Microglia in Alzheimer brain: A neuropathological perspective

International Journal of Alzheimer's Disease

Volumn , Issue , 2012, Pages

  Mrak, Robert E ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; INTERLEUKIN 1;

AGING; ALZHEIMER DISEASE; BRAIN CORTEX; BRAIN REGION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; HEAD INJURY; HEART DISEASE; HUMAN; INTRACTABLE EPILEPSY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 84862322566     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.1155/2012/165021     Document Type: Review

References (67)

1. del Rio Hortega P., Penfield W., Cerebral cicatrix: the reaction of neuroglia and microglia to brain wounds Bulletin of the Johns Hopkins Hospital 1997 41 278 282
2. Glenner G. G., Congophilic microangiopathy in the pathogenesis of alzheimer's syndrome (presenile dementia) Medical Hypotheses 1979 5 11 1231 1236 (Pubitemid 10178492)
3. Vostrikov V. M., lektronno-tsitokhimicheskoe issledovanie mikroglii pri bolezni Al'tsgeimera i senil'noi dementsii Zhurnal Nevropatologii i Psikhiatrii Imeni S-S-Korsakova 1985 85 974 976
4. Rozemuller J. M., Eikelenboom P., Stam F. C., Role of microglia in plaque formation in senile dementia of the alzheimer type. an immunohistochemical study Virchows Archiv Abteilung B Cell Pathology 1986 51 3 247 254 (Pubitemid 16084111)
5. Dickson D. W., Farlo J., Davies P., Crystal H., Fuld P., Yen S. H. C., Alzheimer's disease. a double-labeling immunohistochemical study of senile plaques American Journal of Pathology 1988 132 1 86 101
6. Wegiel J., Wang K. C., Tarnawski M., Lach B., Microglial cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plaque degradation Acta Neuropathologica 2000 100 4 356 364 (Pubitemid 30497003)
7. Bahmanyar S., Higgins G. A., Goldgaber D., Localization of amyloid protein messenger RNA in brains from patients with Alzheimer's disease Science 1987 237 4810 77 80 (Pubitemid 17096940)
8. Griffin W. S. T., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White C. L., Araoz C., Brain interleukin 1 and s-100 immunoreactivity are elevated in down syndrome and alzheimer disease Proceedings of the National Academy of Sciences of the United States of America 1989 86 19 7611 7615 (Pubitemid 19254506)
9. Goldgaber D., Harris H. W., Hla T., Maciag T., Donnelly R. J., Jacobsen J. S., Vitek M. P., Carleton Gajdusek D., Interleukin 1 regulates synthesis of amyloid -protein precursor mrna in human endothelial cells Proceedings of the National Academy of Sciences of the United States of America 1989 86 19 7606 7610 (Pubitemid 19254505)
10. Bauer J., Strauss S., Schreiter-Gasser U., Ganter U., Schlegel P., Witt I., Yolk B., Berger M., Interleukin-6 and -2-macroglobulin indicate an acute-phase state in alzheimer's disease cortices Febs Letters 1991 285 1 111 114
11. Van Der Wal E. A., Gomez-Pinilla F., Cotman C. W., Transforming growth factor- 1 is in plaques in alzheimer and down pathologies Neuroreport 1993 4 1 69 72 (Pubitemid 23066393)
12. Akiyama H., Ikeda K., Katoh M., McGeer E. G., McGeer P. L., Expression of mrp14, 27e10, interferon- and leukocyte common antigen by reactive microglia in postmortem human brain tissue Journal of Neuroimmunology 1994 50 2 195 201 (Pubitemid 24071785)
13. Yamada T., Horisberger M. A., Kawaguchi N., Moroo I., Toyoda T., Immunohistochemistry using antibodies to -interferon and its induced protein, mxa, in alzheimer's and parkinson's disease brain tissues Neuroscience Letters 1994 181 1-2 61 64
14. Araujo D. M., Induction of immune system mediators in the hippocampal formation in alzheimer's and parkinson's diseases: selective effects on specific interleukins and interleukin receptors Neuroscience 1994 61 4 745 754 (Pubitemid 24291917)
15. Nissl F., Ueber einige Beziehungen zwischen Nervenzellerkrankungen und glioesen Erscheinungen bei verschiedenen Psychosen Archiv fur Psychiatrie 1899 32 2 1 21
16. Kim S. U., De Vellis J., Microglia in health and disease Journal of Neuroscience Research 2005 81 3 302 313 (Pubitemid 41359284)
17. Stanley L. C., Mrak R. E., Woody R. C., Perrot L. J., Zhang S., Marshak D. R., Nelson S. J., Griffin W. S. T., Glial cytokines as neuropathogenic factors in hiv infection: pathogenic similarities to alzheimer's disease Journal of Neuropathology and Experimental Neurology 1994 53 3 231 238 (Pubitemid 24146860)
18. Carpenter A. F., Carpenter P. W., Markesbery W. R., Morphometric analysis of microglia in alzheimer's disease Journal of Neuropathology and Experimental Neurology 1993 52 6 601 608 (Pubitemid 23335736)
19. Ulvestad E., Williams K., Matre R., Nyland H., Olivier A., Antel J., Fc receptors for igg on cultured human microglia mediate cytotoxicity and phagocytosis of antibody-coated targets Journal of Neuropathology and Experimental Neurology 1994 53 1 27 36 (Pubitemid 24022084)
20. Colton C. A., Abel C., Patchett J., Keri J., Yao J., Lectin staining of cultured cns microglia Journal of Histochemistry and Cytochemistry 1992 40 4 505 512
21. Mannoji H., Yeger H., Becker L. E., A specific histochemical marker (lectin ricinus communis agglutinin-1) for normal human microglia, and application to routine histopathology Acta Neuropathologica 1986 71 3-4 341 343 (Pubitemid 17006534)
22. Streit W. J., Kreutzberg G. W., Lectin binding by resting and reactive microglia Journal of Neurocytology 1987 16 2 249 260 (Pubitemid 17080832)
23. Maat-Schieman M. L. C., Rozemuller A. J., Van Duinen S. G., Haan J., Eikelenboom P., Roos R. A. C., Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (dutch). an immunohistochemical study Journal of Neuropathology and Experimental Neurology 1994 53 5 483 491 (Pubitemid 24276806)
24. Muhleisen H., Gehrmann J., Meyermann R., Reactive microglia in creutzfeldt-jakob disease Neuropathology and Applied Neurobiology 1995 21 6 505 517 (Pubitemid 26029124)
25. Scholz J., Abele A., Marian C., Hussler A., Herbert T. A., Woolf C. J., Tegeder I., Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats Pain 2008 138 1 130 142
26. Streit W. J., Braak H., Xue Q. S., Bechmann I., Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in alzheimer's disease Acta Neuropathologica 2009 118 4 475 485
27. Lopes K. O., Sparks D. L., Streit W. J., Microglial dystrophy in the aged and alzheimer's disease brain is associated with ferritin immunoreactivity Glia 2008 56 10 1048 1060
28. Li Y., Liu L., Liu D., Woodward S., Barger S. W., Mrak R. E., Griffin W. S. T., Microglial activation by uptake of fdna via a scavenger receptor Journal of Neuroimmunology 2004 147 1-2 50 55 (Pubitemid 38114946)
29. Xiang Z., Haroutunian V., Ho L., Purohit D., Pasinetti G. M., Microglia activation in the brain as inflammatory biomarker of alzheimer's disease neuropathology and clinical dementia Disease Markers 2006 22 1-2 95 102 (Pubitemid 41831608)
30. Vehmas A. K., Kawas C. H., Stewart W. F., Troncoso J. C., Immune reactive cells in senile plaques and cognitive decline in alzheimer's disease Neurobiology of Aging 2003 24 2 321 331 (Pubitemid 36005412)
31. Braak H., Braak E., Neuropathological stageing of alzheimer-related changes Acta Neuropathologica 1991 82 4 239 259
32. Griffin W. S. T., Jin Gen Sheng, Roberts G. W., Mrak R. E., Interleukin-1 expression in different plaque types in alzheimer's disease: significance in plaque evolution Journal of Neuropathology and Experimental Neurology 1995 54 2 276 281
33. Sheng J. G., Mrak R. E., Griffin W. S. T., Microglial interleukin-1 expression in brain regions in alzheimer's disease: correlation with neuritic plaque distribution Neuropathology and Applied Neurobiology 1995 21 4 290 301
34. Sheng J. G., Griffin W. S. T., Royston M. C., Mrak R. E., Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in alzheimer's disease Neuropathology and Applied Neurobiology 1998 24 4 278 283 (Pubitemid 28389124)
35. Rozemuller J. M., Eikelenboom P., Stam F. C., Beyreuther K., Masters C. L., A4 protein in alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition Journal of Neuropathology and Experimental Neurology 1989 48 6 674 691 (Pubitemid 19257817)
36. Sheng J. G., Mrak R. E., Griffin W. S. T., Neuritic plaque evolution in alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms Acta Neuropathologica 1997 94 1 1 5 (Pubitemid 27289095)
37. Mackenzie I. R. A., Hao C., Munoz D. G., Role of microglia in senile plaque formation Neurobiology of Aging 1995 16 5 797 804
38. Ryu J. K., McLarnon J. G., A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed alzheimer's disease brain Journal of Cellular and Molecular Medicine 2009 13 9 A 2911 2925
39. Fukumoto H., Asami-Odaka A., Suzuki N., Iwatsubo T., Association of a 40-positive senile plaques with microglial cells in the brains of patients with alzheimer's disease and in non-demented aged individuals Neurodegeneration 1996 5 1 13 17 (Pubitemid 26132262)
40. Wilcock D. M., Colton C. A., Anti-amyloid- immunotherapy in alzheimer's disease: relevance of transgenic mouse studies to clinical trials Journal of Alzheimer's Disease 2008 15 4 555 569
41. Arends Y. M., Duyckaerts C., Rozemuller J. M., Eikelenboom P., Hauw J. J., Microglia, amyloid and dementia in alzheimer disease: a correlative study Neurobiology of Aging 2000 21 1 39 47 (Pubitemid 30224784)
42. Thal D. R., Arendt T., Waldmann G., Holzer M., Zedlick D., Rb U., Schober R., Progression of neurofibrillary changes and phf- in end-stage alzheimer's disease is different from plaque and cortical microglial pathology Neurobiology of Aging 1998 19 6 517 525 (Pubitemid 29117118)
43. Li Y., Liu L., Barger S. W., Griffin W. S. T., Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-mapk pathway Journal of Neuroscience 2003 23 5 1605 1611 (Pubitemid 36314715)
44. Sheng J. G., Zhou X. Q., Mrak R. E., Griffin W. S. T., Progressive neuronal injury associated with amyloid plaque formation in alzheimer disease Journal of Neuropathology and Experimental Neurology 1998 57 7 714 717 (Pubitemid 28335060)
45. Troncoso J. C., Sukhov R. R., Kawas C. H., Koliatsos V. E., In situ labeling of dying cortical neurons in normal aging and in alzheimer's disease: correlations with senile plaques and disease progression Journal of Neuropathology and Experimental Neurology 1996 55 11 1134 1142 (Pubitemid 26372790)
46. Sheffield L. G., Marquis J. G., Berman N. E. J., Regional distribution of cortical microglia parallels that of neurofibrillary tangles in alzheimer's disease Neuroscience Letters 2000 285 3 165 168 (Pubitemid 30252054)
47. Sheng J. G., Mrak R. E., Griffin W. S. T., Glial-neuronal interactions in alzheimer disease: progressive association of il-1 + microglia and s100 + astrocytes with neurofibrillary tangle stages Journal of Neuropathology and Experimental Neurology 1997 56 3 285 290 (Pubitemid 27461169)
48. Alzheimer A., Ueber eigenartige Krankheitsfaelle des spaeteren Alters Zeitschrift fur Die Gesamte Neurologie und Psychiatrie 1911 4 356 385
49. Lobsiger C. S., Cleveland D. W., Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease Nature Neuroscience 2007 10 11 1355 1360 (Pubitemid 350014678)
50. Moisse K., Strong M. J., Innate immunity in amyotrophic lateral sclerosis Biochimica Et Biophysica Acta 2006 1762 11-12 1083 1093 (Pubitemid 44750573)
51. Sargsyan S. A., Monk P. N., Shaw P. J., Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis Glia 2005 51 4 241 253 (Pubitemid 41532100)
52. Tai Y. F., Pavese N., Gerhard A., Tabrizi S. J., Barker R. A., Brooks D. J., Piccini P., Microglial activation in presymptomatic Huntington's disease gene carriers Brain 2007 130 7 1759 1766 (Pubitemid 47343790)
53. Sawada M., Imamura K., Nagatsu T., Role of cytokines in inflammatory process in parkinson's disease Journal of Neural Transmission, Supplement 2006 70 373 381 (Pubitemid 44622226)
54. McGeer P. L., McGeer E. G., Inflammation and neurodegeneration in parkinson's disease Parkinsonism and Related Disorders 2004 10 1 S3 S7
55. Vila M., Jackson-Lewis V., Guégan C., Chu Wu D., Teismann P., Choi D. K., Tieu K., Przedborski S., The role of glial cells in parkinson's disease Current Opinion in Neurology 2001 14 4 483 489 (Pubitemid 32703541)
56. Iseki E., Marui W., Akiyama H., Uéda K., Kosaka K., Degeneration process of lewy bodies in the brains of patients with dementia with lewy bodies using -synuclein-immunohistochemistry Neuroscience Letters 2000 286 1 69 73 (Pubitemid 30259123)
57. Ishizawa K., Komori T., Sasaki S., Arai N., Mizutani T., Hirose T., Microglial activation parallels system degeneration in multiple system atrophy Journal of Neuropathology and Experimental Neurology 2004 63 1 43 52 (Pubitemid 38030232)
58. Mrak R. E., Griffin W. S. T., Common inflammatory mechanisms in lewy body disease and alzheimer disease Journal of Neuropathology and Experimental Neurology 2007 66 8 683 686 (Pubitemid 47344247)
59. Sheng J. G., Mrak R. E., Griffin W. S. T., Enlarged and phagocytic, but not primed, interleukin-1 -immunoreactive microglia increase with age in normal human brain Acta Neuropathologica 1998 95 3 229 234 (Pubitemid 28120667)
60. Mrak R. E., Griffin W. S. T., Glia and their cytokines in progression of neurodegeneration Neurobiology of Aging 2005 26 3 349 354 (Pubitemid 40082718)
61. Griffin W. S. T., Sheng J. G., Gentleman S. M., Graham D. I., Mrak R. E., Roberts G. W., Microglial interleukin-1 expression in human head injury: correlations with neuronal and neuritic p-amyloid precursor protein expression Neuroscience Letters 1994 176 2 133 136
62. Valente T., Gella A., Fernndez-Busquets X., Unzeta M., Durany N., Immunohistochemical analysis of human brain suggests pathological synergism of alzheimer's disease and diabetes mellitus Neurobiology of Disease 2010 37 1 67 76
63. Streit W. J., Sparks D. L., Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits Journal of Molecular Medicine 1997 75 2 130 138 (Pubitemid 27119492)
64. Sheng J. G., Boop F. A., Mrak R. E., Griffin W. S. T., Increased neuronal -amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 immunoreactivity Journal of Neurochemistry 1994 63 5 1872 1879
65. Stanley L. C., Mrak R. E., Woody R. C., Perrot L. J., Zhang S., Marshak D. R., Nelson S. J., Griffin W. S. T., Glial cytokines as neuropathogenic factors in hiv infection: pathogenic similarities to alzheimer's disease Journal of Neuropathology and Experimental Neurology 1994 53 3 231 238 (Pubitemid 24146860)
66. Mackenzie I. R. A., Miller L. A., Senile plaques in temporal lobe epilepsy Acta Neuropathologica 1994 87 5 504 510 (Pubitemid 24128978)
67. Esiri M. M., Biddolph S. C., Morris C. S., Prevalence of Alzheimer plaques in AIDS Journal of Neurology, Neurosurgery Psychiatyry 1998 65 1 29 33 (Pubitemid 28302353)