
, pp. 86-101
-
-
Dickson, D.W.1
Farlo, J.2
Davies, P.3
Crystal, H.4
Fuld, P.5
Yen, S.H.6
-
40
-
-
0026688723
-
Neuroimmunology of Alzheimer's Disease: A conference report
-
doi: 10.1016/0197-4580(92)90104-6
-
Dickson, D. W., and Rogers, J. (1992). Neuroimmunology of Alzheimer's Disease: a conference report. Neurobiol. Aging 13, 793-798. doi: 10.1016/0197-4580(92)90104-6
-
(1992)
Neurobiol. Aging
, vol.13
, pp. 793-798
-
-
Dickson, D.W.1
Rogers, J.2
-
41
-
-
0031689543
-
Cyclooxygenase in biology and disease
-
Dubois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Van De Putte, L. B. A., et al. (1998). Cyclooxygenase in biology and disease. FASEB J. 12, 1063-1073.
-
(1998)
FASEB J
, vol.12
, pp. 1063-1073
-
-
Dubois, R.N.1
Abramson, S.B.2
Crofford, L.3
Gupta, R.A.4
Simon, L.S.5
Van De Putte, L.B.A.6
-
42
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
doi:, 10.1038/383710a0
-
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Perez-Tur, J., et al. (1996). Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713. doi: 10.1038/383710a0
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
-
43
-
-
0031957224
-
Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease
-
doi: 10.1016/S0197-4580(98)00036-0
-
El Khoury, J., Hickman, S. E., Thomas, C. A., Loike, J. D., and Silverstein, S. C. (1998). Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease. Neurobiol. Aging 19, S81-S84. doi: 10.1016/S0197-4580(98)00036-0
-
(1998)
Neurobiol. Aging
, vol.19
-
-
El Khoury, J.1
Hickman, S.E.2
Thomas, C.A.3
Loike, J.D.4
Silverstein, S.C.5
-
44
-
-
36849063880
-
Induction of complement proteins in a mouse model for cerebral microvascular a beta deposition
-
doi: 10.1186/1742-2094-4-22
-
Fan, R., Defilippis, K., and Van Nostrand, W. E. (2007). Induction of complement proteins in a mouse model for cerebral microvascular a beta deposition. J. Neuroinflammation 4, 22. doi: 10.1186/1742-2094-4-22
-
(2007)
J. Neuroinflammation
, vol.4
, pp. 22
-
-
Fan, R.1
Defilippis, K.2
van Nostrand, W.E.3
-
45
-
-
7344246592
-
Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model
-
Fiala, M., Zhang, L., Gan, X., Sherry, B., Taub, D., Graves, M. C., et al. (1998). Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol. Med. 4, 480-489.
-
(1998)
Mol. Med
, vol.4
, pp. 480-489
-
-
Fiala, M.1
Zhang, L.2
Gan, X.3
Sherry, B.4
Taub, D.5
Graves, M.C.6
-
46
-
-
0025807206
-
Elevated circulating tumor necrosis factor levels in Alzheimer's disease
-
doi:, 10.1016/0304-3940(91)90490-K
-
Fillit, H., Ding, W., Buee, L., Kalman, J., Alstiel, L., Lawlor, B., et al. (1991). Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci. Lett. 129, 318-320. doi: 10.1016/0304-3940(91)90490-K
-
(1991)
Neurosci. Lett
, vol.129
, pp. 318-320
-
-
Fillit, H.1
Ding, W.2
Buee, L.3
Kalman, J.4
Alstiel, L.5
Lawlor, B.6
-
47
-
-
0029046504
-
Altered expression of transforming growth factor-beta in Alzheimer's disease
-
doi:, 10.1212/WNL.45.8.1561
-
Flanders, K. C., Lippa, C. F., Smith, T. W., Pollen, D. A., and Sporn, M. B. (1995). Altered expression of transforming growth factor-beta in Alzheimer's disease. Neurology 45, 1561-1569. doi: 10.1212/WNL.45.8.1561
-
(1995)
Neurology
, vol.45
, pp. 1561-1569
-
-
Flanders, K.C.1
Lippa, C.F.2
Smith, T.W.3
Pollen, D.A.4
Sporn, M.B.5
-
48
-
-
0017162027
-
Inflammatory effects of prostaglandin D2 in rat and human skin
-
doi: 10.1111/j.1476-5381.1976.tb07446.x
-
Flower, R. J., Harvey, E. A and Kingston, W. P. (1976). Inflammatory effects of prostaglandin D2 in rat and human skin. Br. J. Pharmacol. 56, 229-233. doi: 10.1111/j.1476-5381.1976.tb07446.x
-
(1976)
Br. J. Pharmacol
, vol.56
, pp. 229-233
-
-
Flower, R.J.1
Harvey, E.A.2
Kingston, W.P.3
-
49
-
-
69249152289
-
Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease
-
doi: 10.4049/jim, munol.0901005
-
Fonseca, M. I., Ager, R. R., Chu, S. H., Yazan, O., Sanderson, S. D., Laferla, F. M., et al. (2009). Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J. Immunol. 183, 1375-1383. doi: 10.4049/jimmunol.0901005
-
(2009)
J. Immunol
, vol.183
, pp. 1375-1383
-
-
Fonseca, M.I.1
Ager, R.R.2
Chu, S.H.3
Yazan, O.4
Sanderson, S.D.5
Laferla, F.M.6
-
50
-
-
3242766671
-
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
-
doi: 10.1523/ JNEUROSCI.0901-04.2004
-
Fonseca, M. I., Zhou, J., Botto, M., and Tenner, A. J. (2004). Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J. Neurosci. 24, 6457-6465. doi: 10.1523/ JNEUROSCI.0901-04.2004
-
(2004)
J. Neurosci
, vol.24
, pp. 6457-6465
-
-
Fonseca, M.I.1
Zhou, J.2
Botto, M.3
Tenner, A.J.4
-
51
-
-
84862628488
-
The modular serine proteases of the complement cascade
-
doi: 10.1016/j.sbi.2012.04.001
-
Forneris, F., Wu, J., and Gros, P. (2012). The modular serine proteases of the complement cascade. Curr. Opin. Struct. Biol. 22, 333-341. doi: 10.1016/j.sbi.2012.04.001
-
(2012)
Curr. Opin. Struct. Biol
, vol.22
, pp. 333-341
-
-
Forneris, F.1
Wu, J.2
Gros, P.3
-
52
-
-
0030273697
-
Nonsteroidal anti-inflammatory drug use and cognitive function in the elderly: Inconclusive results from a population.based cohort study
-
doi: 10.1016/0895-4356(96) 00202-8
-
Fourrier, A., Letenneur, L., Bégaud, B., and Dartigues, J. F. (1996). Nonsteroidal anti-inflammatory drug use and cognitive function in the elderly: inconclusive results from a population.based cohort study. J. Clin. Epidmiol. 49, 1201. doi: 10.1016/0895-4356(96) 00202-8
-
(1996)
J. Clin. Epidmiol
, vol.49
, pp. 1201
-
-
Fourrier, A.1
Letenneur, L.2
Bégaud, B.3
Dartigues, J.F.4
-
53
-
-
0026783591
-
Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
-
doi: 10.1007/BF00227813
-
Frackowiak, J., Wisniewski, H. M., Wegiel, J., Merz, G. S., Iqbal, K., and Wang, K. C. (1992). Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol. 84, 225-233. doi: 10.1007/BF00227813
-
(1992)
Acta Neuropathol
, vol.84
, pp. 225-233
-
-
Frackowiak, J.1
Wisniewski, H.M.2
Wegiel, J.3
Merz, G.S.4
Iqbal, K.5
Wang, K.C.6
-
54
-
-
0344687380
-
Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients
-
doi: 10.1002/ana.10531
-
Galimberti, D., Schoonenboom, N., Scarpini, E., and Scheltens, P. (2003). Chemokines in serum and cerebrospinal fluid of Alzheimer's disease patients. Ann. Neurol. 53, 547-548. doi: 10.1002/ana.10531
-
(2003)
Ann. Neurol
, vol.53
, pp. 547-548
-
-
Galimberti, D.1
Schoonenboom, N.2
Scarpini, E.3
Scheltens, P.4
-
55
-
-
77956954550
-
Macrophages in Alzheimer's disease: The blood-borne identity
-
doi: 10.1007/s00702-010-0422-7
-
Gate, D., Rezai-Zadeh, K., Jodry, D., Rentsendorj, A., and Town, T. (2010). Macrophages in Alzheimer's disease: the blood-borne identity. J. Neural Transm. 117, 961-970. doi: 10.1007/s00702-010-0422-7
-
(2010)
J. Neural Transm
, vol.117
, pp. 961-970
-
-
Gate, D.1
Rezai-Zadeh, K.2
Jodry, D.3
Rentsendorj, A.4
Town, T.5
-
56
-
-
0021572660
-
The amyloid deposits in Alzheimer's disease: Their nature and pathogenesis
-
Glenner, G. G., Wong, C. W., Quaranta, V., and Eanes, E. D. (1984). The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl. Pathol. 2, 357-369.
-
(1984)
Appl. Pathol
, vol.2
, pp. 357-369
-
-
Glenner, G.G.1
Wong, C.W.2
Quaranta, V.3
Eanes, E.D.4
-
57
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
doi: 10.1038/349704a0
-
Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., et al. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706. doi: 10.1038/349704a0
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
-
58
-
-
0005775566
-
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
-
doi: 10.1073/pnas.86.19.7606
-
Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., Donnelly, R. J., Jacobsen, J. S., et al. (1989). Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 86, 7606-7610. doi: 10.1073/pnas.86.19.7606
-
(1989)
Proc. Natl. Acad. Sci. U.S.A
, vol.86
, pp. 7606-7610
-
-
Goldgaber, D.1
Harris, H.W.2
Hla, T.3
Maciag, T.4
Donnelly, R.J.5
Jacobsen, J.S.6
-
59
-
-
0030879929
-
Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide
-
doi: 10.1016/S0006-8993(97)00653-7
-
Goodwin, J. L., Kehrli, M. E. Jr., and Uemura, E. (1997). Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide. Brain Res. 768, 279-286. doi: 10.1016/S0006-8993(97)00653-7
-
(1997)
Brain Res
, vol.768
, pp. 279-286
-
-
Goodwin, J.L.1
Kehrli Jr., M.E.2
Uemura, E.3
-
60
-
-
33748253471
-
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
-
doi: 10.1523/JNEUROSCI.2797-06.2006
-
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., and Laferla, F. M. (2006). Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 26, 9047-9056. doi: 10.1523/JNEUROSCI.2797-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 9047-9056
-
-
Green, K.N.1
Billings, L.M.2
Roozendaal, B.3
McGaugh, J.L.4
Laferla, F.M.5
-
61
-
-
0028926976
-
Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution
-
doi: 10.1097/00005072-199503000-00014
-
Griffin, W. S., Sheng, J. G., Roberts, G. W., and Mrak, R. E. (1995). Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54, 276-281. doi: 10.1097/00005072-199503000-00014
-
(1995)
J. Neuropathol. Exp. Neurol
, vol.54
, pp. 276-281
-
-
Griffin, W.S.1
Sheng, J.G.2
Roberts, G.W.3
Mrak, R.E.4
-
62
-
-
0001360461
-
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
-
doi: 10.1073/pnas.86.19.7611
-
Griffin, W. S., Stanley, L. C., Ling, C., White, L., Macleod, V., Perrot, L. J., et al. (1989). Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 86, 7611-7615. doi: 10.1073/pnas.86.19.7611
-
(1989)
Proc. Natl. Acad. Sci. U.S.A
, vol.86
, pp. 7611-7615
-
-
Griffin, W.S.1
Stanley, L.C.2
Ling, C.3
White, L.4
Macleod, V.5
Perrot, L.J.6
-
63
-
-
84862307062
-
Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
-
doi: 10.1002/emmm.201200243
-
Guix, F. X., Wahle, T., Vennekens, K., Snellinx, A., Chavez-Gutierrez, L., Ill-Raga, G., et al. (2012). Modification of gamma-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol. Med. 4, 660-673. doi: 10.1002/emmm.201200243
-
(2012)
EMBO Mol. Med
, vol.4
, pp. 660-673
-
-
Guix, F.X.1
Wahle, T.2
Vennekens, K.3
Snellinx, A.4
Chavez-Gutierrez, L.5
Ill-Raga, G.6
-
64
-
-
0027468515
-
Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells
-
doi:, 10.1016/0006-8993(93)91698-R
-
Haga, S., Ikeda, K., Sato, M., and Ishii, T. (1993). Synthetic Alzheimer amyloid beta/A4 peptides enhance production of complement C3 component by cultured microglial cells. Brain Res. 601, 88-94. doi: 10.1016/0006-8993(93)91698-R
-
(1993)
Brain Res
, vol.601
, pp. 88-94
-
-
Haga, S.1
Ikeda, K.2
Sato, M.3
Ishii, T.4
-
65
-
-
77951929051
-
Integrated brain circuits: Astrocytic networks modulate neuronal activity and behavior
-
doi: 10.1146/annurev-physiol-021909-135843
-
Halassa, M. M., and Haydon, P. G. (2010). Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu. Rev. Physiol. 72, 335-355. doi: 10.1146/annurev-physiol-021909-135843
-
(2010)
Annu. Rev. Physiol
, vol.72
, pp. 335-355
-
-
Halassa, M.M.1
Haydon, P.G.2
-
66
-
-
74549135360
-
Long-term potentiation depends on release of D-serine from astrocytes
-
doi: 10.1038/nature08673
-
Henneberger, C., Papouin, T., Oliet, S. H., and Rusakov, D. A. (2010). Long-term potentiation depends on release of D-serine from astrocytes. Nature 463, 232-236. doi: 10.1038/nature08673
-
(2010)
Nature
, vol.463
, pp. 232-236
-
-
Henneberger, C.1
Papouin, T.2
Oliet, S.H.3
Rusakov, D.A.4
-
67
-
-
84856968457
-
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
-
doi: 10.1016/j.neurobiolaging.2011.08.006
-
Hillmann, A., Hahn, S., Schilling, S., Hoffmann, T., Demuth, H.-U., Bulic, B., et al. (2012). No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 33, 833.e39-833.e50. doi: 10.1016/j.neurobiolaging.2011.08.006
-
(2012)
Neurobiol. Aging
, vol.33
, Issue.833
-
-
Hillmann, A.1
Hahn, S.2
Schilling, S.3
Hoffmann, T.4
Demuth, H.-U.5
Bulic, B.6
-
68
-
-
27144513779
-
Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's ß-amyloid fibrils in vitro
-
doi: 10.1016/j.neuropharm.2005.07.004
-
Hirohata, M., Ono, K., Naiki, H., and Yamada, M. (2005). Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's ß-amyloid fibrils in vitro. Neuropharmacology 49, 1088-1099. doi: 10.1016/j.neuropharm.2005.07.004
-
(2005)
Neuropharmacology
, vol.49
, pp. 1088-1099
-
-
Hirohata, M.1
Ono, K.2
Naiki, H.3
Yamada, M.4
-
69
-
-
0035100231
-
Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
-
doi: 10.1001/archneur.58.3.487
-
Ho, L., Purohit, D., Haroutunian, V., Luterman, J. D., Willis, F., Naslund, J., et al. (2001). Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch. Neurol. 58, 487-492. doi: 10.1001/archneur.58.3.487
-
(2001)
Arch. Neurol
, vol.58
, pp. 487-492
-
-
Ho, L.1
Purohit, D.2
Haroutunian, V.3
Luterman, J.D.4
Willis, F.5
Naslund, J.6
-
70
-
-
0038100154
-
Antibodies against ß-amyloid slow cognitive decline in Alzheimer's disease
-
doi: 10.1016/S0896-6273(03)00294-0
-
Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., et al. (2003). Antibodies against ß-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554. doi: 10.1016/S0896-6273(03)00294-0
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
-
71
-
-
28344439699
-
Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease
-
doi: 10.1186/1742-2094-2-27
-
Hoozemans, J. J., Van Haastert, E. S., Veerhuis, R., Arendt, T., Scheper, W., Eikelenboom, P., et al. (2005). Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J. Neuroinflammation 2, 27. doi: 10.1186/1742-2094-2-27
-
(2005)
J. Neuroinflammation
, vol.2
, pp. 27
-
-
Hoozemans, J.J.1
van Haastert, E.S.2
Veerhuis, R.3
Arendt, T.4
Scheper, W.5
Eikelenboom, P.6
-
72
-
-
0034745370
-
Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: Implications for Alzheimer's disease
-
doi: 10.1016/S0531-5565(00)00226-6
-
Hoozemans, J. J., Veerhuis, R., Janssen, I., Rozemuller, A. J., and Eikelenboom, P. (2001). Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. Exp. Gerontol. 36, 559-570. doi: 10.1016/S0531-5565(00)00226-6
-
(2001)
Exp. Gerontol
, vol.36
, pp. 559-570
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Janssen, I.3
Rozemuller, A.J.4
Eikelenboom, P.5
-
73
-
-
0029986869
-
Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques
-
doi: 10.1111/j.1749-6632.1996. tb34420.x
-
Hull, M., Berger, M., Volk, B., and Bauer, J. (1996). Occurrence of interleukin-6 in cortical plaques of Alzheimer's disease patients may precede transformation of diffuse into neuritic plaques. Ann. N.Y. Acad. Sci. 777, 205-212. doi: 10.1111/j.1749-6632.1996. tb34420.x
-
(1996)
Ann. N.Y. Acad. Sci
, vol.777
, pp. 205-212
-
-
Hull, M.1
Berger, M.2
Volk, B.3
Bauer, J.4
-
74
-
-
0035936004
-
Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's Disease
-
doi:, 10.1056/NEJMoa010178
-
In'T Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L., Van Duijn, C. M., Stijnen, T., et al. (2001). Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's Disease. N. Eng. J. Med. 345, 1515-1521. doi: 10.1056/NEJMoa010178
-
(2001)
N. Eng. J. Med
, vol.345
, pp. 1515-1521
-
-
In'T Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.4
van Duijn, C.M.5
Stijnen, T.6
-
75
-
-
0030988629
-
Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease
-
doi: 10.1111/j.1440-1819.1997.tb02375.x
-
Ishizuka, K., Kimura, T., Igata-Yi, R., Katsuragi, S., Takamatsu, J., and Miyakawa, T. (1997). Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci. 51, 135-138. doi: 10.1111/j.1440-1819.1997.tb02375.x
-
(1997)
Psychiatry Clin. Neurosci
, vol.51
, pp. 135-138
-
-
Ishizuka, K.1
Kimura, T.2
Igata-Yi, R.3
Katsuragi, S.4
Takamatsu, J.5
Miyakawa, T.6
-
76
-
-
0028982103
-
The toxicity in vitro of beta-amyloid protein
-
Iversen, L. L., Mortishire-Smith, R. J., Pollack, S. J., and Shearman, M. S. (1995). The toxicity in vitro of beta-amyloid protein. Biochem. J. 311(Pt 1), 1-16.
-
(1995)
Biochem. J
, vol.311
, Issue.1 PART
, pp. 1-16
-
-
Iversen, L.L.1
Mortishire-Smith, R.J.2
Pollack, S.J.3
Shearman, M.S.4
-
77
-
-
80053484102
-
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
-
doi:, 10.1186/1750-1326-6-69
-
Jiang, H., Hampel, H., Prvulovic, D., Wallin, A., Blennow, K., Li, R., et al. (2011). Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol. Neurodegener. 6, 69. doi: 10.1186/1750-1326-6-69
-
(2011)
Mol. Neurodegener
, vol.6
, pp. 69
-
-
Jiang, H.1
Hampel, H.2
Prvulovic, D.3
Wallin, A.4
Blennow, K.5
Li, R.6
-
78
-
-
0037411495
-
Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study
-
doi: 10.1016/S0197-4580(02)00188-4
-
Jonker, C., Comijs, H. C., and Smit, J. H. (2003). Does aspirin or other NSAIDs reduce the risk of cognitive decline in elderly persons? Results from a population-based study. Neurobiol. Aging 24, 583-588. doi: 10.1016/S0197-4580(02)00188-4
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 583-588
-
-
Jonker, C.1
Comijs, H.C.2
Smit, J.H.3
-
79
-
-
30044447532
-
Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's Disease models
-
Joo, Y., Kim, H.-S., Woo, R.-S., Park, C. H., Shin, K.-Y., Lee, J.-P., et al. (2006). Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's Disease models. Mol. Pharmacol. 69, 76-84.
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 76-84
-
-
Joo, Y.1
Kim, H.-S.2
Woo, R.-S.3
Park, C.H.4
Shin, K.-Y.5
Lee, J.-P.6
-
80
-
-
14844327760
-
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
doi: 10.1016/j.cell.2004.12.041
-
Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H., and Karin, M. (2005). Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120, 649-661. doi: 10.1016/j.cell.2004.12.041
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
81
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
doi: 10.1038/325733a0
-
Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., et al. (1987). The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736. doi: 10.1038/325733a0
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
-
82
-
-
9644272489
-
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
-
doi: 10.1074/jbc.M405600200
-
Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., et al. (2004). Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J. Biol. Chem. 279, 50310-50320. doi: 10.1074/jbc.M405600200
-
(2004)
J. Biol. Chem
, vol.279
, pp. 50310-50320
-
-
Keil, U.1
Bonert, A.2
Marques, C.A.3
Scherping, I.4
Weyermann, J.5
Strosznajder, J.B.6
-
83
-
-
83755183781
-
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model
-
doi:, 10.4049/jimmunol.1100620
-
Kitazawa, M., Cheng, D., Tsukamoto, M. R., Koike, M. A., Wes, P. D., Vasilevko, V., et al. (2011). Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal beta-catenin pathway function in an Alzheimer's disease model. J. Immunol. 187, 6539-6549. doi: 10.4049/jimmunol.1100620
-
(2011)
J. Immunol
, vol.187
, pp. 6539-6549
-
-
Kitazawa, M.1
Cheng, D.2
Tsukamoto, M.R.3
Koike, M.A.4
Wes, P.D.5
Vasilevko, V.6
-
84
-
-
14944367845
-
Microglia as a potential bridge between the amyloid beta-peptide and tau
-
doi:, 10.1196/annals.1332.006
-
Kitazawa, M., Yamasaki, T. R., and Laferla, F. M. (2004). Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann. N.Y. Acad. Sci. 1035, 85-103. doi: 10.1196/annals.1332.006
-
(2004)
Ann. N.Y. Acad. Sci
, vol.1035
, pp. 85-103
-
-
Kitazawa, M.1
Yamasaki, T.R.2
Laferla, F.M.3
-
85
-
-
0036278099
-
Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease
-
doi: 10.1046/ j.1365-2990.2002.00390.x
-
Kobayashi, K., Hayashi, M., Nakano, H., Fukutani, Y., Sasaki, K., Shimazaki, M., et al. (2002). Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 28, 238-251. doi: 10.1046/ j.1365-2990.2002.00390.x
-
(2002)
Neuropathol. Appl. Neurobiol
, vol.28
, pp. 238-251
-
-
Kobayashi, K.1
Hayashi, M.2
Nakano, H.3
Fukutani, Y.4
Sasaki, K.5
Shimazaki, M.6
-
86
-
-
16844381310
-
TGF-{beta}1 activates two distinct type I receptors in neurons: Implications for neuronal NF-{kappa}B signaling
-
doi: 10.1083/jcb.200407027
-
Konig, H. G., Kogel, D., Rami, A., and Prehn, J. H. (2005). TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J. Cell Biol. 168, 1077-1086. doi: 10.1083/jcb.200407027
-
(2005)
J. Cell Biol
, vol.168
, pp. 1077-1086
-
-
Konig, H.G.1
Kogel, D.2
Rami, A.3
Prehn, J.H.4
-
87
-
-
0036146345
-
TGF-beta and the regulation of neuron survival and death
-
doi: 10.1016/ S0928-4257(01)00077-8
-
Krieglstein, K., Strelau, J., Schober, A., Sullivan, A., and Unsicker, K. (2002). TGF-beta and the regulation of neuron survival and death. J. Physiol. Paris 96, 25-30. doi: 10.1016/ S0928-4257(01)00077-8
-
(2002)
J. Physiol. Paris
, vol.96
, pp. 25-30
-
-
Krieglstein, K.1
Strelau, J.2
Schober, A.3
Sullivan, A.4
Unsicker, K.5
-
88
-
-
84860704720
-
Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice
-
doi:, 10.1007/s11481-011-9339-7
-
Kummer, M. P., Hulsmann, C., Hermes, M., Axt, D., and Heneka, M. T. (2012). Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice. J. Neuroimmune Pharmacol. 7, 165-172. doi: 10.1007/s11481-011-9339-7
-
(2012)
J. Neuroimmune Pharmacol
, vol.7
, pp. 165-172
-
-
Kummer, M.P.1
Hulsmann, C.2
Hermes, M.3
Axt, D.4
Heneka, M.T.5
-
89
-
-
60649084668
-
Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Aβ 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia
-
doi: 10.1007/s00406-008-0838-3
-
Laske, C., Stransky, E., Fritsche, A., Eschweiler, G., and Leyhe, T. (2009). Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Aβ 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia. Eur. Arch. Psychiatry Clin. Neurosci. 259, 80-85. doi: 10.1007/s00406-008-0838-3
-
(2009)
Eur. Arch. Psychiatry Clin. Neurosci
, vol.259
, pp. 80-85
-
-
Laske, C.1
Stransky, E.2
Fritsche, A.3
Eschweiler, G.4
Leyhe, T.5
-
90
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
doi:, 10.1126/science.7638621
-
Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A., Weber, J. L., et al. (1995). A familial Alzheimer's disease locus on chromosome 1. Science 269, 970-973. doi: 10.1126/science.7638621
-
(1995)
Science
, vol.269
, pp. 970-973
-
-
Levy-Lahad, E.1
Wijsman, E.M.2
Nemens, E.3
Anderson, L.4
Goddard, K.A.5
Weber, J.L.6
-
91
-
-
0026778840
-
A case-control study of Alzheimer's disease in China
-
doi:, 10.1212/WNL.42.8.1481
-
Li, G., Shen, Y. C., Li, Y. T., Chen, C. H., Zhau, Y. W., and Silverman, J. M. (1992). A case-control study of Alzheimer's disease in China. Neurology 42, 1481-1488. doi: 10.1212/WNL.42.8.1481
-
(1992)
Neurology
, vol.42
, pp. 1481-1488
-
-
Li, G.1
Shen, Y.C.2
Li, Y.T.3
Chen, C.H.4
Zhau, Y.W.5
Silverman, J.M.6
-
92
-
-
73649084740
-
Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice
-
doi:, 10.1016/j.ejphar.2009.11.045
-
Li, W.-Z., Li, W.-P., Yao, Y.-Y., Zhang, W., Yin, Y.-Y., Wu, G.-C., et al. (2010). Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice. Eur. J. Pharmacol. 628, 108-115. doi: 10.1016/j.ejphar.2009.11.045
-
(2010)
Eur. J. Pharmacol
, vol.628
, pp. 108-115
-
-
Li, W.-Z.1
Li, W.-P.2
Yao, Y.-Y.3
Zhang, W.4
Yin, Y.-Y.5
Wu, G.-C.6
-
93
-
-
0037336701
-
Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway
-
Li, Y., Liu, L., Barger, S. W., and Griffin, W. S. (2003). Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J. Neurosci. 23, 1605-1611.
-
(2003)
J. Neurosci
, vol.23
, pp. 1605-1611
-
-
Li, Y.1
Liu, L.2
Barger, S.W.3
Griffin, W.S.4
-
94
-
-
0031693662
-
S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures
-
doi: 10.1046/j.1471-4159.1998.71041421.x
-
Li, Y., Wang, J., Sheng, J. G., Liu, L., Barger, S. W., Jones, R. A., et al. (1998). S100 beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures. J. Neurochem. 71, 1421-1428. doi: 10.1046/j.1471-4159.1998.71041421.x
-
(1998)
J. Neurochem
, vol.71
, pp. 1421-1428
-
-
Li, Y.1
Wang, J.2
Sheng, J.G.3
Liu, L.4
Barger, S.W.5
Jones, R.A.6
-
95
-
-
10344238086
-
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretasemediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
-
doi:, 10.1074/jbc.M402034200
-
Liao, Y. F., Wang, B. J., Cheng, H. T., Kuo, L. H., and Wolfe, M. S. (2004). Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretasemediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J. Biol. Chem. 279, 49523-49532. doi: 10.1074/jbc.M402034200
-
(2004)
J. Biol. Chem
, vol.279
, pp. 49523-49532
-
-
Liao, Y.F.1
Wang, B.J.2
Cheng, H.T.3
Kuo, L.H.4
Wolfe, M.S.5
-
96
-
-
0036272473
-
Role of nitric oxide in inflammation-mediated neurodegeneration
-
doi: 10.1111/j.1749-6632.2002.tb04077.x
-
Liu, B., Gao, H. M., Wang, J. Y., Jeohn, G. H., Cooper, C. L., and Hong, J. S. (2002). Role of nitric oxide in inflammation-mediated neurodegeneration. Ann. N.Y. Acad. Sci. 962, 318-331. doi: 10.1111/j.1749-6632.2002.tb04077.x
-
(2002)
Ann. N.Y. Acad. Sci
, vol.962
, pp. 318-331
-
-
Liu, B.1
Gao, H.M.2
Wang, J.Y.3
Jeohn, G.H.4
Cooper, C.L.5
Hong, J.S.6
-
97
-
-
79951563382
-
Passive (Amyloid-β Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice
-
Liu, Y., Lee, M. K., James, M. M., Price, D. L., Borchelt, D. R., Troncoso, J. C., et al. (2011). Passive (Amyloid-β Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice. J. Alzheimer's Dis. 23, 271-279.
-
(2011)
J. Alzheimer's Dis
, vol.23
, pp. 271-279
-
-
Liu, Y.1
Lee, M.K.2
James, M.M.3
Price, D.L.4
Borchelt, D.R.5
Troncoso, J.C.6
-
98
-
-
0034948192
-
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
-
doi:, 10.1002/glia.1072
-
Lue, L. F., Rydel, R., Brigham, E. F., Yang, L. B., Hampel, H., Murphy, G. M. Jr., et al., (2001). Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia 35, 72-79. doi: 10.1002/glia.1072
-
(2001)
Glia
, vol.35
, pp. 72-79
-
-
Lue, L.F.1
Rydel, R.2
Brigham, E.F.3
Yang, L.B.4
Hampel, H.5
Murphy Jr., G.M.6
-
99
-
-
22044446806
-
Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures
-
doi:, 10.1016/j.expneurol.2005.02.021
-
Macpherson, A., Dinkel, K., and Sapolsky, R. (2005). Glucocorticoids worsen excitotoxin-induced expression of pro-inflammatory cytokines in hippocampal cultures. Exp. Neurol. 194, 376-383. doi: 10.1016/j.expneurol.2005.02.021
-
(2005)
Exp. Neurol
, vol.194
, pp. 376-383
-
-
Macpherson, A.1
Dinkel, K.2
Sapolsky, R.3
-
100
-
-
46749087854
-
Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
-
doi: 10.1523/JNEUROSCI.0829-08.2008
-
Maier, M., Peng, Y., Jiang, L., Seabrook, T. J., Carroll, M. C., and Lemere, C. A. (2008). Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J. Neurosci. 28, 6333-6341. doi: 10.1523/JNEUROSCI.0829-08.2008
-
(2008)
J. Neurosci
, vol.28
, pp. 6333-6341
-
-
Maier, M.1
Peng, Y.2
Jiang, L.3
Seabrook, T.J.4
Carroll, M.C.5
Lemere, C.A.6
-
101
-
-
33847128514
-
Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease
-
doi: 10.1016/j., neurobiolaging.2006.02.013
-
Man, S. M., Ma, Y. R., Shang, D. S., Zhao, W. D., Li, B., Guo, D. W., et al. (2007). Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease. Neurobiol. Aging 28, 485-496. doi: 10.1016/j.neurobiolaging.2006.02.013
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 485-496
-
-
Man, S.M.1
Ma, Y.R.2
Shang, D.S.3
Zhao, W.D.4
Li, B.5
Guo, D.W.6
-
102
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
-
doi: 10.1001/arch-neur.2008.65.7.nct70006
-
Martin, B., Szekely, C., Brandt, J., Piantadosi, S., Breitner, J., Craft, S., et al. (2008). Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 65, 896. doi: 10.1001/arch-neur.2008.65.7.nct70006
-
(2008)
Arch. Neurol
, vol.65
, pp. 896
-
-
Martin, B.1
Szekely, C.2
Brandt, J.3
Piantadosi, S.4
Breitner, J.5
Craft, S.6
-
103
-
-
84860751910
-
Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration
-
doi:, 10.1007/s11481-011-9331-2
-
Matousek, S. B., Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., and O'Banion, M. K. (2012). Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7, 156-164. doi: 10.1007/s11481-011-9331-2
-
(2012)
J. Neuroimmune Pharmacol
, vol.7
, pp. 156-164
-
-
Matousek, S.B.1
Ghosh, S.2
Shaftel, S.S.3
Kyrkanides, S.4
Olschowka, J.A.5
O'Banion, M.K.6
-
104
-
-
62249094525
-
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
-
doi: 10.1016/j.nbd.2009.01.006
-
McAlpine, F. E., Lee, J. K., Harms, A. S., Ruhn, K. A., Blurton-Jones, M., Hong, J., et al. (2009). Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol. Dis. 34, 163-177. doi: 10.1016/j.nbd.2009.01.006
-
(2009)
Neurobiol. Dis
, vol.34
, pp. 163-177
-
-
McAlpine, F.E.1
Lee, J.K.2
Harms, A.S.3
Ruhn, K.A.4
Blurton-Jones, M.5
Hong, J.6
-
105
-
-
0024317005
-
Activation of the classical complement pathway in brain tissue of Alzheimer patients
-
doi: 10.1016/0304-3940(89)90843-4
-
McGeer, P. L., Akiyama, H., Itagaki, S., and McGeer, E. G. (1989). Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci. Lett. 107, 341-346. doi: 10.1016/0304-3940(89)90843-4
-
(1989)
Neurosci. Lett
, vol.107
, pp. 341-346
-
-
McGeer, P.L.1
Akiyama, H.2
Itagaki, S.3
McGeer, E.G.4
-
106
-
-
0023782375
-
Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
-
doi: 10.1007/BF00689592
-
McGeer, P. L., Itagaki, S., and McGeer, E. G. (1988). Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 76, 550-557. doi: 10.1007/BF00689592
-
(1988)
Acta Neuropathol
, vol.76
, pp. 550-557
-
-
McGeer, P.L.1
Itagaki, S.2
McGeer, E.G.3
-
107
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
doi:, 10.1016/0165-0173(95)00011-9
-
McGeer, P. L., and McGeer, E. G. (1995). The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Rev. 21, 195-218. doi: 10.1016/0165-0173(95)00011-9
-
(1995)
Brain Res. Rev
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
108
-
-
0032891880
-
Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]
-
doi:, 10.1016/S0165-5728(98)00188-X
-
Meda, L., Baron, P., Prat, E., Scarpini, E., Scarlato, G., Cassatella, M. A., et al. (1999). Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35]. J. Neuroimmunol. 93, 45-52. doi: 10.1016/S0165-5728(98)00188-X
-
(1999)
J. Neuroimmunol
, vol.93
, pp. 45-52
-
-
Meda, L.1
Baron, P.2
Prat, E.3
Scarpini, E.4
Scarlato, G.5
Cassatella, M.A.6
-
109
-
-
84868252916
-
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
-
doi:, 10.1016/j.expneurol.2012.10.007
-
Medeiros, R., and Laferla, F. M. (2013). Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp. Neurol. 239, 133-138. doi: 10.1016/j.expneurol.2012.10.007
-
(2013)
Exp. Neurol
, vol.239
, pp. 133-138
-
-
Medeiros, R.1
Laferla, F.M.2
-
110
-
-
80053268668
-
Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: Implications for chronic pan-TNF-alpha suppressive therapeutic strategies in the brain
-
. doi: 10.1016/j.ajpath.2011.07.001
-
Montgomery, S. L., Mastrangelo, M. A., Habib, D., Narrow, W. C., Knowlden, S. A., Wright, T. W., et al. (2011). Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-alpha suppressive therapeutic strategies in the brain. Am. J. Pathol. 179, 2053-2070. doi: 10.1016/j.ajpath.2011.07.001
-
(2011)
Am. J. Pathol
, vol.179
, pp. 2053-2070
-
-
Montgomery, S.L.1
Mastrangelo, M.A.2
Habib, D.3
Narrow, W.C.4
Knowlden, S.A.5
Wright, T.W.6
-
111
-
-
24944566030
-
The interleukin-1 signalling pathway in astrocytes: A key contributor to inflammation in the brain
-
doi:, 10.1111/j.1469-7580.2005.00445.x
-
Moynagh, P. N. (2005). The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain. J. Anat. 207, 265-269. doi: 10.1111/j.1469-7580.2005.00445.x
-
(2005)
J. Anat
, vol.207
, pp. 265-269
-
-
Moynagh, P.N.1
-
112
-
-
84862322566
-
Microglia in Alzheimer brain: A neuropathological perspective
-
doi: 10.1155/2012/165021
-
Mrak, R. E. (2012). Microglia in Alzheimer brain: a neuropathological perspective. Int. J. Alzheimers Dis. 2012, 165021. doi: 10.1155/2012/165021
-
(2012)
Int. J. Alzheimers Dis
, vol.2012
, pp. 165021
-
-
Mrak, R.E.1
-
113
-
-
33645082486
-
Potential inflammatory biomarkers in Alzheimer's disease
-
Mrak, R. E., and Griffin, W. S. (2005). Potential inflammatory biomarkers in Alzheimer's disease. J. Alzheimers Dis. 8, 369-375.
-
(2005)
J. Alzheimers Dis
, vol.8
, pp. 369-375
-
-
Mrak, R.E.1
Griffin, W.S.2
-
114
-
-
0029670066
-
Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease
-
doi: 10.1097/00005072-199603000-00002
-
Mrak, R. E., Sheng, J. G., and Griffin, W. S. (1996). Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease. J. Neuropathol. Exp. Neurol. 55, 273-279. doi: 10.1097/00005072-199603000-00002
-
(1996)
J. Neuropathol. Exp. Neurol
, vol.55
, pp. 273-279
-
-
Mrak, R.E.1
Sheng, J.G.2
Griffin, W.S.3
-
115
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
-
doi:, 10.1126/science.1925564
-
Murrell, J., Farlow, M., Ghetti, B., and Benson, M. D. (1991). A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97-99. doi: 10.1126/science.1925564
-
(1991)
Science
, vol.254
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.D.4
-
116
-
-
77956393132
-
Involvement of Fc receptors in disorders of the central nervous system
-
doi: 10.1007/s12017-009-8099-5
-
Okun, E., Mattson, M. P., and Arumugam, T. V. (2010). Involvement of Fc receptors in disorders of the central nervous system. Neuromol. Med. 12, 164-178. doi: 10.1007/s12017-009-8099-5
-
(2010)
Neuromol. Med
, vol.12
, pp. 164-178
-
-
Okun, E.1
Mattson, M.P.2
Arumugam, T.V.3
-
117
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
-
doi: 10.1212/01.WNL.0000073623.84147.A8
-
Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L., et al. (2003). Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 61, 46-54. doi: 10.1212/01.WNL.0000073623.84147.A8
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.-M.1
Gilman, S.2
Dartigues, J.-F.3
Laurent, B.4
Puel, M.5
Kirby, L.6
-
118
-
-
18144410635
-
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
-
doi: 10.1186/1742-2094-2-9
-
Patel, N. S., Paris, D., Mathura, V., Quadros, A. N., Crawford, F. C., and Mullan, M. J. (2005). Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J. Neuroinflammation 2, 9. doi: 10.1186/1742-2094-2-9
-
(2005)
J. Neuroinflammation
, vol.2
, pp. 9
-
-
Patel, N.S.1
Paris, D.2
Mathura, V.3
Quadros, A.N.4
Crawford, F.C.5
Mullan, M.J.6
-
119
-
-
79955546564
-
A functional complement system is required for normal T helper cell differentiation
-
doi: 10.1016/j.imbio.2010.10.004
-
Pekkarinen, P. T., Vaali, K., Junnikkala, S., Rossi, L. H., Tuovinen, H., Meri, S., et al. (2011). A functional complement system is required for normal T helper cell differentiation. Immunobiology 216, 737-743. doi: 10.1016/j.imbio.2010.10.004
-
(2011)
Immunobiology
, vol.216
, pp. 737-743
-
-
Pekkarinen, P.T.1
Vaali, K.2
Junnikkala, S.3
Rossi, L.H.4
Tuovinen, H.5
Meri, S.6
-
120
-
-
1642420308
-
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
-
doi:, 10.1016/j.yexcr.2004.01.002
-
Quintanilla, R. A., Orellana, D. I., Gonzalez-Billault, C., and Maccioni, R. B. (2004). Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp. Cell Res. 295, 245-257. doi: 10.1016/j.yexcr.2004.01.002
-
(2004)
Exp. Cell Res
, vol.295
, pp. 245-257
-
-
Quintanilla, R.A.1
Orellana, D.I.2
Gonzalez-Billault, C.3
Maccioni, R.B.4
-
121
-
-
0030183050
-
Chemokines in immune-mediated inflammation of the central nervous system
-
doi:, 10.1016/1359-6101(96)00003-2
-
Ransohoff, R. M., Glabinski, A., and Tani, M. (1996). Chemokines in immune-mediated inflammation of the central nervous system. Cytokine Growth Factor Rev. 7, 35-46. doi: 10.1016/1359-6101(96)00003-2
-
(1996)
Cytokine Growth Factor Rev
, vol.7
, pp. 35-46
-
-
Ransohoff, R.M.1
Glabinski, A.2
Tani, M.3
-
122
-
-
70449534695
-
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease
-
doi:, 10.1007/s11481-009-9166-2
-
Rezai-Zadeh, K., Gate, D., and Town, T. (2009). CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J. Neuroimmune Pharmacol. 4, 462-475. doi: 10.1007/s11481-009-9166-2
-
(2009)
J. Neuroimmune Pharmacol
, vol.4
, pp. 462-475
-
-
Rezai-Zadeh, K.1
Gate, D.2
Town, T.3
-
123
-
-
77955883153
-
Complement: A key system for immune surveillance and homeostasis
-
doi: 10.1038/ni.1923
-
Ricklin, D., Hajishengallis, G., Yang, K., and Lambris, J. D. (2010). Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797. doi: 10.1038/ni.1923
-
(2010)
Nat. Immunol
, vol.11
, pp. 785-797
-
-
Ricklin, D.1
Hajishengallis, G.2
Yang, K.3
Lambris, J.D.4
-
124
-
-
84866042262
-
Nitric oxide synthase and breast cancer: Role of TIMP-1 in NO-mediated Akt activation
-
doi: 10.1371/journal.pone.0044081
-
Ridnour, L. A., Barasch, K. M., Windhausen, A. N., Dorsey, T. H., Lizardo, M. M., Yfantis, H. G., et al. (2012). Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. PLoS ONE 7:e44081. doi: 10.1371/journal.pone.0044081
-
(2012)
PLoS ONE
, vol.7
-
-
Ridnour, L.A.1
Barasch, K.M.2
Windhausen, A.N.3
Dorsey, T.H.4
Lizardo, M.M.5
Yfantis, H.G.6
-
125
-
-
34447618051
-
Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
-
doi: 10.1093/brain/awm102
-
Ringman, J. M., O'Neill, J., Geschwind, D., Medina, L., Apostolova, L. G., Rodriguez, Y., et al. (2007). Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain 130, 1767-1776. doi: 10.1093/brain/awm102
-
(2007)
Brain
, vol.130
, pp. 1767-1776
-
-
Ringman, J.M.1
O'Neill, J.2
Geschwind, D.3
Medina, L.4
Apostolova, L.G.5
Rodriguez, Y.6
-
126
-
-
0032579752
-
Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex
-
doi: 10.1016/S0169-328X(97)00356-2
-
Ringheim, G. E., Szczepanik, A. M., Petko, W., Burgher, K. L., Zhu, S. Z., and Chao, C. C. (1998). Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex. Brain Res. Mol. Brain Res. 55, 35-44. doi: 10.1016/S0169-328X(97)00356-2
-
(1998)
Brain Res. Mol. Brain Res
, vol.55
, pp. 35-44
-
-
Ringheim, G.E.1
Szczepanik, A.M.2
Petko, W.3
Burgher, K.L.4
Zhu, S.Z.5
Chao, C.C.6
-
127
-
-
0026447529
-
Complement activation by beta-amyloid in Alzheimer disease
-
doi: 10.1073/pnas.89.21.10016
-
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., et al. (1992). Complement activation by beta-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 89, 10016-10020. doi: 10.1073/pnas.89.21.10016
-
(1992)
Proc. Natl. Acad. Sci. U.S.A
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Webster, S.3
Schultz, J.4
McGeer, P.L.5
Styren, S.D.6
-
128
-
-
0030583248
-
Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes
-
doi:, 10.1006/bbrc.1996.1197
-
Rossi, F., and Bianchini, E. (1996). Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes. Biochem. Biophys. Res. Commun. 225, 474-478. doi: 10.1006/bbrc.1996.1197
-
(1996)
Biochem. Biophys. Res. Commun
, vol.225
, pp. 474-478
-
-
Rossi, F.1
Bianchini, E.2
-
129
-
-
33646050649
-
Oligodendrocytes damage in Alzheimer's disease: Beta amyloid toxicity and inflammation
-
doi: 10.4067/S0716-97602005000400011
-
Roth, A. D., Ramirez, G., Alarcon, R., and Von Bernhardi, R. (2005). Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biol. Res. 38, 381-387. doi: 10.4067/S0716-97602005000400011
-
(2005)
Biol. Res
, vol.38
, pp. 381-387
-
-
Roth, A.D.1
Ramirez, G.2
Alarcon, R.3
von Bernhardi, R.4
-
130
-
-
0022504686
-
Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study
-
doi: 10.1007/BF02899034
-
Rozemuller, J. M., Eikelenboom, P., and Stam, F. C. (1986). Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 51, 247-254. doi: 10.1007/BF02899034
-
(1986)
Virchows Arch. B Cell Pathol. Incl. Mol. Pathol
, vol.51
, pp. 247-254
-
-
Rozemuller, J.M.1
Eikelenboom, P.2
Stam, F.C.3
-
131
-
-
67649427845
-
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model
-
doi: 10.1016/j.brainres.2009.05.045
-
Rozkalne, A., Spires-Jones, T. L., Stern, E. A., and Hyman, B. T. (2009). A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model. Brain Res. 1280, 178-185. doi: 10.1016/j.brainres.2009.05.045
-
(2009)
Brain Res
, vol.1280
, pp. 178-185
-
-
Rozkalne, A.1
Spires-Jones, T.L.2
Stern, E.A.3
Hyman, B.T.4
-
132
-
-
34548857335
-
Inside, outside, upside down: Damage-associated molecular-pattern molecules (DAMPs) and redox
-
doi: 10.1016/j.it.2007.08.004
-
Rubartelli, A., and Lotze, M. T. (2007). Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol. 28, 429-436. doi: 10.1016/j.it.2007.08.004
-
(2007)
Trends Immunol
, vol.28
, pp. 429-436
-
-
Rubartelli, A.1
Lotze, M.T.2
-
133
-
-
4043058045
-
Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons
-
Saez, T. E., Pehar, M., Vargas, M., Barbeito, L., and Maccioni, R. B. (2004). Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In Vivo 18, 275-280.
-
(2004)
In Vivo
, vol.18
, pp. 275-280
-
-
Saez, T.E.1
Pehar, M.2
Vargas, M.3
Barbeito, L.4
Maccioni, R.B.5
-
134
-
-
73349091534
-
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
-
doi: 10.1212/WNL.0b013e3181c67808
-
Salloway, S., Sperling, R., Gilman, S., Fox, N., Blennow, K., Raskind, M., et al. (2009). A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73, 2061-2070. doi: 10.1212/WNL.0b013e3181c67808
-
(2009)
Neurology
, vol.73
, pp. 2061-2070
-
-
Salloway, S.1
Sperling, R.2
Gilman, S.3
Fox, N.4
Blennow, K.5
Raskind, M.6
-
135
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress -secretase gene promoter activity by the activation of PPAR
-
Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., et al. (2006). Nonsteroidal anti-inflammatory drugs repress -secretase gene promoter activity by the activation of PPAR. Proc. Natl. Acad. Sci. U.S.A. 103, 443-448.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
-
136
-
-
0034042595
-
Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo
-
doi: 10.1006/exnr.2000.7393
-
Sheng, J. G., Zhu, S. G., Jones, R. A., Griffin, W. S., and Mrak, R. E. (2000). Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp. Neurol. 163, 388-391. doi: 10.1006/exnr.2000.7393
-
(2000)
Exp. Neurol
, vol.163
, pp. 388-391
-
-
Sheng, J.G.1
Zhu, S.G.2
Jones, R.A.3
Griffin, W.S.4
Mrak, R.E.5
-
137
-
-
0033362096
-
Function and dysfunction of the presenilins
-
doi:, 10.1086/302475
-
Sisodia, S. S., Kim, S. H., and Thinakaran, G. (1999). Function and dysfunction of the presenilins. Am. J. Hum. Genet. 65, 7-12. doi: 10.1086/302475
-
(1999)
Am. J. Hum. Genet
, vol.65
, pp. 7-12
-
-
Sisodia, S.S.1
Kim, S.H.2
Thinakaran, G.3
-
138
-
-
0028169558
-
Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state
-
doi: 10.1016/0197-4580(94)00055-7
-
Smyth, M. D., Cribbs, D. H., Tenner, A. J., Shankle, W. R., Dick, M., Kesslak, J. P., et al. (1994). Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol. Aging 15, 609-614. doi: 10.1016/0197-4580(94)00055-7
-
(1994)
Neurobiol. Aging
, vol.15
, pp. 609-614
-
-
Smyth, M.D.1
Cribbs, D.H.2
Tenner, A.J.3
Shankle, W.R.4
Dick, M.5
Kesslak, J.P.6
-
139
-
-
77649189116
-
Astrocytes: Biology and pathology
-
doi: 10.1007/s00401-009-0619-8
-
Sofroniew, M. V., and Vinters, H. V. (2010). Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35. doi: 10.1007/s00401-009-0619-8
-
(2010)
Acta Neuropathol
, vol.119
, pp. 7-35
-
-
Sofroniew, M.V.1
Vinters, H.V.2
-
140
-
-
58149490804
-
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
-
doi: 10.1016/j.nbd. 2008.10.011
-
Spires-Jones, T. L., Mielke, M. L., Rozkalne, A., Meyer-Luehmann, M., De Calignon, A., Bacskai, B. J., et al. (2009). Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol. Dis. 33, 213-220. doi: 10.1016/j.nbd. 2008.10.011
-
(2009)
Neurobiol. Dis
, vol.33
, pp. 213-220
-
-
Spires-Jones, T.L.1
Mielke, M.L.2
Rozkalne, A.3
Meyer-Luehmann, M.4
de Calignon, A.5
Bacskai, B.J.6
-
141
-
-
33748952272
-
Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia
-
doi:, 10.1016/j.jneuroim.2006.06.009
-
Sterka, D. Jr., and Marriott, I. (2006). Characterization of nucleotide-binding oligomerization domain (NOD) protein expression in primary murine microglia. J. Neuroimmunol. 179, 65-75. doi: 10.1016/j.jneuroim.2006.06.009
-
(2006)
J. Neuroimmunol
, vol.179
, pp. 65-75
-
-
Sterka Jr., D.1
Marriott, I.2
-
142
-
-
9644275598
-
Modulation of nuclear factor-κb activity by indomethacin influences aβ levels but not aβ precursor protein metabolism in a model of alzheimer's disease
-
doi: 10.1016/ S0002-9440(10)63269-5
-
Sung, S., Yang, H., Uryu, K., Lee, E. B., Zhao, L., Shineman, D., et al. (2004). Modulation of nuclear factor-κb activity by indomethacin influences aβ levels but not aβ precursor protein metabolism in a model of alzheimer's disease. Am. J. Pathol. 165, 2197-2206. doi: 10.1016/ S0002-9440(10)63269-5
-
(2004)
Am. J. Pathol
, vol.165
, pp. 2197-2206
-
-
Sung, S.1
Yang, H.2
Uryu, K.3
Lee, E.B.4
Zhao, L.5
Shineman, D.6
-
143
-
-
0028584381
-
Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid
-
doi: 10.1111/j.1365-2826.1994.tb00635.x
-
Swaab, D. F., Raadsheer, F. C., Endert, E., Hofman, M. A., Kamphorst, W., and Ravid, R. (1994). Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid. J. Neuroendocrinol. 6, 681-687. doi: 10.1111/j.1365-2826.1994.tb00635.x
-
(1994)
J. Neuroendocrinol
, vol.6
, pp. 681-687
-
-
Swaab, D.F.1
Raadsheer, F.C.2
Endert, E.3
Hofman, M.A.4
Kamphorst, W.5
Ravid, R.6
-
144
-
-
46049108790
-
No advantage of "Aβ42-lowering" NSAIDs for prevention of AD insix pooled cohort studies
-
doi: 10.1212/01.wnl.0000313933.17796.f6
-
Szekely, C. A., Green, R. C., Breitner, J. C. S., Ostbye, T., Beiser, A. S., Corrada, M. M., et al. (2008). No advantage of "Aβ42-lowering" NSAIDs for prevention of AD insix pooled cohort studies. Neurology 70, 2291-2298. doi: 10.1212/01.wnl.0000313933.17796.f6
-
(2008)
Neurology
, vol.70
, pp. 2291-2298
-
-
Szekely, C.A.1
Green, R.C.2
Breitner, J.C.S.3
Ostbye, T.4
Beiser, A.S.5
Corrada, M.M.6
-
145
-
-
33746354022
-
Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
-
doi: 10.1074/jbc.M600504200
-
Takeuchi, H., Jin, S., Wang, J., Zhang, G., Kawanokuchi, J., Kuno, R., et al. (2006). Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 281, 21362-21368. doi: 10.1074/jbc.M600504200
-
(2006)
J. Biol. Chem
, vol.281
, pp. 21362-21368
-
-
Takeuchi, H.1
Jin, S.2
Wang, J.3
Zhang, G.4
Kawanokuchi, J.5
Kuno, R.6
-
146
-
-
0033579382
-
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
-
doi:, 10.1126/science.286.5448.2352
-
Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., et al. (1999). Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286, 2352-2355. doi: 10.1126/science.286.5448.2352
-
(1999)
Science
, vol.286
, pp. 2352-2355
-
-
Tan, J.1
Town, T.2
Paris, D.3
Mori, T.4
Suo, Z.5
Crawford, F.6
-
147
-
-
0036167595
-
Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia
-
doi: 10.1016/S0197-4580(01)00285-8
-
Tarkowski, E., Issa, R., Sjogren, M., Wallin, A., Blennow, K., Tarkowski, A., et al. (2002). Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol. Aging 23, 237-243. doi: 10.1016/S0197-4580(01)00285-8.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 237-243
-
-
Tarkowski, E.1
Issa, R.2
Sjogren, M.3
Wallin, A.4
Blennow, K.5
Tarkowski, A.6
-
148
-
-
33750591957
-
Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology
-
doi: 10.1172/JCI27341
-
Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J.V., et al. (2006). Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J. Clin. Invest. 116, 3060-3069. doi: 10.1172/JCI27341
-
(2006)
J. Clin. Invest
, vol.116
, pp. 3060-3069
-
-
Tesseur, I.1
Zou, K.2
Esposito, L.3
Bard, F.4
Berber, E.5
Can, J.V.6
-
149
-
-
21144447586
-
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
-
doi: 10.1038/sj.npp. 1300690
-
Thal, L. J., Ferris, S. H., Kirby, L., Block, G. A., Lines, C. R., Yuen, E., et al. (2005). A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 30, 1204-1215. doi: 10.1038/sj.npp. 1300690
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. 1204-1215
-
-
Thal, L.J.1
Ferris, S.H.2
Kirby, L.3
Block, G.A.4
Lines, C.R.5
Yuen, E.6
-
150
-
-
0032825876
-
Neurodegenerative disorders: The role of peroxynitrite
-
doi:, 10.1016/S0165-0173(99)00014-4
-
Torreilles, F., Salman-Tabcheh, S., Guerin, M., and Torreilles, J. (1999). Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Brain Res. Rev. 30, 153-163. doi: 10.1016/S0165-0173(99)00014-4
-
(1999)
Brain Res. Brain Res. Rev
, vol.30
, pp. 153-163
-
-
Torreilles, F.1
Salman-Tabcheh, S.2
Guerin, M.3
Torreilles, J.4
-
151
-
-
27744464859
-
The microglial activation continuum: From innate to adaptive responses
-
doi: 10.1186/1742-2094-2-24
-
Town, T., Nikolic, V., and Tan, J. (2005). The microglial activation continuum: from innate to adaptive responses. J. Neuroinflammation 2, 24. doi: 10.1186/1742-2094-2-24
-
(2005)
J. Neuroinflammation
, vol.2
, pp. 24
-
-
Town, T.1
Nikolic, V.2
Tan, J.3
-
152
-
-
77953060906
-
Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model
-
doi: 10.1177/0269881108097630
-
Van Dam, D., Coen, K., and De Deyn, P. P. (2010). Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. J. Psychopharmacol. 24, 383-388. doi: 10.1177/0269881108097630
-
(2010)
J. Psychopharmacol
, vol.24
, pp. 383-388
-
-
van Dam, D.1
Coen, K.2
de Deyn, P.P.3
-
153
-
-
0023571572
-
Inflammation and the mechanism of action of anti-inflammmatory drugs
-
Vane, J., and Botting, R. (1987). Inflammation and the mechanism of action of anti-inflammmatory drugs. FASEB J. 1, 89-96.
-
(1987)
FASEB J
, vol.1
, pp. 89-96
-
-
Vane, J.1
Botting, R.2
-
154
-
-
64549152492
-
Long-term follow-up of patients immunized with AN1792: Reduced functional decline in antibody responders
-
doi: 10.2174/156720509787602852
-
Vellas, B., Black, R., Thal, L. J., Fox, N. C., Daniels, M., McLennan, G., et al. (2009). Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders. Curr. Alzheimer Res. 6, 144. doi: 10.2174/156720509787602852
-
(2009)
Curr. Alzheimer Res
, vol.6
, pp. 144
-
-
Vellas, B.1
Black, R.2
Thal, L.J.3
Fox, N.C.4
Daniels, M.5
McLennan, G.6
-
155
-
-
0037276438
-
Tumor necrosis factor signaling
-
doi:, 10.1038/sj.cdd.4401189
-
Wajant, H., Pfizenmaier, K., and Scheurich, P. (2003). Tumor necrosis factor signaling. Cell Death Differ. 10, 45-65. doi: 10.1038/sj.cdd.4401189
-
(2003)
Cell Death Differ
, vol.10
, pp. 45-65
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
156
-
-
0028923898
-
Complement and cytokine gene expression in cultured microglial derived from postmortem human brains
-
doi: 10.1002/jnr.490400407
-
Walker, D. G., Kim, S. U., and McGeer, P. L. (1995). Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J. Neurosci. Res. 40, 478-493. doi: 10.1002/jnr.490400407
-
(1995)
J. Neurosci. Res
, vol.40
, pp. 478-493
-
-
Walker, D.G.1
Kim, S.U.2
McGeer, P.L.3
-
157
-
-
25444505871
-
Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
-
doi:, 10.1002/jnr.20484
-
Walker, D. G., and Lue, L. F. (2005). Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. J. Neurosci. Res. 81, 412-425. doi: 10.1002/jnr.20484
-
(2005)
J. Neurosci. Res
, vol.81
, pp. 412-425
-
-
Walker, D.G.1
Lue, L.F.2
-
158
-
-
0031127418
-
Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
-
doi: 10.1006/exnr.1996.6373
-
Wallace, M. N., Geddes, J. G., Farquhar, D. A., and Masson, M. R. (1997). Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques. Exp. Neurol. 144, 266-272. doi: 10.1006/exnr.1996.6373
-
(1997)
Exp. Neurol
, vol.144
, pp. 266-272
-
-
Wallace, M.N.1
Geddes, J.G.2
Farquhar, D.A.3
Masson, M.R.4
-
159
-
-
0034050540
-
Complement component C1q modulates the phagocytosis of Abeta by microglia
-
doi:, 10.1006/exnr.1999.7260
-
Webster, S. D., Yang, A. J., Margol, L., Garzon-Rodriguez, W., Glabe, C. G., and Tenner, A. J. (2000). Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp. Neurol. 161, 127-138. doi: 10.1006/exnr.1999.7260
-
(2000)
Exp. Neurol
, vol.161
, pp. 127-138
-
-
Webster, S.D.1
Yang, A.J.2
Margol, L.3
Garzon-Rodriguez, W.4
Glabe, C.G.5
Tenner, A.J.6
-
160
-
-
0031694532
-
Definition, function and pathophysiological significance of chemokine receptors
-
doi: 10.1016/S0165-6147(98)01247-4
-
Wells, T. N., Power, C. A., and Proudfoot, A. E. (1998). Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol. Sci. 19, 376-380. doi: 10.1016/S0165-6147(98)01247-4
-
(1998)
Trends Pharmacol. Sci
, vol.19
, pp. 376-380
-
-
Wells, T.N.1
Power, C.A.2
Proudfoot, A.E.3
-
161
-
-
84856383137
-
CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease
-
doi: 10.1371/jour, nal.pone.0030525
-
Westin, K., Buchhave, P., Nielsen, H., Minthon, L., Janciauskiene, S., and Hansson, O. (2012). CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease. PLoS ONE 7:e30525. doi: 10.1371/journal.pone.0030525
-
(2012)
PLoS ONE
, vol.7
-
-
Westin, K.1
Buchhave, P.2
Nielsen, H.3
Minthon, L.4
Janciauskiene, S.5
Hansson, O.6
-
162
-
-
79959670013
-
The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
-
doi: 10.1523/ JNEUROSCI.0293-11.2011
-
Wiessner, C., Wiederhold, K. H., Tissot, A. C., Frey, P., Danner, S., Jacobson, L. H., et al. (2011). The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J. Neurosci. 31, 9323-9331. doi: 10.1523/ JNEUROSCI.0293-11.2011
-
(2011)
J. Neurosci
, vol.31
, pp. 9323-9331
-
-
Wiessner, C.1
Wiederhold, K.H.2
Tissot, A.C.3
Frey, P.4
Danner, S.5
Jacobson, L.H.6
-
163
-
-
0017886417
-
The role of prostaglandins in inflammation
-
Williams, T. J. (1978). The role of prostaglandins in inflammation. Ann. R. Coll. Surg. Engl. 60, 198-201.
-
(1978)
Ann. R. Coll. Surg. Engl
, vol.60
, pp. 198-201
-
-
Williams, T.J.1
-
164
-
-
0025752360
-
Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques
-
doi:, 10.1007/BF00310142
-
Wisniewski, H. M., Barcikowska, M., and Kida, E. (1991). Phagocytosis of beta/A4 amyloid fibrils of the neuritic neocortical plaques. Acta Neuropathol. 81, 588-590. doi: 10.1007/BF00310142
-
(1991)
Acta Neuropathol
, vol.81
, pp. 588-590
-
-
Wisniewski, H.M.1
Barcikowska, M.2
Kida, E.3
-
165
-
-
0034744296
-
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
-
doi: 10.1038/87945
-
Wyss-Coray, T., Lin, C., Yan, F., Yu, G. Q., Rohde, M., McConlogue, L., et al. (2001). TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat. Med. 7, 612-618. doi: 10.1038/87945
-
(2001)
Nat. Med
, vol.7
, pp. 612-618
-
-
Wyss-Coray, T.1
Lin, C.2
Yan, F.3
Yu, G.Q.4
Rohde, M.5
McConlogue, L.6
-
166
-
-
0037394788
-
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ
-
doi:, 10.1038/nm838
-
Wyss-Coray, T., Loike, J. D., Brionne, T. C., Lu, E., Anankov, R., Yan, F., et al. (2003). Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat. Med. 9, 453-457. doi: 10.1038/nm838
-
(2003)
Nat. Med
, vol.9
, pp. 453-457
-
-
Wyss-Coray, T.1
Loike, J.D.2
Brionne, T.C.3
Lu, E.4
Anankov, R.5
Yan, F.6
-
167
-
-
0030764732
-
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease
-
doi: 10.1038/39321
-
Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., et al. (1997). Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature 389, 603-606. doi: 10.1038/39321
-
(1997)
Nature
, vol.389
, pp. 603-606
-
-
Wyss-Coray, T.1
Masliah, E.2
Mallory, M.3
McConlogue, L.4
Johnson-Wood, K.5
Lin, C.6
-
168
-
-
0036679142
-
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
-
doi: 10.1073/pnas.162350199
-
Wyss-Coray, T., Yan, F., Lin, A. H., Lambris, J. D., Alexander, J. J., Quigg, R. J., et al. (2002). Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc. Natl. Acad. Sci. U.S.A. 99, 10837-10842. doi: 10.1073/pnas.162350199
-
(2002)
Proc. Natl. Acad. Sci. U.S.A
, vol.99
, pp. 10837-10842
-
-
Wyss-Coray, T.1
Yan, F.2
Lin, A.H.3
Lambris, J.D.4
Alexander, J.J.5
Quigg, R.J.6
-
169
-
-
0031848322
-
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
-
doi:, 10.1016/S0002-9440(10)65542-3
-
Xia, M. Q., Qin, S. X., Wu, L. J., Mackay, C. R., and Hyman, B. T. (1998). Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153, 31-37. doi: 10.1016/S0002-9440(10)65542-3
-
(1998)
Am. J. Pathol
, vol.153
, pp. 31-37
-
-
Xia, M.Q.1
Qin, S.X.2
Wu, L.J.3
Mackay, C.R.4
Hyman, B.T.5
-
170
-
-
0036227488
-
Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
-
doi: 10.1016/S0197-4580(01)00282-2
-
Xiang, Z., Ho, L., Valdellon, J., Borchelt, D., Kelley, K., Spielman, L., et al. (2002a). Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging 23, 327-334. doi: 10.1016/S0197-4580(01)00282-2
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 327-334
-
-
Xiang, Z.1
Ho, L.2
Valdellon, J.3
Borchelt, D.4
Kelley, K.5
Spielman, L.6
-
171
-
-
0036424134
-
Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
-
Xiang, Z., Ho, L., Yemul, S., Zhao, Z., Qing, W., Pompl, P., et al. (2002b). Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expr. 10, 271-278.
-
(2002)
Gene Expr
, vol.10
, pp. 271-278
-
-
Xiang, Z.1
Ho, L.2
Yemul, S.3
Zhao, Z.4
Qing, W.5
Pompl, P.6
-
172
-
-
0027290813
-
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
-
doi: 10.1016/0896-6273(93)90192-T
-
Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., and Worley, P. F. (1993). Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11, 371-386. doi: 10.1016/0896-6273(93)90192-T
-
(1993)
Neuron
, vol.11
, pp. 371-386
-
-
Yamagata, K.1
Andreasson, K.I.2
Kaufmann, W.E.3
Barnes, C.A.4
Worley, P.F.5
-
173
-
-
17844375420
-
Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition
-
doi: 10.1016/S0002-9440(10)62364-4
-
Yamamoto, M., Horiba, M., Buescher, J. L., Huang, D., Gendelman, H. E., Ransohoff, R. M., et al. (2005). Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am. J. Pathol. 166, 1475-1485. doi: 10.1016/S0002-9440(10)62364-4
-
(2005)
Am. J. Pathol
, vol.166
, pp. 1475-1485
-
-
Yamamoto, M.1
Horiba, M.2
Buescher, J.L.3
Huang, D.4
Gendelman, H.E.5
Ransohoff, R.M.6
-
174
-
-
33947512432
-
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
-
doi: 10.2353/ajpath.2007.060378
-
Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., et al. (2007). Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am. J. Pathol. 170, 680-692. doi: 10.2353/ajpath.2007.060378
-
(2007)
Am. J. Pathol
, vol.170
, pp. 680-692
-
-
Yamamoto, M.1
Kiyota, T.2
Horiba, M.3
Buescher, J.L.4
Walsh, S.M.5
Gendelman, H.E.6
-
175
-
-
34848832897
-
Memory and learning impairment induced by dexamethasone in senescent but not young mice
-
doi: 10.1016/j.ejphar.2007.07.021
-
Yao, Y.-Y., Liu, D.-M., Xu, D.-F., and Li, W.-P. (2007). Memory and learning impairment induced by dexamethasone in senescent but not young mice. Eur. J. Pharmacol. 574, 20-28. doi: 10.1016/j.ejphar.2007.07.021
-
(2007)
Eur. J. Pharmacol
, vol.574
, pp. 20-28
-
-
Yao, Y.-Y.1
Liu, D.-M.2
Xu, D.-F.3
Li, W.-P.4
-
176
-
-
0032725481
-
Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
-
doi: 10.1097/00005072-199911000-00003
-
Yermakova, A. V., Rollins, J., Callahan, L. M., Rogers, J., and O'Banion, M. K. (1999). Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. J. Neuropathol. Exp. Neurol. 58, 1135-1146. doi: 10.1097/00005072-199911000-00003
-
(1999)
J. Neuropathol. Exp. Neurol
, vol.58
, pp. 1135-1146
-
-
Yermakova, A.V.1
Rollins, J.2
Callahan, L.M.3
Rogers, J.4
O'Banion, M.K.5
-
177
-
-
14544306103
-
Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: The MIRAGE Study
-
doi: 10.1186/1471-2318-5-2
-
Yip, A. G., Green, R. C., Huyck, M., Cupples, L. A., and Farrer, L. A. (2005). Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr. 5:2. doi: 10.1186/1471-2318-5-2
-
(2005)
BMC Geriatr
, vol.5
, pp. 2
-
-
Yip, A.G.1
Green, R.C.2
Huyck, M.3
Cupples, L.A.4
Farrer, L.A.5
-
178
-
-
84857770581
-
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
-
doi: 10.1186/1742-2094-9-47
-
Zilka, N., Kazmerova, Z., Jadhav, S., Neradil, P., Madari, A., Obetkova, D., et al. (2012). Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways. J. Neuroinflammation 9, 47. doi: 10.1186/1742-2094-9-47
-
(2012)
J. Neuroinflammation
, vol.9
, pp. 47
-
-
Zilka, N.1
Kazmerova, Z.2
Jadhav, S.3
Neradil, P.4
Madari, A.5
Obetkova, D.6
|